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Gene: Pde5a (phosphodiesterase 5A) Rattus norvegicus

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Symbol:

Pde5a

Name:

phosphodiesterase 5A

RGD ID:

620995

Description:

Enables 3',5'-cyclic-GMP phosphodiesterase activity. Involved in several processes, including blood vessel diameter maintenance; response to testosterone; and short-term memory. Used to study artery disease (multiple); impotence (multiple); and primary biliary cholangitis. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human PDE5A (phosphodiesterase 5A); PARTICIPATES IN purine metabolic pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 1-naphthyl isothiocyanate; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

CGB-PDE; cGMP-binding cGMP specific phosphodiesterase 5A2; cGMP-binding cGMP-specific phosphodiesterase; cGMP-specific 3',5'-cyclic phosphodiesterase; PDE5A2; phosphodiesterase 5A, cGMP-specific; phosphodiesterase type 5

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PDE5A (phosphodiesterase 5A)	HGNC	EggNOG, Ensembl, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Pde5a (phosphodiesterase 5A, cGMP-specific)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pde5a (phosphodiesterase 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PDE5A (phosphodiesterase 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PDE5A (phosphodiesterase 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pde5a (phosphodiesterase 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PDE5A (phosphodiesterase 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PDE5A (phosphodiesterase 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pde5a (phosphodiesterase 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PDE5A (phosphodiesterase 5A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pde5a (phosphodiesterase 5A, cGMP-specific)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pde5ab (phosphodiesterase 5A, cGMP-specific, b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PDE2	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Drosophila melanogaster (fruit fly):	Pde11	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Pde6	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	pde5a	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Allele / Splice:

Pde5a^{Tn(sb-T2/Bart3)2.144Mcwi}

Genetic Models:

F344-Pde5a^{Tn(sb-T2/Bart3)2.144Mcwi}

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	213,542,822 - 213,687,638 (+)	NCBI		GRCr8
mRatBN7.2	2	210,858,515 - 211,003,480 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	210,858,063 - 210,999,701 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	218,537,423 - 218,677,334 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	216,445,209 - 216,585,125 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	211,291,504 - 211,431,374 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	226,899,604 - 227,044,916 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	226,900,619 - 227,041,576 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	246,260,843 - 246,406,296 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	219,410,394 - 219,550,910 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	219,373,455 - 219,513,972 (+)	NCBI
Celera	2	203,287,460 - 203,425,472 (+)	NCBI		Celera
Cytogenetic Map	2	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

RGD Manual Disease Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Pde5a	Rat	Cardiomegaly	treatment	ISO	RGD:737352	1581008		RGD
Pde5a	Rat	Experimental Diabetes Mellitus		IMP		2314461		RGD
Pde5a	Rat	Hearing Loss	treatment	IMP		7775056		RGD
Pde5a	Rat	Hypertriglyceridemia		IMP		2314464		RGD
Pde5a	Rat	IgA glomerulonephritis		ISO	RGD:732674	7248685	DNA:SNP: :rs13124532(human)	RGD
Pde5a	Rat	impotence		IMP		2314519	associated with Hypercholesterolemia	RGD
Pde5a	Rat	impotence		IMP		2314520		RGD
Pde5a	Rat	impotence		IMP		2314521	associated with Diabetes Mellitus, Experimental	RGD
Pde5a	Rat	Inflammation		IMP		2314463		RGD
Pde5a	Rat	myocardial infarction		IMP		2314468		RGD
Pde5a	Rat	pre-eclampsia		IMP		2314465		RGD
Pde5a	Rat	primary biliary cholangitis		IMP		2314466		RGD
Pde5a	Rat	pulmonary hypertension		IMP		2314460		RGD
Pde5a	Rat	Reperfusion Injury		IMP		2314462		RGD
Pde5a	Rat	Right Ventricular Hypertrophy		ISO	RGD:732674	2314467	mRNA, protein:increased expression:myocardium	RGD
Pde5a	Rat	Right Ventricular Hypertrophy		IMP		2314467		RGD
Pde5a	Rat	Stroke		IMP		2314459		RGD
Pde5a	Rat	vasculogenic impotence		IMP		2314469		RGD

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Pde5a	Rat	Neurodevelopmental Disorders		ISO	RGD:732674	8554872	ClinVar Annotator: match by term: Neurodevelopmental disorder	ClinVar	PMID:25741868

Imported Disease Annotations - CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Pde5a	Rat	Neoplasm Metastasis		ISO	RGD:732674	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:12972520

