Sfrp1 (secreted frizzled-related protein 1) - Rat Genome Database

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Gene: Sfrp1 (secreted frizzled-related protein 1) Rattus norvegicus
Analyze
Symbol: Sfrp1
Name: secreted frizzled-related protein 1
RGD ID: 621074
Description: Predicted to enable several functions, including Wnt-protein binding activity; frizzled binding activity; and heparin binding activity. Involved in several processes, including cellular response to prostaglandin E stimulus; negative regulation of canonical Wnt signaling pathway; and negative regulation of osteoclast differentiation. Predicted to be located in several cellular components, including cell surface; collagen-containing extracellular matrix; and extracellular space. Orthologous to human SFRP1 (secreted frizzled related protein 1); PARTICIPATES IN Wnt signaling, canonical pathway; Wnt signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: sFRP-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81675,278,325 - 75,316,736 (-)NCBIGRCr8
GRCr8 Ensembl1675,278,325 - 75,316,736 (-)EnsemblGRCr8 Ensembl
mRatBN7.21668,575,763 - 68,614,180 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1668,575,763 - 68,614,286 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1673,854,196 - 73,892,590 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01677,271,342 - 77,309,732 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01672,520,516 - 72,558,923 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01673,372,007 - 73,410,777 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1673,372,007 - 73,410,777 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01673,006,739 - 73,045,509 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41673,030,458 - 73,067,304 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1666,467,691 - 66,505,810 (-)NCBICelera
RGSC_v3.11673,031,966 - 73,066,892 (-)NCBI
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
3-aminobenzamide  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-formyltetrahydrofolic acid  (EXP)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (EXP,ISO)
biguanides  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
boron nitride  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
calciol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cytarabine  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
glycidyl methacrylate  (ISO)
glyphosate  (EXP)
heparin  (EXP)
hydroquinone  (ISO)
inulin  (ISO)
lead diacetate  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
methimazole  (EXP)
methotrexate  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
microcystin-LR  (EXP)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naphthalene  (ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sporidesmin A  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
theaflavin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)
XL147  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (IEA,ISO)
BMP signaling pathway  (IEA,ISO)
bone trabecula formation  (IEA,ISO)
canonical Wnt signaling pathway  (IEA,ISO)
cell differentiation  (IEA)
cellular response to BMP stimulus  (IEA,ISO)
cellular response to estradiol stimulus  (IEA,ISO)
cellular response to estrogen stimulus  (IEA,ISO)
cellular response to hypoxia  (IEA,ISO)
cellular response to interleukin-1  (IEA,ISO)
cellular response to prostaglandin E stimulus  (IEA,IEP,ISO)
cellular response to starvation  (IEA,ISO)
cellular response to transforming growth factor beta stimulus  (IEA,ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
cellular response to vitamin D  (IEA,ISO)
cellular response to X-ray  (IEA,ISO)
convergent extension involved in axis elongation  (IEA)
convergent extension involved in somitogenesis  (IEA,ISO)
development of primary male sexual characteristics  (IEA,ISO)
developmental process  (IEA)
digestive tract morphogenesis  (IEA,ISO)
dopaminergic neuron differentiation  (IEA,ISO)
dorsal/ventral axis specification  (IEA,ISO)
extrinsic apoptotic signaling pathway  (IEA,ISO)
female gonad development  (IEA,ISO)
hematopoietic progenitor cell differentiation  (IEA,ISO)
hematopoietic stem cell differentiation  (IEA,ISO)
hemopoiesis  (IEA,ISO)
male gonad development  (IEA,ISO)
negative regulation of androgen receptor signaling pathway  (IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of B cell differentiation  (IEA,ISO)
negative regulation of BMP signaling pathway  (IEA,ISO)
negative regulation of bone remodeling  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IDA,IEA,ISO)
negative regulation of cell growth  (IEA,ISO)
negative regulation of cell migration  (IEA,ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of epithelial cell proliferation  (IEA,ISO)
negative regulation of epithelial to mesenchymal transition  (IEA,ISO)
negative regulation of fibroblast apoptotic process  (IEA,ISO)
negative regulation of fibroblast proliferation  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of JUN kinase activity  (ISO)
negative regulation of ossification  (IEA,ISO)
negative regulation of osteoblast differentiation  (IEA,ISO)
negative regulation of osteoblast proliferation  (IEA,ISO)
negative regulation of osteoclast differentiation  (IEA,IMP,ISO)
negative regulation of peptidyl-tyrosine phosphorylation  (ISO)
negative regulation of Wnt signaling pathway  (IDA,IEA,ISO,TAS)
neural crest cell fate commitment  (IEA,ISO)
neural tube closure  (IEA,ISO)
neural tube development  (IEA,ISO)
osteoblast differentiation  (IEA,IEP,ISO)
osteoclast differentiation  (IEA,ISO)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of canonical Wnt signaling pathway  (IEA,ISO)
positive regulation of cell growth  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
positive regulation of fat cell differentiation  (IEA,ISO)
positive regulation of fibroblast apoptotic process  (IEA,ISO)
positive regulation of non-canonical Wnt signaling pathway  (IEA,ISO)
positive regulation of smoothened signaling pathway  (IEA,ISO)
positive regulation of Wnt signaling pathway  (IEA,ISO)
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis  (IEA,ISO)
regionalization  (IEA)
regulation of branching involved in prostate gland morphogenesis  (IEA,ISO)
regulation of cell cycle process  (IEA,ISO)
regulation of establishment of planar polarity  (IEA,ISO)
regulation of midbrain dopaminergic neuron differentiation  (IEA,ISO)
regulation of neuron projection development  (IEA,ISO)
regulation of ossification  (IEA,IMP)
response to xenobiotic stimulus  (IEA,ISO)
somatic stem cell population maintenance  (IEA,ISO)
somitogenesis  (IEA,ISO)
stem cell differentiation  (IEA)
ureteric bud development  (IEA,ISO)
Wnt signaling pathway  (IEA)
Wnt signaling pathway involved in somitogenesis  (IEA,ISO)
Wnt signaling pathway, planar cell polarity pathway  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis. Bodine PV, etal., J Cell Biochem. 2005 Dec 15;96(6):1212-30.
