Tk1 (thymidine kinase 1) - Rat Genome Database

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Gene: Tk1 (thymidine kinase 1) Rattus norvegicus
Analyze
Symbol: Tk1
Name: thymidine kinase 1
RGD ID: 621014
Description: Enables identical protein binding activity. Involved in several processes, including fetal process involved in parturition; response to cortisol; and thymidine metabolic process. Predicted to be located in cytoplasm and nucleus. Orthologous to human TK1 (thymidine kinase 1); PARTICIPATES IN beta-ureidopropionase deficiency pathway; dihydropyrimidinase deficiency pathway; mitochondrial neurogastrointestinal encephalopathy syndrome pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Thymidine kinase 1 soluble; thymidine kinase 1, soluble; thymidine kinase, cytosolic; Tk
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SD-Tg(Gfap-Tk1)Jog  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.210103,034,755 - 103,046,125 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10103,031,521 - 103,046,920 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10108,135,849 - 108,147,124 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010107,598,960 - 107,610,235 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010102,955,543 - 102,966,869 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010106,817,556 - 106,828,888 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10106,817,601 - 106,828,884 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010106,456,781 - 106,468,109 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera10101,594,738 - 101,606,057 (-)NCBICelera
Cytogenetic Map10q32.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-diaminotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
alfacalcidol  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (EXP)
bicalutamide  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diclofenac  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enniatin  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
flavonoids  (ISO)
floxuridine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
hydrogen peroxide  (ISO)
imidacloprid  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
lidocaine  (EXP)
menadione  (ISO)
methotrexate  (EXP)
methyl methanesulfonate  (ISO)
mitomycin C  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
niclosamide  (ISO)
nitric oxide  (ISO)
obeticholic acid  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (EXP)
phenformin  (EXP)
phenobarbital  (ISO)
PhIP  (ISO)
phytoestrogen  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium bromate  (ISO)
potassium dichromate  (ISO)
procarbazine  (ISO)
progesterone  (EXP,ISO)
resveratrol  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trabectedin  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zalcitabine  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The rat thymidine kinase gene 5' region: evolution of a promoter. Arcot SS, etal., DNA Seq 1991;2(2):129-31.
2. Intestinal development in the suckling rat: effects of weaning, diet composition, and glucocorticoids on thymidine kinase activity and DNA synthesis. Buts JP and De Meyer R, Pediatr Res. 1984 Feb;18(2):145-50.
3. Clinical value of thymidine kinase in patients with cervical carcinoma. Fujiwaki R, etal., Oncology. 2001;61(1):47-54.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. The clinical significance of thymidine kinase 1 measurement in serum of breast cancer patients using anti-TK1 antibody. He Q, etal., Int J Biol Markers. 2000 Apr-Jun;15(2):139-46.
7. Glutamate dehydrogenase, alanine aminotransferase, thymidine kinase, and arginase in fetal and adult human and rat liver. Herzfeld A, etal., Pediatr Res. 1976 Dec;10(12):960-4.
8. The ontogeny of thymidine kinase in tissues of man and rat. Herzfeld A, etal., Pediatr Res. 1980 Dec;14(12):1304-10.
9. Serum thymidine kinase 1 is a prognostic and monitoring factor in patients with non-small cell lung cancer. Li HX, etal., Oncol Rep. 2005 Jan;13(1):145-9.
10. Differences in cytosolic and mitochondrial 5'-nucleotidase and deoxynucleoside kinase activities in Sprague-Dawley rat and CD-1 mouse tissues: implication for the toxicity of nucleoside analogs in animal models. Mirzaee S, etal., Toxicology. 2010 Jan 12;267(1-3):159-64. Epub 2009 Nov 12.
11. Cloning vectors for expression of cDNA libraries in mammalian cells. Murphy AJ and Efstratiadis A, Proc Natl Acad Sci U S A 1987 Dec;84(23):8277-81.
12. Thymidine kinase 1 regulatory fine-tuning through tetramer formation. Mutahir Z, etal., FEBS J. 2013 Mar;280(6):1531-41. doi: 10.1111/febs.12154. Epub 2013 Feb 25.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. Activity profiles of deoxynucleoside kinases and 5'-nucleotidases in cultured adipocytes and myoblastic cells: insights into mitochondrial toxicity of nucleoside analogs. Rylova SN, etal., Biochem Pharmacol. 2005 Mar 15;69(6):951-60.
20. Effect of copper and cadmium pretreatments on DNA synthesis and thymidine kinase activity in the liver of dimethylnitrosamine-treated and partially hepatectomized rats. Sakai K, etal., Gann. 1983 Oct;74(5):663-70.
21. Yin Yang-1 inhibits vascular smooth muscle cell growth and intimal thickening by repressing p21WAF1/Cip1 transcription and p21WAF1/Cip1-Cdk4-cyclin D1 assembly. Santiago FS, etal., Circ Res. 2007 Jul 20;101(2):146-55. Epub 2007 Jun 7.
Additional References at PubMed
PMID:204065   PMID:8889548   PMID:15733844   PMID:17407781   PMID:18981415   PMID:19063959   PMID:20544526   PMID:21900206   PMID:22385435  


