Sult1c2 (sulfotransferase family 1C member 2) - Rat Genome Database

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Gene: Sult1c2 (sulfotransferase family 1C member 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Sult1c2 (Ensembl: LOC120093086)
Name: sulfotransferase family 1C member 2 (Ensembl:sulfotransferase 1C2-like)
RGD ID: 621064
Description: Enables aryl sulfotransferase activity. Involved in sulfation. Located in lysosome. Orthologous to human SULT1C2 (sulfotransferase family 1C member 2).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC100910526; MGC112625; MGC124969; rSULT1C2; ST1C2; sulfotransferase 1C2; sulfotransferase 1C2-like; sulfotransferase family, cytosolic, 1C, member 2; sulfotransferase K1; sultK1
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr897,436,981 - 7,486,894 (+)NCBIGRCr8
mRatBN7.296,824,840 - 6,848,830 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl96,745,700 - 7,131,245 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx98,810,620 - 8,834,585 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0913,909,201 - 13,933,166 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0919,619,451 - 19,643,408 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.094,654,278 - 4,685,418 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl94,654,294 - 4,685,383 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl94,807,717 - 4,834,335 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.093,693,343 - 3,725,594 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.49972,522 - 998,125 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.191,030,810 - 1,160,809 (-)NCBI
Cytogenetic Map9q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
sulfation  (IBA,IDA,IEA)

Cellular Component
cytoplasm  (IBA)
lysosome  (IDA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Enzymatic properties, tissue-specific expression, and lysosomal location of two highly homologous rat SULT1C2 sulfotransferases. Xiangrong L, etal., Biochem Biophys Res Commun 2000 May 27;272(1):242-50.
Additional References at PubMed
PMID:12164856   PMID:12477932   PMID:15489334   PMID:24028175   PMID:26427720  


Genomics

Variants

.
Variants in Sult1c2
141 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:394
Count of miRNA genes:209
Interacting mature miRNAs:243
Transcripts:ENSRNOT00000040879, ENSRNOT00000050420, ENSRNOT00000061896
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9114209783Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
1578675Bss17Bone structure and strength QTL 173.8femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)9336865213533896Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat

