Pros1 (protein S) - Rat Genome Database

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Gene: Pros1 (protein S) Rattus norvegicus
Analyze
Symbol: Pros1
Name: protein S
RGD ID: 620971
Description: Predicted to enable calcium ion binding activity. Involved in several processes, including liver development; positive regulation of phagocytosis; and response to lipopolysaccharide. Located in extracellular space. Part of protein-containing complex. Human ortholog(s) of this gene implicated in autosomal dominant thrombophilia due to protein S deficiency; autosomal recessive thrombophilia due to protein S deficiency; cerebral infarction; and protein S deficiency. Orthologous to human PROS1 (protein S); PARTICIPATES IN protein C anticoagulant pathway; coagulation cascade pathway; complement system pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Pros; protein S (alpha); vitamin K-dependent protein S
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81113,676,310 - 13,757,858 (+)NCBIGRCr8
mRatBN7.211230,597 - 311,288 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl11230,696 - 311,286 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx118,826,855 - 8,907,393 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0111,620,112 - 1,700,666 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.011724,894 - 805,450 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.071,206,648 - 1,288,140 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl71,206,648 - 1,288,134 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.071,199,864 - 1,279,998 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera13237,157 - 317,730 (+)NCBICelera
Cytogenetic Map11p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methoxyethanol  (EXP)
3-chloropropane-1,2-diol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphibole asbestos  (EXP)
aristolochic acid A  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDT  (EXP)
deoxynivalenol  (ISO)
desogestrel  (ISO)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dienogest  (ISO)
diuron  (EXP)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenoldopam  (EXP)
fenthion  (ISO)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gestodene  (ISO)
glafenine  (EXP)
isotretinoin  (ISO)
L-ascorbic acid  (EXP)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
norgestimate  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vitamin K  (ISO)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. PROS1 genotype phenotype relationships in a large cohort of adults with suspicion of inherited quantitative protein S deficiency. Alhenc-Gelas M, etal., Thromb Haemost. 2016 Feb 29;115(3):570-9. doi: 10.1160/TH15-05-0391. Epub 2015 Oct 15.
2. Characterization and structural impact of five novel PROS1 mutations in eleven protein S-deficient families. Andersen BD, etal., Thromb Haemost. 2001 Dec;86(6):1392-9.
3. A novel mutation in intron K of the PROS1 gene causes aberrant RNA splicing and is a common cause of protein S deficiency in a UK thrombophilia cohort. Beauchamp NJ, etal., Thromb Haemost. 1998 Jun;79(6):1086-91.
4. Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway. Bouwens EA, etal., J Thromb Haemost. 2013 Jun;11 Suppl 1:242-53. doi: 10.1111/jth.12247.
5. Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis. Burstyn-Cohen T, etal., J Clin Invest. 2009 Oct;119(10):2942-53. doi: 10.1172/JCI39325.
6. The Ser 460 to Pro substitution of the protein S alpha (PROS1) gene is a frequent mutation associated with free protein S (type IIa) deficiency. Duchemin J, etal., Blood. 1995 Nov 1;86(9):3436-43.
7. Genotype and laboratory and clinical phenotypes of protein s deficiency. Duebgen S, etal., Am J Clin Pathol. 2012 Feb;137(2):178-84. doi: 10.1309/AJCP40UXNBTXGKUX.
8. The protein C pathway. Esmon CT, Chest. 2003 Sep;124(3 Suppl):26S-32S.
9. Differential regulation of protein S expression in hepatocytes and sinusoidal endothelial cells in rats with cirrhosis. Fujii K, etal., J Thromb Haemost. 2006 Dec;4(12):2607-15. Epub 2006 Sep 22.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Both protein S and Gas6 stimulate outer segment phagocytosis by cultured rat retinal pigment epithelial cells. Hall MO, etal., Exp Eye Res. 2005 Nov;81(5):581-91. Epub 2005 Jun 9.
12. Lipopolysaccharide-induced decreased protein S expression in liver cells is mediated by MEK/ERK signaling and NFkappaB activation: involvement of membrane-bound CD14 and toll-like receptor-4. Hayashi T, etal., J Thromb Haemost. 2006 Aug;4(8):1763-73.
13. Developmental expression of protein C and protein S in the rat. Jamison CS, etal., Thromb Res 1995 Jun 1;78(5):407-19.
14. Combined occurrence of a heterozygous missense mutation in the protein C gene and allelic exclusion of one protein S allele leading to severe venous thrombosis. Knoll B, etal., Thromb Res. 2001 Jul 1;103(1):3-8.
15. Genetic predisposition of white matter infarction with protein S deficiency and R355C mutation. Leung TW, etal., Neurology. 2010 Dec 14;75(24):2185-9. doi: 10.1212/WNL.0b013e3182020379.
16. Multiple receptor tyrosine kinases are expressed in adult rat retinal ganglion cells as revealed by single-cell degenerate primer polymerase chain reaction. Lindqvist N, etal., Ups J Med Sci. 2010 Feb;115(1):65-80. doi: 10.3109/03009731003597119.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. In vitro aging of rat lung cells. Downregulation of telomerase activity and continuous decrease of telomere length are not incompatible with malignant transformation. Petitot F, etal., Exp Cell Res 2003 May 15;286(1):30-9.