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Pde5a	Rat	1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene	multiple interactions	ISO	RGD:737352	6480464	[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...	CTD	PMID:25510870
Pde5a	Rat	1,3,5-trinitro-1,3,5-triazinane	decreases expression	EXP		6480464	cyclonite results in decreased expression of PDE5A mRNA	CTD	PMID:25559034
Pde5a	Rat	1-naphthyl isothiocyanate	increases expression	EXP		6480464	1-Naphthylisothiocyanate results in increased expression of PDE5A mRNA	CTD	PMID:30723492
Pde5a	Rat	17beta-estradiol	decreases expression	ISO	RGD:737352	6480464	Estradiol results in decreased expression of PDE5A mRNA	CTD	PMID:25210133
Pde5a	Rat	17beta-estradiol	decreases expression	EXP		6480464	Estradiol results in decreased expression of PDE5A mRNA	CTD	PMID:32145629
Pde5a	Rat	17beta-estradiol	affects expression	ISO	RGD:732674	6480464	Estradiol affects the expression of PDE5A mRNA	CTD	PMID:22574217
Pde5a	Rat	17beta-estradiol	multiple interactions	ISO	RGD:732674	6480464	Estradiol promotes the reaction [ESR2 protein results in decreased expression of PDE5A mRNA]	CTD	PMID:20404318
Pde5a	Rat	17beta-estradiol	decreases expression	ISO	RGD:732674	6480464	Estradiol results in decreased expression of PDE5A mRNA	CTD	PMID:19429434
Pde5a	Rat	2,2',4,4',5,5'-hexachlorobiphenyl	multiple interactions	ISO	RGD:737352	6480464	[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...	CTD	PMID:25510870
Pde5a	Rat	2,2',5,5'-tetrachlorobiphenyl	multiple interactions	ISO	RGD:737352	6480464	[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...	CTD	PMID:25510870
Pde5a	Rat	2,2',5,5'-tetrachlorobiphenyl	decreases expression	ISO	RGD:732674	6480464	2,5,2',5'-tetrachlorobiphenyl results in decreased expression of PDE5A mRNA	CTD	PMID:36804509
Pde5a	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	RGD:737352	6480464	Tetrachlorodibenzodioxin results in increased expression of PDE5A mRNA	CTD	PMID:21354282
Pde5a	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		6480464	Tetrachlorodibenzodioxin results in increased expression of PDE5A mRNA	CTD	PMID:34747641
Pde5a	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:737352	6480464	Tetrachlorodibenzodioxin affects the expression of PDE5A mRNA	CTD	PMID:24680724
Pde5a	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	EXP		6480464	Tetrachlorodibenzodioxin affects the expression of PDE5A mRNA	CTD	PMID:22298810
Pde5a	Rat	2,4,4'-trichlorobiphenyl	multiple interactions	ISO	RGD:737352	6480464	[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...	CTD	PMID:25510870
Pde5a	Rat	3',5'-cyclic GMP	decreases abundance	ISO	RGD:732674	6480464	PDE5A protein results in decreased abundance of Cyclic GMP	CTD	PMID:10422958
Pde5a	Rat	3,3',4,4',5-pentachlorobiphenyl	decreases expression	EXP		6480464	3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PDE5A mRNA	CTD	PMID:23196670
Pde5a	Rat	3-chloropropane-1,2-diol	increases expression	EXP		6480464	alpha-Chlorohydrin results in increased expression of PDE5A protein	CTD	PMID:34915118
Pde5a	Rat	3-isobutyl-1-methyl-7H-xanthine	multiple interactions	ISO	RGD:737352	6480464	[1-Methyl-3-isobutylxanthine co-treated with 8-bromocyclic GMP] results in increased expression of PDE5A protein; [1-Methyl-3-isobutylxanthine co-treated with more ...	CTD	PMID:20613715
Pde5a	Rat	3-isobutyl-1-methyl-7H-xanthine	increases expression	ISO	RGD:737352	6480464	1-Methyl-3-isobutylxanthine results in increased expression of PDE5A protein; 1-Methyl-3-isobutylxanthine results in increased expression of PDE5A more ...	CTD	PMID:20613715
Pde5a	Rat	4,4'-diaminodiphenylmethane	increases expression	EXP		6480464	4,4'-diaminodiphenylmethane results in increased expression of PDE5A mRNA	CTD	PMID:30723492
Pde5a	Rat	4,4'-sulfonyldiphenol	increases expression	ISO	RGD:737352	6480464	bisphenol S results in increased expression of PDE5A mRNA	CTD	PMID:30951980
Pde5a	Rat	4,4'-sulfonyldiphenol	multiple interactions	EXP		6480464	[bisphenol S co-treated with diethyl phthalate] results in increased activity of PDE5A protein; morin inhibits more ...	CTD	PMID:35900689
Pde5a	Rat	4-hydroxyphenyl retinamide	increases expression	ISO	RGD:737352	6480464	Fenretinide results in increased expression of PDE5A mRNA	CTD	PMID:28973697
Pde5a	Rat	6-propyl-2-thiouracil	decreases expression	EXP		6480464	Propylthiouracil results in decreased expression of PDE5A mRNA	CTD	PMID:36843608
Pde5a	Rat	8-bromo-3',5'-cyclic GMP	multiple interactions	ISO	RGD:737352	6480464	[1-Methyl-3-isobutylxanthine co-treated with 8-bromocyclic GMP] results in increased expression of PDE5A protein; [1-Methyl-3-isobutylxanthine co-treated with more ...	CTD	PMID:20613715
Pde5a	Rat	acrylamide	decreases expression	ISO	RGD:732674	6480464	Acrylamide results in decreased expression of PDE5A mRNA	CTD	PMID:32763439
Pde5a	Rat	aflatoxin B1	increases methylation	ISO	RGD:732674	6480464	Aflatoxin B1 results in increased methylation of PDE5A intron	CTD	PMID:30157460
Pde5a	Rat	all-trans-retinoic acid	increases expression	ISO	RGD:732674	6480464	Tretinoin results in increased expression of PDE5A mRNA	CTD	PMID:21934132\|PMID:23830798
Pde5a	Rat	ammonium chloride	affects expression	EXP		6480464	Ammonium Chloride affects the expression of PDE5A mRNA	CTD	PMID:16483693
Pde5a	Rat	anthocyanin	decreases activity	ISO	RGD:732674	6480464	Anthocyanins results in decreased activity of PDE5A protein	CTD	PMID:15769121
Pde5a	Rat	arsane	multiple interactions	ISO	RGD:732674	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Pde5a	Rat	arsenic atom	multiple interactions	ISO	RGD:732674	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Pde5a	Rat	arsenite(3-)	decreases expression	ISO	RGD:737352	6480464	arsenite results in decreased expression of PDE5A mRNA	CTD	PMID:33053406
Pde5a	Rat	atrazine	affects activity	ISO	RGD:732674	6480464	Atrazine affects the activity of PDE5 protein	CTD	PMID:21251949
Pde5a	Rat	avobenzone	increases expression	ISO	RGD:732674	6480464	avobenzone results in increased expression of PDE5A mRNA	CTD	PMID:31016361
Pde5a	Rat	benzo[a]pyrene	increases expression	ISO	RGD:732674	6480464	Benzo(a)pyrene results in increased expression of PDE5A mRNA	CTD	PMID:22316170
Pde5a	Rat	benzo[a]pyrene	decreases methylation	ISO	RGD:732674	6480464	Benzo(a)pyrene results in decreased methylation of PDE5A promoter	CTD	PMID:27901495
Pde5a	Rat	benzo[a]pyrene diol epoxide I	affects expression	ISO	RGD:732674	6480464	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of PDE5A mRNA	CTD	PMID:20382639
Pde5a	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of PDE5A mRNA	CTD	PMID:25181051
Pde5a	Rat	bisphenol A	multiple interactions	EXP		6480464	[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of PDE5A protein; bisphenol more ...	CTD	PMID:32172062\|PMID:32428650\|PMID:32810514
Pde5a	Rat	bisphenol A	increases expression	ISO	RGD:732674	6480464	bisphenol A results in increased expression of PDE5A mRNA	CTD	PMID:29275510
Pde5a	Rat	bisphenol A	increases expression	ISO	RGD:737352	6480464	bisphenol A results in increased expression of PDE5A mRNA	CTD	PMID:30951980
Pde5a	Rat	bisphenol A	increases activity	EXP		6480464	bisphenol A results in increased activity of PDE5A protein	CTD	PMID:32172062\|PMID:32428650\|PMID:32810514
Pde5a	Rat	bisphenol AF	increases expression	EXP		6480464	bisphenol AF results in increased expression of PDE5A mRNA	CTD	PMID:27567155
Pde5a	Rat	bisphenol F	increases expression	ISO	RGD:737352	6480464	bisphenol F results in increased expression of PDE5A mRNA	CTD	PMID:30951980
Pde5a	Rat	bromacil	affects activity	ISO	RGD:732674	6480464	bromacil affects the activity of PDE5 protein	CTD	PMID:21251949
Pde5a	Rat	butanal	increases expression	ISO	RGD:732674	6480464	butyraldehyde results in increased expression of PDE5A mRNA	CTD	PMID:26079696
Pde5a	Rat	cadmium dichloride	decreases expression	ISO	RGD:732674	6480464	Cadmium Chloride results in decreased expression of PDE5A mRNA	CTD	PMID:38568856
Pde5a	Rat	caffeine	decreases expression	EXP		6480464	Caffeine results in decreased expression of PDE5A mRNA	CTD	PMID:20864626
Pde5a	Rat	caffeine	increases activity	EXP		6480464	Caffeine results in increased activity of PDE5A protein	CTD	PMID:37865952
Pde5a	Rat	caffeine	multiple interactions	EXP		6480464	[potassium bromate co-treated with Caffeine] results in increased activity of PDE5A protein; naringin inhibits the more ...	CTD	PMID:37865952
Pde5a	Rat	carbamazepine	affects expression	ISO	RGD:732674	6480464	Carbamazepine affects the expression of PDE5A mRNA	CTD	PMID:25979313
Pde5a	Rat	carbon nanotube	decreases expression	ISO	RGD:737352	6480464	Nanotubes, Carbon analog results in decreased expression of PDE5A mRNA	CTD	PMID:25554681
Pde5a	Rat	carbon nanotube	increases expression	ISO	RGD:737352	6480464	Nanotubes, Carbon analog results in increased expression of PDE5A mRNA; Nanotubes, Carbon results in increased more ...	CTD	PMID:25554681\|PMID:25620056
Pde5a	Rat	carmustine	affects response to substance	ISO	RGD:732674	6480464	PDE5A mRNA affects the susceptibility to Carmustine	CTD	PMID:16365179
Pde5a	Rat	carnosic acid	increases expression	ISO	RGD:737352	6480464	salvin results in increased expression of PDE5A protein	CTD	PMID:35926579
Pde5a	Rat	chlordecone	increases expression	ISO	RGD:737352	6480464	Chlordecone results in increased expression of PDE5A mRNA	CTD	PMID:33711761
Pde5a	Rat	chloroprene	decreases expression	ISO	RGD:737352	6480464	Chloroprene results in decreased expression of PDE5A mRNA	CTD	PMID:23125180
Pde5a	Rat	chlorpyrifos	decreases expression	EXP		6480464	Chlorpyrifos results in decreased expression of PDE5A mRNA	CTD	PMID:17452286
Pde5a	Rat	chlorpyrifos	increases expression	ISO	RGD:737352	6480464	Chlorpyrifos results in increased expression of PDE5A mRNA	CTD	PMID:37019170
Pde5a	Rat	cisplatin	multiple interactions	ISO	RGD:732674	6480464	[Cisplatin co-treated with jinfukang] results in decreased expression of PDE5A mRNA	CTD	PMID:27392435
Pde5a	Rat	cisplatin	decreases expression	ISO	RGD:732674	6480464	Cisplatin results in decreased expression of PDE5A mRNA	CTD	PMID:27392435
Pde5a	Rat	copper atom	multiple interactions	ISO	RGD:732674	6480464	[Disulfiram binds to Copper] which results in increased expression of PDE5A mRNA; [NSC 689534 binds more ...	CTD	PMID:20931265\|PMID:20971185\|PMID:24690739
Pde5a	Rat	copper atom	increases expression	EXP		6480464	Copper results in increased expression of PDE5A mRNA	CTD	PMID:30556269
Pde5a	Rat	copper(0)	multiple interactions	ISO	RGD:732674	6480464	[Disulfiram binds to Copper] which results in increased expression of PDE5A mRNA; [NSC 689534 binds more ...	CTD	PMID:20931265\|PMID:20971185\|PMID:24690739
Pde5a	Rat	copper(0)	increases expression	EXP		6480464	Copper results in increased expression of PDE5A mRNA	CTD	PMID:30556269
Pde5a	Rat	cyanazine	affects activity	ISO	RGD:732674	6480464	cyanazine affects the activity of PDE5 protein	CTD	PMID:21251949
Pde5a	Rat	cyclosporin A	decreases expression	ISO	RGD:732674	6480464	Cyclosporine results in decreased expression of PDE5A mRNA	CTD	PMID:27989131
Pde5a	Rat	cyproterone acetate	multiple interactions	EXP		6480464	Cyproterone Acetate inhibits the reaction [testosterone enanthate results in increased expression of PDE5A mRNA]	CTD	PMID:20463352
Pde5a	Rat	decabromodiphenyl ether	increases expression	ISO	RGD:737352	6480464	decabromobiphenyl ether results in increased expression of PDE5A mRNA	CTD	PMID:29151189
Pde5a	Rat	decabromodiphenyl ether	multiple interactions	ISO	RGD:737352	6480464	Dizocilpine Maleate inhibits the reaction [decabromobiphenyl ether results in increased expression of PDE5A mRNA]	CTD	PMID:29151189
Pde5a	Rat	deisopropylatrazine	affects activity	ISO	RGD:732674	6480464	6-deisopropylatrazine affects the activity of PDE5 protein	CTD	PMID:21251949
Pde5a	Rat	diazinon	decreases expression	EXP		6480464	Diazinon results in decreased expression of PDE5A mRNA	CTD	PMID:17452286
Pde5a	Rat	diethyl phthalate	multiple interactions	EXP		6480464	[bisphenol S co-treated with diethyl phthalate] results in increased activity of PDE5A protein; morin inhibits more ...	CTD	PMID:35900689
Pde5a	Rat	dioxygen	multiple interactions	ISO	RGD:737352	6480464	[NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of PDE5A mRNA	CTD	PMID:30529165
Pde5a	Rat	dipyridamole	decreases activity	ISO	RGD:732674	6480464	Dipyridamole results in decreased activity of PDE5A protein	CTD	PMID:11051267
Pde5a	Rat	disulfiram	multiple interactions	ISO	RGD:732674	6480464	[Disulfiram binds to Copper] which results in increased expression of PDE5A mRNA	CTD	PMID:24690739
Pde5a	Rat	dizocilpine maleate	multiple interactions	ISO	RGD:737352	6480464	Dizocilpine Maleate inhibits the reaction [decabromobiphenyl ether results in increased expression of PDE5A mRNA]	CTD	PMID:29151189
Pde5a	Rat	dorsomorphin	multiple interactions	ISO	RGD:732674	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ...	CTD	PMID:27188386
Pde5a	Rat	doxorubicin	decreases expression	ISO	RGD:732674	6480464	Doxorubicin results in decreased expression of PDE5A mRNA	CTD	PMID:29803840
Pde5a	Rat	endosulfan	affects expression	EXP		6480464	Endosulfan affects the expression of PDE5A mRNA	CTD	PMID:31464424
Pde5a	Rat	ethanol	multiple interactions	ISO	RGD:737352	6480464	[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of PDE5A mRNA	CTD	PMID:30517762
Pde5a	Rat	flavonoids	increases expression	EXP		6480464	Flavonoids results in increased expression of PDE5A mRNA	CTD	PMID:18035473
Pde5a	Rat	furan	decreases expression	EXP		6480464	furan results in decreased expression of PDE5A mRNA	CTD	PMID:25539665
Pde5a	Rat	furan	decreases methylation	EXP		6480464	furan results in decreased methylation of PDE5A gene	CTD	PMID:27387713
Pde5a	Rat	furan	increases expression	EXP		6480464	furan results in increased expression of PDE5A mRNA	CTD	PMID:25539665\|PMID:27387713
Pde5a	Rat	haloperidol	multiple interactions	EXP		6480464	Haloperidol inhibits the reaction [potassium bromate results in increased activity of PDE5A protein]	CTD	PMID:37865952
Pde5a	Rat	hemin	decreases expression	EXP		6480464	Hemin results in decreased expression of PDE5A protein	CTD	PMID:16839318
Pde5a	Rat	icariin	decreases expression	EXP		6480464	icariin results in decreased expression of PDE5A mRNA alternative form	CTD	PMID:17120748
Pde5a	Rat	icariin	decreases activity	ISO	RGD:732674	6480464	icariin analog results in decreased activity of PDE5A protein; icariin results in decreased activity of more ...	CTD	PMID:18778098
Pde5a	Rat	Indeno[1,2,3-cd]pyrene	decreases expression	ISO	RGD:737352	6480464	indeno(1,2,3-cd)pyrene results in decreased expression of PDE5A mRNA	CTD	PMID:26377693
Pde5a	Rat	lead diacetate	decreases methylation	EXP		6480464	lead acetate results in decreased methylation of PDE5A gene	CTD	PMID:29571894
Pde5a	Rat	lipopolysaccharide	increases expression	ISO	RGD:732674	6480464	Lipopolysaccharides results in increased expression of PDE5A mRNA	CTD	PMID:35811015
Pde5a	Rat	lipopolysaccharide	multiple interactions	ISO	RGD:732674	6480464	[S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of PDE5A mRNA; [S-(1,2-dichlorovinyl)cysteine more ...	CTD	PMID:35811015
Pde5a	Rat	malvidin	decreases activity	ISO	RGD:732674	6480464	malvidin results in decreased activity of PDE5A protein	CTD	PMID:15769121
Pde5a	Rat	malvidin 3-O-beta-D-glucoside	decreases activity	ISO	RGD:732674	6480464	malvidin-3-glucoside results in decreased activity of PDE5A protein	CTD	PMID:15769121
Pde5a	Rat	manganese atom	multiple interactions	ISO	RGD:732674	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Pde5a	Rat	manganese(0)	multiple interactions	ISO	RGD:732674	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Pde5a	Rat	manganese(II) chloride	multiple interactions	ISO	RGD:732674	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Pde5a	Rat	methoxyacetic acid	decreases expression	EXP		6480464	methoxyacetic acid results in decreased expression of PDE5A mRNA	CTD	PMID:20864626
Pde5a	Rat	methylmercury chloride	decreases expression	EXP		6480464	methylmercuric chloride results in decreased expression of PDE5A mRNA	CTD	PMID:20864626
Pde5a	Rat	methylmercury chloride	decreases expression	ISO	RGD:732674	6480464	methylmercuric chloride results in decreased expression of PDE5A mRNA	CTD	PMID:28001369
Pde5a	Rat	Monobutylphthalate	decreases expression	EXP		6480464	monobutyl phthalate results in decreased expression of PDE5A mRNA	CTD	PMID:20864626
Pde5a	Rat	morin	multiple interactions	EXP		6480464	morin inhibits the reaction [[bisphenol S co-treated with diethyl phthalate] results in increased activity of more ...	CTD	PMID:35900689
Pde5a	Rat	N(gamma)-nitro-L-arginine methyl ester	increases activity	EXP		6480464	NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein	CTD	PMID:32172062\|PMID:32428650\|PMID:32810514
Pde5a	Rat	N(gamma)-nitro-L-arginine methyl ester	multiple interactions	EXP		6480464	[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of PDE5A protein; bisphenol more ...	CTD	PMID:32172062\|PMID:32428650\|PMID:32810514
Pde5a	Rat	N-tosyl-L-phenylalanyl chloromethyl ketone	decreases expression	EXP		6480464	Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of PDE5A mRNA	CTD	PMID:12466227
Pde5a	Rat	naringin	multiple interactions	EXP		6480464	naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity more ...	CTD	PMID:32172062\|PMID:32428650\|PMID:32810514\|PMID:37865952
Pde5a	Rat	nickel atom	decreases expression	ISO	RGD:732674	6480464	Nickel results in decreased expression of PDE5A mRNA	CTD	PMID:24768652\|PMID:25583101
Pde5a	Rat	nitric oxide	increases expression	EXP		6480464	Nitric Oxide results in increased expression of PDE5A mRNA; Nitric Oxide results in increased expression more ...	CTD	PMID:19374906
Pde5a	Rat	nitric oxide	affects response to substance	EXP		6480464	PDE5A protein affects the susceptibility to Nitric Oxide	CTD	PMID:19374906
Pde5a	Rat	orphenadrine	affects expression	EXP		6480464	Orphenadrine affects the expression of PDE5A mRNA	CTD	PMID:23665939
Pde5a	Rat	ozone	multiple interactions	ISO	RGD:737352	6480464	[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased more ...	CTD	PMID:34911549
Pde5a	Rat	paracetamol	increases expression	ISO	RGD:732674	6480464	Acetaminophen results in increased expression of PDE5A mRNA	CTD	PMID:29067470
Pde5a	Rat	paracetamol	increases expression	EXP		6480464	Acetaminophen results in increased expression of PDE5A mRNA	CTD	PMID:33387578
Pde5a	Rat	paraquat	decreases expression	EXP		6480464	Paraquat results in decreased expression of PDE5A mRNA	CTD	PMID:32680482
Pde5a	Rat	PCB138	multiple interactions	ISO	RGD:737352	6480464	[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...	CTD	PMID:25510870
Pde5a	Rat	pentanal	increases expression	ISO	RGD:732674	6480464	pentanal results in increased expression of PDE5A mRNA	CTD	PMID:26079696
Pde5a	Rat	phenobarbital	increases expression	EXP		6480464	Phenobarbital results in increased expression of PDE5A mRNA	CTD	PMID:19162173
Pde5a	Rat	phenylephrine	multiple interactions	EXP		6480464	PDE5A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; PDE5A protein more ...	CTD	PMID:18790048
Pde5a	Rat	phenylmercury acetate	decreases expression	ISO	RGD:732674	6480464	Phenylmercuric Acetate results in decreased expression of PDE5A mRNA	CTD	PMID:26272509
Pde5a	Rat	phenylmercury acetate	multiple interactions	ISO	RGD:732674	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ...	CTD	PMID:27188386
Pde5a	Rat	pirinixic acid	increases expression	EXP		6480464	pirinixic acid results in increased expression of PDE5A mRNA	CTD	PMID:19162173
Pde5a	Rat	potassium bromate	increases activity	EXP		6480464	potassium bromate results in increased activity of PDE5A protein	CTD	PMID:37865952
Pde5a	Rat	potassium bromate	multiple interactions	EXP		6480464	[potassium bromate co-treated with Caffeine] results in increased activity of PDE5A protein; Haloperidol inhibits the more ...	CTD	PMID:37865952
Pde5a	Rat	potassium chromate	increases expression	ISO	RGD:732674	6480464	potassium chromate(VI) results in increased expression of PDE5A mRNA	CTD	PMID:22714537
Pde5a	Rat	pregnenolone 16alpha-carbonitrile	increases expression	EXP		6480464	Pregnenolone Carbonitrile results in increased expression of PDE5A mRNA	CTD	PMID:19162173
Pde5a	Rat	prometon	affects activity	ISO	RGD:732674	6480464	prometone affects the activity of PDE5 protein	CTD	PMID:21251949
Pde5a	Rat	propazine	affects activity	ISO	RGD:732674	6480464	propazine affects the activity of PDE5 protein	CTD	PMID:21251949
Pde5a	Rat	raloxifene	decreases expression	ISO	RGD:732674	6480464	Raloxifene Hydrochloride results in decreased expression of PDE5A mRNA	CTD	PMID:19429434
Pde5a	Rat	resveratrol	decreases activity	ISO	RGD:732674	6480464	resveratrol results in decreased activity of PDE5A protein	CTD	PMID:15769121
Pde5a	Rat	resveratrol	multiple interactions	EXP		6480464	[Sildenafil Citrate co-treated with resveratrol] inhibits the reaction [Streptozocin results in increased expression of PDE5A more ...	CTD	PMID:26006044
Pde5a	Rat	rotenone	increases expression	ISO	RGD:737352	6480464	Rotenone results in increased expression of PDE5A mRNA	CTD	PMID:32937126
Pde5a	Rat	S-(1,2-dichlorovinyl)-L-cysteine	decreases expression	ISO	RGD:732674	6480464	S-(1,2-dichlorovinyl)cysteine results in decreased expression of PDE5A mRNA	CTD	PMID:33725128
Pde5a	Rat	S-(1,2-dichlorovinyl)-L-cysteine	multiple interactions	ISO	RGD:732674	6480464	[S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of PDE5A mRNA; [S-(1,2-dichlorovinyl)cysteine more ...	CTD	PMID:35811015
Pde5a	Rat	SB 431542	multiple interactions	ISO	RGD:732674	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ...	CTD	PMID:27188386
Pde5a	Rat	sildenafil citrate	multiple interactions	EXP		6480464	[Sildenafil Citrate co-treated with resveratrol] inhibits the reaction [Streptozocin results in increased expression of PDE5A more ...	CTD	PMID:26006044
Pde5a	Rat	sildenafil citrate	decreases activity	ISO	RGD:732674	6480464	Sildenafil Citrate results in decreased activity of PDE5A protein	CTD	PMID:10422958\|PMID:15934858\|PMID:16368379\|PMID:17138653\|PMID:18778098\|PMID:8858389
Pde5a	Rat	sildenafil citrate	decreases activity	EXP		6480464	Sildenafil Citrate results in decreased activity of PDE5A protein	CTD	PMID:19374906
Pde5a	Rat	simazine	affects activity	ISO	RGD:732674	6480464	Simazine affects the activity of PDE5 protein	CTD	PMID:21251949
Pde5a	Rat	sodium arsenite	increases expression	ISO	RGD:732674	6480464	sodium arsenite results in increased expression of PDE5A mRNA	CTD	PMID:22714537
Pde5a	Rat	sodium arsenite	multiple interactions	ISO	RGD:732674	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Pde5a	Rat	sodium arsenite	affects expression	ISO	RGD:732674	6480464	sodium arsenite affects the expression of PDE5A mRNA	CTD	PMID:34032870
Pde5a	Rat	streptozocin	multiple interactions	EXP		6480464	[Sildenafil Citrate co-treated with Resveratrol] inhibits the reaction [Streptozocin results in increased expression of PDE5A more ...	CTD	PMID:26006044
Pde5a	Rat	streptozocin	increases expression	EXP		6480464	Streptozocin results in increased expression of PDE5A mRNA; Streptozocin results in increased expression of PDE5A more ...	CTD	PMID:26006044
Pde5a	Rat	sulforaphane	decreases expression	ISO	RGD:732674	6480464	sulforaphane results in decreased expression of PDE5A mRNA	CTD	PMID:31838189
Pde5a	Rat	sulindac sulfone	decreases activity	ISO	RGD:732674	6480464	sulindac sulfone results in decreased activity of PDE5A protein	CTD	PMID:10910034
Pde5a	Rat	sulindac sulfone	multiple interactions	ISO	RGD:732674	6480464	sulindac sulfone binds to and results in decreased activity of PDE5A protein	CTD	PMID:11602670
Pde5a	Rat	tadalafil	decreases activity	ISO	RGD:732674	6480464	Tadalafil results in decreased activity of PDE5A protein	CTD	PMID:15934858\|PMID:16368379\|PMID:17137605\|PMID:17138653
Pde5a	Rat	temozolomide	affects response to substance	ISO	RGD:732674	6480464	PDE5A mRNA affects the susceptibility to temozolomide	CTD	PMID:16365179
Pde5a	Rat	Terbacil	affects activity	ISO	RGD:732674	6480464	terbacil affects the activity of PDE5 protein	CTD	PMID:21251949
Pde5a	Rat	testosterone	increases expression	EXP		6480464	Testosterone results in increased expression of PDE5A	CTD	PMID:22028410
Pde5a	Rat	testosterone	affects expression	EXP		6480464	Testosterone affects the expression of PDE5A mRNA	CTD	PMID:17138653
Pde5a	Rat	testosterone enanthate	increases expression	EXP		6480464	testosterone enanthate results in increased expression of PDE5A mRNA; testosterone enanthate results in increased expression more ...	CTD	PMID:20463352
Pde5a	Rat	testosterone enanthate	multiple interactions	EXP		6480464	[testosterone enanthate co-treated with Triptorelin Pamoate] results in increased expression of PDE5A mRNA; [testosterone enanthate more ...	CTD	PMID:20463352
Pde5a	Rat	tetrachloromethane	increases expression	EXP		6480464	Carbon Tetrachloride results in increased expression of PDE5A mRNA	CTD	PMID:16644059
Pde5a	Rat	tetrachloromethane	multiple interactions	ISO	RGD:737352	6480464	[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of PDE5A mRNA	CTD	PMID:30517762
Pde5a	Rat	tetraphene	decreases expression	ISO	RGD:737352	6480464	benz(a)anthracene results in decreased expression of PDE5A mRNA	CTD	PMID:26377693
Pde5a	Rat	thioacetamide	increases expression	EXP		6480464	Thioacetamide results in increased expression of PDE5A mRNA	CTD	PMID:23411599\|PMID:34492290
Pde5a	Rat	titanium dioxide	decreases methylation	ISO	RGD:737352	6480464	titanium dioxide results in decreased methylation of PDE5A gene	CTD	PMID:35295148
Pde5a	Rat	titanium dioxide	increases methylation	ISO	RGD:737352	6480464	titanium dioxide results in increased methylation of PDE5A gene	CTD	PMID:35295148
Pde5a	Rat	trans-piceid	decreases activity	ISO	RGD:732674	6480464	polydatin results in decreased activity of PDE5A protein	CTD	PMID:15769121
Pde5a	Rat	trichloroethene	increases methylation	EXP		6480464	Trichloroethylene results in increased methylation of PDE5A gene	CTD	PMID:27618143
Pde5a	Rat	trichloroethene	increases expression	EXP		6480464	Trichloroethylene results in increased expression of PDE5A mRNA	CTD	PMID:33387578
Pde5a	Rat	triphenyl phosphate	affects expression	ISO	RGD:732674	6480464	triphenyl phosphate affects the expression of PDE5A mRNA	CTD	PMID:37042841
Pde5a	Rat	triptonide	decreases expression	ISO	RGD:737352	6480464	triptonide results in decreased expression of PDE5A mRNA	CTD	PMID:33045310
Pde5a	Rat	triptorelin	multiple interactions	EXP		6480464	[testosterone enanthate co-treated with Triptorelin Pamoate] results in increased expression of PDE5A mRNA; [testosterone enanthate more ...	CTD	PMID:20463352
Pde5a	Rat	tungsten	decreases expression	ISO	RGD:737352	6480464	Tungsten results in decreased expression of PDE5A mRNA	CTD	PMID:30912803
Pde5a	Rat	udenafil	decreases activity	ISO	RGD:732674	6480464	udenafil results in decreased activity of PDE5A protein	CTD	PMID:17137605
Pde5a	Rat	urethane	decreases expression	ISO	RGD:732674	6480464	Urethane results in decreased expression of PDE5A mRNA	CTD	PMID:28818685
Pde5a	Rat	valproic acid	affects expression	ISO	RGD:732674	6480464	Valproic Acid affects the expression of PDE5A mRNA	CTD	PMID:25979313
Pde5a	Rat	valproic acid	decreases expression	ISO	RGD:732674	6480464	Valproic Acid results in decreased expression of PDE5A mRNA	CTD	PMID:23179753\|PMID:27188386
Pde5a	Rat	valproic acid	decreases methylation	ISO	RGD:732674	6480464	Valproic Acid results in decreased methylation of PDE5A gene	CTD	PMID:29154799
Pde5a	Rat	zoledronic acid	decreases expression	ISO	RGD:732674	6480464	zoledronic acid results in decreased expression of PDE5A mRNA	CTD	PMID:24714768

