Picalm (phosphatidylinositol binding clathrin assembly protein) - Rat Genome Database

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Gene: Picalm (phosphatidylinositol binding clathrin assembly protein) Rattus norvegicus
Analyze
Symbol: Picalm
Name: phosphatidylinositol binding clathrin assembly protein
RGD ID: 621054
Description: Enables several functions, including SH3 domain binding activity; identical protein binding activity; and phosphatidylinositol binding activity. Involved in several processes, including neuron projection morphogenesis; positive regulation of cellular component organization; and positive regulation of dendrite extension. Located in several cellular components, including cytoplasmic vesicle; postsynaptic density; and synaptic membrane. Is active in Schaffer collateral - CA1 synapse; parallel fiber to Purkinje cell synapse; and postsynaptic endocytic zone. Is extrinsic component of presynaptic endocytic zone membrane. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human PICALM (phosphatidylinositol binding clathrin assembly protein); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Calm; clathrin assembly lymphoid myeloid leukemia protein; clathrin-assembly lymphoid leukemia protein; clathrin-assembly lymphoid myeloid leukemia protein; MGC114290; phosphatidylinositol-binding clathrin assembly protein; rCALM
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81153,468,982 - 153,550,086 (+)NCBIGRCr8
mRatBN7.21144,056,415 - 144,138,045 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1144,056,721 - 144,137,557 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1151,982,728 - 152,062,265 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01159,159,274 - 159,238,823 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01152,033,188 - 152,112,743 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01154,377,229 - 154,458,966 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1154,377,247 - 154,458,425 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01160,681,689 - 160,763,382 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41146,754,085 - 146,834,197 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11146,832,490 - 146,912,603 (+)NCBI
Celera1142,288,691 - 142,367,949 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
acetylsalicylic acid  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
Brodifacoum  (EXP)
caffeine  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
eugenol  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
haloperidol  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
tetrahydropalmatine  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance by transcytosis  (IEA,ISO)
axonogenesis  (IEA,IMP,ISO)
clathrin coat assembly  (IDA,IEA,ISO)
clathrin-dependent endocytosis  (IBA,IEA,ISO,ISS)
dendrite morphogenesis  (IEA,IMP,ISO)
endocytosis  (ISO)
endosomal transport  (IEA,ISO)
hemopoiesis  (IEA,ISO)
intracellular iron ion homeostasis  (IEA,ISO)
learning or memory  (IEA,ISO)
membrane bending  (IEA,ISO)
multicellular organismal-level iron ion homeostasis  (IEA,ISO,ISS)
negative regulation of gene expression  (IEA,ISO,ISS)
negative regulation of protein localization to cell surface  (IEA,ISO)
negative regulation of protein localization to plasma membrane  (IEA,ISO)
negative regulation of receptor-mediated endocytosis  (IEA,ISO)
positive regulation of amyloid precursor protein catabolic process  (ISO,ISS)
positive regulation of amyloid-beta formation  (IEA,ISO,ISS)
positive regulation of axonogenesis  (IMP)
positive regulation of dendrite extension  (IMP)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of Ras protein signal transduction  (ISO)
positive regulation of synaptic vesicle clustering  (IMP)
positive regulation of synaptic vesicle endocytosis  (IMP)
receptor internalization  (IEA,ISO)
receptor-mediated endocytosis  (ISO,ISS)
regulation of amyloid precursor protein catabolic process  (ISO,ISS)
regulation of amyloid-beta formation  (ISO)
regulation of endocytosis  (IMP,ISO)
regulation of protein localization  (ISO)
regulation of protein transport  (IMP)
regulation of synaptic vesicle endocytosis  (IMP)
regulation of synaptic vesicle transport  (IMP)
regulation of terminal button organization  (IMP)
regulation of vesicle size  (IEA,ISO)
synaptic vesicle budding from presynaptic endocytic zone membrane  (IBA)
synaptic vesicle endocytosis  (IDA,IMP)
synaptic vesicle maturation  (IEA,ISO,ISS)
vesicle budding from membrane  (IEA,ISO)
vesicle cargo loading  (IEA,ISO,ISS)
vesicle-mediated transport  (IMP)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Clathrin assembly protein AP180 and CALM differentially control axogenesis and dendrite outgrowth in embryonic hippocampal neurons. Bushlin I, etal., J Neurosci. 2008 Oct 8;28(41):10257-71. doi: 10.1523/JNEUROSCI.2471-08.2008.
