Dab2 (DAB adaptor protein 2) - Rat Genome Database

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Gene: Dab2 (DAB adaptor protein 2) Rattus norvegicus
Analyze
Symbol: Dab2
Name: DAB adaptor protein 2
RGD ID: 621007
Description: Enables low-density lipoprotein particle receptor binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; negative regulation of signal transduction; and positive regulation of transport. Located in clathrin-coated vesicle membrane and perinuclear region of cytoplasm. Used to study myocardial infarction. Biomarker of metabolic acidosis and myocardial infarction. Orthologous to human DAB2 (DAB adaptor protein 2); PARTICIPATES IN endocytosis pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adaptor molecule disabled-2; C9; DAB2, clathrin adaptor protein; differentially expressed in ovarian carcinoma 2; disabled 2, mitogen-responsive phosphoprotein; disabled homolog 2; disabled homolog 2 (Drosophila); disabled homolog 2 mitogen-responsive phosphoprotein; disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila); Doc-2; DOC-2 p82 isoform; Doc2; mitogen-responsive phosphoprotein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8257,241,947 - 57,294,893 (+)NCBIGRCr8
mRatBN7.2255,514,692 - 55,567,476 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl255,514,700 - 55,567,476 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx262,644,828 - 62,666,312 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0260,718,369 - 60,739,859 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0255,720,837 - 55,742,323 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0255,747,353 - 55,768,848 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl255,747,318 - 55,768,270 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0275,489,435 - 75,510,930 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4255,714,874 - 55,736,370 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1255,643,109 - 55,664,600 (+)NCBI
Celera251,166,390 - 51,187,877 (+)NCBICelera
Cytogenetic Map2q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
afimoxifene  (ISO)
aldosterone  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clotrimazole  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dichloroacetic acid  (ISO)
dichromium trioxide  (ISO)
diethylstilbestrol  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
etoposide  (ISO)
exemestane  (ISO)
fenamidone  (ISO)
fipronil  (EXP)
flutamide  (EXP)
FR900359  (ISO)
fragrance  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
ivermectin  (ISO)
juglone  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylphenidate  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nimesulide  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
phytoestrogen  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
tetradecane  (EXP)
theophylline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell differentiation  (IEA)
cell morphogenesis  (ISO)
cellular response to epidermal growth factor stimulus  (IDA)
cellular response to transforming growth factor beta stimulus  (IEP,ISO)
clathrin coat assembly  (IMP,ISO)
extrinsic apoptotic signaling pathway  (ISO)
hematopoietic stem cell proliferation  (ISO)
in utero embryonic development  (ISO)
integrin-mediated signaling pathway  (ISO)
leading edge cell differentiation  (IEA,ISO)
myeloid cell differentiation  (ISO)
negative regulation of androgen receptor signaling pathway  (IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IBA,IEA,IGI,ISO)
negative regulation of cell growth  (IMP)
negative regulation of epithelial cell proliferation  (IDA)
negative regulation of ERK1 and ERK2 cascade  (IDA)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of neuron projection development  (IDA)
negative regulation of protein localization to plasma membrane  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of aldosterone biosynthetic process  (IDA)
positive regulation of aldosterone secretion  (IDA)
positive regulation of cell adhesion  (ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of clathrin-dependent endocytosis  (IEA,ISO)
positive regulation of early endosome to late endosome transport  (IEA,ISO)
positive regulation of endocytosis  (IBA,IDA,ISO)
positive regulation of epithelial to mesenchymal transition  (IBA,IEA,ISO)
positive regulation of integrin-mediated signaling pathway  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA,ISO)
positive regulation of protein phosphorylation  (IEA,ISO)
positive regulation of receptor internalization  (ISO)
positive regulation of receptor recycling  (ISO)
positive regulation of SMAD protein signal transduction  (IEA,ISO)
positive regulation of substrate adhesion-dependent cell spreading  (IMP,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transcription elongation by RNA polymerase II  (ISO)
positive regulation of Wnt signaling pathway, planar cell polarity pathway  (IEA,ISO)
protein transport  (IEA)
receptor-mediated endocytosis  (IBA,ISO)
regulation of Rho-dependent protein serine/threonine kinase activity  (IDA)
renal protein absorption  (ISO)
response to salt  (IEP)
response to steroid hormone  (IMP)
transforming growth factor beta receptor signaling pathway  (IEA,ISO)
vesicle-mediated transport  (IEA)
Wnt signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Immunohistochemical studies on disabled-2 protein in the spinal cords of rats with experimental autoimmune encephalomyelitis. Ahn M, etal., Brain Res. 2011 Oct 6;1416:51-60. doi: 10.1016/j.brainres.2011.08.009. Epub 2011 Aug 10.
