Csf2 (colony stimulating factor 2) - Rat Genome Database

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Gene: Csf2 (colony stimulating factor 2) Rattus norvegicus
Symbol: Csf2
Name: colony stimulating factor 2
RGD ID: 621065
Description: Enables cytokine activity. Involved in several processes, including cellular response to lipopolysaccharide; epithelial fluid transport; and response to silicon dioxide. Located in extracellular space. Used to study Parkinsonism and myocardial infarction. Biomarker of abdominal aortic aneurysm; interstitial cystitis; and lung disease (multiple). Human ortholog(s) of this gene implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; neutropenia; pulmonary alveolar proteinosis; and visceral leishmaniasis. Orthologous to human CSF2 (colony stimulating factor 2); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; syndecan signaling pathway; INTERACTS WITH (+)-pilocarpine; 2-amino-2-deoxy-D-glucopyranose; 7,12-dimethyltetraphene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: colony stimulating factor 2 (granulocyte-macrophage); colony-stimulating factor; CSF; Gm-csf; Gmcsf; granulocyte-macrophage colony-stimulating factor
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81038,887,692 - 38,889,673 (-)NCBIGRCr8
mRatBN7.21038,386,945 - 38,388,926 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1038,386,945 - 38,389,199 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1043,071,621 - 43,073,600 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01042,561,720 - 42,563,699 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01038,065,426 - 38,067,405 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01039,602,089 - 39,604,070 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,602,089 - 39,604,070 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01039,379,120 - 39,381,430 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,665,850 - 39,667,831 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11039,679,472 - 39,681,403 (-)NCBI
Celera1037,727,629 - 37,729,611 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IEP)
acute myeloid leukemia  (ISO)
agranulocytosis  (ISO)
amnestic disorder  (ISO)
anemia  (ISO)
aplastic anemia  (ISO)
asthma  (ISO)
B-cell lymphoma  (ISO)
Bacteremia  (ISO)
Brain Injuries  (IDA)
Breast Neoplasms  (ISO)
bronchiolitis obliterans  (IEP)
carcinoma  (ISO)
chronic obstructive pulmonary disease  (ISO)
colon adenocarcinoma  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
Cough  (ISO)
disease of cellular proliferation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
eyelid disease  (ISO)
familial adenomatous polyposis 1  (ISO)
Femoral Fractures  (IEP)
Gastrointestinal Hemorrhage  (ISO)
genetic disease  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Human Influenza  (ISO)
Inflammation  (ISO)
interstitial cystitis  (IEP)
juvenile myelomonocytic leukemia  (ISO)
limb ischemia  (ISO)
Liver Neoplasms  (ISO)
Lymphoma, AIDS-Related  (ISO)
melanoma  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
mucositis  (ISO)
multiple myeloma  (ISO)
Muscle Weakness  (ISO)
myocardial infarction  (IMP)
Neoplasm, Residual  (ISO)
neural tube defect  (ISO)
Neurodevelopmental Disorders  (ISO)
neutropenia  (ISO)
non-Hodgkin lymphoma  (ISO)
Pain  (ISO)
Parkinsonism  (IDA)
pneumocystosis  (IEP)
pneumonia  (ISO)
Pseudomonas Infections  (ISO)
psoriasis  (ISO)
pulmonary alveolar proteinosis  (ISO,ISS)
pulmonary fibrosis  (IEP,ISO)
Radiation Injuries  (ISO)
rheumatoid arthritis  (ISO)
sarcoma  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
silicosis  (IEP)
Spinal Cord Injuries  (ISO)
systemic primary carnitine deficiency disease  (ISO)
temporal arteritis  (ISO)
thrombocytopenia  (ISO)
Thyroid Neoplasms  (ISO)
Venous Thrombosis  (ISO)
Viral Bronchiolitis  (ISO)
visceral leishmaniasis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,4-benzoquinone  (ISO)
1,4-phenylenediamine  (ISO)
1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,5-dihydroxycinnamic acid methyl ester  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-acetyldeoxynivalenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitroquinoline N-oxide  (ISO)
4-nonylphenol  (ISO)
4-phenylbutyric acid  (ISO)
5-fluorouracil  (ISO)
5-oxo-ETE  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7-ketocholesterol  (ISO)
acetaldehyde  (ISO)
acetylcholine  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
albuterol  (ISO)
alclometasone dipropionate  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (ISO)
aluminium hydroxide  (ISO)
aluminium oxide  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
amphotericin B  (ISO)
ampicillin  (ISO)
andrastin A  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthracene-1,8,9-triol  (ISO)
apocynin  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
atorvastatin calcium  (ISO)
baicalein  (ISO)
beclomethasone  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (EXP)
betamethasone valerate  (ISO)
bilirubin IXalpha  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
Botulinum toxin type A  (ISO)
brefeldin A  (ISO)
bromoacetate  (ISO)
budesonide  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