21. Gross deletions/duplications in PROS1 are relatively common in point mutation-negative hereditary protein S deficiency. Pintao MC, etal., Hum Genet. 2009 Sep;126(3):449-56. doi: 10.1007/s00439-009-0687-9. Epub 2009 May 23.
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S-C4b binding protein complex. Rezende SM, etal., Blood. 2004 Feb 15;103(4):1192-201. Epub 2003 Aug 7.
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Purified protein S contains multimeric forms with increased APC-independent anticoagulant activity. Sere KM, etal., Biochemistry 2001 Jul 31;40(30):8852-60.
28. Clarification of the risk for venous thrombosis associated with hereditary protein S deficiency by investigation of a large kindred with a characterized gene defect. Simmonds RE, etal., Ann Intern Med. 1998 Jan 1;128(1):8-14.
29. Identification of a novel PROS1 c.1113T-->GG frameshift mutation in a family with mixed type I/type III protein S deficiency. ten Kate MK, etal., Haematologica. 2006 Aug;91(8):1151-2.
30. Molecular cloning and functional characterization of rat plasma protein S. Yasuda F, etal., J Biochem. 1995 Feb;117(2):374-83.
31. Protein S Protects against Podocyte Injury in Diabetic Nephropathy. Zhong F, etal., J Am Soc Nephrol. 2018 Mar 6. pii: ASN.2017030234. doi: 10.1681/ASN.2017030234.
Additional References at PubMed
PMID:1299299   PMID:1302274   PMID:12477932   PMID:14607961   PMID:22516433   PMID:23533145   PMID:24006456   PMID:31028740  


Genomics

Comparative Map Data
Pros1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81113,676,310 - 13,757,858 (+)NCBIGRCr8
mRatBN7.211230,597 - 311,288 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl11230,696 - 311,286 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx118,826,855 - 8,907,393 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0111,620,112 - 1,700,666 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.011724,894 - 805,450 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.071,206,648 - 1,288,140 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl71,206,648 - 1,288,134 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.071,199,864 - 1,279,998 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera13237,157 - 317,730 (+)NCBICelera
Cytogenetic Map11p12NCBI
PROS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38393,873,051 - 93,973,896 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl393,873,051 - 93,980,003 (-)EnsemblGRCh38hg38GRCh38
GRCh37393,591,895 - 93,692,740 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36395,074,647 - 95,175,395 (-)NCBINCBI36Build 36hg18NCBI36
Build 34395,074,646 - 95,175,395NCBI
Celera391,974,425 - 92,076,408 (-)NCBICelera
Cytogenetic Map3q11.1NCBI
HuRef390,954,621 - 91,055,633 (-)NCBIHuRef
CHM1_1393,558,922 - 93,656,016 (-)NCBICHM1_1
T2T-CHM13v2.0396,571,223 - 96,678,047 (-)NCBIT2T-CHM13v2.0
Pros1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391662,674,670 - 62,749,709 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1662,674,670 - 62,749,709 (+)EnsemblGRCm39 Ensembl
GRCm381662,854,307 - 62,929,346 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1662,854,307 - 62,929,346 (+)EnsemblGRCm38mm10GRCm38
MGSCv371662,854,160 - 62,929,166 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361662,796,624 - 62,871,347 (+)NCBIMGSCv36mm8
Celera1663,162,946 - 63,237,718 (+)NCBICelera
Cytogenetic Map16C1.3NCBI
cM Map1636.43NCBI
Pros1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554073,535,388 - 3,565,058 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554073,514,900 - 3,566,165 (+)NCBIChiLan1.0ChiLan1.0
PROS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2291,781,226 - 91,886,734 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1391,785,656 - 91,890,489 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0390,934,641 - 91,039,059 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1397,615,734 - 97,719,057 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl397,615,734 - 97,718,756 (-)Ensemblpanpan1.1panPan2
PROS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1331,628,074 - 1,691,441 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl331,628,105 - 1,692,058 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha331,807,559 - 1,871,177 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0331,727,844 - 1,791,314 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl331,727,846 - 1,791,431 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1331,637,294 - 1,700,492 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0331,671,507 - 1,735,141 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0331,896,104 - 1,960,217 (-)NCBIUU_Cfam_GSD_1.0
Pros1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602155,405,321 - 155,496,524 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493666619,387 - 110,014 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493666618,303 - 110,357 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PROS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13165,911,366 - 165,999,811 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113165,915,298 - 165,999,118 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PROS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12286,728,089 - 86,840,413 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2286,728,339 - 86,840,356 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604179,820,400 - 79,954,563 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pros1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247896,621,803 - 6,704,033 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pros1
