Socs3 (suppressor of cytokine signaling 3) - Rat Genome Database

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Gene: Socs3 (suppressor of cytokine signaling 3) Rattus norvegicus
Symbol: Socs3
Name: suppressor of cytokine signaling 3
RGD ID: 621087
Description: Predicted to enable kinase regulator activity; miRNA binding activity; and phosphotyrosine residue binding activity. Involved in several processes, including cell surface receptor signaling pathway via JAK-STAT; cellular response to type II interferon; and response to peptide hormone. Predicted to be part of phosphatidylinositol 3-kinase complex. Predicted to be active in cytoplasmic side of plasma membrane. Biomarker of obesity; status epilepticus; and type 2 diabetes mellitus. Orthologous to human SOCS3 (suppressor of cytokine signaling 3); PARTICIPATES IN erythropoietin signaling pathway; insulin signaling pathway; interleukin-2 signaling pathway; INTERACTS WITH (S)-nicotine; 1-naphthyl isothiocyanate; 15-deoxy-Delta(12,14)-prostaglandin J2.
Type: protein-coding
Previously known as: Cish3; cytokine inducible SH2-containing protein 3; cytokine-inducible SH2 protein 3; Socs-3; Ssi-3
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Slep8 Insul15
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr810103,692,579 - 103,695,975 (-)NCBIGRCr8
mRatBN7.210103,193,909 - 103,197,322 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10103,193,537 - 103,197,787 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10108,296,539 - 108,297,401 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010107,759,666 - 107,760,528 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010103,115,997 - 103,116,859 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010106,973,863 - 106,976,969 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10106,975,178 - 106,976,040 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010106,611,459 - 106,616,694 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410107,958,468 - 107,959,330 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110107,972,971 - 107,973,834 (-)NCBI
Celera10101,756,900 - 101,757,762 (-)NCBICelera
Cytogenetic Map10q32.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (EXP,ISO)
3-phenylprop-2-enal  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
5-formyltetrahydrofolic acid  (ISO)
8-Br-cAMP  (ISO)
acetic acid  (EXP)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
ammonium hexachloroplatinate  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
aristolochic acids  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atropine  (ISO)
avobenzone  (ISO)
azoxystrobin  (EXP)
Bardoxolone methyl  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
berberine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGS-21680  (EXP)
chenodeoxycholic acid  (ISO)
chloroethene  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
cisplatin  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyproconazole  (ISO)
D-glucose  (ISO)
delta-tocotrienol  (ISO)
deoxynivalenol  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethyl maleate  (ISO)
dimercaprol  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
entinostat  (ISO)
erlotinib hydrochloride  (EXP)
estriol  (ISO)
ethanol  (EXP)
fenofibrate  (EXP)
fenthion  (ISO)
fipronil  (EXP)
flavone  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
galanthamine  (EXP)
gemfibrozil  (ISO)
genistein  (ISO)
gentamycin  (EXP)
ginsenoside Re  (ISO)
glucose  (ISO)
glyphosate  (EXP)
GW 3965  (EXP)
hesperetin  (EXP)
hexachlorobenzene  (EXP)
hexaconazole  (ISO)
hexadecanoic acid  (ISO)
hexamethylene diisocyanate  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
imidacloprid  (EXP)
isoeugenol  (ISO)
isoflavones  (ISO)
isoprenaline  (ISO)
ketamine  (ISO)
KT 5720  (ISO)
L-methionine  (ISO)
Licochalcone B  (ISO)
linagliptin  (EXP)
lipopolysaccharide  (ISO)
LY294002  (ISO)
malathion  (ISO)
melittin  (ISO)
mesalamine  (EXP)
methamphetamine  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
Monobutylphthalate  (ISO)
monosodium L-glutamate  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP)
nitrobenzenes  (EXP)
ochratoxin A  (EXP)