Calcimycin  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
carvedilol  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
choline  (ISO)
ciprofloxacin  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt atom  (EXP,ISO)
columbamine  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
cyanidin cation  (EXP,ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cytochalasin B  (ISO)
cytochalasin D  (ISO)
D-penicillamine  (EXP)
deoxycholic acid  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dichlorine  (ISO)
dihydroxyacetone  (ISO)
dinitrogen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ethyl acetate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fenofibrate  (EXP)
ferroheme b  (ISO)
flavonoids  (EXP)
fluticasone  (ISO)
formaldehyde  (ISO)
formoterol fumarate  (ISO)
fulvestrant  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (ISO)
GW 4064  (ISO)
heme b  (ISO)
histamine  (EXP,ISO)
HU-308  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
IC-87114  (ISO)
indometacin  (ISO)
ionomycin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
iron(2+) sulfate (anhydrous)  (ISO)
isotretinoin  (EXP)
kaempferol  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leukotriene B4  (ISO)
leukotriene D4  (ISO)
linuron  (ISO)
lipoarabinomannan  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (ISO)
luteolin  (EXP,ISO)
LY294002  (ISO)
lycopene  (ISO)
malathion  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (ISO)
mercury dichloride  (ISO)
metam  (ISO)
methamphetamine  (ISO)
methanol  (ISO)
methylmercury chloride  (ISO)
metronidazole  (ISO)
microcystin-LR  (ISO)
ML-7  (ISO)
mometasone furoate  (ISO)
monensin A  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N,N-dimethylacetamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
naproxen  (EXP)
neomycin  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
nicotine  (ISO)
nitrates  (EXP)
nitric oxide  (EXP,ISO)
nitro blue tetrazolium dichloride  (ISO)
nitrogen dioxide  (ISO)
nocodazole  (ISO)
octadecanoic acid  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraoxon  (EXP)
paraquat  (ISO)
parathion  (EXP)
pentachlorophenol  (ISO)
pentanal  (ISO)
peptidoglycan  (ISO)
permethrin  (EXP)
phenethyl isothiocyanate  (ISO)
Phomenone  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pimecrolimus  (ISO)
piperine  (ISO)
poly(ethylene)  (ISO)
poly(I:C)  (ISO)
polymyxin B2  (ISO)
pomalidomide  (ISO)
procyanidin B3  (ISO)
propan-2-ol  (ISO)
prostaglandin E2  (ISO)
Psi-tectorigenin  (ISO)
Pyridostigmine bromide  (EXP)
quartz  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rutin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salmeterol xinafoate  (ISO)
SB 203580  (ISO)
scopolamine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
spironolactone  (ISO)
staurosporine  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sumatriptan  (EXP)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
taurocholic acid  (ISO)
temozolomide  (ISO)
terameprocol  (ISO)
testosterone  (ISO)
tetracyclines  (ISO)
thalidomide  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thymidine  (ISO)
tipifarnib  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
triamcinolone acetonide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tubocurarine  (ISO)
tungsten  (EXP)
tyrphostin AG 1478  (ISO)
U-73122  (ISO)
urethane  (ISO)
usnic acid  (ISO)
vanadyl sulfate  (ISO)
vancomycin  (ISO)
vincristine  (ISO)
vitamin K  (EXP)
wortmannin  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell population proliferation  (ISO)
cell surface receptor signaling pathway via JAK-STAT  (ISO)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (ISO)
cellular response to lipopolysaccharide  (IEP)
dendritic cell differentiation  (IDA,ISO)
embryonic placenta development  (ISO)
epithelial cell proliferation  (TAS)
epithelial fluid transport  (IDA)
granulocyte-macrophage colony-stimulating factor signaling pathway  (ISO)
histamine secretion  (IDA)
immune response  (IEA)
macrophage differentiation  (ISO)
monocyte differentiation  (ISO)
myeloid cell differentiation  (IBA)
myeloid dendritic cell differentiation  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
neutrophil differentiation  (ISO)
positive regulation of cell migration  (IMP)
positive regulation of cell population proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-23 production  (ISO)
positive regulation of leukocyte proliferation  (ISO)
positive regulation of macrophage derived foam cell differentiation  (ISO)
positive regulation of macrophage differentiation  (TAS)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of podosome assembly  (ISO)
positive regulation of trophectodermal cell proliferation  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
regulation of cell population proliferation  (ISO)
regulation of circadian sleep/wake cycle, sleep  (IMP)
regulation of gene expression  (ISO)
response to fluid shear stress  (IEP)
response to silicon dioxide  (IEP)
TOR signaling  (ISO)

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Early granulocyte-macrophage colony-stimulating factor expression by alveolar inflammatory cells during bleomycin-induced rat lung fibrosis. Andreutti D, etal., Lab Invest. 1998 Dec;78(12):1493-502.