2. Secreted and transmembrane wnt inhibitors and activators. Cruciat CM and Niehrs C, Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a015081. doi: 10.1101/cshperspect.a015081.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Identification of genes differentially expressed in testes containing carcinoma in situ. Hoei-Hansen CE, etal., Mol Hum Reprod. 2004 Jun;10(6):423-31.
5. A DNA microarray analysis of chemokine and receptor genes in the rat dental follicle--role of secreted frizzled-related protein-1 in osteoclastogenesis. Liu D and Wise GE, Bone. 2007 Aug;41(2):266-72. Epub 2007 Apr 24.
6. Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma. Liu H, etal., BMC Syst Biol. 2010 Apr 27;4:51.
7. Overexpression of the Wnt5b gene in leiomyoma cells: implications for a role of the Wnt signaling pathway in the uterine benign tumor. Mangioni S, etal., J Clin Endocrinol Metab. 2005 Sep;90(9):5349-55. Epub 2005 Jun 21.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Secreted frizzled-related protein 1 modulates glucocorticoid attenuation of osteogenic activities and bone mass. Wang FS, etal., Endocrinology. 2005 May;146(5):2415-23. Epub 2005 Jan 27.
15. Transcriptional regulation of the promoter of the rat frizzled related protein gene by CREB. Yam JW, etal., Oncogene 2003 Jun 19;22(25):3901-10.
Additional References at PubMed
PMID:1927703   PMID:9192640   PMID:9391078   PMID:9724099   PMID:10347172   PMID:10654605   PMID:10660608   PMID:10980594   PMID:11287180   PMID:11741940   PMID:11932307   PMID:12055200  
PMID:14581477   PMID:14976225   PMID:15886250   PMID:16077939   PMID:16288033   PMID:16467359   PMID:16532032   PMID:16545622   PMID:17035233   PMID:17443492   PMID:17462603   PMID:17471511  
PMID:17500071   PMID:17994217   PMID:18257070   PMID:18371946   PMID:18787224   PMID:18941195   PMID:19072540   PMID:19095296   PMID:19100252   PMID:19199708   PMID:19254787   PMID:19277043  
PMID:19300477   PMID:19569235   PMID:19664990   PMID:19723665   PMID:19734317   PMID:19778523   PMID:19850029   PMID:19896444   PMID:20033841   PMID:20130188   PMID:20208569   PMID:20234818  
PMID:20551380   PMID:22206666   PMID:22290867   PMID:22313323   PMID:22535492   PMID:23073828   PMID:23376485   PMID:24006456   PMID:24080158   PMID:25046226   PMID:26282432   PMID:27048460  
PMID:27559042   PMID:29319176   PMID:31799642   PMID:32238888   PMID:34572140   PMID:36174667   PMID:37936560  


Genomics

Comparative Map Data
Sfrp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81675,278,325 - 75,316,736 (-)NCBIGRCr8
GRCr8 Ensembl1675,278,325 - 75,316,736 (-)EnsemblGRCr8 Ensembl
mRatBN7.21668,575,763 - 68,614,180 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1668,575,763 - 68,614,286 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1673,854,196 - 73,892,590 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01677,271,342 - 77,309,732 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01672,520,516 - 72,558,923 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01673,372,007 - 73,410,777 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1673,372,007 - 73,410,777 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01673,006,739 - 73,045,509 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41673,030,458 - 73,067,304 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1666,467,691 - 66,505,810 (-)NCBICelera
RGSC_v3.11673,031,966 - 73,066,892 (-)NCBI
Cytogenetic Map16q12.5NCBI
SFRP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38841,261,962 - 41,309,473 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl841,261,962 - 41,309,473 (-)EnsemblGRCh38hg38GRCh38
GRCh37841,119,481 - 41,166,992 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36841,238,635 - 41,286,137 (-)NCBINCBI36Build 36hg18NCBI36
Build 34841,238,635 - 41,286,137NCBI
Celera840,068,517 - 40,116,053 (-)NCBICelera
Cytogenetic Map8p11.21NCBI
HuRef839,647,919 - 39,695,566 (-)NCBIHuRef
CHM1_1841,167,412 - 41,215,102 (-)NCBICHM1_1
T2T-CHM13v2.0841,535,586 - 41,583,179 (-)NCBIT2T-CHM13v2.0
Sfrp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39823,901,401 - 23,939,648 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl823,901,518 - 23,939,648 (+)EnsemblGRCm39 Ensembl
GRCm38823,411,383 - 23,449,632 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl823,411,502 - 23,449,632 (+)EnsemblGRCm38mm10GRCm38