oleic acid  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphane  (EXP)
pirinixic acid  (EXP,ISO)
poly(I:C)  (ISO)
potassium cyanide  (ISO)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
prostaglandin F2alpha  (EXP)
protein kinase inhibitor  (ISO)
pyrimethamine  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (EXP)
rofecoxib  (ISO)
rolipram  (ISO)
rotenone  (ISO)
rutin  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
selumetinib  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP,ISO)
stattic  (ISO)
streptozocin  (EXP)
succimer  (ISO)
sulfasalazine  (EXP)
sulpiride  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tofacitinib  (ISO)
topotecan  (EXP)
trans-isoeugenol  (ISO)
tremolite asbestos  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (IEP)
branching involved in labyrinthine layer morphogenesis  (IEA,ISO)
cell differentiation  (IEA,ISO)
cell surface receptor signaling pathway via JAK-STAT  (IDA,TAS)
cellular response to interleukin-17  (IEA,ISO)
cellular response to leukemia inhibitory factor  (IEA,ISO)
cellular response to thyrotropin-releasing hormone  (IEP)
cellular response to type II interferon  (IEP)
intracellular signal transduction  (IDA,IEA)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of insulin receptor signaling pathway  (IEA,ISO)
negative regulation of receptor signaling pathway via JAK-STAT  (ISO)
negative regulation of signal transduction  (ISO)
negative regulation of tyrosine phosphorylation of STAT protein  (IEA,ISO)
phosphatidylinositol phosphate biosynthetic process  (IBA)
placenta blood vessel development  (IEA,ISO)
positive regulation of cell differentiation  (IEA,ISO)
protein ubiquitination  (IEA)
regulation of cell growth  (TAS)
regulation of protein phosphorylation  (ISO)
response to bacterium  (IEP)
response to cytokine  (IEP)
response to estradiol  (IEP)
response to food  (IEP)
response to gamma radiation  (IEP)
response to glucocorticoid  (IEP)
response to hormone  (IEP)
response to hypoxia  (IEP)
response to insulin  (IEP)
response to lipopolysaccharide  (IEP)
response to organic cyclic compound  (IEP)
response to peptide hormone  (IEP)
response to progesterone  (IEP)
response to xenobiotic stimulus  (IEP)
signal transduction  (ISO)

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. SOCS3 was induced by hypoxia and suppressed STAT3 phosphorylation in pulmonary arterial smooth muscle cells. Bai L, etal., Respir Physiol Neurobiol. 2006 May;152(1):83-91. Epub 2005 Aug 24.
2. Suppressor of cytokine signaling 3 is induced by angiotensin II in heart and isolated cardiomyocytes, and participates in desensitization. Calegari VC, etal., Endocrinology 2003 Oct;144(10):4586-96. Epub 2003 Jun 26.
3. Expression of suppressors of cytokine signaling-3 in Helicobacter pylori-infected rat gastric mucosal RGM-1cells. Cha B, etal., Ann N Y Acad Sci. 2007 Jan;1096:24-8.
4. A prostaglandin f(2alpha) analog induces suppressors of cytokine signaling-3 expression in the corpus luteum of the pregnant rat: a potential new mechanism in luteolysis. Curlewis JD, etal., Endocrinology 2002 Oct;143(10):3984-93.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Caffeic acid phenethyl ester modifies the Th1/Th2 balance in ileal mucosa after gamma-irradiation in the rat by modulating the cytokine pattern. Gremy O, etal., World J Gastroenterol. 2006 Aug 21;12(31):4996-5004.
8. Sepsis-induced muscle growth hormone resistance occurs independently of STAT5 phosphorylation. Hong-Brown LQ, etal., Am J Physiol Endocrinol Metab. 2003 Jul;285(1):E63-72. Epub 2003 Mar 18.
9. Attenuation of leptin and insulin signaling by SOCS proteins. Howard JK and Flier JS, Trends Endocrinol Metab. 2006 Nov;17(9):365-71. Epub 2006 Sep 28.
10. Insulin attenuates the systemic inflammatory response in endotoxemic rats. Jeschke MG, etal., Endocrinology. 2004 Sep;145(9):4084-93. Epub 2004 Jun 10.
11. Differential expression of suppressors of cytokine signalling genes in response to nutrition and growth hormone in the septic rat. Johnson TS, etal., J Endocrinol 2001 May;169(2):409-15.
12. Signaling through the JAK/STAT pathway, recent advances and future challenges. Kisseleva T, etal., Gene 2002 Feb 20;285(1-2):1-24.
