Lamc2 (laminin subunit gamma 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Lamc2 (laminin subunit gamma 2) Rattus norvegicus
Analyze
Symbol: Lamc2
Name: laminin subunit gamma 2
RGD ID: 621053
Description: Predicted to enable heparin binding activity. Predicted to be involved in several processes, including axon guidance; positive regulation of cell migration; and positive regulation of cell population proliferation. Located in cell cortex; extracellular space; and perinuclear region of cytoplasm. Part of laminin-2 complex. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and lung small cell carcinoma. Orthologous to human LAMC2 (laminin subunit gamma 2); PARTICIPATES IN cell-extracellular matrix signaling pathway; Entamoebiasis pathway; small cell lung carcinoma pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: lamimin, gamma 2; laminin subunit gamma-2; laminin, gamma 2; LOC289096
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81367,835,199 - 67,894,694 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1367,835,199 - 67,895,102 (-)EnsemblGRCr8
mRatBN7.21365,284,664 - 65,344,164 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1365,284,664 - 65,344,200 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1367,888,292 - 67,947,715 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01369,176,423 - 69,235,915 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01366,427,734 - 66,487,220 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01370,566,643 - 70,632,126 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1370,566,643 - 70,626,252 (-)Ensemblrn6Rnor6.0
Rnor_5.01375,532,726 - 75,598,249 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41368,151,074 - 68,211,117 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1365,189,676 - 65,249,215 (-)NCBICelera
RGSC_v3.11368,192,400 - 68,195,295 (-)NCBI
Cytogenetic Map13q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(E)-roxithromycin  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
ethylparaben  (ISO)
fentanyl  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
furfural  (ISO)
genistein  (ISO)
gentamycin  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
indinavir  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lamivudine  (ISO)
lipopolysaccharide  (ISO)
lornoxicam  (EXP)
LY-2157299  (ISO)
lysophosphatidylcholine  (ISO)
maneb  (ISO)
mechlorethamine  (ISO)
mercury dibromide  (ISO)
metformin  (EXP)
methylparaben  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
palbociclib  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentanal  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenacetin  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
pyridaben  (ISO)
rac-lactic acid  (ISO)
saquinavir  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP)
sodium arsenite  (ISO)
sodium chloride  (ISO)
Soman  (EXP)
sotorasib  (ISO)
sphingosine 1-phosphate  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Serum LAMC2 enhances the prognostic value of a multi-parametric panel in non-small cell lung cancer. Korbakis D, etal., Br J Cancer. 2015 Jul 28;113(3):484-91. doi: 10.1038/bjc.2015.171. Epub 2015 Jul 16.
3. Differential expression of the LAMB3 and LAMC2 genes between small cell and non-small cell lung carcinomas. Manda R, etal., Biochem Biophys Res Commun. 2000 Aug 28;275(2):440-5. doi: 10.1006/bbrc.2000.3331.
4. Laminin-5¿2 chain expression is associated with tumor cell invasiveness and prognosis of lung squamous cell carcinoma. Masuda R, etal., Biomed Res. 2012;33(5):309-17.
5. LAMC2 enhances the metastatic potential of lung adenocarcinoma. Moon YW, etal., Cell Death Differ. 2015 Aug;22(8):1341-52. doi: 10.1038/cdd.2014.228. Epub 2015 Jan 16.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. Mutations in the gamma 2 chain gene (LAMC2) of kalinin/laminin 5 in the junctional forms of epidermolysis bullosa. Pulkkinen L, etal., Nat Genet. 1994 Mar;6(3):293-7.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Epigenetic inactivation of laminin-5-encoding genes in lung cancers. Sathyanarayana UG, etal., Clin Cancer Res. 2003 Jul;9(7):2665-72.
15. Laminin alpha 5, a major transcript of normal and malignant rat liver epithelial cells, is differentially expressed in developing and adult liver. Seebacher T, etal., Exp Cell Res 1997 Nov 25;237(1):70-6.
16. Differential localization of laminin gamma and integrin beta in primary cultures of the rat gingival epithelium. Tanno M, etal., J Periodontal Res. 2006 Feb;41(1):15-22.