2. Dynamics and nanoscale organization of the postsynaptic endocytic zone at excitatory synapses. Catsburg LA, etal., Elife. 2022 Jan 24;11:e74387. doi: 10.7554/eLife.74387.
3. Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes. Ford MG, etal., Science. 2001 Feb 9;291(5506):1051-5.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Clathrin and clathrin-accessory proteins in rat kidney cortex epithelia. Hasse S, etal., Histochem Cell Biol. 2006 Aug;126(2):219-29. Epub 2006 Apr 20.
7. Purification of clathrin assembly protein from rat liver. Kim HL and Kim JA, Exp Mol Med. 2000 Dec 31;32(4):222-6.
8. Molecular cloning of clathrin assembly protein gene (rCALM) and its differential expression to AP180 in rat brain. Kim HL and Lee SC, Exp Mol Med 1999 Dec 31;31(4):191-6.
9. Properties of GST-CALM expressed in E. coli. Kim JA, etal., Exp Mol Med. 2000 Jun 30;32(2):93-9.
10. SNARE motif-mediated sorting of synaptobrevin by the endocytic adaptors clathrin assembly lymphoid myeloid leukemia (CALM) and AP180 at synapses. Koo SJ, etal., Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13540-5. doi: 10.1073/pnas.1107067108. Epub 2011 Aug 1.
11. The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM. Miller SE, etal., Cell. 2011 Nov 23;147(5):1118-31. doi: 10.1016/j.cell.2011.10.038.
12. CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. Miller SE, etal., Dev Cell. 2015 Apr 20;33(2):163-75. doi: 10.1016/j.devcel.2015.03.002.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. AP180 and CALM in the developing hippocampus: expression at the nascent synapse and localization to trafficking organelles. Petralia RS and Yao PJ, J Comp Neurol. 2007 Sep 20;504(3):314-27.
16. Reduction of AP180 and CALM produces defects in synaptic vesicle size and density. Petralia RS, etal., Neuromolecular Med. 2013 Mar;15(1):49-60. doi: 10.1007/s12017-012-8194-x. Epub 2012 Aug 1.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fuses MLL to CALM, a gene that encodes a clathrin assembly protein. Wechsler DS, etal., Genes Chromosomes Cancer. 2003 Jan;36(1):26-36.
21. Synaptic distribution of the endocytic accessory proteins AP180 and CALM. Yao PJ, etal., J Comp Neurol. 2005 Jan 3;481(1):58-69.