13. Thermal injury-induced increases of hepatocyte SOCS3 lead to decreases in STAT3. Kong F, etal., Shock 2002 Oct;18(4):374-9.
14. Regulation of the acid-labile subunit in sustained endotoxemia. Kong SE, etal., Am J Physiol Endocrinol Metab 2002 Oct;283(4):E692-701.
15. Genetic association analysis of 30 genes related to obesity in a European American population. Li P, etal., Int J Obes (Lond). 2014 May;38(5):724-9. doi: 10.1038/ijo.2013.140. Epub 2013 Jul 31.
16. Acute induction of inflammatory cytokine expression after gamma-irradiation in the rat: effect of an NF-kappaB inhibitor. Linard C, etal., Int J Radiat Oncol Biol Phys. 2004 Feb 1;58(2):427-34.
17. Suppressors of cytokine-signaling proteins induce insulin resistance in the retina and promote survival of retinal cells. Liu X, etal., Diabetes. 2008 Jun;57(6):1651-8. Epub 2008 Mar 20.
18. Unique expression of suppressor of cytokine signaling 3 is essential for classical macrophage activation in rodents in vitro and in vivo. Liu Y, etal., J Immunol. 2008 May 1;180(9):6270-8.
19. Momordica charantia extracts ameliorate insulin resistance by regulating the expression of SOCS-3 and JNK in type 2 diabetes mellitus rats. Ma C, etal., Pharm Biol. 2017 Dec;55(1):2170-2177. doi: 10.1080/13880209.2017.1396350.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. 1Alpha,25-dihydroxyvitamin D3 inhibits GH-induced expression of SOCS-3 and CIS and prolongs growth hormone signaling via the Janus kinase (JAK2)/signal transducers and activators of transcription (STAT5) system in osteoblast-like cells. Morales O, etal., J Biol Chem 2002 Sep 20;277(38):34879-84.
22. Suppression of SOCS3 expression in the pancreatic beta-cell leads to resistance to type 1 diabetes. Mori H, etal., Biochem Biophys Res Commun. 2007 Aug 10;359(4):952-8. Epub 2007 Jun 4.
23. Decreased expression of SOCS-3 mRNA in breast cancer with lymph node metastasis. Nakagawa T, etal., Oncol Rep. 2008 Jan;19(1):33-9.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. In situ detection of SOCS and cytokine expression in the uterine cervix from HIV/HPV coinfected women. Nicol AF, etal., Exp Mol Pathol. 2006 Aug;81(1):42-7.
26. Type 2 diabetes impairs insulin receptor substrate-2-mediated phosphatidylinositol 3-kinase activity in primary macrophages to induce a state of cytokine resistance to IL-4 in association with overexpression of suppressor of cytokine signaling-3. O'Connor JC, etal., J Immunol. 2007 Jun 1;178(11):6886-93.
27. 15d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia. Park EJ, etal., J Biol Chem 2003 Apr 25;278(17):14747-52. Epub 2003 Feb 12.
28. Thyrotropin induces SOCS-1 (suppressor of cytokine signaling-1) and SOCS-3 in FRTL-5 thyroid cells. Park ES, etal., Mol Endocrinol. 2000 Mar;14(3):440-8. doi: 10.1210/mend.14.3.0433.
29. Regulation of expression of the rat SOCS-3 gene in hepatocytes by growth hormone, interleukin-6 and glucocorticoids mRNA analysis and promoter characterization. Paul C, etal., Eur J Biochem. 2000 Oct;267(19):5849-57.
30. Leptin receptor expression and suppressor of cytokine signaling transcript levels in high-fat-fed rats. Peiser C, etal., Life Sci. 2000 Nov 3;67(24):2971-81.
31. Ageing increases SOCS-3 expression in rat hypothalamus: effects of food restriction. Peralta S, etal., Biochem Biophys Res Commun 2002 Aug 16;296(2):425-8.
32. Ageing increases SOCS-3 expression in rat hypothalamus: effects of food restriction. Peralta S, etal., Biochem Biophys Res Commun 2002 Aug 16;296(2):425.
33. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
34. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
35. Suppressor of cytokine signalling gene expression is elevated in breast carcinoma. Raccurt M, etal., Br J Cancer. 2003 Aug 4;89(3):524-32.
