P4ha1 (prolyl 4-hydroxylase subunit alpha 1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: P4ha1 (prolyl 4-hydroxylase subunit alpha 1) Rattus norvegicus
Analyze
Symbol: P4ha1
Name: prolyl 4-hydroxylase subunit alpha 1
RGD ID: 621000
Description: Predicted to enable identical protein binding activity and procollagen-proline 4-dioxygenase activity. Predicted to be involved in collagen fibril organization. Predicted to be located in endoplasmic reticulum lumen. Predicted to be part of procollagen-proline 4-dioxygenase complex. Predicted to be active in endoplasmic reticulum. Orthologous to human P4HA1 (prolyl 4-hydroxylase subunit alpha 1); PARTICIPATES IN arginine and proline metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4-PH alpha-1; PHalphaI; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I; procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1; prolyl 4-hydroxylase alpha subunit; prolyl 4-hydroxylase subunit alpha-1; prolyl 4-hydroxylase, alpha polypeptide I
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82027,784,696 - 27,895,785 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2027,845,141 - 27,895,404 (+)EnsemblGRCr8
mRatBN7.22027,302,046 - 27,352,098 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2027,302,141 - 27,352,786 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2028,311,476 - 28,361,143 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02027,697,734 - 27,747,401 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02028,442,360 - 28,492,030 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02028,920,616 - 28,972,576 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2028,920,616 - 28,971,966 (+)Ensemblrn6Rnor6.0
Rnor_5.02030,726,604 - 30,776,891 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera2028,745,570 - 28,795,338 (+)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
benzoates  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chloroacetaldehyde  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethyl phthalate  (EXP,ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fenofibrate  (EXP)
ferric ammonium citrate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glucose  (ISO)
GSK-J4  (ISO)
hydrogen sulfide  (ISO)
ifosfamide  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
ivermectin  (ISO)
ketamine  (EXP)
leflunomide  (EXP)
lipopolysaccharide  (EXP)
mercury dichloride  (EXP)
methamphetamine  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
monoethyl phthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel dichloride  (EXP,ISO)
nitric oxide  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
pirinixic acid  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
ranitidine  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
topotecan  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
Yessotoxin  (ISO)
zinc atom  (EXP)
zinc dichloride  (ISO)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. The complete cDNA derived sequence of the rat prolyl 4-hydroxylase alpha subunit. Hopkinson I, etal., Gene 1994 Nov 18;149(2):391-2.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
10. Cloning and characterization of the 5'-flanking region of the rat P4Halpha gene encoding the prolyl 4-hydroxylase alpha(I) subunit. Takahashi S, etal., Biochim Biophys Acta 2002 Apr 12;1574(3):354-8.
Additional References at PubMed
PMID:7753822   PMID:10799490   PMID:15489334   PMID:17135260   PMID:19946888   PMID:24207127   PMID:33450132  


Genomics

Comparative Map Data
P4ha1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82027,784,696 - 27,895,785 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2027,845,141 - 27,895,404 (+)EnsemblGRCr8
mRatBN7.22027,302,046 - 27,352,098 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2027,302,141 - 27,352,786 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2028,311,476 - 28,361,143 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02027,697,734 - 27,747,401 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02028,442,360 - 28,492,030 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02028,920,616 - 28,972,576 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2028,920,616 - 28,971,966 (+)Ensemblrn6Rnor6.0
Rnor_5.02030,726,604 - 30,776,891 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera2028,745,570 - 28,795,338 (+)NCBICelera
Cytogenetic Map20q11NCBI
P4HA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381073,007,217 - 73,096,866 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1073,005,811 - 73,096,983 (-)Ensemblhg38GRCh38
GRCh371074,766,975 - 74,856,624 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361074,436,981 - 74,526,630 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341074,436,987 - 74,526,614NCBI
Celera1068,052,119 - 68,141,888 (-)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1068,760,779 - 68,850,247 (-)NCBIHuRef
CHM1_11075,048,716 - 75,138,475 (-)NCBICHM1_1
T2T-CHM13v2.01073,878,593 - 73,968,258 (-)NCBIT2T-CHM13v2.0