Additional References at PubMed
PMID:10436022   PMID:11425879   PMID:12477932   PMID:12832620   PMID:14985334   PMID:15182197   PMID:16262731   PMID:16491119   PMID:18182011   PMID:19946888   PMID:20653035   PMID:21221849  
PMID:22539346   PMID:22952941   PMID:23589030   PMID:24577224   PMID:25468996   PMID:26005850   PMID:30053369  


Genomics

Comparative Map Data
Picalm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81153,468,982 - 153,550,086 (+)NCBIGRCr8
mRatBN7.21144,056,415 - 144,138,045 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1144,056,721 - 144,137,557 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1151,982,728 - 152,062,265 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01159,159,274 - 159,238,823 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01152,033,188 - 152,112,743 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01154,377,229 - 154,458,966 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1154,377,247 - 154,458,425 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01160,681,689 - 160,763,382 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41146,754,085 - 146,834,197 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11146,832,490 - 146,912,603 (+)NCBI
Celera1142,288,691 - 142,367,949 (+)NCBICelera
Cytogenetic Map1q32NCBI
PICALM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381185,957,175 - 86,069,860 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1185,957,175 - 86,069,882 (-)EnsemblGRCh38hg38GRCh38
GRCh371185,668,218 - 85,780,902 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361185,346,133 - 85,457,756 (-)NCBINCBI36Build 36hg18NCBI36
Build 341185,346,133 - 85,457,756NCBI
Celera1182,977,768 - 83,089,435 (-)NCBICelera
Cytogenetic Map11q14.2NCBI
HuRef1181,965,384 - 82,078,030 (-)NCBIHuRef
CHM1_11185,553,010 - 85,665,742 (-)NCBICHM1_1
T2T-CHM13v2.01185,893,875 - 86,006,599 (-)NCBIT2T-CHM13v2.0
Picalm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39789,778,711 - 89,858,655 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl789,779,421 - 89,862,673 (+)EnsemblGRCm39 Ensembl
GRCm38790,130,192 - 90,209,447 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl790,130,213 - 90,213,465 (+)EnsemblGRCm38mm10GRCm38
MGSCv37797,278,742 - 97,357,442 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36790,005,424 - 90,084,124 (+)NCBIMGSCv36mm8
Celera787,455,394 - 87,534,538 (+)NCBICelera
Cytogenetic Map7D3NCBI
cM Map750.47NCBI
Picalm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554146,871,520 - 6,969,208 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554146,871,220 - 6,970,569 (+)NCBIChiLan1.0ChiLan1.0
PICALM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2986,878,789 - 86,989,754 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11187,929,638 - 88,040,190 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01181,011,324 - 81,122,352 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11184,619,241 - 84,730,516 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1184,619,241 - 84,730,684 (-)Ensemblpanpan1.1panPan2
PICALM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12113,437,819 - 13,540,167 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2113,437,925 - 13,539,616 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2113,303,451 - 13,405,757 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02113,619,410 - 13,719,561 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2113,619,520 - 13,719,419 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12113,405,869 - 13,508,626 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02113,478,428 - 13,581,047 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02113,531,568 - 13,633,911 (+)NCBIUU_Cfam_GSD_1.0
Picalm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494772,186,022 - 72,286,358 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649813,784,886 - 13,886,167 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649813,785,638 - 13,885,931 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PICALM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl919,835,938 - 20,123,566 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1919,835,934 - 19,947,239 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2922,107,100 - 22,184,702 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PICALM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1177,214,391 - 77,325,626 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl177,213,836 - 77,324,875 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604348,400,453 - 48,511,604 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Picalm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248453,891,061 - 3,990,342 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248453,875,601 - 3,990,347 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Picalm