36. Gene expression analysis of spontaneously hypertensive rat cerebral cortex following transient focal cerebral ischemia. Raghavendra Rao VL, etal., J Neurochem 2002 Dec;83(5):1072-86.
37. GOA pipeline RGD automated data pipeline
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. Suppressor of cytokine signaling 3 expression and insulin resistance in skeletal muscle of obese and type 2 diabetic patients. Rieusset J, etal., Diabetes. 2004 Sep;53(9):2232-41.
40. Differential expression of suppressors of cytokine signaling-1, -2, and -3 in the rat hippocampus after seizure: implications for neuromodulation by gp130 cytokines. Rosell DR, etal., Neuroscience. 2003;122(2):349-58.
41. Activation of signal transducer and activator transcription 3 and expression of suppressor of cytokine signal 1 during liver regeneration in rats. Sakuda S, etal., J Hepatol. 2002 Mar;36(3):378-84.
42. Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women. Seron K, etal., Biochem Biophys Res Commun. 2006 Oct 6;348(4):1232-8. Epub 2006 Jul 24.
43. Identification of blood biomarkers of rheumatoid arthritis by transcript profiling of peripheral blood mononuclear cells from the rat collagen-induced arthritis model. Shou J, etal., Arthritis Res Ther. 2006;8(1):R28. Epub 2006 Jan 10.
44. Hormonal regulation of suppressors of cytokine signaling (SOCS) messenger ribonucleic acid in the arcuate nucleus during late pregnancy. Steyn FJ, etal., Endocrinology. 2008 Jun;149(6):3206-14. Epub 2008 Mar 6.
45. Growth hormone reduces the severity of fibrosis associated with chronic intestinal inflammation. Theiss AL, etal., Gastroenterology. 2005 Jul;129(1):204-19.
46. The dual function of hepatic SOCS3 in insulin resistance in vivo. Torisu T, etal., Genes Cells. 2007 Feb;12(2):143-54.
47. Peroxisome proliferator-activated receptor-gamma agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents. Tureyen K, etal., J Neurochem. 2007 Apr;101(1):41-56.
48. Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Ueki K, etal., Mol Cell Biol. 2004 Jun;24(12):5434-46.
49. Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. Ueki K, etal., Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10422-7. Epub 2004 Jul 6.
50. The Prognostic Role of SOCS3 and A20 in Human Cholangiocarcinoma. Wang Y, etal., PLoS One. 2015 Oct 20;10(10):e0141165. doi: 10.1371/journal.pone.0141165. eCollection 2015.
51. Leptin resistance of adipocytes in obesity: role of suppressors of cytokine signaling. Wang Z, etal., Biochem Biophys Res Commun. 2000 Oct 14;277(1):20-6.
52. Galantamine anti-colitic effect: Role of alpha-7 nicotinic acetylcholine receptor in modulating Jak/STAT3, NF-κB/HMGB1/RAGE and p-AKT/Bcl-2 pathways. Wazea SA, etal., Sci Rep. 2018 Mar 23;8(1):5110. doi: 10.1038/s41598-018-23359-6.
53. Signatures associated with rejection or recurrence in HER-2/neu-positive mammary tumors. Worschech A, etal., Cancer Res. 2008 Apr 1;68(7):2436-46.