Genomics

Comparative Map Data
Tk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.210103,034,755 - 103,046,125 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10103,031,521 - 103,046,920 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10108,135,849 - 108,147,124 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010107,598,960 - 107,610,235 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010102,955,543 - 102,966,869 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010106,817,556 - 106,828,888 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10106,817,601 - 106,828,884 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010106,456,781 - 106,468,109 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera10101,594,738 - 101,606,057 (-)NCBICelera
Cytogenetic Map10q32.2NCBI
TK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381778,174,079 - 78,187,204 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1778,174,091 - 78,187,233 (-)EnsemblGRCh38hg38GRCh38
GRCh371776,170,160 - 76,183,285 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361773,681,755 - 73,694,880 (-)NCBINCBI36Build 36hg18NCBI36
Build 341773,681,775 - 73,694,726NCBI
Celera1772,766,591 - 72,779,726 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1771,594,292 - 71,607,377 (-)NCBIHuRef
CHM1_11776,234,697 - 76,247,823 (-)NCBICHM1_1
T2T-CHM13v2.01779,068,173 - 79,081,298 (-)NCBIT2T-CHM13v2.0
Tk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911117,706,345 - 117,716,913 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11117,706,352 - 117,716,918 (-)EnsemblGRCm39 Ensembl
GRCm3811117,815,519 - 117,826,087 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11117,815,526 - 117,826,092 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711117,676,833 - 117,687,328 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611117,631,616 - 117,642,043 (-)NCBIMGSCv36mm8
Celera11129,560,644 - 129,571,039 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1182.96NCBI
Tk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555064,379,830 - 4,394,713 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555064,379,830 - 4,390,729 (+)NCBIChiLan1.0ChiLan1.0
TK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11799,053,616 - 99,067,499 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01772,251,416 - 72,265,308 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11777,803,938 - 77,816,747 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1777,803,749 - 77,816,747 (-)Ensemblpanpan1.1panPan2
TK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.192,959,450 - 2,970,908 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl92,959,488 - 2,971,064 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha93,642,982 - 3,654,416 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.093,637,295 - 3,648,793 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl93,637,262 - 3,648,777 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.193,660,373 - 3,671,812 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.093,784,580 - 3,796,015 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.093,866,010 - 3,877,445 (+)NCBIUU_Cfam_GSD_1.0
Tk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056023,599,359 - 3,627,016 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365942,784,226 - 2,794,830 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365942,784,891 - 2,794,693 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl123,786,031 - 3,795,917 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1123,785,997 - 3,794,824 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11670,186,103 - 70,200,689 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1670,186,767 - 70,200,610 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607741,294,951 - 41,309,587 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248017,685,017 - 7,692,872 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248017,685,003 - 7,692,949 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tk1
42 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:46
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000071420
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1558652Bw57Body weight QTL 574.20.0008body mass (VT:0001259)body weight (CMO:0000012)1090910316107211142Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091228102104060283Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1096703043107057807Rat
631539Oia6Oil induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1097010147104670812Rat

Markers in Region
PMC86057P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23109,191,235 - 109,191,478 (+)MAPPERmRatBN7.2
mRatBN7.210103,036,286 - 103,036,632 (+)MAPPERmRatBN7.2
Rnor_6.010106,819,088 - 106,819,433NCBIRnor6.0
Rnor_6.03114,182,471 - 114,182,713NCBIRnor6.0
Rnor_5.03120,723,143 - 120,723,385UniSTSRnor5.0
Rnor_5.010106,458,313 - 106,458,658UniSTSRnor5.0
RGSC_v3.43109,022,992 - 109,023,234UniSTSRGSC3.4
Celera10101,596,270 - 101,596,615UniSTS
Celera3108,089,043 - 108,089,285UniSTS
Cytogenetic Map3q35UniSTS