2. Choroid plexus megalin is involved in neuroprotection by serum insulin-like growth factor I. Carro E, etal., J Neurosci. 2005 Nov 23;25(47):10884-93. doi: 10.1523/JNEUROSCI.2909-05.2005.
3. Dab2 regulates clathrin assembly and cell spreading. Chetrit D, etal., Biochem J. 2009 Mar 15;418(3):701-15. doi: 10.1042/BJ20081288.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Megalin and nonmuscle myosin heavy chain IIA interact with the adaptor protein Disabled-2 in proximal tubule cells. Hosaka K, etal., Kidney Int. 2009 Jun;75(12):1308-15. Epub 2009 Apr 1.
7. Evaluation of the role of Disabled-2 in nerve growth factor-mediated neurite outgrowth and cellular signalling. Huang CH, etal., Cell Signal. 2007 Jun;19(6):1339-47. Epub 2007 Jan 24.
8. Identification of functionally important sites in the first intracellular loop of the NaPi-IIa cotransporter. Kohler K, etal., Am J Physiol Renal Physiol. 2002 Apr;282(4):F687-96.
9. PKB/Akt partners with Dab2 in albumin endocytosis. Koral K and Erkan E, Am J Physiol Renal Physiol. 2012 Apr 15;302(8):F1013-24. doi: 10.1152/ajprenal.00289.2011. Epub 2012 Jan 4.
10. miR-145 is differentially regulated by TGF-beta1 and ischaemia and targets Disabled-2 expression and wnt/beta-catenin activity. Mayorga ME and Penn MS, J Cell Mol Med. 2012 May;16(5):1106-13. doi: 10.1111/j.1582-4934.2011.01385.x.
11. Central role for disabled-2 in mesenchymal stem cardiac protein expression and functional consequences after engraftment in acute myocardial infarction. Mayorga ME, etal., Stem Cells Dev. 2011 Apr;20(4):681-93. doi: 10.1089/scd.2010.0151. Epub 2010 Sep 13.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Involvement of Disabled-2 protein in the central nervous system inflammation following experimental cryoinjury of rat brains. Moon C, etal., Neurosci Lett. 2005 Apr 18;378(2):88-91. Epub 2005 Jan 1.
14. Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nakayama M, etal., Nat Cell Biol. 2013 Mar;15(3):249-60. doi: 10.1038/ncb2679. Epub 2013 Jan 27.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin. Oleinikov AV, etal., Biochem J. 2000 May 1;347 Pt 3:613-21.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Disabled-2 is expressed in adrenal zona glomerulosa and is involved in aldosterone secretion. Romero DG, etal., Endocrinology. 2007 Jun;148(6):2644-52. Epub 2007 Feb 15.
21. Regulation of rat DOC-2 gene during castration-induced rat ventral prostate degeneration and its growth inhibitory function in human prostatic carcinoma cells. Tseng CP, etal., Endocrinology 1998 Aug;139(8):3542-53.
22. Regulation of Dab2 expression in intestinal and renal epithelia by development. Vazquez-Carretero MD, etal., J Cell Biochem. 2011 Jan;112(1):354-61. doi: 10.1002/jcb.22931.
23. Proteomic profiling of the effect of metabolic acidosis on the apical membrane of the proximal convoluted tubule. Walmsley SJ, etal., Am J Physiol Renal Physiol. 2012 Jun 1;302(11):F1465-77. doi: 10.1152/ajprenal.00390.2011. Epub 2012 Feb 22.
24. The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2. Wang Z, etal., J Biol Chem 2002 Apr 12;277(15):12622-31.
25. Disabled-2 and Axin are concurrently colocalized and underexpressed in lung cancers. Xu HT, etal., Hum Pathol. 2011 Oct;42(10):1491-8. doi: 10.1016/j.humpath.2011.01.004. Epub 2011 Apr 14.
26. The inhibitory role of DOC-2/DAB2 in growth factor receptor-mediated signal cascade. DOC-2/DAB2-mediated inhibition of ERK phosphorylation via binding to Grb2. Zhou J and Hsieh JT, J Biol Chem 2001 Jul 27;276(30):27793-8. Epub 2001 May 22.
