Rnpep (arginyl aminopeptidase) - Rat Genome Database

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Gene: Rnpep (arginyl aminopeptidase) Rattus norvegicus
Analyze
Symbol: Rnpep
Name: arginyl aminopeptidase
RGD ID: 621137
Description: Enables metalloaminopeptidase activity; peptide binding activity; and transition metal ion binding activity. Involved in negative regulation of blood pressure; protein processing; and retina development in camera-type eye. Located in external side of plasma membrane; extracellular space; and secretory granule. Used to study hypertension. Biomarker of hypertension. Orthologous to human RNPEP (arginyl aminopeptidase); PARTICIPATES IN angiotensin IV signaling pathway; renin-angiotensin cascade pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aminopeptidase B; AP-B; arginine aminopeptidase; arginyl aminopeptidase (aminopeptidase B); cytosol aminopeptidase IV
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Bp328 Bp396
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21346,699,458 - 46,717,829 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1346,699,463 - 46,717,998 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1349,306,528 - 49,324,611 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01350,594,605 - 50,612,686 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01347,860,650 - 47,879,132 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01352,092,863 - 52,124,006 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1352,092,859 - 52,111,363 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01357,144,697 - 57,163,164 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41348,267,923 - 48,286,295 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11348,281,967 - 48,300,338 (-)NCBI
Celera1347,022,135 - 47,040,506 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-naphthylamine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dehydroepiandrosterone  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
diethylstilbestrol  (ISO)
elemental selenium  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
Mesaconitine  (EXP)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
ozone  (EXP,ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
pentachlorophenol  (ISO)
phenobarbital  (ISO)
pirimiphos-methyl  (EXP)
rotenone  (EXP)
selenium atom  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
trimellitic anhydride  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Aminopeptidase B: a processing enzyme secreted and associated with the plasma membrane of rat pheochromocytoma (PC12) cells. Balogh A, etal., J Cell Sci. 1998 Jan;111 ( Pt 2):161-9.
2. Aminopeptidase B from the rat testis is a bifunctional enzyme structurally related to leukotriene-A4 hydrolase. Cadel S, etal., Proc Natl Acad Sci U S A 1997 Apr 1;94(7):2963-8.
3. Renin-angiotensin system-regulating aminopeptidase activities are modified in the pineal gland of rats with breast cancer induced by N-methyl-nitrosourea. Carrera MP, etal., Cancer Invest. 2006 Mar;24(2):149-53.
4. Congenic mapping and sequence analysis of the Renin locus. Flister MJ, etal., Hypertension. 2013 Apr;61(4):850-6. doi: 10.1161/HYPERTENSIONAHA.111.01008. Epub 2013 Mar 4.
5. Miniglucagon (MG)-generating endopeptidase, which processes glucagon into MG, is composed of N-arginine dibasic convertase and aminopeptidase B. Fontes G, etal., Endocrinology. 2005 Feb;146(2):702-12. Epub 2004 Nov 11.
6. Aminopeptidase B is structurally related to leukotriene-A4 hydrolase but is not a bifunctional enzyme with epoxide hydrolase activity. Fukasawa KM, etal., Biochem J 1999 May 1;339 ( Pt 3):497-502.
7. Molecular cloning and expression of rat liver aminopeptidase B. Fukasawa KM, etal., J Biol Chem 1996 Nov 29;271(48):30731-5.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Characterization of the metal-binding site in aminopeptidase B. Hirose J, etal., Biol Pharm Bull. 2006 Dec;29(12):2378-82.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Expression of aminopeptidase B in the developing and adult rat retina. Piesse C, etal., Exp Eye Res. 2004 Nov;79(5):639-48.
14. Insulin-regulated aminopeptidase/placental leucil Aminopeptidase (IRAP/P-lAP) and angiotensin IV-forming activities are modified in serum of rats with breast cancer induced by N-methyl-nitrosourea. Pilar Carrera M, etal., Anticancer Res. 2006 Mar-Apr;26(2A):1011-4.
15. Activities of aminopeptidases in a rat saline model of volume hypertension. Prieto I, etal., Horm Metab Res. 1998 May;30(5):246-8.
16. Developmental and ageing changes in aminopeptidase activities in selected tissues of the rat. Ramirez M, etal., Experientia. 1993 Apr 15;49(4):300-3.