MGSCv37824,521,974 - 24,560,104 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36824,877,063 - 24,915,177 (+)NCBIMGSCv36mm8
Celera824,905,624 - 24,944,019 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map811.48NCBI
Sfrp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555361,663,344 - 1,703,514 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555361,663,721 - 1,702,678 (+)NCBIChiLan1.0ChiLan1.0
SFRP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2759,714,926 - 59,762,921 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1835,432,207 - 35,480,221 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0840,507,027 - 40,555,053 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1837,956,423 - 38,001,865 (-)NCBIpanpan1.1PanPan1.1panPan2
SFRP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11624,262,451 - 24,306,162 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1624,261,946 - 24,302,964 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1624,766,734 - 24,810,532 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01626,010,215 - 26,053,984 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1626,010,215 - 26,053,974 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11624,382,043 - 24,425,801 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01624,943,898 - 24,987,804 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01624,995,596 - 25,039,359 (+)NCBIUU_Cfam_GSD_1.0
Sfrp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494347,320,083 - 47,364,001 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367851,276,420 - 1,321,017 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367851,276,478 - 1,320,397 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SFRP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1710,436,426 - 10,489,748 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11710,436,414 - 10,489,773 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21711,790,230 - 11,878,539 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SFRP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1839,243,775 - 39,289,050 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl839,243,780 - 39,288,984 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660522,558,131 - 2,612,751 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sfrp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247802,132,960 - 2,174,508 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247802,133,105 - 2,172,301 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sfrp1
468 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:41
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000024128
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164445512389455123Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)163692878281928782Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)164199206486992064Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164909919691442908Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)166241446475736480Rat
1298527Arunc2Aerobic running capacity QTL 22.9exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)167523528581732231Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)163236104377361043Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)163105803976058039Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165942871491442908Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163439829479398294Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)163188527176885271Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164445512389455123Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165942871491442908Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165942871491442908Rat

Markers in Region
RH135173  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21668,579,854 - 68,580,064 (+)MAPPERmRatBN7.2
Rnor_6.01673,376,095 - 73,376,304NCBIRnor6.0
Rnor_5.01673,010,827 - 73,011,036UniSTSRnor5.0
RGSC_v3.41673,032,774 - 73,032,983UniSTSRGSC3.4
Celera1666,471,780 - 66,471,989UniSTS
RH 3.4 Map16635.6UniSTS
Cytogenetic Map16q12.5UniSTS
RH135431  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81675,280,096 - 75,280,290 (+)Marker Load Pipeline
mRatBN7.21668,577,534 - 68,577,728 (+)MAPPERmRatBN7.2
Rnor_6.01673,373,779 - 73,373,972NCBIRnor6.0
Rnor_5.01673,008,511 - 73,008,704UniSTSRnor5.0
RGSC_v3.41673,030,458 - 73,030,651UniSTSRGSC3.4
Celera1666,469,463 - 66,469,656UniSTS
RH 3.4 Map16660.2UniSTS