27. Characterization of a novel negative regulator (DOC-2/DAB2) of c-Src in normal prostatic epithelium and cancer. Zhou J, etal., J Biol Chem. 2003 Feb 28;278(9):6936-41. Epub 2002 Dec 8.
Additional References at PubMed
PMID:11104669   PMID:11247302   PMID:11387212   PMID:11823414   PMID:11927540   PMID:12234931   PMID:12413896   PMID:12477932   PMID:12805222   PMID:12826668   PMID:12857860   PMID:15489334  
PMID:15734730   PMID:15837803   PMID:15894542   PMID:16263760   PMID:16267015   PMID:16984970   PMID:17255372   PMID:19581412   PMID:20448150   PMID:20881059   PMID:21146513   PMID:21423176  
PMID:21995445   PMID:22411869   PMID:22525672   PMID:23376485   PMID:23677864   PMID:24122887   PMID:25432322   PMID:29925839   PMID:30052485   PMID:31868265  


Genomics

Comparative Map Data
Dab2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8257,241,947 - 57,294,893 (+)NCBIGRCr8
mRatBN7.2255,514,692 - 55,567,476 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl255,514,700 - 55,567,476 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx262,644,828 - 62,666,312 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0260,718,369 - 60,739,859 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0255,720,837 - 55,742,323 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0255,747,353 - 55,768,848 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl255,747,318 - 55,768,270 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0275,489,435 - 75,510,930 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4255,714,874 - 55,736,370 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1255,643,109 - 55,664,600 (+)NCBI
Celera251,166,390 - 51,187,877 (+)NCBICelera
Cytogenetic Map2q16NCBI
DAB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38539,371,677 - 39,424,980 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl539,371,675 - 39,462,300 (-)EnsemblGRCh38hg38GRCh38
GRCh37539,371,779 - 39,425,082 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map5p13.1NCBI
HuRef539,323,383 - 39,377,010 (-)NCBIHuRef
CHM1_1539,373,679 - 39,427,330 (-)NCBICHM1_1
T2T-CHM13v2.0539,621,190 - 39,674,588 (-)NCBIT2T-CHM13v2.0
Dab2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39156,329,269 - 6,470,196 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl156,329,269 - 6,470,193 (+)EnsemblGRCm39 Ensembl
GRCm38156,299,788 - 6,440,715 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl156,299,788 - 6,440,712 (+)EnsemblGRCm38mm10GRCm38
MGSCv37156,249,789 - 6,390,712 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36156,247,064 - 6,387,927 (+)NCBIMGSCv36mm8
Celera156,148,799 - 6,289,867 (+)NCBICelera
Cytogenetic Map15A1NCBI
cM Map152.15NCBI
Dab2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542623,852,752 - 23,883,030 (-)NCBIChiLan1.0ChiLan1.0
DAB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2470,912,082 - 70,967,698 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1569,067,621 - 69,121,333 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0570,951,198 - 71,004,836 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1575,954,815 - 76,044,789 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl576,022,143 - 76,041,443 (+)Ensemblpanpan1.1panPan2
DAB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1469,625,874 - 69,648,349 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl469,625,527 - 69,648,321 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha469,274,405 - 69,324,807 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0470,113,533 - 70,163,994 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl470,113,545 - 70,163,987 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1469,862,358 - 69,913,299 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0469,975,198 - 70,025,729 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0470,513,789 - 70,564,779 (+)NCBIUU_Cfam_GSD_1.0
Dab2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213228,434,139 - 228,472,266 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365182,915,764 - 2,937,875 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365182,915,819 - 2,936,474 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DAB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1624,590,645 - 24,646,122 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11624,590,638 - 24,776,937 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21625,732,883 - 25,757,751 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DAB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1438,171,320 - 38,224,275 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl438,173,026 - 38,224,231 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607128,550,756 - 28,603,647 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dab2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475915,459,288 - 15,520,924 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475915,459,436 - 15,520,225 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dab2