359 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:16
Count of miRNA genes:15
Interacting mature miRNAs:15
Transcripts:ENSRNOT00000025415
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1136745990163747690Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat

Markers in Region
RH66557  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21144,137,248 - 144,137,411 (+)MAPPERmRatBN7.2
Rnor_6.01154,458,117 - 154,458,279NCBIRnor6.0
Rnor_5.01160,762,577 - 160,762,739UniSTSRnor5.0
RGSC_v3.41146,835,123 - 146,835,285UniSTSRGSC3.4
Celera1142,368,875 - 142,369,037UniSTS
Cytogenetic Map1q32UniSTS
SHGC-24065  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21144,137,408 - 144,137,535 (+)MAPPERmRatBN7.2
mRatBN7.2X97,527,445 - 97,527,572 (+)MAPPERmRatBN7.2
Rnor_6.01154,458,277 - 154,458,403NCBIRnor6.0
Rnor_6.0X105,158,590 - 105,158,716NCBIRnor6.0
Rnor_5.01160,762,736 - 160,762,863NCBIRnor5.0
Rnor_5.0X105,051,438 - 105,051,565NCBIRnor5.0
RGSC_v3.41146,835,283 - 146,835,409UniSTSRGSC3.4
RGSC_v3.4X121,797,723 - 121,797,849UniSTSRGSC3.4
CeleraX98,568,913 - 98,569,039UniSTS
Celera1142,369,035 - 142,369,161UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic MapXq34UniSTS
RH136706  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21144,076,269 - 144,076,487 (+)MAPPERmRatBN7.2
Rnor_6.01154,397,011 - 154,397,228NCBIRnor6.0
Rnor_5.01160,701,471 - 160,701,688UniSTSRnor5.0
RGSC_v3.41146,773,591 - 146,773,808UniSTSRGSC3.4
Celera1142,308,197 - 142,308,414UniSTS
RH 3.4 Map11122.99UniSTS
Cytogenetic Map1q32UniSTS
Picalm  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21144,137,213 - 144,137,363 (+)MAPPERmRatBN7.2
Rnor_6.01154,458,082 - 154,458,231NCBIRnor6.0
Rnor_5.01160,762,542 - 160,762,691UniSTSRnor5.0
RGSC_v3.41146,835,088 - 146,835,237UniSTSRGSC3.4
Celera1142,368,840 - 142,368,989UniSTS
Cytogenetic Map1q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 10 74 35 41 11 8
Low 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006229685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF041373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF041374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY699717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY706215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY724477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000025415   ⟹   ENSRNOP00000025415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1154,377,529 - 154,457,089 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084268   ⟹   ENSRNOP00000068834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1144,056,729 - 144,137,555 (+)Ensembl
Rnor_6.0 Ensembl1154,377,447 - 154,457,287 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091470   ⟹   ENSRNOP00000069185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1144,103,449 - 144,137,534 (+)Ensembl
Rnor_6.0 Ensembl1154,377,505 - 154,457,191 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092086   ⟹   ENSRNOP00000075591
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1154,377,505 - 154,457,191 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092945   ⟹   ENSRNOP00000076067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1144,056,729 - 144,137,555 (+)Ensembl
Rnor_6.0 Ensembl1154,377,247 - 154,458,425 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093052   ⟹   ENSRNOP00000076050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1154,446,156 - 154,457,391 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111120   ⟹   ENSRNOP00000082147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1144,056,721 - 144,137,557 (+)Ensembl
RefSeq Acc Id: NM_053554   ⟹   NP_446006
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81153,469,297 - 153,548,854 (+)NCBI
mRatBN7.21144,056,761 - 144,136,323 (+)NCBI
Rnor_6.01154,377,505 - 154,457,191 (+)NCBI
Rnor_5.01160,681,689 - 160,763,382 (+)NCBI
RGSC_v3.41146,754,085 - 146,834,197 (+)RGD
Celera1142,288,691 - 142,367,949 (+)RGD
Sequence:
RefSeq Acc Id: XM_006229669   ⟹   XP_006229731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81153,468,982 - 153,548,954 (+)NCBI
mRatBN7.21144,056,415 - 144,138,045 (+)NCBI
Rnor_6.01154,377,230 - 154,458,966 (+)NCBI
Rnor_5.01160,681,689 - 160,763,382 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229670   ⟹   XP_006229732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81153,468,982 - 153,548,954 (+)NCBI