Additional References at PubMed
PMID:9264260   PMID:11733994   PMID:15895400   PMID:18757743   PMID:20039268   PMID:20301201   PMID:23142791   PMID:24091622   PMID:35352799  


Genomics

Comparative Map Data
Lamc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81367,835,199 - 67,894,694 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1367,835,199 - 67,895,102 (-)EnsemblGRCr8
mRatBN7.21365,284,664 - 65,344,164 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1365,284,664 - 65,344,200 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1367,888,292 - 67,947,715 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01369,176,423 - 69,235,915 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01366,427,734 - 66,487,220 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01370,566,643 - 70,632,126 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1370,566,643 - 70,626,252 (-)Ensemblrn6Rnor6.0
Rnor_5.01375,532,726 - 75,598,249 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41368,151,074 - 68,211,117 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1365,189,676 - 65,249,215 (-)NCBICelera
RGSC_v3.11368,192,400 - 68,195,295 (-)NCBI
Cytogenetic Map13q21NCBI
LAMC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381183,186,264 - 183,258,968 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1183,186,057 - 183,245,127 (+)Ensemblhg38GRCh38
GRCh371183,155,399 - 183,214,262 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361181,421,797 - 181,480,885 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1156,266,276 - 156,325,361 (+)NCBICelera
Cytogenetic Map1q25.3NCBI
HuRef1154,390,994 - 154,450,096 (+)NCBIHuRef
CHM1_11184,578,284 - 184,637,373 (+)NCBICHM1_1
T2T-CHM13v2.01182,538,023 - 182,618,306 (+)NCBIT2T-CHM13v2.0
Lamc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391152,998,502 - 153,062,193 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1152,998,502 - 153,062,193 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381153,122,756 - 153,186,447 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,122,756 - 153,186,447 (-)Ensemblmm10GRCm38
MGSCv371154,969,886 - 155,033,577 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361154,884,977 - 154,948,235 (-)NCBIMGSCv36mm8
Celera1155,543,898 - 155,607,447 (-)NCBICelera
Cytogenetic Map1G3NCBI
cM Map165.26NCBI
Lamc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540622,020,024 - 22,075,942 (+)Ensembl
ChiLan1.0NW_00495540622,020,330 - 22,074,271 (+)NCBIChiLan1.0ChiLan1.0
LAMC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2166,485,132 - 66,565,152 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,164,250 - 66,248,653 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01158,697,084 - 158,763,209 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11162,862,789 - 162,921,864 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1162,862,785 - 162,921,864 (+)EnsemblpanPan2panpan1.1
LAMC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1716,543,541 - 16,625,304 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl716,569,086 - 16,624,085 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha716,155,023 - 16,210,026 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0716,274,543 - 16,357,226 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl716,299,574 - 16,357,226 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1716,209,554 - 16,264,409 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0716,318,705 - 16,373,685 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0716,449,666 - 16,504,660 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lamc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934488,742,049 - 88,800,517 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364816,588,865 - 6,647,188 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364816,588,797 - 6,647,167 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LAMC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9124,435,807 - 124,495,351 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.19124,427,545 - 124,499,672 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LAMC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12546,133,079 - 46,199,960 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2546,131,827 - 46,199,753 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605547,351,190 - 47,417,763 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lamc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462481410,476,323 - 10,536,724 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462481410,475,629 - 10,536,694 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Lamc2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11032,601,822 - 32,663,367 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lamc2
346 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:221
Count of miRNA genes:142
Interacting mature miRNAs:183
Transcripts:ENSRNOT00000036947
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132485392569853925Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
LAMC2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21365,299,458 - 65,299,908 (+)MAPPERmRatBN7.2
Rnor_6.01370,581,515 - 70,581,964NCBIRnor6.0
Rnor_5.01375,547,598 - 75,548,047UniSTSRnor5.0
RGSC_v3.41368,165,868 - 68,166,317UniSTSRGSC3.4
Celera1365,204,468 - 65,204,917UniSTS
Cytogenetic Map13q21UniSTS
RH129354  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21365,284,864 - 65,285,061 (+)MAPPERmRatBN7.2
Rnor_6.01370,566,844 - 70,567,040NCBIRnor6.0