24 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:818
Count of miRNA genes:216
Interacting mature miRNAs:260
Transcripts:ENSRNOT00000043580, ENSRNOT00000050655
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22238462767384627Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)238573329122609194Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)24280460760653831Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
12879863Bp402Blood pressure QTL 4020.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24112578956532139Rat
1354592Rf50Renal function QTL 503.5urine output (VT:0003620)timed urine volume (CMO:0000260)25382274774786777Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)228484589169504100Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)228484589169504100Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat

Markers in Region
SGC34180  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2255,555,434 - 55,555,559 (+)MAPPERmRatBN7.2
Rnor_6.0255,757,905 - 55,758,029NCBIRnor6.0
Rnor_5.0275,499,987 - 75,500,111UniSTSRnor5.0
RGSC_v3.4255,725,426 - 55,725,550UniSTSRGSC3.4
Celera251,176,940 - 51,177,064UniSTS
Cytogenetic Map2q16UniSTS
Dab2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2255,565,896 - 55,566,873 (+)MAPPERmRatBN7.2
Rnor_6.0255,768,366 - 55,769,342NCBIRnor6.0
Rnor_5.0275,510,448 - 75,511,424UniSTSRnor5.0
Celera251,187,395 - 51,188,371UniSTS
Cytogenetic Map2q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000050655   ⟹   ENSRNOP00000043878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl255,544,883 - 55,566,368 (+)Ensembl
Rnor_6.0 Ensembl255,747,318 - 55,768,270 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095085   ⟹   ENSRNOP00000089617
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl255,514,737 - 55,567,476 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096270   ⟹   ENSRNOP00000085091
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl255,514,852 - 55,555,668 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107345   ⟹   ENSRNOP00000085574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl255,514,700 - 55,566,368 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107382   ⟹   ENSRNOP00000076603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl255,514,737 - 55,567,476 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115810   ⟹   ENSRNOP00000087413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl255,514,700 - 55,555,255 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117029   ⟹   ENSRNOP00000095083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl255,514,700 - 55,566,368 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119991   ⟹   ENSRNOP00000079483
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl255,544,883 - 55,566,368 (+)Ensembl
RefSeq Acc Id: NM_024159   ⟹   NP_077073
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8257,272,300 - 57,293,796 (+)NCBI
mRatBN7.2255,544,883 - 55,566,379 (+)NCBI
Rnor_6.0255,747,353 - 55,768,848 (+)NCBI
Rnor_5.0275,489,435 - 75,510,930 (+)NCBI
RGSC_v3.4255,714,874 - 55,736,370 (+)RGD
Celera251,166,390 - 51,187,877 (+)RGD
Sequence:
RefSeq Acc Id: XM_039103192   ⟹   XP_038959120
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8257,241,947 - 57,294,893 (+)NCBI
mRatBN7.2255,514,692 - 55,567,476 (+)NCBI
RefSeq Acc Id: XM_039103193   ⟹   XP_038959121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8257,241,947 - 57,294,893 (+)NCBI
mRatBN7.2255,514,700 - 55,566,379 (+)NCBI
RefSeq Acc Id: XM_039103194   ⟹   XP_038959122
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8257,241,947 - 57,283,160 (+)NCBI
mRatBN7.2255,514,693 - 55,557,344 (+)NCBI
RefSeq Acc Id: XM_063282609   ⟹   XP_063138679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8257,241,947 - 57,294,893 (+)NCBI
RefSeq Acc Id: XM_063282610   ⟹   XP_063138680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8257,241,998 - 57,283,160 (+)NCBI
RefSeq Acc Id: NP_077073   ⟸   NM_024159
- UniProtKB: O88798 (UniProtKB/Swiss-Prot),   O55051 (UniProtKB/Swiss-Prot),   O55050 (UniProtKB/Swiss-Prot),   O55049 (UniProtKB/Swiss-Prot),   O55048 (UniProtKB/Swiss-Prot),   Q4QRA2 (UniProtKB/Swiss-Prot),   O88797 (UniProtKB/Swiss-Prot),   F1LMP9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000043878   ⟸   ENSRNOT00000050655
RefSeq Acc Id: XP_038959120   ⟸   XM_039103192
- Peptide Label: isoform X1