mRatBN7.21144,056,416 - 144,138,045 (+)NCBI
Rnor_6.01154,377,230 - 154,458,966 (+)NCBI
Rnor_5.01160,681,689 - 160,763,382 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229671   ⟹   XP_006229733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81153,468,982 - 153,548,954 (+)NCBI
mRatBN7.21144,056,415 - 144,138,045 (+)NCBI
Rnor_6.01154,377,229 - 154,458,966 (+)NCBI
Rnor_5.01160,681,689 - 160,763,382 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229672   ⟹   XP_006229734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81153,468,982 - 153,548,954 (+)NCBI
mRatBN7.21144,056,416 - 144,138,045 (+)NCBI
Rnor_6.01154,377,230 - 154,458,966 (+)NCBI
Rnor_5.01160,681,689 - 160,763,382 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229673   ⟹   XP_006229735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81153,468,982 - 153,548,954 (+)NCBI
mRatBN7.21144,056,417 - 144,138,045 (+)NCBI
Rnor_6.01154,377,230 - 154,458,966 (+)NCBI
Rnor_5.01160,681,689 - 160,763,382 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229674   ⟹   XP_006229736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81153,468,982 - 153,548,954 (+)NCBI
mRatBN7.21144,056,416 - 144,138,045 (+)NCBI
Rnor_6.01154,377,230 - 154,458,966 (+)NCBI
Rnor_5.01160,681,689 - 160,763,382 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229675   ⟹   XP_006229737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81153,468,982 - 153,548,954 (+)NCBI
mRatBN7.21144,056,416 - 144,138,045 (+)NCBI
Rnor_6.01154,377,230 - 154,458,966 (+)NCBI
Rnor_5.01160,681,689 - 160,763,382 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229676   ⟹   XP_006229738
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81153,468,982 - 153,550,086 (+)NCBI
mRatBN7.21144,056,418 - 144,138,045 (+)NCBI
Rnor_6.01154,377,231 - 154,458,966 (+)NCBI
Rnor_5.01160,681,689 - 160,763,382 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229677   ⟹   XP_006229739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81153,468,982 - 153,550,086 (+)NCBI
mRatBN7.21144,056,419 - 144,138,045 (+)NCBI
Rnor_6.01154,377,231 - 154,458,966 (+)NCBI
Rnor_5.01160,681,689 - 160,763,382 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229678   ⟹   XP_006229740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81153,468,982 - 153,550,086 (+)NCBI
mRatBN7.21144,056,419 - 144,138,045 (+)NCBI
Rnor_6.01154,377,232 - 154,458,922 (+)NCBI
Rnor_5.01160,681,689 - 160,763,382 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229679   ⟹   XP_006229741
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81153,468,982 - 153,548,954 (+)NCBI
mRatBN7.21144,056,417 - 144,138,045 (+)NCBI
Rnor_6.01154,377,231 - 154,458,966 (+)NCBI
Rnor_5.01160,681,689 - 160,763,382 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229680   ⟹   XP_006229742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81153,468,982 - 153,548,954 (+)NCBI
mRatBN7.21144,056,418 - 144,138,045 (+)NCBI
Rnor_6.01154,377,232 - 154,458,966 (+)NCBI
Rnor_5.01160,681,689 - 160,763,382 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229681   ⟹   XP_006229743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81153,468,982 - 153,548,954 (+)NCBI
mRatBN7.21144,056,418 - 144,138,045 (+)NCBI
Rnor_6.01154,377,232 - 154,458,966 (+)NCBI
Rnor_5.01160,681,689 - 160,763,382 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229682   ⟹   XP_006229744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81153,468,982 - 153,548,954 (+)NCBI
mRatBN7.21144,056,419 - 144,138,045 (+)NCBI
Rnor_6.01154,377,232 - 154,458,966 (+)NCBI
Rnor_5.01160,681,689 - 160,763,382 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229683   ⟹   XP_006229745
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81153,468,982 - 153,550,086 (+)NCBI
mRatBN7.21144,056,419 - 144,138,045 (+)NCBI
Rnor_6.01154,377,233 - 154,458,966 (+)NCBI
Rnor_5.01160,681,689 - 160,763,382 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229684   ⟹   XP_006229746
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81153,468,982 - 153,550,086 (+)NCBI
mRatBN7.21144,056,420 - 144,138,045 (+)NCBI
Rnor_6.01154,377,233 - 154,458,966 (+)NCBI
Rnor_5.01160,681,689 - 160,763,382 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229685   ⟹   XP_006229747
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81153,468,982 - 153,550,086 (+)NCBI
mRatBN7.21144,056,420 - 144,138,045 (+)NCBI
Rnor_6.01154,377,234 - 154,458,922 (+)NCBI
Rnor_5.01160,681,689 - 160,763,382 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039093093   ⟹   XP_038949021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81153,468,982 - 153,517,027 (+)NCBI