Rnor_5.01375,532,927 - 75,533,123UniSTSRnor5.0
RGSC_v3.41368,151,275 - 68,151,471UniSTSRGSC3.4
Celera1365,189,877 - 65,190,073UniSTS
RH 3.4 Map13301.5UniSTS
Cytogenetic Map13q21UniSTS
RH140304  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21365,285,384 - 65,285,571 (+)MAPPERmRatBN7.2
Rnor_6.01370,567,364 - 70,567,550NCBIRnor6.0
Rnor_5.01375,533,447 - 75,533,633UniSTSRnor5.0
RGSC_v3.41368,151,795 - 68,151,981UniSTSRGSC3.4
Celera1365,190,397 - 65,190,583UniSTS
Cytogenetic Map13q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 138 90 90 59 45 59 6 308 144 10 118 81 92 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000036947   ⟹   ENSRNOP00000037099
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1367,835,199 - 67,895,102 (-)Ensembl
mRatBN7.2 Ensembl1365,284,664 - 65,344,200 (-)Ensembl
Rnor_6.0 Ensembl1370,566,643 - 70,626,252 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1370,607,681 - 70,608,152 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092339   ⟹   ENSRNOP00000075879
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1370,570,927 - 70,573,572 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092499   ⟹   ENSRNOP00000075844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1370,567,635 - 70,625,842 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092548
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1370,603,044 - 70,626,252 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000123631   ⟹   ENSRNOP00000101294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1367,835,199 - 67,885,634 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000131794   ⟹   ENSRNOP00000099868
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1367,835,199 - 67,894,568 (-)Ensembl
RefSeq Acc Id: NM_001100640   ⟹   NP_001094110
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81367,835,199 - 67,894,694 (-)NCBI
mRatBN7.21365,284,664 - 65,344,164 (-)NCBI
Rnor_6.01370,566,643 - 70,626,252 (-)NCBI
Rnor_5.01375,532,726 - 75,598,249 (-)NCBI
RGSC_v3.41368,151,074 - 68,211,117 (-)RGD
Celera1365,189,676 - 65,249,215 (-)RGD
Sequence:
RefSeq Acc Id: XM_008769603   ⟹   XP_008767825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81367,835,202 - 67,894,530 (-)NCBI
mRatBN7.21365,284,664 - 65,343,981 (-)NCBI
Rnor_6.01370,566,643 - 70,632,126 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001094110 (Get FASTA)   NCBI Sequence Viewer  
  XP_008767825 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA70095 (Get FASTA)   NCBI Sequence Viewer  
  EDM09550 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000037099
  ENSRNOP00000037099.5
  ENSRNOP00000099868
  ENSRNOP00000099868.1
  ENSRNOP00000101294.1
RefSeq Acc Id: NP_001094110   ⟸   NM_001100640
- Peptide Label: precursor
- UniProtKB: F1LRH4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767825   ⟸   XM_008769603
- Peptide Label: isoform X1
- UniProtKB: F1LRH4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075879   ⟸   ENSRNOT00000092339
Ensembl Acc Id: ENSRNOP00000075844   ⟸   ENSRNOT00000092499
Ensembl Acc Id: ENSRNOP00000037099   ⟸   ENSRNOT00000036947
Ensembl Acc Id: ENSRNOP00000101294   ⟸   ENSRNOT00000123631
Ensembl Acc Id: ENSRNOP00000099868   ⟸   ENSRNOT00000131794
Protein Domains
Laminin EGF-like   Laminin IV type A

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LRH4-F1-model_v2 AlphaFold F1LRH4 1-1192 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698903
Promoter ID:EPDNEW_R9419
Type:single initiation site
Name:Lamc2_1
Description:laminin subunit gamma 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01370,625,867 - 70,625,927EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621053 AgrOrtholog
BioCyc Gene G2FUF-17890 BioCyc
Ensembl Genes ENSRNOG00000002667 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036947 ENTREZGENE
  ENSRNOT00000036947.7 UniProtKB/TrEMBL
  ENSRNOT00000123631.1 UniProtKB/TrEMBL
  ENSRNOT00000131794 ENTREZGENE
  ENSRNOT00000131794.1 UniProtKB/TrEMBL
Gene3D-CATH Laminin UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/TrEMBL
  EGF_laminin UniProtKB/TrEMBL
  Laminin/Netrin_ECM UniProtKB/TrEMBL
  Laminin_B_type_IV UniProtKB/TrEMBL
  LMN_ATRN_NET-like_EGF UniProtKB/TrEMBL
KEGG Report rno:192362 UniProtKB/TrEMBL
NCBI Gene 192362 ENTREZGENE
PANTHER LAMININ SUBUNIT GAMMA-2 UniProtKB/TrEMBL
  NETRIN/LAMININ-RELATED UniProtKB/TrEMBL
Pfam EGF_LMN_ATRN UniProtKB/TrEMBL
  Laminin_B UniProtKB/TrEMBL
  Laminin_EGF UniProtKB/TrEMBL
PhenoGen Lamc2 PhenoGen
PRINTS EGFLAMININ UniProtKB/TrEMBL
PROSITE EGF_LAM_1 UniProtKB/TrEMBL
  EGF_LAM_2 UniProtKB/TrEMBL
  LAMININ_IVA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002667 RatGTEx
SMART EGF UniProtKB/TrEMBL
  EGF_Lam UniProtKB/TrEMBL
  LamB UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
UniProt A0ABK0KY61_RAT UniProtKB/TrEMBL
  A0ABK0LM30_RAT UniProtKB/TrEMBL
  A6ICU7_RAT UniProtKB/TrEMBL
  F1LRH4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Lamc2  laminin subunit gamma 2  Lamc2  laminin, gamma 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-03-02 Lamc2  laminin, gamma 2  Lamc2  lamimin, gamma 2  Name updated 1299863 APPROVED
2006-04-28 Lamc2  lamimin, gamma 2  Lamc2_predicted  laminin, gamma 2 (predicted)  Data merged from RGD:1306650 737654 APPROVED
2005-01-20 Lamc2  lamimin, gamma 2      Symbol and Name status set to approved 1299863 APPROVED
2005-01-12 Lamc2_predicted  laminin, gamma 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in normal and malignant liver 633095