Pde5a (phosphodiesterase 5A) - Rat Genome Database

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Gene: Pde5a (phosphodiesterase 5A) Rattus norvegicus
Symbol: Pde5a
Name: phosphodiesterase 5A
RGD ID: 620995
Description: Enables 3',5'-cyclic-GMP phosphodiesterase activity. Involved in several processes, including blood vessel diameter maintenance; response to testosterone; and short-term memory. Used to study artery disease (multiple); impotence (multiple); and primary biliary cholangitis. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human PDE5A (phosphodiesterase 5A); PARTICIPATES IN purine metabolic pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
Previously known as: CGB-PDE; cGMP-binding cGMP specific phosphodiesterase 5A2; cGMP-binding cGMP-specific phosphodiesterase; cGMP-specific 3',5'-cyclic phosphodiesterase; PDE5A2; phosphodiesterase 5A, cGMP-specific; phosphodiesterase type 5
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Pde5aTn(sb-T2/Bart3)2.144Mcwi  
Genetic Models: F344-Pde5aTn(sb-T2/Bart3)2.144Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr82213,542,822 - 213,687,638 (+)NCBIGRCr8
mRatBN7.22210,858,515 - 211,003,480 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2210,858,063 - 210,999,701 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2218,537,423 - 218,677,334 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02216,445,209 - 216,585,125 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02211,291,504 - 211,431,374 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02226,899,604 - 227,044,916 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2226,900,619 - 227,041,576 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02246,260,843 - 246,406,296 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42219,410,394 - 219,550,910 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12219,373,455 - 219,513,972 (+)NCBI
Celera2203,287,460 - 203,425,472 (+)NCBICelera
Cytogenetic Map2q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3',5'-cyclic GMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-bromo-3',5'-cyclic GMP  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
anthocyanin  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromacil  (ISO)
butanal  (ISO)
caffeine  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
carnosic acid  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cyanazine  (ISO)
cyclosporin A  (ISO)
cyproterone acetate  (EXP)
decabromodiphenyl ether  (ISO)
deisopropylatrazine  (ISO)
diazinon  (EXP)
diethyl phthalate  (EXP)
dioxygen  (ISO)
dipyridamole  (ISO)
disulfiram  (ISO)
dizocilpine maleate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
flavonoids  (EXP)
furan  (EXP)
hemin  (EXP)
icariin  (EXP,ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
malvidin  (ISO)
malvidin 3-O-beta-D-glucoside  (ISO)
methoxyacetic acid  (EXP)
methylmercury chloride  (EXP,ISO)
Monobutylphthalate  (EXP)
morin  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP)
naringin  (EXP)
nickel atom  (ISO)
nitric oxide  (EXP)
orphenadrine  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (ISO)
pentanal  (ISO)
phenobarbital  (EXP)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prometon  (ISO)
propazine  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sildenafil citrate  (EXP,ISO)
simazine  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sulindac sulfone  (ISO)
tadalafil  (ISO)
temozolomide  (ISO)
Terbacil  (ISO)
testosterone  (EXP)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
trans-piceid  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
triptorelin  (EXP)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zoledronic acid  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Temporal changes in vascular reactivity in early diabetes mellitus in rats: role of changes in endothelial factors and in phosphodiesterase activity. Abboud K, etal., Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H836-45. Epub 2009 Jun 19.
2. The effect of PDE5 inhibition on the erectile function in streptozotocin-induced diabetic rats. Ahn GJ, etal., Int J Impot Res. 2005 Mar-Apr;17(2):134-41.
3. DA-8159 reverses selective serotonin reuptake inhibitor-induced erectile dysfunction in rats. Ahn GJ, etal., Urology. 2005 Jan;65(1):202-7.
4. Impact of a long-term sildenafil treatment on pressor response in conscious rats with insulin resistance and hypertriglyceridemia. Behr-Roussel D, etal., Am J Hypertens. 2008 Nov;21(11):1258-63. Epub 2008 Sep 11.
