Map3k1 (mitogen-activated protein kinase kinase kinase 1) - Rat Genome Database

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Gene: Map3k1 (mitogen-activated protein kinase kinase kinase 1) Rattus norvegicus
Analyze
Symbol: Map3k1
Name: mitogen-activated protein kinase kinase kinase 1
RGD ID: 620966
Description: Enables several functions, including JUN kinase kinase kinase activity; protein kinase binding activity; and sphingolipid binding activity. Involved in several processes, including positive regulation of signal transduction; positive regulation of viral transcription; and protein phosphorylation. Located in cytoplasm and membrane. Colocalizes with cytoskeleton. Human ortholog(s) of this gene implicated in 46,XY sex reversal 6; breast cancer; gastrointestinal system cancer (multiple); and lung non-small cell carcinoma. Orthologous to human MAP3K1 (mitogen-activated protein kinase kinase kinase 1); PARTICIPATES IN altered Wnt signaling, canonical pathway; adenosine signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100912399; MAPK/ERK kinase kinase 1; MEK kinase 1; MEKK 1; Mekk1; mitogen activated protein kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; mitogen-activated protein kinase kinase kinase 1-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2243,348,572 - 43,414,706 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl243,350,098 - 43,414,463 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx250,464,742 - 50,530,977 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0248,523,204 - 48,589,428 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0243,374,713 - 43,440,941 (-)NCBIRnor_WKY
Rnor_6.0243,329,516 - 43,393,203 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl243,329,516 - 43,393,207 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0262,373,717 - 62,440,715 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4243,062,252 - 43,126,058 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1242,987,560 - 43,051,968 (-)NCBI
Celera239,134,930 - 39,199,049 (-)NCBICelera
Cytogenetic Map2q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2,4-trimethylbenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,5-hexanedione  (EXP)
2-methylcholine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetazolamide  (ISO)
alachlor  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amino acid  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
cefaloridine  (EXP)
CGP 52608  (ISO)
cisplatin  (EXP,ISO)
clozapine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dacarbazine  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
endosulfan  (EXP)
enniatin  (EXP)
epoxiconazole  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
furan  (EXP)
geldanamycin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
haloperidol  (EXP)
heptachlor  (ISO)
hexachlorobenzene  (EXP)
hyaluronic acid  (ISO)
iohexol  (ISO)
iopamidol  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
microcystin-LR  (ISO)
monosodium L-glutamate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nickel sulfate  (ISO)
o-anisidine  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 203580  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (EXP)
sodium fluoride  (ISO)
sulindac sulfide  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
tipifarnib  (EXP)
topotecan  (EXP)
tungsten  (ISO)
undecane  (EXP)
urethane  (ISO)
Urolithin A  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
zinc atom  (EXP)
zinc dichloride  (ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2. Chadee DN, etal., Mol Cell Biol 2002 Feb;22(3):737-49.
2. Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention. Chang F, etal., Leukemia 2003 Jul;17(7):1263-93.
3. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. Charlaftis N, etal., EMBO J. 2014 Nov 3;33(21):2581-96. doi: 10.15252/embj.201488351. Epub 2014 Sep 26.
4. MEKK1 controls matrix degradation and tumor cell dissemination during metastasis of polyoma middle-T driven mammary cancer. Cuevas BD, etal., Oncogene. 2006 Aug 17;25(36):4998-5010. doi: 10.1038/sj.onc.1209507. Epub 2006 Mar 27.
5. Genome-wide association study identifies novel breast cancer susceptibility loci. Easton DF, etal., Nature. 2007 Jun 28;447(7148):1087-93.
6. MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42. Fanger GR, etal., EMBO J. 1997 Aug 15;16(16):4961-72.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Establishment of a hepatocellular carcinoma patient-derived xenograft platform and its application in biomarker identification. Hu B, etal., Int J Cancer. 2020 Mar 15;146(6):1606-1617. doi: 10.1002/ijc.32564. Epub 2019 Aug 9.
10. Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases. Huijts PE, etal., Breast Cancer Res. 2007;9(6):R78.
11. Differential binding of ceramide to MEKK1 in glomerular endothelial and mesangial cells. Huwiler A, etal., Biochim Biophys Acta. 2004 Mar 22;1636(2-3):159-68.