2. Recombinant human granulocyte-macrophage colony-stimulating factor reverses neutropenia and reduces secondary infections in visceral leishmaniasis. Badaro R, etal., J Infect Dis. 1994 Aug;170(2):413-8.
3. Protection against gram-negative bacteremia in neutropenic mice with recombinant granulocyte-macrophage colony-stimulating factor. Bermudez LE, etal., Cytokine. 1990 Jul;2(4):287-93.
4. Azithromycin and clarithromycin inhibit lipopolysaccharide-induced murine pulmonary neutrophilia mainly through effects on macrophage-derived granulocyte-macrophage colony-stimulating factor and interleukin-1beta. Bosnar M, etal., J Pharmacol Exp Ther. 2009 Oct;331(1):104-13. Epub 2009 Jul 24.
5. Simultaneous administration of granulocyte-macrophage colony-stimulating factor and cytosine arabinoside for the treatment of relapsed acute myeloid leukemia. Cannistra SA, etal., Leukemia. 1991 Mar;5(3):230-8.
6. Bone marrow and splenic granulocyte-macrophage colony-stimulating factor and transforming growth factor-beta mRNA levels in irradiated mice. Chang CM, etal., Blood. 1995 Sep 15;86(6):2130-6.
7. The role of TNF-alpha in eosinophilic inflammation associated with RSV bronchiolitis. Choi J, etal., Pediatr Allergy Immunol. 2010 May;21(3):474-9. Epub 2009 Jan 14.
8. Therapeutic efficacy of intranasally delivered mesenchymal stem cells in a rat model of Parkinson disease. Danielyan L, etal., Rejuvenation Res. 2011 Feb;14(1):3-16. Epub 2011 Feb 3.
9. A dual role for the immune response in a mouse model of inflammation-associated lung cancer. Dougan M, etal., J Clin Invest. 2011 Jun 1;121(6):2436-46. doi: 10.1172/JCI44796. Epub 2011 May 2.
10. The ability of recombinant murine granulocyte-macrophage colony-stimulating factor to protect neonatal rats from septic death due to Staphylococcus aureus. Frenck RW, etal., J Infect Dis. 1990 Jul;162(1):109-14.
11. Cross-talk of the related bioactivity mediators in serum after injection of soluble TNF-alpha receptor on silicosis model of rats. Gao HS, etal., Toxicol Ind Health. 2011 Aug;27(7):607-16. doi: 10.1177/0748233710393778. Epub 2011 Apr 19.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Chronic cough resembles asthma with IL-5 and granulocyte-macrophage colony-stimulating factor gene expression in bronchoalveolar cells. Gibson PG, etal., J Allergy Clin Immunol. 1998 Mar;101(3):320-6.
14. Role of granulocyte-macrophage colony-stimulating factor in preventing apoptosis and improving functional outcome in experimental spinal cord contusion injury. Ha Y, etal., J Neurosurg Spine. 2005 Jan;2(1):55-61.
15. Biologically active recombinant rat granulocyte macrophage colony-stimulating factor produced in Escherichia coli. Holowachuk EW and Ruhoff MS, Protein Expr Purif. 1995 Oct;6(5):588-96.
16. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Huang C, etal., Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
17. GM-CSF in the Lung Protects Against Lethal Influenza Infection. Huang FF, etal., Am J Respir Crit Care Med. 2011 Apr 7.
18. Protective effects of recombinant human granulocyte macrophage colony stimulating factor on H1N1 influenza virus-induced pneumonia in mice. Huang H, etal., Cytokine. 2010 Aug;51(2):151-7. Epub 2010 Apr 27.