5. The presence and function of phosphodiesterase type 5 in the rat myometrium. Buhimschi CS, etal., Am J Obstet Gynecol. 2004 Jan;190(1):268-74.
6. Pretreatment of sildenafil attenuates ischemia-reperfusion renal injury in rats. Choi DE, etal., Am J Physiol Renal Physiol. 2009 Aug;297(2):F362-70. Epub 2009 May 27.
7. Long-term continuous treatment with sildenafil ameliorates aging-related erectile dysfunction and the underlying corporal fibrosis in the rat. Ferrini MG, etal., Biol Reprod. 2007 May;76(5):915-23. Epub 2007 Feb 7.
8. Characterization and functional role of androgen-dependent PDE5 activity in the bladder. Filippi S, etal., Endocrinology. 2007 Mar;148(3):1019-29. Epub 2006 Nov 30.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Effect of chronic administration of sildenafil on sodium retention and on the hemodynamic complications associated with liver cirrhosis in the rat. Ghali-Ghoul R, etal., Eur J Pharmacol. 2007 Oct 15;572(1):49-56. Epub 2007 Jun 13.
11. Phosphodiesterase-5 gene (PDE5A) polymorphisms are associated with progression of childhood IgA nephropathy. Hahn WH, etal., Pediatr Nephrol. 2010 Sep;25(9):1663-71. doi: 10.1007/s00467-010-1579-x. Epub 2010 Jun 20.
12. cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function. Jaumann M, etal., Nat Med. 2012 Jan 22;18(2):252-9. doi: 10.1038/nm.2634.
13. The effect of DA-8159, a novel PDE5 inhibitor, on erectile function in the rat model of hypercholesterolemic erectile dysfunction. Kang KK, etal., Int J Impot Res. 2005 Sep-Oct;17(5):409-16.
14. Angiotensin II increases phosphodiesterase 5A expression in vascular smooth muscle cells: a mechanism by which angiotensin II antagonizes cGMP signaling. Kim D, etal., J Mol Cell Cardiol. 2005 Jan;38(1):175-84. Epub 2004 Dec 8.
15. Expression of rat cGMP-binding cGMP-specific phosphodiesterase mRNA in Purkinje cell layers during postnatal neuronal development. Kotera J, etal., Eur J Biochem 1997 Oct 15;249(2):434-42.
16. Genomic origin and transcriptional regulation of two variants of cGMP-binding cGMP-specific phosphodiesterases. Kotera J, etal., Eur J Biochem. 1999 Jun;262(3):866-73.
17. Increased phosphodiesterase-5 expression is involved in the decreased vasodilator response to nitric oxide in cirrhotic rat livers. Loureiro-Silva MR, etal., J Hepatol. 2006 May;44(5):886-93. Epub 2006 Feb 28.
18. PDE5A inhibitors improve functional recovery after stroke in rats: optimized dosing regimen with implications for mechanism. Menniti FS, etal., J Pharmacol Exp Ther. 2009 Sep 3.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Increased expression of the cGMP-inhibited cAMP-specific (PDE3) and cGMP binding cGMP-specific (PDE5) phosphodiesterases in models of pulmonary hypertension. Murray F, etal., Br J Pharmacol. 2002 Dec;137(8):1187-94.
21. Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility. Nagendran J, etal., Circulation. 2007 Jul 17;116(3):238-48. Epub 2007 Jul 2.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. Increased activity of cGMP-specific phosphodiesterase (PDE5) contributes to resistance to atrial natriuretic peptide natriuresis in the pregnant rat. Ni XP, etal., J Am Soc Nephrol. 2004 May;15(5):1254-60.
24. Phosphodiesterase 5A inhibition induces Na+/H+ exchanger blockade and protection against myocardial infarction. Perez NG, etal., Hypertension. 2007 May;49(5):1095-103. Epub 2007 Mar 5.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. GOA pipeline RGD automated data pipeline
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Tadalafil, a Long-Acting Inhibitor of PDE5, Improves Pulmonary Hemodynamics and Survival Rate of Monocrotaline-Induced Pulmonary Artery Hypertension in Rats. Sawamura F, etal., J Pharmacol Sci. 2009 Oct 31.
29. Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy. Takimoto E, etal., Nat Med. 2005 Feb;11(2):214-22. Epub 2005 Jan 23.
30. The effect of sildenafil on the altered thoracic aorta smooth muscle responses in rat pre-eclampsia model. Turgut NH, etal., Eur J Pharmacol. 2008 Jul 28;589(1-3):180-7. Epub 2008 Jun 4.
31. Effect of sildenafil on acrolein-induced airway inflammation and mucus production in rats. Wang T, etal., Eur Respir J. 2009 May;33(5):1122-32. Epub 2009 Jan 7.
32. Expression and activity of cGMP-dependent phosphodiesterases is up-regulated by lipopolysaccharide (LPS) in rat peritoneal macrophages. Witwicka H, etal., Biochim Biophys Acta. 2007 Feb;1773(2):209-18. Epub 2006 Oct 24.
Additional References at PubMed
PMID:12554648   PMID:14687666   PMID:15075333   PMID:16150726   PMID:16651469   PMID:17101732   PMID:17690141   PMID:18534985   PMID:18723505   PMID:18790048   PMID:19127022   PMID:19338748  
PMID:19474061   PMID:19961855   PMID:20039971   PMID:20177073   PMID:20511540   PMID:21063091   PMID:24068049   PMID:26657792   PMID:27923787   PMID:32311453   PMID:33009887  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr82213,542,822 - 213,687,638 (+)NCBIGRCr8
mRatBN7.22210,858,515 - 211,003,480 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2210,858,063 - 210,999,701 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2218,537,423 - 218,677,334 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02216,445,209 - 216,585,125 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02211,291,504 - 211,431,374 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02226,899,604 - 227,044,916 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2226,900,619 - 227,041,576 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02246,260,843 - 246,406,296 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42219,410,394 - 219,550,910 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12219,373,455 - 219,513,972 (+)NCBI
Celera2203,287,460 - 203,425,472 (+)NCBICelera
Cytogenetic Map2q42NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh384119,494,403 - 119,628,804 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4119,494,397 - 119,628,804 (-)EnsemblGRCh38hg38GRCh38
GRCh374120,415,558 - 120,549,959 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364120,634,998 - 120,769,429 (-)NCBINCBI36Build 36hg18NCBI36
Build 344120,777,035 - 120,907,578NCBI
Celera4117,795,077 - 117,929,505 (-)NCBICelera
Cytogenetic Map4q26NCBI
HuRef4116,136,584 - 116,271,133 (-)NCBIHuRef
CHM1_14120,392,140 - 120,526,523 (-)NCBICHM1_1
T2T-CHM13v2.04122,799,522 - 122,933,950 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm393122,522,822 - 122,653,023 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3122,522,596 - 122,653,023 (+)EnsemblGRCm39 Ensembl
GRCm383122,729,158 - 122,859,374 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3122,728,947 - 122,859,374 (+)EnsemblGRCm38mm10GRCm38
MGSCv373122,432,076 - 122,562,292 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363122,721,209 - 122,848,174 (+)NCBIMGSCv36mm8
Celera3129,135,905 - 129,269,158 (+)NCBICelera
Cytogenetic Map3G1NCBI
cM Map353.69NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495542820,785,423 - 20,904,717 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542820,785,497 - 20,904,717 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v23117,271,752 - 117,406,487 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14117,568,528 - 117,702,985 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04111,682,772 - 111,817,234 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14122,832,175 - 122,966,636 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4122,832,175 - 122,966,636 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13238,272,573 - 38,407,517 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3238,244,338 - 38,407,522 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha323,669,951 - 3,799,959 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03238,496,474 - 38,627,836 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3238,493,466 - 38,627,842 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13238,518,841 - 38,648,697 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03238,242,041 - 38,371,891 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0321,427,303 - 1,557,236 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440530167,158,923 - 67,251,772 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493686939,122 - 117,127 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493686924,265 - 117,120 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl8104,270,881 - 104,420,953 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18104,270,858 - 104,420,955 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28111,948,578 - 112,077,533 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1766,826,316 - 66,955,220 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl766,826,315 - 66,955,036 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603745,686,701 - 45,815,681 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462496414,216 - 126,553 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462496411,085 - 126,027 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Pde5a