82 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:89
Interacting mature miRNAs:94
Transcripts:ENSRNOT00000073689
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
634341Bw121Body weight QTL 1213.56abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)11121836709Rat

Markers in Region
D0Got467  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.071,268,153 - 1,268,342NCBIRnor6.0
Rnor_5.071,260,009 - 1,260,198UniSTSRnor5.0
Celera13297,743 - 297,932UniSTS
Cytogenetic Map11q21UniSTS
RH128863  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.211310,057 - 310,240 (+)MAPPERmRatBN7.2
Rnor_6.071,286,910 - 1,287,092NCBIRnor6.0
Rnor_5.071,278,766 - 1,278,948UniSTSRnor5.0
Celera13316,500 - 316,682UniSTS
Cytogenetic Map11q21UniSTS
AU048234  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.211291,305 - 291,440 (+)MAPPERmRatBN7.2
Rnor_6.071,268,158 - 1,268,292NCBIRnor6.0
Rnor_5.071,260,014 - 1,260,148UniSTSRnor5.0
Celera13297,748 - 297,882UniSTS
Cytogenetic Map11q21UniSTS
RH140134  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.211310,572 - 310,774 (+)MAPPERmRatBN7.2
Rnor_6.071,287,425 - 1,287,626NCBIRnor6.0
Rnor_5.071,279,281 - 1,279,482UniSTSRnor5.0
Celera13317,015 - 317,216UniSTS
Cytogenetic Map11q21UniSTS
RH141031  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.211310,976 - 311,178 (+)MAPPERmRatBN7.2
Rnor_6.071,287,829 - 1,288,030NCBIRnor6.0
Rnor_5.071,279,685 - 1,279,886UniSTSRnor5.0
Celera13317,419 - 317,620UniSTS
Cytogenetic Map11q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000073689   ⟹   ENSRNOP00000064737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl11230,696 - 311,286 (+)Ensembl
Rnor_6.0 Ensembl71,206,648 - 1,288,134 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096661   ⟹   ENSRNOP00000091181
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl11263,481 - 311,286 (+)Ensembl
RefSeq Acc Id: NM_031086   ⟹   NP_112348
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81113,677,299 - 13,757,858 (+)NCBI
mRatBN7.211230,721 - 311,288 (+)NCBI
Rnor_6.071,206,648 - 1,288,140 (+)NCBI
Rnor_5.071,199,864 - 1,279,998 (+)NCBI
Celera13237,157 - 317,730 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039088635   ⟹   XP_038944563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81113,713,404 - 13,757,858 (+)NCBI
mRatBN7.211263,546 - 311,288 (+)NCBI
RefSeq Acc Id: XM_039088636   ⟹   XP_038944564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81113,730,980 - 13,757,858 (+)NCBI
mRatBN7.211284,412 - 311,288 (+)NCBI
RefSeq Acc Id: XR_010055967
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81113,676,310 - 13,750,062 (+)NCBI
Protein Sequences
Protein RefSeqs NP_112348 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944563 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944564 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83250 (Get FASTA)   NCBI Sequence Viewer  
  EDL83251 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064737.1
  ENSRNOP00000091181.1
GenBank Protein P53813 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112348   ⟸   NM_031086
- Peptide Label: precursor
- UniProtKB: P53813 (UniProtKB/Swiss-Prot),   M0R5R0 (UniProtKB/TrEMBL),   A6KT01 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064737   ⟸   ENSRNOT00000073689
RefSeq Acc Id: XP_038944563   ⟸   XM_039088635
- Peptide Label: isoform X1
- UniProtKB: A0A8I6APZ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944564   ⟸   XM_039088636
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000091181   ⟸   ENSRNOT00000096661
Protein Domains
EGF-like   Gla   Laminin G   Laminin G-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P53813-F1-model_v2 AlphaFold P53813 1-675 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694914
Promoter ID:EPDNEW_R5439
Type:initiation region
Name:Pros1_1
Description:protein S
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.071,206,630 - 1,206,690EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620971 AgrOrtholog
BioCyc Gene G2FUF-22336 BioCyc
Ensembl Genes ENSRNOG00000048723 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000073689.2 UniProtKB/TrEMBL
  ENSRNOT00000096661.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.740.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Coagulation_fac-like_Gla_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GAS-SHBG-PROS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA-like_dom_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81750 UniProtKB/TrEMBL
NCBI Gene 81750 ENTREZGENE
PANTHER LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24040:SF0 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FXa_inhibition UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gla UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PROS1 RGD
PhenoGen Pros1 PhenoGen
PRINTS GLABLOOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LAM_G_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048723 RatGTEx
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LamG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6APZ0 ENTREZGENE, UniProtKB/TrEMBL
  A6KT00_RAT UniProtKB/TrEMBL
  A6KT01 ENTREZGENE, UniProtKB/TrEMBL
  M0R5R0 ENTREZGENE, UniProtKB/TrEMBL
  P53813 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-22 Pros1  protein S  Pros1  protein S (alpha)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Pros1  protein S (alpha)    protein S  Name updated 1299863 APPROVED
2002-08-07 Pros1  protein S      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology human homolog interacts with factor Xa, factor Va, and phospholipids to inhibit prothrombin activation 1299299