mRatBN7.21144,056,419 - 144,104,507 (+)NCBI
RefSeq Acc Id: XM_063275985   ⟹   XP_063132055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81153,468,982 - 153,550,086 (+)NCBI
RefSeq Acc Id: XM_063275986   ⟹   XP_063132056
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81153,468,982 - 153,550,086 (+)NCBI
RefSeq Acc Id: XM_063275988   ⟹   XP_063132058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81153,468,982 - 153,550,086 (+)NCBI
RefSeq Acc Id: XM_063275989   ⟹   XP_063132059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81153,469,313 - 153,548,954 (+)NCBI
Protein Sequences
Protein RefSeqs NP_446006 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229731 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229732 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229733 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229734 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229735 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229736 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229737 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229738 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229739 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229740 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229741 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229742 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229743 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229744 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229745 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229746 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229747 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949021 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132055 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132056 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132058 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132059 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB97078 (Get FASTA)   NCBI Sequence Viewer  
  AAB97079 (Get FASTA)   NCBI Sequence Viewer  
  AAI00143 (Get FASTA)   NCBI Sequence Viewer  
  AAU06231 (Get FASTA)   NCBI Sequence Viewer  
  AAU10101 (Get FASTA)   NCBI Sequence Viewer  
  EDM18554 (Get FASTA)   NCBI Sequence Viewer  
  EDM18555 (Get FASTA)   NCBI Sequence Viewer  
  EDM18556 (Get FASTA)   NCBI Sequence Viewer  
  EDM18557 (Get FASTA)   NCBI Sequence Viewer  
  EDM18558 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068834
  ENSRNOP00000068834.2
  ENSRNOP00000069185.3
  ENSRNOP00000076067
  ENSRNOP00000076067.2
  ENSRNOP00000082147
  ENSRNOP00000082147.1
GenBank Protein O55012 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446006   ⟸   NM_053554
- UniProtKB: O55011 (UniProtKB/Swiss-Prot),   O55012 (UniProtKB/Swiss-Prot),   A6I624 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229734   ⟸   XM_006229672
- Peptide Label: isoform X4
- UniProtKB: A6I624 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229733   ⟸   XM_006229671
- Peptide Label: isoform X3
- UniProtKB: A6I624 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229736   ⟸   XM_006229674
- Peptide Label: isoform X6
- UniProtKB: A6I624 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229731   ⟸   XM_006229669
- Peptide Label: isoform X1
- UniProtKB: A6I624 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229735   ⟸   XM_006229673
- Peptide Label: isoform X5
- UniProtKB: A6I624 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229737   ⟸   XM_006229675
- Peptide Label: isoform X7
- UniProtKB: A6I624 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229732   ⟸   XM_006229670
- Peptide Label: isoform X2
- UniProtKB: A6I624 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229743   ⟸   XM_006229681
- Peptide Label: isoform X15
- UniProtKB: A6I624 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229741   ⟸   XM_006229679
- Peptide Label: isoform X13
- UniProtKB: A6I624 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229744   ⟸   XM_006229682
- Peptide Label: isoform X16
- UniProtKB: A6I624 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229739   ⟸   XM_006229677
- Peptide Label: isoform X10
- UniProtKB: A0A1B0GWY4 (UniProtKB/TrEMBL),   A6I624 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229742   ⟸   XM_006229680
- Peptide Label: isoform X14
- UniProtKB: A6I624 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229738   ⟸   XM_006229676
- Peptide Label: isoform X8
- UniProtKB: A0A0G2JTT2 (UniProtKB/TrEMBL),   A6I624 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229740   ⟸   XM_006229678