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Pde5a	Rat	cAMP-mediated signaling	involved_in	IBA	CGD:CAL0000178266\|PANTHER:PTN001682918	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Pde5a	Rat	cGMP catabolic process	involved_in	IEA	UniPathway:UPA00763	1600115	GO_REF:0000041	UniProt	GO_REF:0000041
Pde5a	Rat	cGMP catabolic process	acts_upstream_of_or_within	ISO	RGD:737352	1624291	PMID:12554648	RGD	PMID:12554648
Pde5a	Rat	cGMP metabolic process	acts_upstream_of_or_within	ISO	RGD:737352	1624291	PMID:19474061, PMID:20511540	RGD	PMID:19474061\|PMID:20511540
Pde5a	Rat	negative regulation of cardiac muscle contraction	involved_in	ISO	RGD:737352	1624291	PMID:19127022	RGD	PMID:19127022
Pde5a	Rat	negative regulation of T cell proliferation	acts_upstream_of_or_within	ISO	RGD:737352	1624291	PMID:17101732	RGD	PMID:17101732
Pde5a	Rat	nervous system development		IEP		729513		RGD
Pde5a	Rat	oocyte development	acts_upstream_of	ISO	RGD:737352	1624291	MGI:1860764 PMID:19474061	RGD	PMID:19474061
Pde5a	Rat	positive regulation of apoptotic process		IMP		2314462		RGD
Pde5a	Rat	positive regulation of cardiac muscle hypertrophy	involved_in	ISO	RGD:737352	1624291	PMID:19127022	RGD	PMID:19127022
Pde5a	Rat	positive regulation of chronic inflammatory response		IMP		2314463		RGD
Pde5a	Rat	positive regulation of MAP kinase activity	involved_in	ISO	RGD:737352	1624291	PMID:19127022	RGD	PMID:19127022
Pde5a	Rat	positive regulation of oocyte development	acts_upstream_of_or_within	ISO	RGD:737352	1624291	MGI:1860764 PMID:19474061	RGD	PMID:19474061
Pde5a	Rat	positive regulation of vasoconstriction		IMP		2314461		RGD
Pde5a	Rat	regulation of nitric oxide mediated signal transduction	acts_upstream_of_or_within	ISO	RGD:737352	1624291	MGI:2446107 PMID:16150726	RGD	PMID:16150726
Pde5a	Rat	regulation of the force of heart contraction		IMP		2314467		RGD
Pde5a	Rat	relaxation of cardiac muscle	involved_in	ISO	RGD:737352	1624291	PMID:19127022	RGD	PMID:19127022
Pde5a	Rat	response to hypoxia		IEP		1582528		RGD
Pde5a	Rat	response to lipopolysaccharide		IEP		2314470		RGD
Pde5a	Rat	response to testosterone		IEP		2314518		RGD
Pde5a	Rat	short-term memory		IMP		2314463		RGD
Pde5a	Rat	signal transduction	involved_in	IEA	InterPro:IPR002073\|InterPro:IPR036971	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Pde5a	Rat	T cell proliferation	acts_upstream_of	ISO	RGD:737352	1624291	PMID:17101732	RGD	PMID:17101732
Pde5a	Rat	vasodilation		IEP		1582534		RGD