17. Soluble and membrane-bound leucyl- and arginyl-aminopeptidase activities in subcellular fractions of young and adult rat brains. Ramirez M, etal., Rev Esp Fisiol. 1990 Dec;46(4):393-7.
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
22. Dysfunction of central angiotensinergic aminopeptidase activity in spontaneously hypertensive rats. Wright JW, etal., Neurosci Lett. 1985 Nov 11;61(3):351-6.
Additional References at PubMed
PMID:10467730   PMID:12119107   PMID:18547641   PMID:18571504   PMID:19056867   PMID:19199708   PMID:21237246   PMID:23376485   PMID:23533145   PMID:27068509   PMID:32357304  


Genomics

Comparative Map Data
Rnpep
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21346,699,458 - 46,717,829 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1346,699,463 - 46,717,998 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1349,306,528 - 49,324,611 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01350,594,605 - 50,612,686 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01347,860,650 - 47,879,132 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01352,092,863 - 52,124,006 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1352,092,859 - 52,111,363 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01357,144,697 - 57,163,164 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41348,267,923 - 48,286,295 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11348,281,967 - 48,300,338 (-)NCBI
Celera1347,022,135 - 47,040,506 (-)NCBICelera
Cytogenetic Map13q13NCBI
RNPEP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381201,982,648 - 202,006,143 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1201,982,372 - 202,006,147 (+)EnsemblGRCh38hg38GRCh38
GRCh371201,951,776 - 201,975,271 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361200,218,389 - 200,241,898 (+)NCBINCBI36Build 36hg18NCBI36
Build 341198,683,422 - 198,706,931NCBI
Celera1175,075,517 - 175,099,029 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1173,117,652 - 173,141,163 (+)NCBIHuRef
CHM1_11203,373,998 - 203,397,522 (+)NCBICHM1_1
T2T-CHM13v2.01201,240,334 - 201,263,798 (+)NCBIT2T-CHM13v2.0
Rnpep
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,190,447 - 135,211,765 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1135,190,450 - 135,211,822 (-)EnsemblGRCm39 Ensembl
GRCm381135,262,699 - 135,284,423 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1135,262,712 - 135,284,084 (-)EnsemblGRCm38mm10GRCm38
MGSCv371137,159,276 - 137,180,661 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361137,079,123 - 137,100,445 (-)NCBIMGSCv36mm8
Celera1137,887,970 - 137,909,160 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map158.43NCBI
Rnpep
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540638,103,426 - 38,122,358 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540638,103,701 - 38,122,162 (+)NCBIChiLan1.0ChiLan1.0
RNPEP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1147,341,586 - 47,366,097 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01177,579,349 - 177,602,865 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11181,881,128 - 181,904,334 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1181,880,404 - 181,903,906 (+)Ensemblpanpan1.1panPan2
RNPEP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.17966,563 - 985,169 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl7966,607 - 984,714 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha71,018,226 - 1,036,397 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.07974,388 - 992,561 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl7974,388 - 992,593 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.17962,438 - 980,611 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.071,070,635 - 1,088,791 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.071,094,644 - 1,112,818 (-)NCBIUU_Cfam_GSD_1.0
Rnpep
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934473,269,882 - 73,290,311 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365672,504,537 - 2,525,018 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365672,504,544 - 2,524,977 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RNPEP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1024,218,139 - 24,235,518 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11024,218,144 - 24,235,520 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21028,635,318 - 28,639,788 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RNPEP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12527,401,749 - 27,426,371 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2527,401,757 - 27,426,410 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605528,184,309 - 28,208,990 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rnpep
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248078,737,839 - 8,754,414 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rnpep
74 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:158
Count of miRNA genes:119
Interacting mature miRNAs:129
Transcripts:ENSRNOT00000009198
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
