Nucks1 (nuclear casein kinase and cyclin-dependent kinase substrate 1) - Rat Genome Database

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Gene: Nucks1 (nuclear casein kinase and cyclin-dependent kinase substrate 1) Rattus norvegicus
Analyze
Symbol: Nucks1
Name: nuclear casein kinase and cyclin-dependent kinase substrate 1
RGD ID: 620993
Description: Exhibits single-stranded DNA binding activity. Predicted to be involved in several processes, including DNA metabolic process; modulation by host of viral process; and regulation of cellular macromolecule biosynthetic process. Localizes to cytoplasm and nucleus. Orthologous to human NUCKS1 (nuclear casein kinase and cyclin dependent kinase substrate 1); INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 2,6-dinitrotoluene; aconitine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cyclin-dependent kinase substrate; LOC100910083; Nucks; nuclear ubiquitous casein and cyclin-dependent kinase substrate 1; nuclear ubiquitous casein and cyclin-dependent kinases substrate; nuclear ubiquitous casein and cyclin-dependent kinases substrate-like; nuclear ubiquitous casein kinase 2; nuclear ubiquitous casein kinase and cyclin-dependent kinase substrate
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21343,345,091 - 43,374,316 (+)NCBI
Rnor_6.0 Ensembl1348,679,774 - 48,705,575 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01348,679,726 - 48,709,663 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01353,753,029 - 53,782,671 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46142,904,062 - 142,905,783 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16142,910,248 - 142,911,961 (+)NCBI
Celera1343,682,215 - 43,706,828 (+)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
aconitine  (EXP)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
aflatoxin M1  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
Brodifacoum  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
calciol  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
cycloheximide  (ISO)
deoxynivalenol  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
heroin  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (EXP,ISO)
methyl methanesulfonate  (ISO)
nefazodone  (EXP)
nickel dichloride  (EXP)
oxaliplatin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
rac-lactic acid  (ISO)
rotenone  (EXP)
Salinomycin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

References

Additional References at PubMed
PMID:1298022   PMID:3000779   PMID:11298763   PMID:15489334   PMID:15632090   PMID:16641100   PMID:17604136   PMID:22681889   PMID:24140890   PMID:24931609   PMID:25116364   PMID:26205492  
PMID:26323318  


Genomics

Comparative Map Data
Nucks1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21343,345,091 - 43,374,316 (+)NCBI
Rnor_6.0 Ensembl1348,679,774 - 48,705,575 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01348,679,726 - 48,709,663 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01353,753,029 - 53,782,671 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46142,904,062 - 142,905,783 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16142,910,248 - 142,911,961 (+)NCBI
Celera1343,682,215 - 43,706,828 (+)NCBICelera
Cytogenetic Map13q13NCBI
NUCKS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1205,712,822 - 205,750,182 (-)EnsemblGRCh38hg38GRCh38
GRCh381205,712,822 - 205,750,220 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371205,681,950 - 205,719,310 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361203,953,732 - 203,985,916 (-)NCBINCBI36hg18NCBI36
Build 341202,418,765 - 202,450,950NCBI
Celera1178,818,181 - 178,855,596 (-)NCBI
Cytogenetic Map1q32.1NCBI
HuRef1176,846,753 - 176,884,077 (-)NCBIHuRef
CHM1_11207,105,250 - 207,142,880 (-)NCBICHM1_1
Nucks1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391131,838,196 - 131,864,059 (+)NCBIGRCm39mm39
GRCm39 Ensembl1131,838,272 - 131,864,059 (+)Ensembl
GRCm381131,910,458 - 131,936,321 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1131,910,534 - 131,936,321 (+)EnsemblGRCm38mm10GRCm38
MGSCv371133,807,035 - 133,832,898 (+)NCBIGRCm37mm9NCBIm37
MGSCv361133,738,080 - 133,760,518 (+)NCBImm8
Celera1134,514,788 - 134,540,507 (+)NCBICelera
Cytogenetic Map1E4NCBI
Nucks1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540641,417,983 - 41,449,177 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540641,412,855 - 41,448,551 (-)NCBIChiLan1.0ChiLan1.0
NUCKS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11185,606,796 - 185,642,984 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1185,606,796 - 185,642,984 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01181,322,760 - 181,359,321 (-)NCBIMhudiblu_PPA_v0panPan3
NUCKS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1382,157,109 - 2,188,543 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl382,160,233 - 2,170,560 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha382,247,878 - 2,281,320 (-)NCBI
ROS_Cfam_1.0382,151,877 - 2,185,307 (-)NCBI
UMICH_Zoey_3.1382,146,543 - 2,180,007 (-)NCBI
UNSW_CanFamBas_1.0382,538,314 - 2,571,710 (-)NCBI
UU_Cfam_GSD_1.0382,738,657 - 2,772,120 (-)NCBI
Nucks1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934469,472,785 - 69,487,729 (+)NCBI
SpeTri2.0NW_0049365576,713,065 - 6,728,011 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUCKS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl966,398,227 - 66,435,577 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1966,398,845 - 66,435,548 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2972,663,549 - 72,701,529 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NUCKS1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12523,597,210 - 23,634,262 (+)NCBI
ChlSab1.1 Ensembl2523,597,464 - 23,629,169 (+)Ensembl
Nucks1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248075,495,770 - 5,535,907 (+)NCBI