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Pde5a	Rat	3',5'-cyclic-AMP phosphodiesterase activity	enables	IBA	FB:FBgn0085370\|FB:FBgn0264815\|MGI:108413\|MGI:1201792\|MGI:1202402\|MGI:1277116\|MGI:1333863\|MGI:1352752\|MGI:1860764\|MGI:2443999\|MGI:2446107\|MGI:99555\|MGI:99558\|PANTHER:PTN001682918\|RGD:3278\|RGD:3279\|RGD:3280\|RGD:61943\|RGD:621016\|RGD:68332\|SGD:S000005887\|UniProtKB:O00408\|UniProtKB:O60658\|UniProtKB:O95263\|UniProtKB:P14099\|UniProtKB:P14100\|UniProtKB:P27815\|UniProtKB:P54750\|UniProtKB:Q01061\|UniProtKB:Q01064\|UniProtKB:Q07343\|UniProtKB:Q08493\|UniProtKB:Q08499\|UniProtKB:Q13370\|UniProtKB:Q13946\|UniProtKB:Q14123\|UniProtKB:Q14432\|UniProtKB:Q8I6Z7\|UniProtKB:Q9NP56\|WB:WBGene00011433\|dictyBase:DDB_G0284331\|dictyBase:DDB_G0289121	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Pde5a	Rat	3',5'-cyclic-GMP phosphodiesterase activity		TAS		729513		RGD
Pde5a	Rat	3',5'-cyclic-GMP phosphodiesterase activity	enables	IEA	RHEA:16957	1600115	GO_REF:0000116	RHEA	GO_REF:0000116
Pde5a	Rat	3',5'-cyclic-GMP phosphodiesterase activity	enables	IBA	FB:FBgn0038237\|FB:FBgn0085370\|FB:FBgn0264815\|MGI:108413\|MGI:1201792\|MGI:1277179\|MGI:2446107\|PANTHER:PTN001682918\|RGD:61943\|RGD:620995\|RGD:68329\|RGD:68332\|UniProtKB:O00408\|UniProtKB:O60658\|UniProtKB:O76074\|UniProtKB:O76083\|UniProtKB:P14099\|UniProtKB:P14100\|UniProtKB:P54750\|UniProtKB:Q01061\|UniProtKB:Q01064\|UniProtKB:Q14123\|UniProtKB:Q14432\|UniProtKB:Q8I5V4\|UniProtKB:Q8I6Z7\|UniProtKB:Q8IKD3\|WB:WBGene00011433\|dictyBase:DDB_G0268634	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Pde5a	Rat	3',5'-cyclic-GMP phosphodiesterase activity	enables	IEA	EC:3.1.4.35	1600115	GO_REF:0000003	UniProt	GO_REF:0000003
Pde5a	Rat	3',5'-cyclic-GMP phosphodiesterase activity	enables	ISO	RGD:732674	1624291	PMID:14687666	RGD	PMID:14687666
Pde5a	Rat	3',5'-cyclic-GMP phosphodiesterase activity		IDA		1582533		RGD
Pde5a	Rat	3',5'-cyclic-GMP phosphodiesterase activity		IDA		1582531		RGD
Pde5a	Rat	3',5'-cyclic-nucleotide phosphodiesterase activity	enables	IEA	InterPro:IPR002073\|InterPro:IPR036971	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Pde5a	Rat	3',5'-cyclic-nucleotide phosphodiesterase activity	enables	ISO	RGD:737352	1624291	PMID:19474061	RGD	PMID:19474061
Pde5a	Rat	catalytic activity	enables	IEA	UniProtKB-KW:KW-0021	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Pde5a	Rat	cGMP binding	enables	IEA	UniProtKB-KW:KW-0142	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Pde5a	Rat	cGMP binding	enables	ISO	RGD:737352	1624291	PMID:12554648, PMID:18534985	RGD	PMID:12554648\|PMID:18534985
Pde5a	Rat	cyclic-nucleotide phosphodiesterase activity	enables	ISO	RGD:737352	1624291	PMID:12554648	RGD	PMID:12554648
Pde5a	Rat	hydrolase activity	enables	IEA	UniProtKB-KW:KW-0378	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Pde5a	Rat	metal ion binding	enables	IEA	UniProtKB-KW:KW-0479	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Pde5a	Rat	nucleotide binding	enables	IEA	UniProtKB-KW:KW-0547	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Pde5a	Rat	phosphoric diester hydrolase activity	enables	IEA	InterPro:IPR023088\|InterPro:IPR023174	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Pde5a	Rat	protein binding	enables	ISO	RGD:732674	1624291	UniProtKB:Q13976\|UniProtKB:Q9NZD8 PMID:18757735, PMID:32296183	RGD	PMID:18757735\|PMID:32296183

Molecular Pathway Annotations Click to see Annotation Detail View

Imported Annotations - KEGG (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Pde5a	Rat	purine metabolic pathway		IEA		6907045		KEGG	rno:00230

Disease Annotations Click to see Annotation Detail View

Cardiomegaly (ISO)

Experimental Diabetes Mellitus (IMP)

Hearing Loss (IMP)

Hypertriglyceridemia (IMP)

IgA glomerulonephritis (ISO)

impotence (IMP)

Inflammation (IMP)

myocardial infarction (IMP)

Neoplasm Metastasis (ISO)

Neurodevelopmental Disorders (ISO)

pre-eclampsia (IMP)

primary biliary cholangitis (IMP)

pulmonary hypertension (IMP)

Reperfusion Injury (IMP)

Right Ventricular Hypertrophy (IMP,ISO)

Stroke (IMP)

vasculogenic impotence (IMP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,3,5-trinitro-1,3,5-triazinane (EXP)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,4'-trichlorobiphenyl (ISO)

3',5'-cyclic GMP (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (EXP,ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

8-bromo-3',5'-cyclic GMP (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

anthocyanin (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

atrazine (ISO)

avobenzone (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (EXP)

bisphenol F (ISO)

bromacil (ISO)

butanal (ISO)

cadmium dichloride (ISO)

caffeine (EXP)

carbamazepine (ISO)

carbon nanotube (ISO)

carmustine (ISO)

carnosic acid (ISO)

chlordecone (ISO)

chloroprene (ISO)

chlorpyrifos (EXP,ISO)

cisplatin (ISO)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

cyanazine (ISO)

cyclosporin A (ISO)

cyproterone acetate (EXP)

decabromodiphenyl ether (ISO)

deisopropylatrazine (ISO)

diazinon (EXP)

diethyl phthalate (EXP)

dioxygen (ISO)

dipyridamole (ISO)

disulfiram (ISO)

dizocilpine maleate (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

ethanol (ISO)

flavonoids (EXP)

furan (EXP)

haloperidol (EXP)

hemin (EXP)

icariin (EXP,ISO)

