Tkt (transketolase) - Rat Genome Database

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Gene: Tkt (transketolase) Rattus norvegicus
Analyze
Symbol: Tkt
Name: transketolase
RGD ID: 621036
Description: Enables cation binding activity; monosaccharide binding activity; and transketolase activity. Involved in pentose-phosphate shunt, non-oxidative branch. Located in endoplasmic reticulum membrane and peroxisome. Orthologous to human TKT (transketolase); PARTICIPATES IN pentose phosphate pathway; pentose phosphate pathway - non-oxidative phase; ribose 5-phosphate isomerase deficiency pathway; INTERACTS WITH 1,3-dinitrobenzene; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: TK
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8165,729,381 - 5,755,170 (+)NCBIGRCr8
mRatBN7.2165,723,764 - 5,748,702 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl165,723,762 - 5,748,698 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx165,735,981 - 5,760,697 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0166,881,435 - 6,906,151 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0165,734,559 - 5,759,275 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0166,609,670 - 6,634,608 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl166,609,668 - 6,634,595 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0166,543,529 - 6,568,467 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4165,908,759 - 5,933,695 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1165,908,756 - 5,933,689 (+)NCBI
Celera169,440,328 - 9,465,209 (-)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astaxanthin  (ISO)
atrazine  (ISO)
Augmentin  (ISO)
azoxystrobin  (EXP)
benfotiamine  (EXP,ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
buspirone  (EXP)
butan-1-ol  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlormequat chloride  (EXP)
chloropicrin  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
cisplatin  (ISO)
clavulanic acid  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
felbamate  (EXP)
fenthion  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
gabapentin  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hydroquinone  (ISO)
imidacloprid  (EXP)
inulin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
L-methionine  (ISO)
lead(II) chloride  (ISO)
levofloxacin  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
mercury dibromide  (ISO)
methapyrilene  (EXP,ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
morphine  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenethyl caffeate  (EXP)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
PhIP  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
T-2 toxin  (EXP)
tetrachloromethane  (EXP)
thiabendazole  (EXP)
thimerosal  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vitamin E  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Nucleotide and predicted amino acid sequence of a cDNA clone encoding part of human transketolase. Abedinia M, etal., Biochem Biophys Res Commun 1992 Mar 31;183(3):1159-66.
2. In situ localization of transketolase activity in epithelial cells of different rat tissues and subcellularly in liver parenchymal cells. Boren J, etal., J Histochem Cytochem. 2006 Feb;54(2):191-9. Epub 2005 Aug 22.
3. The pentose phosphate pathway in the endoplasmic reticulum. Bublitz C and Steavenson S, J Biol Chem. 1988 Sep 15;263(26):12849-53.
4. The interdependence of glycolytic and pentose cycle intermediates in ad libitum fed rats. Casazza JP and Veech RL, J Biol Chem. 1986 Jan 15;261(2):690-8.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Properties and functions of the thiamin diphosphate dependent enzyme transketolase. Schenk G, etal., Int J Biochem Cell Biol. 1998 Dec;30(12):1297-318.
16. Effect of Anabolic Steroid Nandrolone Decanoate on the Properties of Certain Enzymes in the Heart, Liver, and Muscle of Rats, and their Effect on Rats' Cardiac Electrophysiology. Tylicki A, etal., Horm Metab Res. 2007 Apr;39(4):268-72.
17. A humble hexose monophosphate pathway metabolite regulates short- and long-term control of lipogenesis. Veech RL Proc Natl Acad Sci U S A. 2003 May 13;100(10):5578-80. Epub 2003 Apr 29.
Additional References at PubMed
PMID:8419340   PMID:9357955   PMID:9611778   PMID:12167708   PMID:17634366   PMID:19056867   PMID:19190083   PMID:20458337   PMID:20667822   PMID:22871113   PMID:23376485   PMID:23533145  
PMID:25028661   PMID:33450132  


Genomics

Comparative Map Data
Tkt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8165,729,381 - 5,755,170 (+)NCBIGRCr8
mRatBN7.2165,723,764 - 5,748,702 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl165,723,762 - 5,748,698 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx165,735,981 - 5,760,697 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0166,881,435 - 6,906,151 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0165,734,559 - 5,759,275 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0166,609,670 - 6,634,608 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl166,609,668 - 6,634,595 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0166,543,529 - 6,568,467 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4165,908,759 - 5,933,695 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1165,908,756 - 5,933,689 (+)NCBI
Celera169,440,328 - 9,465,209 (-)NCBICelera
Cytogenetic Map16p16NCBI
TKT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38353,224,712 - 53,256,022 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl353,224,712 - 53,256,052 (-)EnsemblGRCh38hg38GRCh38
GRCh37353,258,728 - 53,290,038 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36353,234,704 - 53,264,998 (-)NCBINCBI36Build 36hg18NCBI36
Build 34353,234,705 - 53,264,998NCBI
Celera353,225,747 - 53,257,192 (-)NCBICelera
Cytogenetic Map3p21.1NCBI
HuRef353,308,475 - 53,339,480 (-)NCBIHuRef
CHM1_1353,210,297 - 53,241,712 (-)NCBICHM1_1
T2T-CHM13v2.0353,257,622 - 53,288,998 (-)NCBIT2T-CHM13v2.0
Tkt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391430,271,088 - 30,296,681 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1430,270,316 - 30,296,677 (+)EnsemblGRCm39 Ensembl
GRCm381430,549,131 - 30,574,724 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1430,548,359 - 30,574,720 (+)EnsemblGRCm38mm10GRCm38
MGSCv371431,362,335 - 31,387,908 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361429,378,158 - 29,403,731 (+)NCBIMGSCv36mm8
Celera1426,805,317 - 26,830,435 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1418.79NCBI
Tkt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554303,178,830 - 3,193,345 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554303,178,830 - 3,193,241 (-)NCBIChiLan1.0ChiLan1.0
TKT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2253,207,948 - 53,252,434 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1353,212,734 - 53,257,204 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0353,168,426 - 53,199,003 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1354,389,549 - 54,420,704 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl354,389,549 - 54,420,704 (-)Ensemblpanpan1.1panPan2
TKT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12036,690,540 - 36,705,980 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2036,681,531 - 36,742,199 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2036,617,359 - 36,642,352 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02036,959,138 - 36,984,142 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2036,958,981 - 36,984,141 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12036,395,903 - 36,420,888 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02036,757,580 - 36,782,577 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02036,972,262 - 36,997,252 (+)NCBIUU_Cfam_GSD_1.0
Tkt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118170,812,273 - 170,840,216 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364733,950,920 - 3,978,672 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364733,950,846 - 3,978,778 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TKT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1335,348,915 - 35,377,587 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11335,348,921 - 35,377,518 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21338,418,457 - 38,447,124 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TKT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12214,620,340 - 14,650,694 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2214,620,287 - 14,650,655 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041152,245,198 - 152,275,549 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tkt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248223,989,299 - 4,014,269 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248223,989,292 - 4,014,150 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tkt
216 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:30
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000021862
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat

Markers in Region
BE117994  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2165,747,569 - 5,747,727 (+)MAPPERmRatBN7.2
Rnor_6.0166,633,476 - 6,633,633NCBIRnor6.0
Rnor_5.0166,567,335 - 6,567,492UniSTSRnor5.0
RGSC_v3.4165,932,565 - 5,932,722UniSTSRGSC3.4
Celera169,441,301 - 9,441,458UniSTS
RH 3.4 Map1633.2UniSTS
Cytogenetic Map16p16UniSTS
TKT  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2165,744,917 - 5,745,156 (+)MAPPERmRatBN7.2
Rnor_6.0166,630,824 - 6,631,062NCBIRnor6.0
Rnor_5.0166,564,683 - 6,564,921UniSTSRnor5.0
RGSC_v3.4165,929,913 - 5,930,151UniSTSRGSC3.4
Cytogenetic Map16p16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000021862   ⟹   ENSRNOP00000021862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl165,723,762 - 5,748,689 (+)Ensembl
Rnor_6.0 Ensembl166,609,668 - 6,634,595 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113496   ⟹   ENSRNOP00000095976
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl165,724,393 - 5,748,698 (+)Ensembl
RefSeq Acc Id: NM_022592   ⟹   NP_072114
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8165,730,232 - 5,755,168 (+)NCBI
mRatBN7.2165,723,764 - 5,748,700 (+)NCBI
Rnor_6.0166,609,670 - 6,634,606 (+)NCBI
Rnor_5.0166,543,529 - 6,568,467 (+)NCBI
RGSC_v3.4165,908,759 - 5,933,695 (+)RGD
Celera169,440,328 - 9,465,209 (-)RGD
Sequence:
RefSeq Acc Id: XM_006252661   ⟹   XP_006252723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8165,729,381 - 5,755,170 (+)NCBI
mRatBN7.2165,724,347 - 5,748,702 (+)NCBI
Rnor_6.0166,610,253 - 6,634,608 (+)NCBI
Rnor_5.0166,543,529 - 6,568,467 (+)NCBI
Sequence:
RefSeq Acc Id: NP_072114   ⟸   NM_022592
- UniProtKB: A6KG34 (UniProtKB/TrEMBL),   G3V826 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252723   ⟸   XM_006252661
- Peptide Label: isoform X1
- UniProtKB: P50137 (UniProtKB/Swiss-Prot),   A6KG36 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021862   ⟸   ENSRNOT00000021862
Ensembl Acc Id: ENSRNOP00000095976   ⟸   ENSRNOT00000113496
Protein Domains
Transketolase N-terminal   Transketolase-like pyrimidine-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50137-F1-model_v2 AlphaFold P50137 1-623 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621036 AgrOrtholog
BioCyc Gene G2FUF-12189 BioCyc
BioCyc Pathway NONOXIPENT-PWY [pentose phosphate pathway (non-oxidative branch) I] BioCyc
BioCyc Pathway Image NONOXIPENT-PWY BioCyc
Ensembl Genes ENSRNOG00000016064 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021862.7 UniProtKB/TrEMBL
  ENSRNOT00000113496.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.970 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro THDP-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketo_C/PFOR_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketolase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketolase-like_Pyr-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketolase_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketolase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketolase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketolase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64524 UniProtKB/Swiss-Prot
NCBI Gene 64524 ENTREZGENE
PANTHER TRANSKETOLASE UniProtKB/Swiss-Prot
  TRANSKETOLASE UniProtKB/Swiss-Prot
  TRANSKETOLASE UniProtKB/TrEMBL
  TRANSKETOLASE UniProtKB/TrEMBL
Pfam Transket_pyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketolase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transketolase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tkt PhenoGen
PROSITE TRANSKETOLASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSKETOLASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016064 RatGTEx
SMART Transket_pyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52518 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52922 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AQ92_RAT UniProtKB/TrEMBL
  A6KG34 ENTREZGENE, UniProtKB/TrEMBL
  A6KG35_RAT UniProtKB/TrEMBL
  A6KG36 ENTREZGENE, UniProtKB/TrEMBL
  A6KG37_RAT UniProtKB/TrEMBL
  A6KG38_RAT UniProtKB/TrEMBL
  G3V826 ENTREZGENE, UniProtKB/TrEMBL
  P50137 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Tkt  transketolase      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Tkt  transketolase      Symbol and Name status set to provisional 70820 PROVISIONAL