Additional References at PubMed
PMID:10579313   PMID:11108838   PMID:11481489   PMID:15118263   PMID:15358627   PMID:15514089   PMID:15578154   PMID:15893771   PMID:15998644   PMID:16185683   PMID:16258063   PMID:16289836  
PMID:16300827   PMID:16302975   PMID:16306356   PMID:16484300   PMID:16956890   PMID:16971535   PMID:17223256   PMID:17986523   PMID:18421861   PMID:18586073   PMID:19080716   PMID:19176113  
PMID:19272793   PMID:19293294   PMID:19386987   PMID:19408656   PMID:19639229   PMID:19643162   PMID:19693688   PMID:19862646   PMID:20185635   PMID:20193756   PMID:20303731   PMID:20439489  
PMID:20530874   PMID:20816823   PMID:20819948   PMID:20848345   PMID:21145973   PMID:21168220   PMID:21255014   PMID:21364493   PMID:21521717   PMID:21545521   PMID:22253420   PMID:22982470  
PMID:23007031   PMID:23222907   PMID:23401297   PMID:23669042   PMID:23948778   PMID:24078776   PMID:24088176   PMID:24091940   PMID:24142708   PMID:24463741   PMID:24660535   PMID:24685947  
PMID:24959867   PMID:25019494   PMID:25086044   PMID:25352752   PMID:25847945   PMID:26384335   PMID:27118613   PMID:28036111   PMID:28111888   PMID:28129651   PMID:28326931   PMID:29550470  
PMID:30763670   PMID:31799684   PMID:31857078   PMID:32030968   PMID:32438059   PMID:32630102   PMID:32989761   PMID:33255404   PMID:33300076   PMID:33522063   PMID:35702948   PMID:36793115  
PMID:37154979   PMID:37856074  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr810103,692,579 - 103,695,975 (-)NCBIGRCr8
mRatBN7.210103,193,909 - 103,197,322 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10103,193,537 - 103,197,787 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10108,296,539 - 108,297,401 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010107,759,666 - 107,760,528 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010103,115,997 - 103,116,859 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010106,973,863 - 106,976,969 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10106,975,178 - 106,976,040 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010106,611,459 - 106,616,694 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410107,958,468 - 107,959,330 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110107,972,971 - 107,973,834 (-)NCBI
Celera10101,756,900 - 101,757,762 (-)NCBICelera
Cytogenetic Map10q32.2NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381778,356,778 - 78,360,925 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1778,356,778 - 78,360,077 (-)EnsemblGRCh38hg38GRCh38
GRCh371776,352,859 - 76,357,006 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361773,864,454 - 73,867,753 (-)NCBINCBI36Build 36hg18NCBI36
Build 341773,864,458 - 73,867,753NCBI
Celera1772,946,889 - 72,950,188 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1771,775,516 - 71,778,779 (-)NCBIHuRef
CHM1_11776,416,767 - 76,420,069 (-)NCBICHM1_1
T2T-CHM13v2.01779,250,300 - 79,254,447 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3911117,856,905 - 117,860,192 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11117,856,905 - 117,860,873 (-)EnsemblGRCm39 Ensembl
GRCm3811117,966,079 - 117,970,336 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11117,966,079 - 117,970,047 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711117,827,393 - 117,830,680 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611117,782,169 - 117,785,252 (-)NCBIMGSCv36mm8
Celera11129,709,800 - 129,713,087 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1182.96NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049555064,222,455 - 4,225,563 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555064,222,455 - 4,225,563 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21994,406,250 - 94,409,543 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11799,235,744 - 99,239,041 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01772,433,206 - 72,436,500 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11777,981,752 - 77,985,059 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1777,983,389 - 77,984,066 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.192,859,267 - 2,859,944 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha93,516,096 - 3,516,773 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.093,509,383 - 3,512,579 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl93,510,193 - 3,510,870 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.193,533,406 - 3,534,083 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.093,657,845 - 3,658,522 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.093,738,946 - 3,739,623 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_0244056023,476,572 - 3,479,692 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365942,933,747 - 2,934,451 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365942,932,297 - 2,935,358 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl123,643,929 - 3,647,009 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1123,643,832 - 3,647,015 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap12p15NCBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11670,353,099 - 70,356,401 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1670,354,746 - 70,355,423 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607741,479,311 - 41,482,614 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248017,840,889 - 7,843,860 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248017,841,230 - 7,843,912 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Socs3