- Peptide Label: isoform X12
- UniProtKB: Q498N4 (UniProtKB/TrEMBL),   A6I624 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229745   ⟸   XM_006229683
- Peptide Label: isoform X17
- UniProtKB: Q66SY1 (UniProtKB/TrEMBL),   E9PTD2 (UniProtKB/TrEMBL),   A6I624 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229746   ⟸   XM_006229684
- Peptide Label: isoform X18
- UniProtKB: A6I625 (UniProtKB/TrEMBL),   A6I624 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229747   ⟸   XM_006229685
- Peptide Label: isoform X20
- UniProtKB: Q66WT9 (UniProtKB/TrEMBL),   A0A0G2KAZ9 (UniProtKB/TrEMBL),   A6I624 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075591   ⟸   ENSRNOT00000092086
RefSeq Acc Id: ENSRNOP00000076067   ⟸   ENSRNOT00000092945
RefSeq Acc Id: ENSRNOP00000069185   ⟸   ENSRNOT00000091470
RefSeq Acc Id: ENSRNOP00000076050   ⟸   ENSRNOT00000093052
RefSeq Acc Id: ENSRNOP00000025415   ⟸   ENSRNOT00000025415
RefSeq Acc Id: ENSRNOP00000068834   ⟸   ENSRNOT00000084268
RefSeq Acc Id: XP_038949021   ⟸   XM_039093093
- Peptide Label: isoform X22
RefSeq Acc Id: ENSRNOP00000082147   ⟸   ENSRNOT00000111120
RefSeq Acc Id: XP_063132055   ⟸   XM_063275985
- Peptide Label: isoform X9
- UniProtKB: A6I624 (UniProtKB/TrEMBL),   A6I622 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132056   ⟸   XM_063275986
- Peptide Label: isoform X11
- UniProtKB: A6I624 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132058   ⟸   XM_063275988
- Peptide Label: isoform X19
- UniProtKB: A6I624 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132059   ⟸   XM_063275989
- Peptide Label: isoform X21
- UniProtKB: A6I624 (UniProtKB/TrEMBL)
Protein Domains
ENTH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O55012-F1-model_v2 AlphaFold O55012 1-640 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690191
Promoter ID:EPDNEW_R711
Type:initiation region
Name:Picalm_1
Description:phosphatidylinositol binding clathrin assembly protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R712  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01154,377,220 - 154,377,280EPDNEW
RGD ID:13690195
Promoter ID:EPDNEW_R712
Type:initiation region
Name:Picalm_2
Description:phosphatidylinositol binding clathrin assembly protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R711  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01154,377,481 - 154,377,541EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621054 AgrOrtholog
BioCyc Gene G2FUF-58534 BioCyc
Ensembl Genes ENSRNOG00000018322 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000084268.2 UniProtKB/TrEMBL
  ENSRNOT00000091470.3 UniProtKB/TrEMBL
  ENSRNOT00000092945.2 UniProtKB/TrEMBL
  ENSRNOT00000111120.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7456159 IMAGE-MGC_LOAD
InterPro ANTH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AP180-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clathrin_AP_dom2 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  ENTH UniProtKB/TrEMBL
  ENTH_VHS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Epsin-like_N UniProtKB/Swiss-Prot
KEGG Report rno:89816 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114290 IMAGE-MGC_LOAD
NCBI Gene 89816 ENTREZGENE
PANTHER PTHR22951 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR22951:SF16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ANTH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Picalm PhenoGen
PROSITE ENTH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018322 RatGTEx
SMART ENTH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP ENTH_VHS UniProtKB/Swiss-Prot
  GAT-like domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48464 UniProtKB/TrEMBL
UniProt A0A0G2JTT2 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JUQ5_RAT UniProtKB/TrEMBL
  A0A0G2KAZ9 ENTREZGENE
  A0A1B0GWY4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G718_RAT UniProtKB/TrEMBL
  A6I622 ENTREZGENE, UniProtKB/TrEMBL
  A6I624 ENTREZGENE, UniProtKB/TrEMBL
  A6I625 ENTREZGENE, UniProtKB/TrEMBL
  E9PTD2 ENTREZGENE
  O55011 ENTREZGENE
  O55012 ENTREZGENE, UniProtKB/Swiss-Prot
  Q498N4 ENTREZGENE, UniProtKB/TrEMBL
  Q66SY1 ENTREZGENE, UniProtKB/TrEMBL
  Q66WT9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A0G2KAZ9 UniProtKB/TrEMBL
  E9PTD2 UniProtKB/TrEMBL
  O55011 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Picalm  phosphatidylinositol binding clathrin assembly protein      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Picalm  phosphatidylinositol binding clathrin assembly protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression enriched in brain 633906
gene_protein 69 kD 633906