19. Inhibition of granulocyte-macrophage colony-stimulating factor prevents dissemination and induces remission of juvenile myelomonocytic leukemia in engrafted immunodeficient mice. Iversen PO, etal., Blood. 1997 Dec 15;90(12):4910-7.
20. Propofol pretreatment attenuates LPS-induced granulocyte-macrophage colony-stimulating factor production in cultured hepatocytes by suppressing MAPK/ERK activity and NF-kappaB translocation. Jawan B, etal., Toxicol Appl Pharmacol. 2008 Jun 15;229(3):362-73. Epub 2008 Feb 21.
21. Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes. Jin DK, etal., Nat Med. 2006 May;12(5):557-67. Epub 2006 Apr 30.
22. Plasma concentrations of granulocyte-macrophage colony-stimulating factor and interleukin-6 in septic and healthy preterms. Kantar M, etal., Eur J Pediatr. 2000 Mar;159(3):156-7.
23. Genetic kininogen deficiency contributes to aortic aneurysm formation but not to atherosclerosis. Kaschina E, etal., Physiol Genomics 2004 Sep 16;19(1):41-9. Epub 2004 Jul 06.
24. An Open-Label Trial of Rituximab Therapy in Pulmonary Alveolar Proteinosis. Kavuru MS, etal., Eur Respir J. 2011 Apr 8.
25. Antibody to Granulocyte-Macrophage Colony-Stimulating Factor Reduces the Number of Activated Tissue Macrophages and Improves Left Ventricular Function Following Myocardial Infarction in a Rat Coronary-Artery Ligation Model. Kellar RS, etal., J Cardiovasc Pharmacol. 2011 Feb 12.
26. Involvement of granulocyte-macrophage colony-stimulating factor (GM-CSF) in pregnancy-enhanced sleep. Kimura M and Inoue S, Psychiatry Clin Neurosci. 2002 Jun;56(3):337-8.
27. Effects of decreased calmodulin protein on the survival mechanisms of alveolar macrophages during Pneumocystis pneumonia. Lasbury ME, etal., Infect Immun. 2009 Aug;77(8):3344-54. Epub 2009 Jun 1.
28. Antitumoral vaccination with granulocyte-macrophage colony-stimulating factor or interleukin-12-expressing DHD/K12 colon adenocarcinoma cells. Lechanteur C, etal., Cancer Gene Ther. 2000 May;7(5):676-82.
29. Compartmentalized transgene expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) in mouse lung enhances allergic airways inflammation. Lei XF, etal., Clin Exp Immunol. 1998 Aug;113(2):157-65.
30. Chronic aspiration of gastric fluid induces the development of obliterative bronchiolitis in rat lung transplants. Li B, etal., Am J Transplant. 2008 Aug;8(8):1614-21. Epub 2008 Jun 28.
31. In vivo disruption of TGF-beta signaling by Smad7 in airway epithelium alleviates allergic asthma but aggravates lung carcinogenesis in mouse. Luo X, etal., PLoS One. 2010 Apr 13;5(4):e10149.
32. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
33. In vitro proliferation of axotomized rat facial nucleus-derived activated microglia in an autocrine fashion. Nakajima K, etal., J Neurosci Res. 2006 Aug 1;84(2):348-59. doi: 10.1002/jnr.20882.
34. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
35. Subcutaneous injection containing IL-3 and GM-CSF ameliorates stab wound-induced brain injury in rats. Nishihara T, etal., Exp Neurol. 2011 Jun;229(2):507-16. Epub 2011 Apr 16.
36. Cytokine gene expression in the marrow stromal cells of patients with giant cell arteritis. Orphanos V, etal., Clin Exp Rheumatol. 1998 Nov-Dec;16(6):683-8.
37. Granulocyte-macrophage colony stimulating factor (GM-CSF) treatment improves alveolar epithelial barrier function in the alcoholic rat lung. Pelaez A, etal., Am J Physiol Lung Cell Mol Physiol 2004 Jan;286(1):L106-11. Epub 2003 Sep 22.
38. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
39. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
40. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
41. Granulocyte macrophage-colony stimulating factor (GM-CSF) in neonatal neutropenia. Ray M, etal., Indian J Pediatr. 2000 Jan;67(1):67-8.
42. GOA pipeline RGD automated data pipeline
43. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
44. Granulocyte-macrophage colony-stimulating factor expression in induced sputum and bronchial mucosa in asthma and COPD. Saha S, etal., Thorax. 2009 Aug;64(8):671-6. Epub 2009 Feb 12.