Related Rat Strains
The following Strains have been annotated to Tk1


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 28 40 31 18 31 1 1 55 27 30 4 1
Low 15 17 10 1 10 7 10 19 8 11 7 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_052800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ006455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW919734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF547747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP495650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK471539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV072953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV770793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M22642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X54173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y17296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000071420   ⟹   ENSRNOP00000067459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10103,034,754 - 103,046,095 (-)Ensembl
Rnor_6.0 Ensembl10106,817,601 - 106,828,884 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098570   ⟹   ENSRNOP00000088672
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10103,031,521 - 103,046,920 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119820   ⟹   ENSRNOP00000092303
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10103,031,521 - 103,046,920 (-)Ensembl
RefSeq Acc Id: NM_052800   ⟹   NP_434687
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210103,034,755 - 103,046,083 (-)NCBI
Rnor_6.010106,817,556 - 106,828,884 (-)NCBI
Rnor_5.010106,456,781 - 106,468,109 (-)NCBI
Celera10101,594,738 - 101,606,057 (-)RGD
Sequence:
RefSeq Acc Id: XM_017597017   ⟹   XP_017452506
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210103,034,764 - 103,046,094 (-)NCBI
Rnor_6.010106,817,565 - 106,828,888 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085225   ⟹   XP_038941153
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210103,042,388 - 103,046,125 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_434687   ⟸   NM_052800
- UniProtKB: P27158 (UniProtKB/Swiss-Prot),   M0RCX2 (UniProtKB/TrEMBL),   A6HL31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452506   ⟸   XM_017597017
- Peptide Label: isoform X1
- UniProtKB: A6HL32 (UniProtKB/TrEMBL),   M0RCX2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000067459   ⟸   ENSRNOT00000071420
RefSeq Acc Id: XP_038941153   ⟸   XM_039085225
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000092303   ⟸   ENSRNOT00000119820
RefSeq Acc Id: ENSRNOP00000088672   ⟸   ENSRNOT00000098570

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27158-F1-model_v2 AlphaFold P27158 1-121 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621014 AgrOrtholog
BioCyc Gene G2FUF-22538 BioCyc
Ensembl Genes ENSRNOG00000047314 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000067459 ENTREZGENE
  ENSRNOP00000067459.2 UniProtKB/TrEMBL
  ENSRNOP00000088672 ENTREZGENE
  ENSRNOP00000088672.1 UniProtKB/TrEMBL
  ENSRNOP00000092303.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071420 ENTREZGENE
  ENSRNOT00000071420.3 UniProtKB/TrEMBL
  ENSRNOT00000098570 ENTREZGENE
  ENSRNOT00000098570.1 UniProtKB/TrEMBL
  ENSRNOT00000119820.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.60.20 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thymidine_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thymidine_kinase_CS UniProtKB/TrEMBL
KEGG Report rno:24834 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24834 ENTREZGENE
PANTHER PTHR11441 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THYMIDINE KINASE, CYTOSOLIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB TK1 RGD
PhenoGen Tk1 PhenoGen
PIRSF TK_cell UniProtKB/TrEMBL
PROSITE TK_CELLULAR_TYPE UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A703_RAT UniProtKB/TrEMBL
  A0A8I6AHW8_RAT UniProtKB/TrEMBL
  A6HL31 ENTREZGENE, UniProtKB/TrEMBL
  A6HL32 ENTREZGENE, UniProtKB/TrEMBL
  KITH_RAT UniProtKB/Swiss-Prot
  M0RCX2 ENTREZGENE, UniProtKB/TrEMBL
  P27158 ENTREZGENE
UniProt Secondary Q6LAG4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Tk1  thymidine kinase 1  Tk1  thymidine kinase 1, soluble  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Tk1  thymidine kinase 1, soluble  Tk1  thymidine kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Tk1  thymidine kinase 1      Symbol and Name updated 629477 APPROVED
2003-03-07 Tk1  thymidine kinase 1  Tk  Thymidine kinase 1, soluble  Data Merged 628472 PROVISIONAL
2002-08-07 Tk1        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Tk  Thymidine kinase 1, soluble      Symbol and Name status set to approved 70586 APPROVED