Indeno[1,2,3-cd]pyrene (ISO)

lead diacetate (EXP)

lipopolysaccharide (ISO)

malvidin (ISO)

malvidin 3-O-beta-D-glucoside (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methoxyacetic acid (EXP)

methylmercury chloride (EXP,ISO)

Monobutylphthalate (EXP)

morin (EXP)

N(gamma)-nitro-L-arginine methyl ester (EXP)

N-tosyl-L-phenylalanyl chloromethyl ketone (EXP)

naringin (EXP)

nickel atom (ISO)

nitric oxide (EXP)

orphenadrine (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

PCB138 (ISO)

pentanal (ISO)

phenobarbital (EXP)

phenylephrine (EXP)

phenylmercury acetate (ISO)

pirinixic acid (EXP)

potassium bromate (EXP)

potassium chromate (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

prometon (ISO)

propazine (ISO)

raloxifene (ISO)

resveratrol (EXP,ISO)

rotenone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

sildenafil citrate (EXP,ISO)

simazine (ISO)

sodium arsenite (ISO)

streptozocin (EXP)

sulforaphane (ISO)

sulindac sulfone (ISO)

tadalafil (ISO)

temozolomide (ISO)

Terbacil (ISO)

testosterone (EXP)

testosterone enanthate (EXP)

tetrachloromethane (EXP,ISO)

tetraphene (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trans-piceid (ISO)

trichloroethene (EXP)

triphenyl phosphate (ISO)

triptonide (ISO)

triptorelin (EXP)

tungsten (ISO)

udenafil (ISO)

urethane (ISO)

valproic acid (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cAMP-mediated signaling (IBA)

cGMP catabolic process (IEA,ISO)

cGMP metabolic process (ISO)

negative regulation of cardiac muscle contraction (ISO)

negative regulation of T cell proliferation (ISO)

nervous system development (IEP)

oocyte development (ISO)

positive regulation of apoptotic process (IMP)

positive regulation of cardiac muscle hypertrophy (ISO)

positive regulation of chronic inflammatory response (IMP)

positive regulation of MAP kinase activity (ISO)

positive regulation of oocyte development (ISO)

positive regulation of vasoconstriction (IMP)

regulation of nitric oxide mediated signal transduction (ISO)

regulation of the force of heart contraction (IMP)

relaxation of cardiac muscle (ISO)

response to hypoxia (IEP)

response to lipopolysaccharide (IEP)

response to testosterone (IEP)

short-term memory (IMP)

signal transduction (IEA)

T cell proliferation (ISO)

vasodilation (IEP)

Molecular Function

3',5'-cyclic-AMP phosphodiesterase activity (IBA)

3',5'-cyclic-GMP phosphodiesterase activity (IBA,IDA,IEA,ISO,TAS)

3',5'-cyclic-nucleotide phosphodiesterase activity (IEA,ISO)

catalytic activity (IEA)

cGMP binding (IEA,ISO)

cyclic-nucleotide phosphodiesterase activity (ISO)

hydrolase activity (IEA)

metal ion binding (IEA)

nucleotide binding (IEA)

phosphoric diester hydrolase activity (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

purine metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Temporal changes in vascular reactivity in early diabetes mellitus in rats: role of changes in endothelial factors and in phosphodiesterase activity.	Abboud K, etal., Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H836-45. Epub 2009 Jun 19.
2.	The effect of PDE5 inhibition on the erectile function in streptozotocin-induced diabetic rats.	Ahn GJ, etal., Int J Impot Res. 2005 Mar-Apr;17(2):134-41.
3.	DA-8159 reverses selective serotonin reuptake inhibitor-induced erectile dysfunction in rats.	Ahn GJ, etal., Urology. 2005 Jan;65(1):202-7.
4.	Impact of a long-term sildenafil treatment on pressor response in conscious rats with insulin resistance and hypertriglyceridemia.	Behr-Roussel D, etal., Am J Hypertens. 2008 Nov;21(11):1258-63. Epub 2008 Sep 11.
5.	The presence and function of phosphodiesterase type 5 in the rat myometrium.	Buhimschi CS, etal., Am J Obstet Gynecol. 2004 Jan;190(1):268-74.
6.	Pretreatment of sildenafil attenuates ischemia-reperfusion renal injury in rats.	Choi DE, etal., Am J Physiol Renal Physiol. 2009 Aug;297(2):F362-70. Epub 2009 May 27.
7.	Long-term continuous treatment with sildenafil ameliorates aging-related erectile dysfunction and the underlying corporal fibrosis in the rat.	Ferrini MG, etal., Biol Reprod. 2007 May;76(5):915-23. Epub 2007 Feb 7.
8.	Characterization and functional role of androgen-dependent PDE5 activity in the bladder.	Filippi S, etal., Endocrinology. 2007 Mar;148(3):1019-29. Epub 2006 Nov 30.
9.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10.	Effect of chronic administration of sildenafil on sodium retention and on the hemodynamic complications associated with liver cirrhosis in the rat.	Ghali-Ghoul R, etal., Eur J Pharmacol. 2007 Oct 15;572(1):49-56. Epub 2007 Jun 13.
11.	Phosphodiesterase-5 gene (PDE5A) polymorphisms are associated with progression of childhood IgA nephropathy.	Hahn WH, etal., Pediatr Nephrol. 2010 Sep;25(9):1663-71. doi: 10.1007/s00467-010-1579-x. Epub 2010 Jun 20.
12.	cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function.	Jaumann M, etal., Nat Med. 2012 Jan 22;18(2):252-9. doi: 10.1038/nm.2634.
13.	The effect of DA-8159, a novel PDE5 inhibitor, on erectile function in the rat model of hypercholesterolemic erectile dysfunction.	Kang KK, etal., Int J Impot Res. 2005 Sep-Oct;17(5):409-16.
14.	Angiotensin II increases phosphodiesterase 5A expression in vascular smooth muscle cells: a mechanism by which angiotensin II antagonizes cGMP signaling.	Kim D, etal., J Mol Cell Cardiol. 2005 Jan;38(1):175-84. Epub 2004 Dec 8.
15.	Expression of rat cGMP-binding cGMP-specific phosphodiesterase mRNA in Purkinje cell layers during postnatal neuronal development.	Kotera J, etal., Eur J Biochem 1997 Oct 15;249(2):434-42.
16.	Genomic origin and transcriptional regulation of two variants of cGMP-binding cGMP-specific phosphodiesterases.	Kotera J, etal., Eur J Biochem. 1999 Jun;262(3):866-73.
17.	Increased phosphodiesterase-5 expression is involved in the decreased vasodilator response to nitric oxide in cirrhotic rat livers.	Loureiro-Silva MR, etal., J Hepatol. 2006 May;44(5):886-93. Epub 2006 Feb 28.
18.	PDE5A inhibitors improve functional recovery after stroke in rats: optimized dosing regimen with implications for mechanism.	Menniti FS, etal., J Pharmacol Exp Ther. 2009 Sep 3.
19.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
20.	Increased expression of the cGMP-inhibited cAMP-specific (PDE3) and cGMP binding cGMP-specific (PDE5) phosphodiesterases in models of pulmonary hypertension.	Murray F, etal., Br J Pharmacol. 2002 Dec;137(8):1187-94.
21.	Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility.	Nagendran J, etal., Circulation. 2007 Jul 17;116(3):238-48. Epub 2007 Jul 2.
22.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
23.	Increased activity of cGMP-specific phosphodiesterase (PDE5) contributes to resistance to atrial natriuretic peptide natriuresis in the pregnant rat.	Ni XP, etal., J Am Soc Nephrol. 2004 May;15(5):1254-60.
24.	Phosphodiesterase 5A inhibition induces Na+/H+ exchanger blockade and protection against myocardial infarction.	Perez NG, etal., Hypertension. 2007 May;49(5):1095-103. Epub 2007 Mar 5.
25.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
26.	GOA pipeline	RGD automated data pipeline
27.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
28.	Tadalafil, a Long-Acting Inhibitor of PDE5, Improves Pulmonary Hemodynamics and Survival Rate of Monocrotaline-Induced Pulmonary Artery Hypertension in Rats.	Sawamura F, etal., J Pharmacol Sci. 2009 Oct 31.
29.	Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy.	Takimoto E, etal., Nat Med. 2005 Feb;11(2):214-22. Epub 2005 Jan 23.
30.	The effect of sildenafil on the altered thoracic aorta smooth muscle responses in rat pre-eclampsia model.	Turgut NH, etal., Eur J Pharmacol. 2008 Jul 28;589(1-3):180-7. Epub 2008 Jun 4.
31.	Effect of sildenafil on acrolein-induced airway inflammation and mucus production in rats.	Wang T, etal., Eur Respir J. 2009 May;33(5):1122-32. Epub 2009 Jan 7.
32.	Expression and activity of cGMP-dependent phosphodiesterases is up-regulated by lipopolysaccharide (LPS) in rat peritoneal macrophages.	Witwicka H, etal., Biochim Biophys Acta. 2007 Feb;1773(2):209-18. Epub 2006 Oct 24.

Additional References at PubMed

PMID:12554648	PMID:14687666	PMID:15075333	PMID:16150726	PMID:16651469	PMID:17101732	PMID:17690141	PMID:18534985	PMID:18723505	PMID:18790048	PMID:19127022	PMID:19338748
PMID:19474061	PMID:19961855	PMID:20039971	PMID:20177073	PMID:20511540	PMID:21063091	PMID:24068049	PMID:26657792	PMID:27923787	PMID:32311453	PMID:33009887

Genomics

Comparative Map Data

Pde5a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	213,542,822 - 213,687,638 (+)	NCBI		GRCr8
mRatBN7.2	2	210,858,515 - 211,003,480 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	210,858,063 - 210,999,701 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	218,537,423 - 218,677,334 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	216,445,209 - 216,585,125 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	211,291,504 - 211,431,374 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	226,899,604 - 227,044,916 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	226,900,619 - 227,041,576 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	246,260,843 - 246,406,296 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	219,410,394 - 219,550,910 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	219,373,455 - 219,513,972 (+)	NCBI
Celera	2	203,287,460 - 203,425,472 (+)	NCBI		Celera
Cytogenetic Map	2	q42	NCBI

PDE5A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	119,494,403 - 119,628,804 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	119,494,397 - 119,628,804 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	120,415,558 - 120,549,959 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	120,634,998 - 120,769,429 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	120,777,035 - 120,907,578	NCBI
Celera	4	117,795,077 - 117,929,505 (-)	NCBI		Celera
Cytogenetic Map	4	q26	NCBI
HuRef	4	116,136,584 - 116,271,133 (-)	NCBI		HuRef
CHM1_1	4	120,392,140 - 120,526,523 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	122,799,522 - 122,933,950 (-)	NCBI		T2T-CHM13v2.0

Pde5a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	122,522,822 - 122,653,023 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	122,522,596 - 122,653,023 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	122,729,158 - 122,859,374 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	122,728,947 - 122,859,374 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	122,432,076 - 122,562,292 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	122,721,209 - 122,848,174 (+)	NCBI		MGSCv36	mm8
Celera	3	129,135,905 - 129,269,158 (+)	NCBI		Celera
Cytogenetic Map	3	G1	NCBI
cM Map	3	53.69	NCBI

Pde5a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955428	20,785,423 - 20,904,717 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955428	20,785,497 - 20,904,717 (+)	NCBI	ChiLan1.0	ChiLan1.0

PDE5A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	117,271,752 - 117,406,487 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	117,568,528 - 117,702,985 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	111,682,772 - 111,817,234 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	122,832,175 - 122,966,636 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	122,832,175 - 122,966,636 (-)	Ensembl	panpan1.1		panPan2