45. Correlation of measurable serum markers of inflammation with lung levels following bilateral femur fracture in a rat model. Sears BW, etal., J Inflamm Res. 2010 Aug 1;2010(3):105-114.
46. Therapeutic efficacy of granulocyte-macrophage colony-stimulating factor in patients with idiopathic acquired alveolar proteinosis. Seymour JF, etal., Am J Respir Crit Care Med. 2001 Feb;163(2):524-31.
47. Attenuated hematopoietic response to granulocyte-macrophage colony-stimulating factor in patients with acquired pulmonary alveolar proteinosis. Seymour JF, etal., Blood. 1998 Oct 15;92(8):2657-67.
48. Identification of histamine-production-increasing factor produced by stimulated RBL-2H3 rat basophilic leukemia cells as granulocyte-macrophage colony-stimulating factor. Shiraishi M, etal., Biochim Biophys Acta. 1998 Jul 24;1403(3):273-80.
49. Hemodynamic forces regulate mural macrophage infiltration in experimental aortic aneurysms. Sho E, etal., Exp Mol Pathol. 2004 Apr;76(2):108-16.
50. Multiplex analysis of urinary cytokine levels in rat model of cyclophosphamide-induced cystitis. Smaldone MC, etal., Urology. 2009 Feb;73(2):421-6. Epub 2008 Oct 9.
51. Nucleotide sequence of the Lewis rat granulocyte-macrophage colony stimulating factor. Smith LR, etal., Immunogenetics 1994;39(1):80.
52. Concurrent delivery of GM-CSF and endostatin genes by a single adenoviral vector provides a synergistic effect on the treatment of orthotopic liver tumors. Tai KF, etal., J Gene Med. 2003 May;5(5):386-98.
53. Idiotype/granulocyte-macrophage colony-stimulating factor fusion protein as a vaccine for B-cell lymphoma. Tao MH and Levy R, Nature. 1993 Apr 22;362(6422):755-8.
54. Macrophage colony-stimulating factor release and receptor expression in bone cells. Weir EC, etal., J Bone Miner Res. 1993 Dec;8(12):1507-18. doi: 10.1002/jbmr.5650081214.
55. Technical Advance: The rat aorta contains resident mononuclear phagocytes with proliferative capacity and proangiogenic properties. Zorzi P, etal., J Leukoc Biol. 2010 Nov;88(5):1051-9. Epub 2010 Jul 13.
Additional References at PubMed
PMID:1350248   PMID:3925454   PMID:7690439   PMID:9697835   PMID:9722506   PMID:10652277   PMID:10666185   PMID:10678181   PMID:12021780   PMID:12071442   PMID:14557677   PMID:14651956  
PMID:15220135   PMID:15958400   PMID:16116184   PMID:16276414   PMID:16606666   PMID:16792532   PMID:16877635   PMID:17457367   PMID:17478029   PMID:17953750   PMID:18832728   PMID:19022682  
PMID:19032770   PMID:19109256   PMID:19228596   PMID:19560459   PMID:20027291   PMID:21148126   PMID:21149635   PMID:21932404   PMID:24520418   PMID:24942581   PMID:25677907   PMID:27364613  
PMID:28550897   PMID:28898718  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81038,887,692 - 38,889,673 (-)NCBIGRCr8
mRatBN7.21038,386,945 - 38,388,926 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1038,386,945 - 38,389,199 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1043,071,621 - 43,073,600 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01042,561,720 - 42,563,699 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01038,065,426 - 38,067,405 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01039,602,089 - 39,604,070 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,602,089 - 39,604,070 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01039,379,120 - 39,381,430 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,665,850 - 39,667,831 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11039,679,472 - 39,681,403 (-)NCBI
Celera1037,727,629 - 37,729,611 (-)NCBICelera
Cytogenetic Map10q22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh385132,073,789 - 132,076,170 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5132,073,789 - 132,076,170 (+)EnsemblGRCh38hg38GRCh38
GRCh375131,409,482 - 131,411,863 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365131,437,384 - 131,439,758 (+)NCBINCBI36Build 36hg18NCBI36
Build 345131,437,383 - 131,439,758NCBI
Celera5127,539,561 - 127,541,935 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5126,601,846 - 126,604,224 (+)NCBIHuRef
CHM1_15130,842,312 - 130,844,690 (+)NCBICHM1_1
T2T-CHM13v2.05132,593,659 - 132,596,040 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391154,138,096 - 54,140,725 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1154,138,097 - 54,140,493 (-)EnsemblGRCm39 Ensembl
GRCm381154,247,270 - 54,249,899 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1154,247,271 - 54,249,667 (-)EnsemblGRCm38mm10GRCm38
MGSCv371154,060,772 - 54,063,401 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361154,090,687 - 54,093,065 (-)NCBIMGSCv36mm8