P4ha1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391059,159,019 - 59,209,126 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1059,159,118 - 59,209,126 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381059,323,197 - 59,373,304 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1059,323,296 - 59,373,304 (+)Ensemblmm10GRCm38
MGSCv371058,786,044 - 58,836,052 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361058,718,730 - 58,767,701 (+)NCBIMGSCv36mm8
Celera1060,423,571 - 60,473,579 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1029.52NCBI
P4ha1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543718,604,525 - 18,668,800 (+)Ensembl
ChiLan1.0NW_00495543718,604,525 - 18,668,800 (+)NCBIChiLan1.0ChiLan1.0
P4HA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2885,183,074 - 85,250,236 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11085,188,541 - 85,277,170 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01069,554,722 - 69,643,765 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11072,017,493 - 72,106,083 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1072,017,500 - 72,106,083 (-)EnsemblpanPan2panpan1.1
P4HA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1423,600,399 - 23,677,820 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl423,601,636 - 23,677,762 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha423,738,890 - 23,816,335 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0423,886,920 - 23,964,071 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl423,886,987 - 23,964,060 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1423,785,865 - 23,863,342 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0423,984,840 - 24,062,302 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0424,339,447 - 24,416,949 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
P4ha1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721357,488,533 - 57,552,472 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365215,981,079 - 6,047,499 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365215,981,205 - 6,045,195 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P4HA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1475,825,148 - 75,919,016 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11475,827,207 - 75,919,121 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21481,892,533 - 82,002,926 (-)NCBISscrofa10.2Sscrofa10.2susScr3
P4HA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1958,178,350 - 58,259,303 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl958,178,461 - 58,259,802 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604818,766,319 - 18,856,093 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
P4ha1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247546,705,322 - 6,802,312 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247546,707,429 - 6,802,333 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
P4ha1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11824,068,198 - 25,228,650 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in P4ha1
715 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:134
Count of miRNA genes:109
Interacting mature miRNAs:116
Transcripts:ENSRNOT00000070897
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202668936256021148Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)202074558556021148Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202668936256021148Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202679235356021148Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)201224324249189476Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202668936256021148Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202668936256021148Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000070897   ⟹   ENSRNOP00000064405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2027,845,141 - 27,894,805 (+)Ensembl
mRatBN7.2 Ensembl2027,302,148 - 27,351,821 (+)Ensembl
Rnor_6.0 Ensembl2028,920,616 - 28,971,966 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100609   ⟹   ENSRNOP00000096087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2027,302,141 - 27,352,786 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104909   ⟹   ENSRNOP00000088456
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2027,845,141 - 27,894,805 (+)Ensembl
mRatBN7.2 Ensembl2027,302,141 - 27,352,786 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106077   ⟹   ENSRNOP00000084000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2027,302,141 - 27,352,786 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117090   ⟹   ENSRNOP00000096608
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2027,845,141 - 27,895,404 (+)Ensembl
mRatBN7.2 Ensembl2027,302,141 - 27,352,417 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119688   ⟹   ENSRNOP00000077480
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2027,845,141 - 27,891,854 (+)Ensembl
mRatBN7.2 Ensembl2027,302,160 - 27,352,404 (+)Ensembl
RefSeq Acc Id: NM_172062   ⟹   NP_742059
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82027,845,046 - 27,894,823 (+)NCBI
mRatBN7.22027,302,046 - 27,351,824 (+)NCBI
Rnor_6.02028,920,616 - 28,971,984 (+)NCBI
Rnor_5.02030,726,604 - 30,776,891 (+)NCBI