PDE5A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	38,272,573 - 38,407,517 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	38,244,338 - 38,407,522 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	3,669,951 - 3,799,959 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	38,496,474 - 38,627,836 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	38,493,466 - 38,627,842 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	38,518,841 - 38,648,697 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	38,242,041 - 38,371,891 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	1,427,303 - 1,557,236 (+)	NCBI		UU_Cfam_GSD_1.0

Pde5a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	67,158,923 - 67,251,772 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936869	39,122 - 117,127 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936869	24,265 - 117,120 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PDE5A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	104,270,881 - 104,420,953 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	104,270,858 - 104,420,955 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	111,948,578 - 112,077,533 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PDE5A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	66,826,316 - 66,955,220 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	66,826,315 - 66,955,036 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	45,686,701 - 45,815,681 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pde5a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624964	14,216 - 126,553 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624964	11,085 - 126,027 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pde5a
1379 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	184
Count of miRNA genes:	134
Interacting mature miRNAs:	150
Transcripts:	ENSRNOT00000019638
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578648	Bss11	Bone structure and strength QTL 11	4.7		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	2	114837527	211674221	Rat
1358356	Srcrt1	Stress Responsive Cort QTL1	3.66		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	2	161699179	222436696	Rat
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	168358098	223265385	Rat
2301408	Kidm36	Kidney mass QTL 36		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	190613715	226808892	Rat
2307174	Activ3	Activity QTL 3	4.83	0.000058	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	168594495	213594495	Rat
1598813	Memor9	Memory QTL 9	2.7		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	199341726	234244620	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	141194931	223265385	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	141194931	223265385	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
2298479	Eau5	Experimental allergic uveoretinitis QTL 5		0.0021	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	2	202446871	237938339	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	112456140	212696837	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	18960362	228801039	Rat
61458	Bp10	Blood pressure QTL 10	3.42		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	189020722	215287351	Rat
70162	Bp63	Blood pressure QTL 63	5.64		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	2	169745596	214745596	Rat
738013	Alc15	Alcohol consumption QTL 15	4.1	0.00022	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	2	184165752	229165752	Rat
61398	Bp50	Blood pressure QTL 50	4.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	189599258	234599258	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	114837675	212549332	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	78665619	219826953	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	112456140	212696837	Rat
2317752	Glom23	Glomerulus QTL 23	3.6		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	2	193452645	245889826	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	221167075	Rat
61469	Bp16	Blood pressure QTL 16	5.64		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	2	169745596	214745596	Rat
1358900	Bw48	Body weight QTL 48	4.88		body mass (VT:0001259)	body weight (CMO:0000012)	2	157142078	211086598	Rat
1359031	Bp275	Blood pressure QTL 275			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	185876309	219753474	Rat
1581499	Esta2	Estrogen-induced thymic atrophy QTL 2			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	189599258	226936289	Rat
9589044	Scfw1	Subcutaneous fat weight QTL 1	5.8	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	2	182171407	227171407	Rat
8694435	Bw166	Body weight QTL 166	14.08	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	2	182171407	227171407	Rat
61417	Cia10	Collagen induced arthritis QTL 10	3.4		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	2	179946951	224946951	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	81754530	222436696	Rat
631203	Gluco14	Glucose level QTL 14		0.0001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	2	206665645	219003804	Rat
8694383	Bw158	Body weight QTL 158	7.69	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	2	182171407	227171407	Rat
1598835	Anxrr18	Anxiety related response QTL 18	2.98		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	2	200990457	245990457	Rat
1598838	Bp290	Blood pressure QTL 290	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	166539266	211539266	Rat
1298083	Bp158	Blood pressure QTL 158	2.62		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	189020722	215287351	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	81689826	221035911	Rat
1331745	Bp203	Blood pressure QTL 203	4.377		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	189599258	218414891	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	164073756	227146641	Rat
8694194	Abfw1	Abdominal fat weight QTL 1	11.7	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	2	182171407	227171407	Rat
61366	Iddm3	Insulin dependent diabetes mellitus QTL 3	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	189599258	234599258	Rat
1359022	Ppulsi1	Prepulse inhibition QTL 1	3.63		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	2	136916935	213594495	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	249053267	Rat
2299161	Iddm33	Insulin dependent diabetes mellitus QTL 33	2.98		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	206312063	220876787	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
2293084	Iddm26	Insulin dependent diabetes mellitus QTL 26	2.9		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	174930955	213594495	Rat
2300189	Bmd48	Bone mineral density QTL 48	5.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	179335906	224335906	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	157142078	226277316	Rat

Genetic Models

This gene Pde5a is modified in the following models/strains:

F344-Pde5a^{Tn(sb-T2/Bart3)2.144Mcwi}

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_133584	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006233260	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB017580	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB017582	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY155460	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY155461	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D89093	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U76032	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000019638 ⟹ ENSRNOP00000019637

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	210,859,419 - 210,999,701 (+)	Ensembl
Rnor_6.0 Ensembl	2	226,900,619 - 227,041,576 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000101437 ⟹ ENSRNOP00000082778

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	210,883,601 - 210,999,701 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119258 ⟹ ENSRNOP00000095374

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	210,858,063 - 210,999,701 (+)	Ensembl

RefSeq Acc Id:

NM_133584 ⟹ NP_598268

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	213,544,026 - 213,684,298 (+)	NCBI
mRatBN7.2	2	210,859,419 - 210,999,701 (+)	NCBI
Rnor_6.0	2	226,900,619 - 227,041,576 (+)	NCBI
Rnor_5.0	2	246,260,843 - 246,406,296 (+)	NCBI
RGSC_v3.4	2	219,410,394 - 219,550,910 (+)	RGD
Celera	2	203,287,460 - 203,425,472 (+)	RGD

Sequence:

show sequence

GCAGACTTGAGAGTGGAGCGGAGGGACGAGAGGGTGGAGCGGAGTGCGTGGCGGGCGGGTCCCC
CGAAGCTCGAGGAGTCGCCGCGAAGCCCGCGCGCGCGCTTGCCTCCGGCGCGCCGATCTGGGCT
GAACTAACAAGCTCTGCTTTGGAGAAGGGGCTGGAGCCCCGCCACCGGCGCCTTGGGGCAACGG
CCGTCGAGCAGCTGGTGCTGGCCGCCCGAGCCGGGAGGTCGACTCTCGCCGGGCGGGGATGGTG
GACGAGCCGGCGGGGACTCGCCCGCGCGCGGCCGCCACAGGGCCCGGCGCTGCCCGCCAGGGGG
CGACGCCACGCGGGGTCCGCAGCCGGCGACCCGCAGCGAAGAGGCGGCGGGGGCCATAAGGGAG
CCGGTCGGGCACCCACGGAACTCCGCGGGCCCCCAGAGTCTCCCCAGTCCACCATCCGAGGAGT
TCGGAAACGAGCGCCCCACCTCTGCTATGTTGCCCTTTGGAGACAAAACGAGAGACATGGTCAA
TGCATGGTTTTCAGAGAGAGTTCACAACATTCCTGTGTGCAAGGAAGGCATCCGGGCCCACACC
GAGTCCTGCTCTTGCTCTCTGCCTCAAAGTCCTCATGCAGATAATACCACCCCTGGAGCACCAG
CCAGAAAAATCTCTGCCTCTGAATTTGACCGACCTCTTAGACCCATTGTTGTCAAGGATTCTGA
GGGAACCGTGAGCTTTCTCTCTGACTCAGGAAAAAAGGAACAGATGCCACTAACCTCTCCAAGA
TTTGATAGTGATGAAGGGGACCAGTGCTCAAGACTCTTGGAACTAGTAAAAGATATTTCCAGTC
ATTTGGATGTCACAGCCTTGTGTCACAAAATTTTCTTGCATATCCATGGACTTATCTCTGCTGA
TCGCTATTCCCTGTTCCTTGTCTGTGAGGACAGCTCTAAAGACAAATTTCTCGTCAGTCGCCTC
TTTGATGTTGCTGAAGGTTCAACACTGGAGGAAGCTTCAAATAACTGTATCCGTTTAGAATGGA
ACAAAGGCATTGTGGGACATGTGGCAGCTTTTGGAGAGCCCTTGAACATCAAAGATGCCTATGA
GGATCCCCGGTTCAATGCAGAAGTTGACCAAATTACAGGCTACAAGACACAAAGTATCCTTTGT
ATGCCAATTAAGAACCACAGGGAAGAGGTCGTTGGTGTAGCTCAGGCCATCAACAAGAAATCAG
GAAACGGTGGGACATTCACTGAAAAAGATGAAAAGGACTTTGCTGCCTATCTGGCATTTTGTGG
CATTGTTCTTCACAACGCCCAGCTCTATGAAACGTCACTGCTGGAGAACAAAAGAAATCAGGTA
TTACTTGACCTTGCTAGCTTAATTTTCGAGGAGCAGCAGTCATTGGAAGTAATTCTGAAGAAAA
TAGCCGCCACTATTATCTCCTTCATGCAGGTGCAGAAGTGCACCATCTTCATCGTGGATGAAGA
CTGCCCTGACTCGTTCTCTCGTGTGTTTCAAATGGAGTGGGAGGAAGTAGGGAAATCCTCCGAG
CCTTTGACAAGGGAGCACGATGCAAACAAAATCAATTACATGTATGCTCAGTATGTCAAAAACA
CGATGGAGCCACTTAATATCCCAGATGTCACCAAGGACAACAGATTTCCCTGGACAAATGAAAA
CATGGGCCATATAAACACGCACTGCATCAGAAGTTTGCTTTGCACGCCTATAAAAAATGGGAAG
AAGAACAAAGTCATAGGGGTTTGCCAACTTGTTAATAAGATGGAGGAGAAGACTGGCAAGATTA
AGGCTTTCAACCAAAACGATGAACAATTCCTGGAGGCTTTTGTCATCTTCTGTGGCTTGGGGAT
CCAGAACACACAGATGTACGAAGCGGTGGAGAGAGCCATGGCCAAGCAGATGGTGACGTTAGAG
GTCCTGTCTTATCACGCATCAGCGGCGGAGGAAGAAACAAGGGAGCTCCAGGCTCTAGCGGCTG
CTGTGGTACCGTCTGCCCAAACCCTTAAAATTACCGACTTCAGCTTCAGTGACTTCGAGCTGTC
TGATCTGGAAACAGCGCTGTGTACAATTCGGATGTTCACTGACCTCAACCTTGTGCAGAACTTC
CAGATGAAACACGAGGTTCTTTGCCGATGGATTTTGAGTGTCAAGAAGAATTATCGGAAGAACG
TTGCCTACCACAATTGGAGGCACGCCTTTAACACGGCACAGTGCATGTTTGCTGCTCTGAAAGC
AGGCAAGATTCAGAACAAGTTGACGGATCTGGAGACGCTTGCATTGCTGATTGCCGCTTTAAGC
CATGATTTGGACCATCGTGGTGTGAACAACTCATACATACAGCGGAGCGAGCACCCCCTGGCCC
AGCTGTACTGCCACTCCACCATGGAGCACCATCACTTCGACCAGTGCTTGATGGTTCTAAACAG
CCCAGGCAACCAGATCCTCAGTGGCCTCTCCATTGAAGAATATAAGACCACATTGAAAATAATC
AAGCAAGCAATTTTAGCCACTGACCTAGCACTGTACATTAAGAGACGAGGAGAATTTTTTGAAC
TTATAAGAAAAAATGAATTCAGTTTTGAAGATCCTCTTCAAAAGGAGTTGTTTCTGGCAATGCT
GATGACTGCCTGTGATCTCTCCGCCATTACTAAGCCCTGGCCTATTCAACAACGGATAGCAGAA
CTCGTGGCAGCCGAATTCTTTGATCAAGGAGACAGAGAGAGAAAAGAACTTAACATGGAGCCCG
CTGATCTAATGAACAGGGAGAAGAAAAATAAAATCCCAAGTATGCAAGTTGGGTTCATAGACGC
CATCTGCTTGCAGCTGTATGAGGCCCTGACCCACGTCTCAGAAGACTGTTTGCCCCTGCTGGAT
GGCTGCAGGAAGAACAGGCAGAAATGGCAAGCCCTCGCAGACCAGCAGGAGAAGACGCTCCTTA
ATGGGGAGAGCGGCCAGGCCAAGCGGGACTGACCTTCTCCCCCTCCTCCCCTCCCCCACCCCCA
CCGGGTGTTCGAACTGCCCTAGGCCTGGTTTCGCCATACACTATGCAGACTCGAGTGCACTTTG
CCACTGCTGTATTTTATTTTTGCACAACTTCTGAGAGCATGAGGTGTTTCAGAGATTGCTACCT
ACTTTCCGTGCTTTTGTTTTATGCCACTGAAGTGGAGCCGTCAGTCATGCCCACTCTAACACTT
TGATAAGAGTGGTGTAAACTGCATTCCCACACGCAGCTTGGTTATGCTTGGGGAGTATGAATAA
CCGGCCTTTGTGTTTCTGAGTCACCAGTCTTTCAAACACGTTAGGAATCGTTCTCGGAAGTGGG
TTAGGGGCGAACTGAATGTGTCCTGGGACATTTAAAGCCATCCTGAAATTAACGCTGAGTGGAT
GTTAG

hide sequence

RefSeq Acc Id:

XM_006233260 ⟹ XP_006233322

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	213,542,822 - 213,687,638 (+)	NCBI
mRatBN7.2	2	210,858,515 - 211,003,480 (+)	NCBI
Rnor_6.0	2	226,899,604 - 227,044,916 (+)	NCBI
Rnor_5.0	2	246,260,843 - 246,406,296 (+)	NCBI

Sequence:

show sequence

ACTGCAGGGCAAAGGGGGAGGGTCTCGAACACTGTCCTGCTCCTCTGAGAGAGGGACCCTGCCG
GGTGGAAATCCGGCATCAGCGAGCCGCAGAAACCCGCGGCAAACACCATGGAACGAGCGGGCCC
CAGCTCCGTGCAGTCGCAGCAGCAGCGGGACCAGGACTGGGTGGAAGCGTGGCTGGATGATCAC
CGGGACTTTACCTTCTCTTACTTTGTTAGAAAGGCCACCAGAGACATGGTCAATGCATGGTTTT
CAGAGAGAGTTCACAACATTCCTGTGTGCAAGGAAGGCATCCGGGCCCACACCGAGTCCTGCTC
TTGCTCTCTGCCTCAAAGTCCTCATGCAGATAATACCACCCCTGGAGCACCAGCCAGAAAAATC
TCTGCCTCTGAATTTGACCGACCTCTTAGACCCATTGTTGTCAAGGATTCTGAGGGAACCGTGA
GCTTTCTCTCTGACTCAGGAAAAAAGGAACAGATGCCACTAACCTCTCCAAGATTTGATAGTGA
TGAAGGGGACCAGTGCTCAAGACTCTTGGAACTAGTAAAAGATATTTCCAGTCATTTGGATGTC
ACAGCCTTGTGTCACAAAATTTTCTTGCATATCCATGGACTTATCTCTGCTGATCGCTATTCCC
TGTTCCTTGTCTGTGAGGACAGCTCTAAAGACAAATTTCTCGTCAGTCGCCTCTTTGATGTTGC
TGAAGGTTCAACACTGGAGGAAGCTTCAAATAACTGTATCCGTTTAGAATGGAACAAAGGCATT
GTGGGACATGTGGCAGCTTTTGGAGAGCCCTTGAACATCAAAGATGCCTATGAGGATCCCCGGT
TCAATGCAGAAGTTGACCAAATTACAGGCTACAAGACACAAAGTATCCTTTGTATGCCAATTAA
GAACCACAGGGAAGAGGTCGTTGGTGTAGCTCAGGCCATCAACAAGAAATCAGGAAACGGTGGG
ACATTCACTGAAAAAGATGAAAAGGACTTTGCTGCCTATCTGGCATTTTGTGGCATTGTTCTTC
ACAACGCCCAGCTCTATGAAACGTCACTGCTGGAGAACAAAAGAAATCAGGTATTACTTGACCT
TGCTAGCTTAATTTTCGAGGAGCAGCAGTCATTGGAAGTAATTCTGAAGAAAATAGCCGCCACT
ATTATCTCCTTCATGCAGGTGCAGAAGTGCACCATCTTCATCGTGGATGAAGACTGCCCTGACT
CGTTCTCTCGTGTGTTTCAAATGGAGTGGGAGGAAGTAGGGAAATCCTCCGAGCCTTTGACAAG
GGAGCACGATGCAAACAAAATCAATTACATGTATGCTCAGTATGTCAAAAACACGATGGAGCCA
CTTAATATCCCAGATGTCACCAAGGACAACAGATTTCCCTGGACAAATGAAAACATGGGCCATA
TAAGCACGCACTGCATCGGAAGTTTGCTTTGCACGCCTATAAAAAATGGGAAGAAGAACAAAGT
CATAGGGGTTTGCCAACTTGTTAATAAGATGGAGGAGAAGACTGGCAAGATTAAGGCTTTCAAC
CAAAACGATGAACAATTCCTGGAGGCTTTTGTCATCTTCTGTGGCTTGGGGATCCAGAACACAC
AGATGTACGAAGCGGTGGAGAGAGCCATGGCCAAGCAGATGGTGACGTTAGAGGTCCTGTCTTA
TCACGCATCAGCGGCGGAGGAAGAAACAAGGGAGCTCCAGGCTCTAGCGGCTGCTGTGGTACCG
TCTGCCCAAACCCTTAAAATTACCGACTTCAGCTTCAGTGACTTCGAGCTGTCTGATCTGGAAA
CAGCGCTGTGTACAATTCGGATGTTCACTGACCTCAACCTTGTGCAGAACTTCCAGATGAAACA
CGAGGTTCTTTGCCGATGGATTTTGAGTGTCAAGAAGAATTATCGGAAGAACGTTGCCTACCAC
AATTGGAGGCACGCCTTTAACACGGCACAGTGCATGTTTGCTGCTCTGAAAGCAGGCAAGATTC
AGAACAAGTTGACGGATCTGGAGACGCTTGCATTGCTGATTGCCGCTTTAAGCCATGATTTGGA
CCATCGTGGTGTGAACAACTCATACATACAGCGGAGCGAGCACCCCCTGGCCCAGCTGTACTGC
CACTCCACCATGGAGCACCACCACTTCGACCAGTGCTTGATGGTTCTAAACAGCCCAGGCAACC
AGATCCTCAGTGGCCTCTCCATTGAAGAATATAAGACCACATTGAAAATAATCAAGCAAGCAAT
TTTAGCCACTGACCTAGCACTGTACATTAAGAGACGAGGAGAATTTTTTGAACTTATAAGAAAA
AATGAATTCAGTTTTGAAGATCCTCTTCAAAAGGAGTTGTTTCTGGCAATGCTGATGACTGCCT
GTGATCTCTCCGCCATTACTAAGCCCTGGCCTATTCAACAACGGATAGCAGAACTCGTGGCAGC
CGAATTCTTTGATCAAGGAGACAGAGAGAGAAAAGAACTTAACATGGAGCCCGCTGATCTAATG
AACAGGGAGAAGAAAAATAAAATCCCAAGTATGCAAGTTGGGTTCATAGACGCCATCTGCTTGC
AGCTGTATGAGGCCCTGACCCACGTCTCAGAAGACTGTTTGCCCCTGCTGGATGGCTGCAGGAA
GAACAGGCAGAAATGGCAAGCCCTCGCAGACCAGCAGGAGAAGACGCTCCTTAATGGGGAGAGC
GGCCAGGCCAAGCGGGACTGACCTTCTCCCCCTCCTCCCCTCCCCCACCCCCACCGGGTGTTCG
AACTGCCCTAGGCCTGGTTTCGCCATACACTATGCAGACTCGAGTGCACTTTGCCACTGCTGTA
TTTTATTTTTGCACAACTTCTGAGAGCATGAGGTGTTTCAGAGATTGCTACCTACTTTCCGTGC
TTTTGTTTTATGCCACTGAAGTGGAGCCGTCAGTCATGCCCACTCTAACACTTTGATAAGAGTG
GTGTAAACTGCATTCCCACACGCAGCTTGGTTATGCTTGGGGAGTATGAATAACCGGCCTTTGT
GTTTCTGAGTCACCAGTCTTTCAAACACGTTAGGAATCGTTCTCGGAAGTGGGTTAGGGGCGAA
CTGAATGTGTCCTGGGACATTTAAAGCCATCCTGAAATTAACGCTGAGTGGATGTTAGGGAGAA
ATGAATGTGTTTTAACTTGTCGGAAGTGTCTCGACCAAGTTAAAGACTTGTGAAGCAAGAAAAC
GTGGTACCTAATTGCTCTGCTCTCTCTGGGATGGAGAGAACTAGCAGTGCATCCCATCTGTGGC
CGAACAAACTTAAGCGACAGCCCATCCACGCAGTCTCCCTTCAGCATGCAGAACGCCCGGGCCA
GATGATTCCTCCCCCCACTGACTGTCCTAAGAGAGAGTGCCTGTCAGACATGGGAGGGCCCTGG
ATAGCCCTCAGCCAAGAGAAATGTTTTACTTGAAGGTCTTTCTGACAATCCACTTTTTTAAACG
CTGAAAACTTTTTAAACTCTCCTTTTTGAATTTTTCTTTTACTTCTCATCTCCTTAATTCAACA
GTTTTAAGTTTCAACAGAGAAGTGGTCACAGGAGTGCCTGCCTGAAGGTAGATAGGATGGCACA
TATGTGAGTGCAAGTATGGTCTCTATTCCTTCTGTCACCTGAAATTGACAGGAAAAAATGAATA
ATTCTATGAGTAGGGGAGGTCTGTTTCCAATTGGCAGGCCAGACAATGAATTCAAAGGAGCAGT
GTGTGAAAAAGTCTTCCTGCCCAAACAAAACAACGTTTAGTACTGGGGGAATAGAAAATGGATC
GAACCAAGCGACTGCAGTGGGGGAAGAGTATCTGCTCCACGTGTGCAGGATGGTTTGGGTCTGG
GCAGAATTAGAAGGGTATGATTTCTTAATTCCCACCCTCTCCCCCAGTTCTCCCAATGAGGGTG
AAGTACTTGGTCTGGGTTTCTAGCATTAATTTGCCTTAAAATGGTTTCTTTCCCCTTTCCTCTC
TGTTTAAAACTCACCATGGTCATTTTAATCCTGTGTATGTATATTTTATTGGGGTTTTGTTCTT
CCTCGGATATGGAAGGGCAAGGCTGGTATTGCTTTGTGCTGGTCAAGGCTAGTCCAGGGAATTG
TCACCCACTGCTAAATGTATTCTTGTTGTAATACGTGTATTTTATTTTCAGAATTTTATTTTAT
TTTTATTCCATGTCGTGTAGATGAAACCTGTAAGGTTGCTGTAATGCACTGGTGTGTAAATGAT
TAGACTTTCACTAATACTAATCATATCAGCATTGAATACGCCTACGCAGAGTGTGGACGTGCTG
CCTAGAGGATGCCCACAAGCCTGGCGTTGTACCCCACACACTGAGACTGAGCAGCTCTGCTGAA
ATACCGCCATAGACATGTGTAGCTTCTCCACACTCCTCTGACTTGAGCCACTGAGAGTATTTTT
AAAGATGACAGATCATAAGTGGAGGATTTGTCTAACATAGTAATAGGCAAGAAGTCCTATGTAG
ATTGGAAATTATCTGCTTGCTTTAGGCAATGGTTTGTTTTACTCTAGACATTAACATAGGAAAA
GCAGTGTCGTGCCTGTGACATTTTTACTGCTAGGTATTTTAGTTCAGACAGAGGAGAATGCTAT
TTAATTCAAGTAATTTTTTTTATTTTATAGGAAAACCATTCCATACGTGGATTTCTATCTGTGG
TACAAGAAAACAAGTCATAGGTTTTGTTCTTAATGTGAATATTGCCTTTTCAGTATCCACTCAA
GTTGGAATATATTTATCACATTGTAATATTATAATTCCCCTCTCATGCTGCCGCGAATCGATAG
TGCCCGTTATGAACAAGATGGTGCTCTGGTCCTGGACTCTTTGTTTGACAAACTGCTTGGCCGG
CTGTAGTGAAATAATACGATATCATTTCATTTTAACTTTCAGCCAGAAAAATCCTCATGGTTTG
GTGACTTGTGTGTAAAGTGTCCTGATCTTACACGTTTAGAAGAGTCGCCTTTGCCAGTCAGGAT
GCTTAACCTCTGGACCTAAGGAAGGTGTGCAGCAGTTCGGAAAGAGCTTGTGTTTGAGGGGAAT
GTCCCAGGAAGCAGCTCTTAAGCCTTCCTTATGGCCTTTGAGACCCCGTCGGAAAACGGGGTAT
TGAGGCAGAGTGACCCCAAGTACTTTTGATTCACTCCACACAGACCTGGCTCAGAGCACAGACG
CAGGATGACACTCTCACTGGTTGGCTAATGATGACAGAGCTTCTTTTAGGGACAGCATGGAGAT
GAGGGAGTATGTGAAAATGTACTGGAGATAATGGTTTCTTGGAGGAACTTGAGTCCCCGAGACT
CTTGCCTACCTGTTAAGTGCCTTTACTCTCAGAACGTTGCCGAAGTGTGAGGCTTGGCACCTGT
TACATTTCCAAACTTCCCGAGTTTCTCGCTAGGTTACACTCCTAAACCTTATCGGTGAGCGGCA
TGGCCTTTTCTTTAACTTGATTTAAGGTGAGAAGAGACGAAATGTTCCCCGCTCTCCTGGAAAC
AGCTGTCTCAAATAAGGTGGCAGAATTTAATTACTCAGCATCCACCGTGCTTCAGCCCCTTTTT
ATTAGATCCTCTCCTTACGTTAGGTACAGTGCTCAGATGCTGAAACAGCAGGGAGTCCGGGGAG
CTCATGGGCCACACAGGAAATGACTAAGAGTGCCATTCCTCGACCTGCCAACCTAACATGCAAG
GGCACAAGGCTTTGTATCGCTGTCCTCTTCGTCTGTAACACACGCTGTGCACTTTTATCCAAAA
CCTCTTAAGAAGCTGTCAGTGAACATTCTGTCTTCCTGTTGGCATGGATCATTTACCTTGCTGA
TAGCTTTAAGAACACCTTACATAAGGAGTCCCATCTTCCGTGACATAGGTCATGCAACCAGAGA
GAGAGAGAGAGAGAGAGAGAGAGAGAGAGATCAGAGTTCTCGGACCATTCAACTGCAGATTTGG
ACTTTCTGCCCTCTCACAGAGAGCAAATAAGGAAGTATTAAAGCTTACCTCACCTCTCCACGTT
GTTATCAAAAGCCTGTGTAGACATGTCTTGAATGTCATTGAAAGTGATGTAAATAGCTGAAAAA
TAGAAATTTCTATTACAGTTTAAGAACTCTAATGAACAGTCACTCGCCACTGTTGACGATCTAT
TTGTATTCTTATGCCTTTTCAATATATCTGAACAAATATATAGTTTCTGCCACTATTTTTATAC
TAGCATCAAAGAGTTACTATGTAAATTATGTTTTGCTGTGAAGTCATCCAAAAACGACTGAAAT
GTTGGTTTCTTTCCTTTCCTCACCCCACATGATAAACCATTTCCAGTGATCCTTCTTCGAGGGT
GTCATTCTCCAGAAGCACACACCCACCTGGCCCCGGGTCCCTGTGGAGTCAGACCTGGTCAGGG
AAGGGGAGAACTCACCACTTTGCTGGTTCTCATTTTGCAGTGCTGTAAAAATAAAGGGAATGAA
CGAGAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_598268	(Get FASTA)	NCBI Sequence Viewer
	XP_006233322	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD09578	(Get FASTA)	NCBI Sequence Viewer
	AAN87278	(Get FASTA)	NCBI Sequence Viewer
	AAN87279	(Get FASTA)	NCBI Sequence Viewer
	BAA23672	(Get FASTA)	NCBI Sequence Viewer
	BAA84641	(Get FASTA)	NCBI Sequence Viewer
	BAA84659	(Get FASTA)	NCBI Sequence Viewer
	BAA84660	(Get FASTA)	NCBI Sequence Viewer
	EDL82105	(Get FASTA)	NCBI Sequence Viewer
	EDL82106	(Get FASTA)	NCBI Sequence Viewer
	EDL82107	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000019637
	ENSRNOP00000095374
GenBank Protein	O54735	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_598268 ⟸ NM_133584