4145117Mcs27Mammary carcinoma susceptibility QTL 270.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)134343790447841255Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134372077062022792Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879472Bp399Blood pressure QTL 399arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134522835847841255Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat

Markers in Region
D13Hmgc24  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21346,706,087 - 46,706,205 (+)MAPPERmRatBN7.2
Rnor_6.01352,099,496 - 52,099,613NCBIRnor6.0
Rnor_5.01357,151,330 - 57,151,447UniSTSRnor5.0
RGSC_v3.41348,274,553 - 48,274,670UniSTSRGSC3.4
Celera1347,028,765 - 47,028,882UniSTS
Cytogenetic Map13q13UniSTS
BF400237  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21346,710,130 - 46,710,311 (+)MAPPERmRatBN7.2
Rnor_6.01352,103,539 - 52,103,719NCBIRnor6.0
Rnor_5.01357,155,373 - 57,155,553UniSTSRnor5.0
RGSC_v3.41348,278,596 - 48,278,776UniSTSRGSC3.4
Celera1347,032,808 - 47,032,988UniSTS
RH 3.4 Map13163.8UniSTS
Cytogenetic Map13q13UniSTS
BF386633  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21346,703,639 - 46,703,836 (+)MAPPERmRatBN7.2
Rnor_6.01352,097,048 - 52,097,244NCBIRnor6.0
Rnor_5.01357,148,882 - 57,149,078UniSTSRnor5.0
RGSC_v3.41348,272,105 - 48,272,301UniSTSRGSC3.4
Celera1347,026,317 - 47,026,513UniSTS
RH 3.4 Map13168.1UniSTS
Cytogenetic Map13q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 40 43 31 19 31 2 4 74 35 41 11 2
Low 3 14 10 10 6 7 6
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000009198   ⟹   ENSRNOP00000009198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1346,699,463 - 46,717,998 (-)Ensembl
Rnor_6.0 Ensembl1352,092,859 - 52,111,363 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115357   ⟹   ENSRNOP00000091649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1346,699,463 - 46,717,998 (-)Ensembl
RefSeq Acc Id: NM_031097   ⟹   NP_112359
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21346,699,458 - 46,717,829 (-)NCBI
Rnor_6.01352,092,866 - 52,111,237 (-)NCBI
Rnor_5.01357,144,697 - 57,163,164 (-)NCBI
RGSC_v3.41348,267,923 - 48,286,295 (-)RGD
Celera1347,022,135 - 47,040,506 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_112359 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB52971 (Get FASTA)   NCBI Sequence Viewer  
  AAH61718 (Get FASTA)   NCBI Sequence Viewer  
  BAA13413 (Get FASTA)   NCBI Sequence Viewer  
  EDM09701 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009198
  ENSRNOP00000009198.3
  ENSRNOP00000091649.1
GenBank Protein O09175 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112359   ⟸   NM_031097
- UniProtKB: G3V6V1 (UniProtKB/TrEMBL),   A6ICE6 (UniProtKB/TrEMBL),   Q6P7D2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009198   ⟸   ENSRNOT00000009198
RefSeq Acc Id: ENSRNOP00000091649   ⟸   ENSRNOT00000115357
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O09175-F1-model_v2 AlphaFold O09175 1-650 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698841
Promoter ID:EPDNEW_R9365
Type:initiation region
Name:Rnpep_1
Description:arginyl aminopeptidase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01352,111,259 - 52,111,319EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621137 AgrOrtholog
BioCyc Gene G2FUF-18212 BioCyc
Ensembl Genes ENSRNOG00000006720 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009198 ENTREZGENE
  ENSRNOT00000009198.6 UniProtKB/TrEMBL
  ENSRNOT00000115357.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.320 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1730 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.2010.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598331 IMAGE-MGC_LOAD
InterPro Aminopeptidase_N-like_N UniProtKB/Swiss-Prot
  Aminopeptidase_N-like_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aminopeptidase_N-like_N UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M1_LTA-4_hydro/amino_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M1_LTA4H UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M4/M1_CTD_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81761 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72412 IMAGE-MGC_LOAD
NCBI Gene 81761 ENTREZGENE
PANTHER PTHR45726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45726:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Leuk-A4-hydro_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rnpep PhenoGen
PRINTS ALADIPTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006720 RatGTEx
SMART Leuk-A4-hydro_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63737 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6GJU0_RAT UniProtKB/TrEMBL
  A6ICE6 ENTREZGENE, UniProtKB/TrEMBL
  AMPB_RAT UniProtKB/Swiss-Prot
  G3V6V1 ENTREZGENE, UniProtKB/TrEMBL
  O09175 ENTREZGENE
  Q6P7D2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P97530 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Rnpep  arginyl aminopeptidase  Rnpep  arginyl aminopeptidase (aminopeptidase B)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Rnpep  arginyl aminopeptidase (aminopeptidase B)    aminopeptidase B  Name updated 1299863 APPROVED
2002-08-07 Rnpep  aminopeptidase B      Symbol and Name status set to provisional 70820 PROVISIONAL