- UniProtKB: O88798 (UniProtKB/Swiss-Prot),   O88797 (UniProtKB/Swiss-Prot),   O55051 (UniProtKB/Swiss-Prot),   O55050 (UniProtKB/Swiss-Prot),   O55049 (UniProtKB/Swiss-Prot),   O55048 (UniProtKB/Swiss-Prot),   Q4QRA2 (UniProtKB/Swiss-Prot),   F1LMP9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959122   ⟸   XM_039103194
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A2J0 (UniProtKB/TrEMBL),   A0A8I6A5T4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959121   ⟸   XM_039103193
- Peptide Label: isoform X2
- UniProtKB: A6KGF1 (UniProtKB/TrEMBL),   A0A8I6GLG3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000087413   ⟸   ENSRNOT00000115810
Ensembl Acc Id: ENSRNOP00000085091   ⟸   ENSRNOT00000096270
Ensembl Acc Id: ENSRNOP00000085574   ⟸   ENSRNOT00000107345
Ensembl Acc Id: ENSRNOP00000089617   ⟸   ENSRNOT00000095085
Ensembl Acc Id: ENSRNOP00000095083   ⟸   ENSRNOT00000117029
Ensembl Acc Id: ENSRNOP00000076603   ⟸   ENSRNOT00000107382
Ensembl Acc Id: ENSRNOP00000079483   ⟸   ENSRNOT00000119991
RefSeq Acc Id: XP_063138679   ⟸   XM_063282609
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GLG3 (UniProtKB/TrEMBL),   A6KGF1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138680   ⟸   XM_063282610
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A5T4 (UniProtKB/TrEMBL),   A0A8I6A2J0 (UniProtKB/TrEMBL)
Protein Domains
PID

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88797-F1-model_v2 AlphaFold O88797 1-768 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621007 AgrOrtholog
BioCyc Gene G2FUF-54157 BioCyc
Ensembl Genes ENSRNOG00000028930 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055006390 UniProtKB/Swiss-Prot
  ENSRNOG00060023909 UniProtKB/Swiss-Prot
  ENSRNOG00065021860 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000050655 UniProtKB/TrEMBL
  ENSRNOT00000050655.6 UniProtKB/Swiss-Prot
  ENSRNOT00000095085.1 UniProtKB/TrEMBL
  ENSRNOT00000096270.1 UniProtKB/TrEMBL
  ENSRNOT00000107345.1 UniProtKB/Swiss-Prot
  ENSRNOT00000107382.1 UniProtKB/TrEMBL
  ENSRNOT00000115810.1 UniProtKB/TrEMBL
  ENSRNOT00000117029.1 UniProtKB/TrEMBL
  ENSRNOT00000119991.1 UniProtKB/TrEMBL
  ENSRNOT00055010406 UniProtKB/Swiss-Prot
  ENSRNOT00060041814 UniProtKB/Swiss-Prot
  ENSRNOT00065037420 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7444786 IMAGE-MGC_LOAD
InterPro DAB1/2_SBM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dab_PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTB/PI_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79128 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114312 IMAGE-MGC_LOAD
NCBI Gene 79128 ENTREZGENE
PANTHER DISABLED HOMOLOG 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PID DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DAB2_SBM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dab2 PhenoGen
PROSITE PID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028930 RatGTEx
  ENSRNOG00055006390 RatGTEx
  ENSRNOG00060023909 RatGTEx
  ENSRNOG00065021860 RatGTEx
SMART PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y0J1_RAT UniProtKB/TrEMBL
  A0A8I5ZNL6_RAT UniProtKB/TrEMBL
  A0A8I6A2J0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A5T4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A956_RAT UniProtKB/TrEMBL
  A0A8I6GLG3 ENTREZGENE, UniProtKB/TrEMBL
  A6KGF1 ENTREZGENE, UniProtKB/TrEMBL
  A6KGF2_RAT UniProtKB/TrEMBL
  DAB2_RAT UniProtKB/Swiss-Prot
  F1LMP9 ENTREZGENE, UniProtKB/TrEMBL
  O55048 ENTREZGENE
  O55049 ENTREZGENE
  O55050 ENTREZGENE
  O55051 ENTREZGENE
  O88797 ENTREZGENE
  O88798 ENTREZGENE
  Q4QRA2 ENTREZGENE
UniProt Secondary O55048 UniProtKB/Swiss-Prot
  O55049 UniProtKB/Swiss-Prot
  O55050 UniProtKB/Swiss-Prot
  O55051 UniProtKB/Swiss-Prot
  O88798 UniProtKB/Swiss-Prot
  Q4QRA2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Dab2  DAB adaptor protein 2  Dab2  DAB2, clathrin adaptor protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-07-11 Dab2  DAB2, clathrin adaptor protein  Dab2  disabled 2, mitogen-responsive phosphoprotein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-16 Dab2  disabled 2, mitogen-responsive phosphoprotein  Dab2  disabled homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-11-06 Dab2  disabled homolog 2 (Drosophila)  Dab2  disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Dab2  disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)  Dab2  disabled homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Dab2  disabled homolog 2 (Drosophila)    disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)  Name updated 1299863 APPROVED
2002-08-07 Dab2  disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein p82 and p59 isoforms are products of alternative splicing 728288