Celera1158,835,805 - 58,838,455 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.13NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554083,451,965 - 3,454,312 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554083,452,009 - 3,454,255 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v24127,392,221 - 127,394,601 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15125,531,784 - 125,534,164 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05127,496,951 - 127,499,325 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15133,660,775 - 133,663,146 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5133,660,775 - 133,663,146 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11120,342,880 - 20,346,959 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,344,648 - 20,346,959 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,140,218 - 19,142,512 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01121,128,373 - 21,132,476 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1121,129,967 - 21,132,524 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11119,849,460 - 19,851,754 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01119,697,439 - 19,699,733 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01120,339,024 - 20,341,318 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024407213116,079,008 - 116,081,102 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366473,081,896 - 3,083,864 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366473,081,896 - 3,083,864 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl2134,354,724 - 134,357,155 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12134,354,724 - 134,357,155 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22139,706,386 - 139,708,817 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12334,906,987 - 34,911,252 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2334,908,911 - 34,911,140 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603443,046,561 - 43,048,998 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462473340,039,414 - 40,041,294 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473340,039,127 - 40,041,294 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Csf2
8 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:77
Interacting mature miRNAs:91
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system renal system reproductive system respiratory system appendage
Medium 2
Low 8 9 9
Below cutoff 3 3 4 4 9 4 1 1 5 12 1


RefSeq Acc Id: ENSRNOT00000032333   ⟹   ENSRNOP00000034235
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1038,386,945 - 38,389,199 (-)Ensembl
Rnor_6.0 Ensembl1039,602,089 - 39,604,070 (-)Ensembl
RefSeq Acc Id: NM_053852   ⟹   NP_446304
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr81038,887,692 - 38,889,673 (-)NCBI
mRatBN7.21038,386,945 - 38,388,926 (-)NCBI
Rnor_6.01039,602,089 - 39,604,070 (-)NCBI
Rnor_5.01039,379,120 - 39,381,430 (-)NCBI
Celera1037,727,629 - 37,729,611 (-)NCBI
Protein Sequences
Protein RefSeqs NP_446304 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA18281 (Get FASTA)   NCBI Sequence Viewer  
  EDM04426 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000034235
GenBank Protein P48750 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446304   ⟸   NM_053852
- Peptide Label: precursor
- UniProtKB: P48750 (UniProtKB/Swiss-Prot),   A6HEH1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000034235   ⟸   ENSRNOT00000032333

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48750-F1-model_v2 AlphaFold P48750 1-144 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697187
Promoter ID:EPDNEW_R7711
Type:single initiation site
Description:colony stimulating factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01039,604,102 - 39,604,162EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621065 AgrOrtholog
BioCyc Gene G2FUF-25118 BioCyc
Ensembl Genes ENSRNOG00000026805 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055025963 UniProtKB/Swiss-Prot
  ENSRNOG00060025697 UniProtKB/Swiss-Prot
  ENSRNOG00065005786 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000032333 ENTREZGENE
  ENSRNOT00000032333.4 UniProtKB/Swiss-Prot
  ENSRNOT00055044803 UniProtKB/Swiss-Prot
  ENSRNOT00060044451 UniProtKB/Swiss-Prot
  ENSRNOT00065008646 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GM_colony-stim-fac UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116630 UniProtKB/Swiss-Prot
Pfam GM_CSF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Csf2 PhenoGen
RatGTEx ENSRNOG00000026805 RatGTEx
  ENSRNOG00055025963 RatGTEx
  ENSRNOG00060025697 RatGTEx
  ENSRNOG00065005786 RatGTEx
SMART CSF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP 4-helical cytokines UniProtKB/TrEMBL, UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-20 Csf2  colony stimulating factor 2  Csf2  colony stimulating factor 2 (granulocyte-macrophage)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Csf2  colony stimulating factor 2 (granulocyte-macrophage)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Csf2  colony stimulating factor 2 (granulocyte-macrophage)      Symbol and Name status set to provisional 70820 PROVISIONAL