1375 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:184
Count of miRNA genes:134
Interacting mature miRNAs:150
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
2299161Iddm33Insulin dependent diabetes mellitus QTL 332.98blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2206312063220876787Rat
631203Gluco14Glucose level QTL 140.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)2206665645219003804Rat

Genetic Models
This gene Pde5a is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 6 16 10 5 10 53 23 30 11
Low 1 36 40 30 14 30 8 11 21 12 9 8
Below cutoff 1 1 1 1 2


RefSeq Acc Id: ENSRNOT00000019638   ⟹   ENSRNOP00000019637
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2210,859,419 - 210,999,701 (+)Ensembl
Rnor_6.0 Ensembl2226,900,619 - 227,041,576 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101437   ⟹   ENSRNOP00000082778
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2210,883,601 - 210,999,701 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119258   ⟹   ENSRNOP00000095374
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2210,858,063 - 210,999,701 (+)Ensembl
RefSeq Acc Id: NM_133584   ⟹   NP_598268
Rat AssemblyChrPosition (strand)Source
GRCr82213,544,026 - 213,684,298 (+)NCBI
mRatBN7.22210,859,419 - 210,999,701 (+)NCBI
Rnor_6.02226,900,619 - 227,041,576 (+)NCBI
Rnor_5.02246,260,843 - 246,406,296 (+)NCBI
RGSC_v3.42219,410,394 - 219,550,910 (+)RGD
Celera2203,287,460 - 203,425,472 (+)RGD
RefSeq Acc Id: XM_006233260   ⟹   XP_006233322
Rat AssemblyChrPosition (strand)Source
GRCr82213,542,822 - 213,687,638 (+)NCBI
mRatBN7.22210,858,515 - 211,003,480 (+)NCBI
Rnor_6.02226,899,604 - 227,044,916 (+)NCBI
Rnor_5.02246,260,843 - 246,406,296 (+)NCBI
RefSeq Acc Id: NP_598268   ⟸   NM_133584
- UniProtKB: O54735 (UniProtKB/Swiss-Prot),   A6HVH1 (UniProtKB/TrEMBL),   G3V7V8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233322   ⟸   XM_006233260
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GLL2 (UniProtKB/TrEMBL),   A6HVG9 (UniProtKB/TrEMBL),   A6HVH0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019637   ⟸   ENSRNOT00000019638
RefSeq Acc Id: ENSRNOP00000082778   ⟸   ENSRNOT00000101437
RefSeq Acc Id: ENSRNOP00000095374   ⟸   ENSRNOT00000119258
Protein Domains
GAF   PDEase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54735-F1-model_v2 AlphaFold O54735 1-833 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691727
Promoter ID:EPDNEW_R2252
Type:single initiation site
Description:phosphodiesterase 5A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.02226,900,606 - 226,900,666EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620995 AgrOrtholog
BioCyc Gene G2FUF-51351 BioCyc
Ensembl Genes ENSRNOG00000014443 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019638 ENTREZGENE
  ENSRNOT00000019638.5 UniProtKB/TrEMBL
  ENSRNOT00000101437.1 UniProtKB/TrEMBL
  ENSRNOT00000119258.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1300.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.450.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GAF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GAF-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HD/PDEase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_catalytic_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_catalytic_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171115 UniProtKB/Swiss-Prot
Pfam GAF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pde5a PhenoGen
  PDEASE_I_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014443 RatGTEx
SMART GAF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HDc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP GAF domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HD-domain/PDEase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  O54735 ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Pde5a  phosphodiesterase 5A, cGMP-specific      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Pde5a  phosphodiesterase 5A, cGMP-specific      Symbol and Name status set to provisional 70820 PROVISIONAL