Position Markers
RH131493  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21343,346,742 - 43,346,926 (+)MAPPER
mRatBN7.2176,288,728 - 6,288,911 (+)MAPPER
Rnor_6.0176,690,477 - 6,690,659NCBIRnor6.0
Rnor_6.01348,681,415 - 48,681,598NCBIRnor6.0
Rnor_5.01353,754,936 - 53,755,119UniSTSRnor5.0
Rnor_5.0178,894,850 - 8,895,032UniSTSRnor5.0
RGSC_v3.41712,219,543 - 12,219,725UniSTSRGSC3.4
Celera176,398,439 - 6,398,621UniSTS
Celera1343,683,783 - 43,683,966UniSTS
Cytogenetic Map6q33UniSTS
Cytogenetic Map17p14UniSTS
RH143279  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26136,595,009 - 136,595,145 (+)MAPPER
Rnor_6.06143,661,333 - 143,661,468NCBIRnor6.0
Rnor_6.06143,504,256 - 143,504,391NCBIRnor6.0
Rnor_5.06152,603,380 - 152,603,515UniSTSRnor5.0
Rnor_5.06152,451,046 - 152,451,181UniSTSRnor5.0
RGSC_v3.46142,904,197 - 142,904,332UniSTSRGSC3.4
Celera6134,266,292 - 134,266,427UniSTS
RH 3.4 Map6938.0UniSTS
Cytogenetic Map6q33UniSTS
RH138087  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.06152,416,475 - 152,416,620NCBIRnor5.0
Rnor_5.06152,603,994 - 152,604,139NCBIRnor5.0
Rnor_5.01353,777,622 - 53,777,767NCBIRnor5.0
RGSC_v3.46142,904,812 - 142,904,956UniSTSRGSC3.4
Celera6134,266,907 - 134,267,051UniSTS
Cytogenetic Map6q33UniSTS
RH139043  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26136,595,011 - 136,595,166 (+)MAPPER
Rnor_6.06143,661,335 - 143,661,489NCBIRnor6.0
Rnor_6.06143,504,258 - 143,504,412NCBIRnor6.0
Rnor_5.06152,603,382 - 152,603,536UniSTSRnor5.0
Rnor_5.06152,451,048 - 152,451,202UniSTSRnor5.0
RGSC_v3.46142,904,199 - 142,904,353UniSTSRGSC3.4
Celera6134,266,294 - 134,266,448UniSTS
RH 3.4 Map6916.0UniSTS
Cytogenetic Map6q33UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131107975663Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13901674250513953Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13901690682995569Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13901690682995569Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1312193394108478121Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)131409633059096330Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)131409633059096330Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131444158250799665Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131444158251577031Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131462463159624631Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131462463159624631Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131981081464810814Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)132005247765052477Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)132148248158537177Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1324502279108770533Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132800833873008338Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132858445273584452Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132907693474076934Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132907693474076934Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1335301263107975663Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133614753364868393Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133614753399968921Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133734634882346348Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133937292784372927Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133950130093652524Rat
4889861Pur29Proteinuria QTL 2913.80.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)134231074486833540Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)134231074487310744Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)134250834587508345Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)134250834587508345Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134357571788575717Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134567662990676629Rat
2303032Bp328Blood pressure QTL 328arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134644457050799665Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:336
Count of miRNA genes:200
Interacting mature miRNAs:227
Transcripts:ENSRNOT00000075674
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 10 74 35 38 11 8
Low 1 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000075674   ⟹   ENSRNOP00000065540
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1348,679,774 - 48,705,575 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000079707   ⟹   ENSRNOP00000074382
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1348,689,962 - 48,704,771 (+)Ensembl
RefSeq Acc Id: NM_022799   ⟹   NP_073636
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21343,345,145 - 43,370,229 (+)NCBI
Rnor_6.01348,679,774 - 48,705,577 (+)NCBI
Rnor_5.01353,753,029 - 53,782,671 (+)NCBI
RGSC_v3.46142,904,062 - 142,905,783 (+)RGD
Celera1343,682,215 - 43,706,828 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006249797   ⟹   XP_006249859
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21343,345,091 - 43,374,316 (+)NCBI
Rnor_6.01348,679,726 - 48,709,663 (+)NCBI
Rnor_5.01353,753,029 - 53,782,671 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_073636 (Get FASTA)   NCBI Sequence Viewer  
  XP_006249859 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH78818 (Get FASTA)   NCBI Sequence Viewer  
  CAC20862 (Get FASTA)   NCBI Sequence Viewer  
  EDL89067 (Get FASTA)   NCBI Sequence Viewer  
  Q9EPJ0 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_073636   ⟸   NM_022799
- UniProtKB: Q9EPJ0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006249859   ⟸   XM_006249797
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000074382   ⟸   ENSRNOT00000079707
RefSeq Acc Id: ENSRNOP00000065540   ⟸   ENSRNOT00000075674