Markers in Region
RH141565  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hepatobiliary system renal system reproductive system
High
Medium 1
Low 3 3 3 16
Below cutoff 2 11 11 11 2 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_133547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006244250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000040879   ⟹   ENSRNOP00000046569
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl94,817,854 - 4,834,255 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000061864   ⟹   ENSRNOP00000058580
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl96,962,130 - 6,971,922 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000061896   ⟹   ENSRNOP00000058611
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl94,654,294 - 4,685,383 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000065839   ⟹   ENSRNOP00000062844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl97,112,875 - 7,129,379 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081413   ⟹   ENSRNOP00000072861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl94,654,294 - 4,683,160 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082579   ⟹   ENSRNOP00000069149
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl96,831,219 - 7,131,245 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092159   ⟹   ENSRNOP00000071426
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl94,807,717 - 4,834,335 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106188   ⟹   ENSRNOP00000096879
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl96,745,700 - 6,848,830 (+)Ensembl
RefSeq Acc Id: NM_133547   ⟹   NP_598231
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr897,436,981 - 7,486,894 (+)NCBI
mRatBN7.296,824,840 - 6,848,812 (+)NCBI
Rnor_6.094,654,296 - 4,683,160 (-)NCBI
Rnor_5.093,693,343 - 3,725,594 (-)NCBI
RGSC_v3.49972,522 - 998,125 (+)RGD
Sequence:
RefSeq Acc Id: NP_598231   ⟸   NM_133547
- UniProtKB: A0A8I6ARK1 (UniProtKB/TrEMBL),   A0A0G2JUM0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071426   ⟸   ENSRNOT00000092159
RefSeq Acc Id: ENSRNOP00000072861   ⟸   ENSRNOT00000081413
RefSeq Acc Id: ENSRNOP00000058611   ⟸   ENSRNOT00000061896
RefSeq Acc Id: ENSRNOP00000046569   ⟸   ENSRNOT00000040879
RefSeq Acc Id: ENSRNOP00000096879   ⟸   ENSRNOT00000106188
RefSeq Acc Id: ENSRNOP00000069149   ⟸   ENSRNOT00000082579
RefSeq Acc Id: ENSRNOP00000058580   ⟸   ENSRNOT00000061864
RefSeq Acc Id: ENSRNOP00000062844   ⟸   ENSRNOT00000065839
Protein Domains
Sulfotransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WUW8-F1-model_v2 AlphaFold Q9WUW8 1-296 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696424
Promoter ID:EPDNEW_R6949
Type:initiation region
Name:LOC100910526_1
Description:sulfotransferase 1C2-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6950  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.094,683,172 - 4,683,232EPDNEW
RGD ID:13696426
Promoter ID:EPDNEW_R6950
Type:initiation region
Name:LOC100910526_2
Description:sulfotransferase 1C2-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6949  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.094,685,397 - 4,685,457EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621064 AgrOrtholog
BioCyc Gene G2FUF-28390 BioCyc
Ensembl Genes ENSRNOG00000040215 Ensembl
  ENSRNOG00000050885 Ensembl
  ENSRNOG00000065530 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055018845 UniProtKB/Swiss-Prot
  ENSRNOG00055018873 UniProtKB/Swiss-Prot
  ENSRNOG00060023965 UniProtKB/Swiss-Prot
  ENSRNOG00060025885 UniProtKB/Swiss-Prot
  ENSRNOG00065014883 UniProtKB/Swiss-Prot
  ENSRNOG00065014894 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000061864.5 UniProtKB/TrEMBL
  ENSRNOT00000065839.4 UniProtKB/TrEMBL
  ENSRNOT00000082579.2 UniProtKB/TrEMBL
  ENSRNOT00000106188.1 UniProtKB/TrEMBL
  ENSRNOT00055032109 UniProtKB/Swiss-Prot
  ENSRNOT00055032174 UniProtKB/Swiss-Prot
  ENSRNOT00060041524 UniProtKB/Swiss-Prot
  ENSRNOT00060044818 UniProtKB/Swiss-Prot
  ENSRNOT00065024611 UniProtKB/Swiss-Prot
  ENSRNOT00065024633 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7106590 IMAGE-MGC_LOAD
  IMAGE:7108290 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sulfotransferase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171072 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112625 IMAGE-MGC_LOAD
  MGC:124969 IMAGE-MGC_LOAD
NCBI Gene 171072 ENTREZGENE
PANTHER SULFOTRANSFERASE 1C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SULFOTRANSFERASE SULT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sulfotransfer_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sult1c2 PhenoGen
RatGTEx ENSRNOG00000040215 RatGTEx
  ENSRNOG00000050885 RatGTEx
  ENSRNOG00000065530 RatGTEx
  ENSRNOG00055018845 RatGTEx
  ENSRNOG00055018873 RatGTEx
  ENSRNOG00060023965 RatGTEx
  ENSRNOG00060025885 RatGTEx
  ENSRNOG00065014883 RatGTEx
  ENSRNOG00065014894 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JUM0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ARK1 ENTREZGENE, UniProtKB/TrEMBL
  F1LNK1_RAT UniProtKB/TrEMBL
  F1LZI5_RAT UniProtKB/TrEMBL
  Q9WUW8 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary F1LZL1 UniProtKB/Swiss-Prot
  Q3ZAV3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Sult1c2  sulfotransferase family 1C member 2  LOC100910526  sulfotransferase 1C2-like  Data merged from RGD:6497849 737654 PROVISIONAL
2015-11-12 Sult1c2  sulfotransferase family 1C member 2  Sult1c2  sulfotransferase family, cytosolic, 1C, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100910526  sulfotransferase 1C2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-07-08 Sult1c2  sulfotransferase family, cytosolic, 1C, member 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Sult1c2  sulfotransferase family, cytosolic, 1C, member 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in kidney proximal tubule epithelial cells, in the epithelium of gastric mucosal glands and of bile duct, and in hepatocytes 634073