Cytogenetic Map16q12.5UniSTS
RH137493  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81675,280,711 - 75,280,911 (+)Marker Load Pipeline
mRatBN7.21668,578,149 - 68,578,349 (+)MAPPERmRatBN7.2
Rnor_6.01673,374,394 - 73,374,593NCBIRnor6.0
Rnor_5.01673,009,126 - 73,009,325UniSTSRnor5.0
RGSC_v3.41673,031,073 - 73,031,272UniSTSRGSC3.4
Celera1666,470,078 - 66,470,275UniSTS
Cytogenetic Map16q12.5UniSTS
RH141094  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21668,577,204 - 68,577,385 (+)MAPPERmRatBN7.2
Rnor_6.01673,373,449 - 73,373,629NCBIRnor6.0
Rnor_5.01673,008,181 - 73,008,361UniSTSRnor5.0
RGSC_v3.41673,030,128 - 73,030,308UniSTSRGSC3.4
Celera1666,469,133 - 66,469,313UniSTS
RH 3.4 Map16659.7UniSTS
Cytogenetic Map16q12.5UniSTS
RH141243  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21668,575,913 - 68,576,115 (+)MAPPERmRatBN7.2
Rnor_6.01673,372,158 - 73,372,359NCBIRnor6.0
Rnor_5.01673,006,890 - 73,007,091UniSTSRnor5.0
RGSC_v3.41673,028,256 - 73,028,457UniSTSRGSC3.4
Celera1666,467,842 - 66,468,043UniSTS
RH 3.4 Map16570.32UniSTS
Cytogenetic Map16q12.5UniSTS
Sfrp1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21668,578,094 - 68,578,875 (+)MAPPERmRatBN7.2
Rnor_6.01673,374,339 - 73,375,119NCBIRnor6.0
Rnor_5.01673,009,071 - 73,009,851UniSTSRnor5.0
RGSC_v3.41673,031,018 - 73,031,798UniSTSRGSC3.4
Celera1666,470,023 - 66,470,801UniSTS
Cytogenetic Map16q12.5UniSTS
Sfrp1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21668,578,094 - 68,578,873 (+)MAPPERmRatBN7.2
Rnor_6.01673,374,339 - 73,375,117NCBIRnor6.0
Rnor_5.01673,009,071 - 73,009,849UniSTSRnor5.0
RGSC_v3.41673,031,018 - 73,031,796UniSTSRGSC3.4
Celera1666,470,023 - 66,470,799UniSTS
Cytogenetic Map16q12.5UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 218 97 11 93 45 60 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000024128   ⟹   ENSRNOP00000024128
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1675,278,325 - 75,316,736 (-)Ensembl
mRatBN7.2 Ensembl1668,575,763 - 68,614,286 (-)Ensembl
Rnor_6.0 Ensembl1673,372,007 - 73,410,777 (-)Ensembl
RefSeq Acc Id: NM_001276712   ⟹   NP_001263641
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81675,278,325 - 75,316,736 (-)NCBI
mRatBN7.21668,575,763 - 68,614,180 (-)NCBI
Rnor_6.01673,372,007 - 73,410,777 (-)NCBI
Rnor_5.01673,006,739 - 73,045,509 (-)NCBI
Celera1666,467,691 - 66,505,810 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001263641 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD49337 (Get FASTA)   NCBI Sequence Viewer  
  EDM09033 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024128
GenBank Protein Q9R168 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001263641   ⟸   NM_001276712
- Peptide Label: precursor
- UniProtKB: F1LLX7 (UniProtKB/TrEMBL),   A6IW39 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024128   ⟸   ENSRNOT00000024128
Protein Domains
FZ   NTR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R168-F1-model_v2 AlphaFold Q9R168 1-158 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621074 AgrOrtholog
BioCyc Gene G2FUF-10906 BioCyc
Ensembl Genes ENSRNOG00000017783 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000024128 ENTREZGENE
Gene3D-CATH 1.10.2000.10 UniProtKB/Swiss-Prot
  2.40.50.120 UniProtKB/Swiss-Prot
InterPro Frizzled/SFRP UniProtKB/Swiss-Prot
  Frizzled_dom UniProtKB/Swiss-Prot
  Frizzled_dom_sf UniProtKB/Swiss-Prot
  Netrin_domain UniProtKB/Swiss-Prot
  Netrin_module_non-TIMP UniProtKB/Swiss-Prot
  TIMP-like_OB-fold UniProtKB/Swiss-Prot
NCBI Gene 84402 ENTREZGENE
PANTHER PTHR11309 UniProtKB/Swiss-Prot
  PTHR11309:SF87 UniProtKB/Swiss-Prot
Pfam NTR UniProtKB/Swiss-Prot
PhenoGen Sfrp1 PhenoGen
PROSITE NTR UniProtKB/Swiss-Prot
  PS50038 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017783 RatGTEx
SMART C345C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50242 UniProtKB/Swiss-Prot
  SSF63501 UniProtKB/Swiss-Prot
UniProt A6IW39 ENTREZGENE, UniProtKB/TrEMBL
  F1LLX7 ENTREZGENE, UniProtKB/TrEMBL
  Q9R168 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Sfrp1  secreted frizzled-related protein 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Sfrp1  secreted frizzled-related protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation promoter activity is induced by phosphorylated CREB and the adaptor protein CBP 724587
gene_transcript region -202 to -144 contains the transcriptional activation domain 724587