Celera2028,745,570 - 28,795,338 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256424   ⟹   XP_006256486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82027,845,099 - 27,895,785 (+)NCBI
mRatBN7.22027,302,109 - 27,352,098 (+)NCBI
Rnor_6.02028,920,631 - 28,972,576 (+)NCBI
Rnor_5.02030,726,604 - 30,776,891 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256425   ⟹   XP_006256487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82027,845,032 - 27,895,785 (+)NCBI
mRatBN7.22027,302,052 - 27,351,860 (+)NCBI
Rnor_6.02028,920,622 - 28,972,576 (+)NCBI
Rnor_5.02030,726,604 - 30,776,891 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063279493   ⟹   XP_063135563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82027,845,096 - 27,895,785 (+)NCBI
RefSeq Acc Id: XM_063279494   ⟹   XP_063135564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82027,784,696 - 27,895,785 (+)NCBI
RefSeq Acc Id: NP_742059   ⟸   NM_172062
- Peptide Label: precursor
- UniProtKB: Q6AZ74 (UniProtKB/Swiss-Prot),   P54001 (UniProtKB/Swiss-Prot),   A6K3U6 (UniProtKB/TrEMBL),   A0A8L2QWJ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256487   ⟸   XM_006256425
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ASU1 (UniProtKB/TrEMBL),   A6K3U5 (UniProtKB/TrEMBL),   A0A8L2QWJ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256486   ⟸   XM_006256424
- Peptide Label: isoform X2
- UniProtKB: Q6AZ74 (UniProtKB/Swiss-Prot),   P54001 (UniProtKB/Swiss-Prot),   A6K3U6 (UniProtKB/TrEMBL),   A0A8L2QWJ8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064405   ⟸   ENSRNOT00000070897
Ensembl Acc Id: ENSRNOP00000096087   ⟸   ENSRNOT00000100609
Ensembl Acc Id: ENSRNOP00000084000   ⟸   ENSRNOT00000106077
Ensembl Acc Id: ENSRNOP00000077480   ⟸   ENSRNOT00000119688
Ensembl Acc Id: ENSRNOP00000088456   ⟸   ENSRNOT00000104909
Ensembl Acc Id: ENSRNOP00000096608   ⟸   ENSRNOT00000117090
RefSeq Acc Id: XP_063135564   ⟸   XM_063279494
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063135563   ⟸   XM_063279493
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ASU1 (UniProtKB/TrEMBL),   A6K3U5 (UniProtKB/TrEMBL),   A0A8L2QWJ8 (UniProtKB/TrEMBL)
Protein Domains
Fe2OG dioxygenase   Prolyl 4-hydroxylase alpha subunit

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P54001-F1-model_v2 AlphaFold P54001 1-534 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701587
Promoter ID:EPDNEW_R12111
Type:multiple initiation site
Name:P4ha1_1
Description:prolyl 4-hydroxylase subunit alpha 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02028,920,711 - 28,920,771EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621000 AgrOrtholog
BioCyc Gene G2FUF-3769 BioCyc
BioCyc Pathway PWY-7894 [procollagen hydroxylation and glycosylation] BioCyc
BioCyc Pathway Image PWY-7894 BioCyc
Ensembl Genes ENSRNOG00000050655 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000070897 ENTREZGENE
  ENSRNOT00000106077.1 UniProtKB/Swiss-Prot
  ENSRNOT00000117090 ENTREZGENE
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot
  6.10.140.1460 UniProtKB/Swiss-Prot
  q2cbj1_9rhob like domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7115543 IMAGE-MGC_LOAD
InterPro Oxoglu/Fe-dep_dioxygenase UniProtKB/Swiss-Prot
  P4HA-like UniProtKB/Swiss-Prot
  Pro_4_hyd_alph UniProtKB/Swiss-Prot
  Pro_4_hyd_alph_FE2OG_OXY UniProtKB/Swiss-Prot
  Pro_4_hyd_alph_N UniProtKB/Swiss-Prot
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot
  TPR_repeat UniProtKB/Swiss-Prot
KEGG Report rno:64475 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93107 IMAGE-MGC_LOAD
NCBI Gene 64475 ENTREZGENE
PANTHER PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-1 UniProtKB/Swiss-Prot
  PTHR10869 UniProtKB/Swiss-Prot
Pfam 2OG-FeII_Oxy_3 UniProtKB/Swiss-Prot
  P4Ha_N UniProtKB/Swiss-Prot
  TPR_P4H UniProtKB/Swiss-Prot
PhenoGen P4ha1 PhenoGen
PROSITE FE2OG_OXY UniProtKB/Swiss-Prot
  TPR UniProtKB/Swiss-Prot
  TPR_REGION UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000050655 RatGTEx
SMART P4Hc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48452 UniProtKB/Swiss-Prot
UniProt A0A8I5ZKB2_RAT UniProtKB/TrEMBL
  A0A8I6A688_RAT UniProtKB/TrEMBL
  A0A8I6ASU1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QWJ8 ENTREZGENE, UniProtKB/TrEMBL
  A6K3U5 ENTREZGENE, UniProtKB/TrEMBL
  A6K3U6 ENTREZGENE, UniProtKB/TrEMBL
  P4HA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6AZ74 ENTREZGENE
UniProt Secondary Q6AZ74 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 P4ha1  prolyl 4-hydroxylase subunit alpha 1  P4ha1  prolyl 4-hydroxylase, alpha polypeptide I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-23 P4ha1  prolyl 4-hydroxylase, alpha polypeptide I  P4ha1  procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 P4ha1  procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I  P4ha1  procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 P4ha1  procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide    prolyl 4-hydroxylase alpha subunit  Name updated 1299863 APPROVED
2002-08-07 P4ha1  prolyl 4-hydroxylase alpha subunit      Symbol and Name status set to provisional 70820 PROVISIONAL