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698803
Promoter ID:EPDNEW_R9328
Type:initiation region
Name:Nucks1_1
Description:nuclear casein kinase and cyclin-dependent kinase substrate 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01348,679,746 - 48,679,806EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620993 AgrOrtholog
Ensembl Genes ENSRNOG00000047287 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000065540 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000074382 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075674 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000079707 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7128528 IMAGE-MGC_LOAD
InterPro NUCKS1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64709 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93427 IMAGE-MGC_LOAD
NCBI Gene 64709 ENTREZGENE
PANTHER PTHR15361:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nucks1 PhenoGen
UniProt A0A0G2K7X3_RAT UniProtKB/TrEMBL
  NUCKS_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-04-17 Nucks1  nuclear casein kinase and cyclin-dependent kinase substrate 1  LOC100910083  nuclear ubiquitous casein and cyclin-dependent kinases substrate-like  Data Merged 737654 PROVISIONAL
2012-07-05 LOC100910083  nuclear ubiquitous casein and cyclin-dependent kinases substrate-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-02-22 Nucks1  nuclear casein kinase and cyclin-dependent kinase substrate 1  Nucks  nuclear ubiquitous casein kinase and cyclin-dependent kinase substrate  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Nucks  nuclear ubiquitous casein kinase and cyclin-dependent kinase substrate      Symbol and Name status set to approved 1299863 APPROVED
2004-04-20   nuclear ubiquitous casein kinase and cyclin-dependent kinase substrate  Nucks  nuclear ubiquitous casein kinase 2  Name updated 625702 PROVISIONAL
2002-08-07 Nucks  nuclear ubiquitous casein kinase 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization located in nucleus in interphase cells and throughout cytoplasm during mitosis 1298022
gene_domains contains a GRP domain in the DNA binding AT hook 1298022
gene_expression expressed in all tissues and cell types examined 1298022
gene_physical_interaction phosphorylation inhibits binding in metaphase cells 1298022
gene_process substrate for several kinases involved in cell growth and survival 1298022
gene_transcript three transcripts of 1.5, 2.2, 7.0 kb 1298022