14 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:84
Interacting mature miRNAs:91
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091228102104060283Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1096703043107057807Rat
631539Oia6Oil induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1097010147104670812Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210103,195,568 - 103,196,081 (+)MAPPERmRatBN7.2
Rnor_6.010106,975,511 - 106,976,023NCBIRnor6.0
Rnor_5.010106,613,107 - 106,613,619UniSTSRnor5.0
RGSC_v3.410107,958,801 - 107,959,313UniSTSRGSC3.4
Celera10101,757,233 - 101,757,745UniSTS
Cytogenetic Map10q32.3UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210103,195,944 - 103,196,081 (+)MAPPERmRatBN7.2
Rnor_6.010106,975,887 - 106,976,023NCBIRnor6.0
Rnor_5.010106,613,483 - 106,613,619UniSTSRnor5.0
RGSC_v3.410107,959,177 - 107,959,313UniSTSRGSC3.4
Celera10101,757,609 - 101,757,745UniSTS
Cytogenetic Map10q32.3UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.010106,976,490 - 106,977,356NCBIRnor6.0
Rnor_5.010106,614,086 - 106,614,754UniSTSRnor5.0
RGSC_v3.410107,959,780 - 107,960,863UniSTSRGSC3.4
Celera10101,758,212 - 101,759,056UniSTS
Cytogenetic Map10q32.3UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 9 1 18 1 6 1 10 11
Low 1 43 48 40 1 40 8 11 68 34 30 8
Below cutoff 1


RefSeq Acc Id: ENSRNOT00000003940   ⟹   ENSRNOP00000003940
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl10106,975,178 - 106,976,040 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118098   ⟹   ENSRNOP00000097273
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10103,193,537 - 103,197,787 (-)Ensembl
RefSeq Acc Id: NM_053565   ⟹   NP_446017
Rat AssemblyChrPosition (strand)Source
GRCr810103,693,906 - 103,694,768 (-)NCBI
mRatBN7.210103,195,236 - 103,196,098 (-)NCBI
Rnor_6.010106,975,178 - 106,976,040 (-)NCBI
Rnor_5.010106,611,459 - 106,616,694 (-)NCBI
RGSC_v3.410107,958,468 - 107,959,330 (-)RGD
Celera10101,756,900 - 101,757,762 (-)RGD
RefSeq Acc Id: XM_008768398   ⟹   XP_008766620
Rat AssemblyChrPosition (strand)Source
GRCr810103,692,579 - 103,695,975 (-)NCBI
mRatBN7.210103,193,909 - 103,197,322 (-)NCBI
Rnor_6.010106,973,863 - 106,976,969 (-)NCBI
Protein Sequences
Protein RefSeqs NP_446017 (Get FASTA)   NCBI Sequence Viewer  
  XP_008766620 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC26223 (Get FASTA)   NCBI Sequence Viewer  
  CAB56083 (Get FASTA)   NCBI Sequence Viewer  
  EDM06745 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000097273
GenBank Protein O88583 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446017   ⟸   NM_053565
- UniProtKB: Q9QYV5 (UniProtKB/Swiss-Prot),   O88583 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008766620   ⟸   XM_008768398
- Peptide Label: isoform X1
- UniProtKB: G3V6D2 (UniProtKB/TrEMBL),   A6HL40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003940   ⟸   ENSRNOT00000003940
RefSeq Acc Id: ENSRNOP00000097273   ⟸   ENSRNOT00000118098
Protein Domains
SH2   SOCS box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88583-F1-model_v2 AlphaFold O88583 1-225 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621087 AgrOrtholog
BioCyc Gene G2FUF-22526 BioCyc
Ensembl Genes ENSRNOG00000002946 Ensembl
  ENSRNOG00000063373 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000118098.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS3_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:89829 UniProtKB/Swiss-Prot
  PTHR10155:SF11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Socs3 PhenoGen
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002946 RatGTEx
  ENSRNOG00000063373 RatGTEx
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF158235 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS3_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q9QYV5 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Socs3  suppressor of cytokine signaling 3  Cish3  cytokine inducible SH2-containing protein 3  Symbol and Name updated 1299863 APPROVED
2002-08-07 Cish3  cytokine inducible SH2-containing protein 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression increases in the hypothalamus with aging 625538
gene_expression expressed in mammary galnd with increases during the initial stages of mammary gland involution caused by pup withdrawal 625667
gene_process inhibits JAK activity and may mediate hypothalamic leptin resistance in aged Wistar rats. 625538
gene_process may play a role in the initiation of luteolysis via rapid suppression of luteotropic support from placental lactogen (PL) 625667
gene_product member of the suppressor-of-cytokine-signaling family 625538
gene_regulation transcription is induced by 15-deoxy-Delta12,14-prostaglandin J(2) and rosiglitazone 632385
gene_regulation cloprostenol, a PGF2 analog, rapidly increases mRNA level and is also strongly induced by STAT3 625667