- UniProtKB:

O54735 (UniProtKB/Swiss-Prot), A6HVH1 (UniProtKB/TrEMBL), G3V7V8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLPFGDKTRDMVNAWFSERVHNIPVCKEGIRAHTESCSCSLPQSPHADNTTPGAPARKISASEF
DRPLRPIVVKDSEGTVSFLSDSGKKEQMPLTSPRFDSDEGDQCSRLLELVKDISSHLDVTALCH
KIFLHIHGLISADRYSLFLVCEDSSKDKFLVSRLFDVAEGSTLEEASNNCIRLEWNKGIVGHVA
AFGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEK
DEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFM
QVQKCTIFIVDEDCPDSFSRVFQMEWEEVGKSSEPLTREHDANKINYMYAQYVKNTMEPLNIPD
VTKDNRFPWTNENMGHINTHCIRSLLCTPIKNGKKNKVIGVCQLVNKMEEKTGKIKAFNQNDEQ
FLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQALAAAVVPSAQTL
KITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHA
FNTAQCMFAALKAGKIQNKLTDLETLALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSTME
HHHFDQCLMVLNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNEFSF
EDPLQKELFLAMLMTACDLSAITKPWPIQQRIAELVAAEFFDQGDRERKELNMEPADLMNREKK
NKIPSMQVGFIDAICLQLYEALTHVSEDCLPLLDGCRKNRQKWQALADQQEKTLLNGESGQAKR
D

hide sequence

RefSeq Acc Id:	XP_006233322 ⟸ XM_006233260
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6GLL2 (UniProtKB/TrEMBL), A6HVG9 (UniProtKB/TrEMBL), A6HVH0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MERAGPSSVQSQQQRDQDWVEAWLDDHRDFTFSYFVRKATRDMVNAWFSERVHNIPVCKEGIRA HTESCSCSLPQSPHADNTTPGAPARKISASEFDRPLRPIVVKDSEGTVSFLSDSGKKEQMPLTS PRFDSDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSKDKFLVS RLFDVAEGSTLEEASNNCIRLEWNKGIVGHVAAFGEPLNIKDAYEDPRFNAEVDQITGYKTQSI LCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRN QVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCPDSFSRVFQMEWEEVGKS SEPLTREHDANKINYMYAQYVKNTMEPLNIPDVTKDNRFPWTNENMGHISTHCIGSLLCTPIKN GKKNKVIGVCQLVNKMEEKTGKIKAFNQNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVT LEVLSYHASAAEEETRELQALAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQ NFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLETLALLIAA LSHDLDHRGVNNSYIQRSEHPLAQLYCHSTMEHHHFDQCLMVLNSPGNQILSGLSIEEYKTTLK IIKQAILATDLALYIKRRGEFFELIRKNEFSFEDPLQKELFLAMLMTACDLSAITKPWPIQQRI AELVAAEFFDQGDRERKELNMEPADLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCLPL LDGCRKNRQKWQALADQQEKTLLNGESGQAKRD hide sequence

Ensembl Acc Id:

ENSRNOP00000019637 ⟸ ENSRNOT00000019638

Ensembl Acc Id:

ENSRNOP00000082778 ⟸ ENSRNOT00000101437

Ensembl Acc Id:

ENSRNOP00000095374 ⟸ ENSRNOT00000119258

Protein Domains

GAF PDEase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O54735-F1-model_v2	AlphaFold	O54735	1-833	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691727

Promoter ID:

EPDNEW_R2252

Type:

single initiation site

Name:

Pde5a_1

Description:

phosphodiesterase 5A

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	226,900,606 - 226,900,666	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620995	AgrOrtholog
BioCyc Gene	G2FUF-51351	BioCyc
Ensembl Genes	ENSRNOG00000014443	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000019638	ENTREZGENE
	ENSRNOT00000119258	ENTREZGENE
Gene3D-CATH	1.10.1300.10	UniProtKB/Swiss-Prot
	3.30.450.40	UniProtKB/Swiss-Prot
InterPro	GAF	UniProtKB/Swiss-Prot
	GAF-like_dom_sf	UniProtKB/Swiss-Prot
	HD/PDEase_dom	UniProtKB/Swiss-Prot
	PDEase	UniProtKB/Swiss-Prot
	PDEase_catalytic_dom	UniProtKB/Swiss-Prot
	PDEase_catalytic_dom_sf	UniProtKB/Swiss-Prot
	PDEase_CS	UniProtKB/Swiss-Prot
KEGG Report	rno:171115	UniProtKB/Swiss-Prot
NCBI Gene	171115	ENTREZGENE
PANTHER	CYCLIC NUCLEOTIDE PHOSPHODIESTERASE	UniProtKB/Swiss-Prot
Pfam	GAF	UniProtKB/Swiss-Prot
	PDEase_I	UniProtKB/Swiss-Prot
PhenoGen	Pde5a	PhenoGen
PRINTS	PDIESTERASE1	UniProtKB/Swiss-Prot
PROSITE	PDEASE_I_1	UniProtKB/Swiss-Prot
	PDEASE_I_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000014443	RatGTEx
SMART	GAF	UniProtKB/Swiss-Prot
	HDc	UniProtKB/Swiss-Prot
Superfamily-SCOP	GAF domain-like	UniProtKB/Swiss-Prot
	HD-domain/PDEase-like	UniProtKB/Swiss-Prot
UniProt	A0A8I5ZVK4_RAT	UniProtKB/TrEMBL
	A0A8I6GLL2	ENTREZGENE, UniProtKB/TrEMBL
	A6HVG9	ENTREZGENE, UniProtKB/TrEMBL
	A6HVH0	ENTREZGENE, UniProtKB/TrEMBL
	A6HVH1	ENTREZGENE, UniProtKB/TrEMBL
	G3V7V8	ENTREZGENE, UniProtKB/TrEMBL
	O54735	ENTREZGENE, UniProtKB/Swiss-Prot
	Q6YF34_RAT	UniProtKB/TrEMBL
	Q6YF35_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-02-26	Pde5a	phosphodiesterase 5A, cGMP-specific			Symbol and Name status set to approved	625702	APPROVED
2002-08-07	Pde5a	phosphodiesterase 5A, cGMP-specific			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)