12. The c-jun kinase/stress-activated pathway: regulation, function and role in human disease. Johnson GL and Nakamura K, Biochim Biophys Acta. 2007 Aug;1773(8):1341-8. Epub 2007 Jan 4.
13. Reconstitution of mitogen-activated protein kinase phosphorylation cascades in bacteria. Efficient synthesis of active protein kinases. Khokhlatchev A, etal., J Biol Chem. 1997 Apr 25;272(17):11057-62.
14. Genetic variations in multiple drug action pathways and survival in advanced stage non-small cell lung cancer treated with chemotherapy. Li Y, etal., Clin Cancer Res. 2011 Jun 1;17(11):3830-40. doi: 10.1158/1078-0432.CCR-10-2877.
15. The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2. Lu Z, etal., Mol Cell 2002 May;9(5):945-56.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Genes harbouring susceptibility SNPs are differentially expressed in the breast cancer subtypes. Nordgard SH, etal., Breast Cancer Res. 2007;9(6):113.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. MEK mediates v-Src-induced disruption of the actin cytoskeleton via inactivation of the Rho-ROCK-LIM kinase pathway. Pawlak G and Helfman DM, J Biol Chem 2002 Jul 26;277(30):26927-33.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
23. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. MAP kinase genes and colon and rectal cancer. Slattery ML, etal., Carcinogenesis. 2012 Dec;33(12):2398-408. doi: 10.1093/carcin/bgs305. Epub 2012 Oct 1.
28. Dietary influence on MAPK-signaling pathways and risk of colon and rectal cancer. Slattery ML, etal., Nutr Cancer. 2013;65(5):729-38. doi: 10.1080/01635581.2013.795599.
29. MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway. Sue Ng S, etal., Biol Chem. 2010 Feb-Mar;391(2-3):171-180. doi: 10.1515/bc.2010.028.
30. Modulation of human cytomegalovirus immediate-early gene enhancer by mitogen-activated protein kinase kinase kinase-1. Sun B, etal., J Cell Biochem. 2001;83(4):563-73.
31. MAP kinase- and Rho-dependent signals interact to regulate gene expression but not actin morphology in cardiac muscle cells. Thorburn J, etal., EMBO J. 1997 Apr 15;16(8):1888-900.
32. MEKK1 controls neurite regrowth after experimental injury by balancing ERK1/2 and JNK2 signaling. Waetzig V and Herdegen T, Mol Cell Neurosci. 2005 Sep;30(1):67-78.
33. A MAP3k1 SNP predicts survival of gastric cancer in a Chinese population. Wei X, etal., PLoS One. 2014 Apr 23;9(4):e96083. doi: 10.1371/journal.pone.0096083. eCollection 2014.
34. MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress. Xia Y, etal., Mol Cell Biol. 2007 Jan;27(2):510-7. Epub 2006 Nov 13.
35. Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain. Xu S, etal., Proc Natl Acad Sci U S A 1996 May 28;93(11):5291-5.
36. MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase. Xu S, etal., Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):6808-12.
37. MAP3K1 rs889312 genotypes influence survival outcomes of Chinese gastric cancer patients who received adjuvant chemotherapy based on platinum and fluorouracil regimes. Yang J, etal., Onco Targets Ther. 2019 Aug 22;12:6843-6855. doi: 10.2147/OTT.S205438. eCollection 2019.
38. Interaction effects between genes involved in the AKT signaling pathway and phytoestrogens in gastric carcinogenesis: a nested case-control study from the Korean Multi-Center Cancer Cohort. Yang JJ, etal., Mol Nutr Food Res. 2012 Nov;56(11):1617-26. doi: 10.1002/mnfr.201200169. Epub 2012 Oct 5.
39. Association Study of MAP3K1 SNPs and Risk Factors with Susceptibility to Esophageal Squamous Cell Carcinoma in a Chinese Population: A Case-Control Study. Yang Y, etal., Pharmgenomics Pers Med. 2020 Jul 3;13:189-197. doi: 10.2147/PGPM.S256230. eCollection 2020.
40. Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption. Yujiri T, etal., Science 1998 Dec 4;282(5395):1911-4.
41. Caspase-3 mediated cleavage of MEKK1 promotes p53 transcriptional activity. Zebrowski DC, etal., J Mol Cell Cardiol. 2006 May;40(5):605-18. Epub 2006 Jan 19.
Additional References at PubMed
PMID:7997270   PMID:9065412   PMID:9078260   PMID:9639556   PMID:10523642   PMID:12941696   PMID:14967141   PMID:15001576   PMID:15037605   PMID:15189336   PMID:15882989   PMID:16491099  
PMID:17906693   PMID:18308848   PMID:19593445   PMID:21605499   PMID:22993404   PMID:23201579   PMID:25224220   PMID:27662850  


Genomics

Comparative Map Data
Map3k1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2243,348,572 - 43,414,706 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl243,350,098 - 43,414,463 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx250,464,742 - 50,530,977 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0248,523,204 - 48,589,428 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0243,374,713 - 43,440,941 (-)NCBIRnor_WKY
Rnor_6.0243,329,516 - 43,393,203 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl243,329,516 - 43,393,207 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0262,373,717 - 62,440,715 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4243,062,252 - 43,126,058 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1242,987,560 - 43,051,968 (-)NCBI
Celera239,134,930 - 39,199,049 (-)NCBICelera
Cytogenetic Map2q14NCBI
MAP3K1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38556,815,549 - 56,896,152 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl556,815,549 - 56,896,152 (+)EnsemblGRCh38hg38GRCh38
GRCh37556,111,376 - 56,191,979 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36556,146,657 - 56,227,736 (+)NCBINCBI36Build 36hg18NCBI36
Celera553,065,179 - 53,146,179 (+)NCBICelera
Cytogenetic Map5q11.2NCBI
HuRef553,082,897 - 53,163,892 (+)NCBIHuRef
CHM1_1556,113,966 - 56,195,023 (+)NCBICHM1_1
T2T-CHM13v2.0557,643,875 - 57,724,397 (+)NCBIT2T-CHM13v2.0
Map3k1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913111,882,962 - 111,954,803 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13111,882,962 - 111,945,527 (-)EnsemblGRCm39 Ensembl
GRCm3813111,746,428 - 111,818,269 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13111,746,428 - 111,808,993 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713112,536,641 - 112,599,191 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613112,867,468 - 112,929,861 (-)NCBIMGSCv36mm8
Celera13116,043,507 - 116,076,666 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1363.36NCBI
Map3k1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544611,021,971 - 11,090,136 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544611,022,091 - 11,090,136 (-)NCBIChiLan1.0ChiLan1.0
MAP3K1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1558,745,573 - 58,826,959 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl558,745,579 - 58,826,959 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0557,116,405 - 57,197,017 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MAP3K1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1243,918,210 - 43,996,817 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl243,917,604 - 43,995,209 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha240,979,535 - 41,058,128 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0244,400,091 - 44,478,773 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl244,400,091 - 44,476,998 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1241,477,057 - 41,555,639 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0242,280,433 - 42,359,075 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0243,100,342 - 43,179,022 (+)NCBIUU_Cfam_GSD_1.0
Map3k1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213202,144,631 - 202,220,196 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648011,083,605 - 11,156,691 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493648011,082,811 - 11,156,691 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP3K1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1635,872,131 - 35,946,987 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11635,872,301 - 35,947,097 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21638,138,087 - 38,212,844 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAP3K1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1453,040,731 - 53,120,784 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl453,084,023 - 53,120,772 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660491,934,475 - 2,010,412 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map3k1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247592,363,076 - 2,428,273 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247592,360,655 - 2,429,189 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Map3k1
275 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:63
Count of miRNA genes:60
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000017968
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22997159351729300Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
731179Mamtr3Mammary tumor resistance QTL 30.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)23237377043665178Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
12879863Bp402Blood pressure QTL 4020.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24112578956532139Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)24280460760653831Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)243162366111362592Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat

Markers in Region
REN28005  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2243,413,750 - 43,413,978 (+)MAPPERmRatBN7.2
Rnor_6.0243,392,495 - 43,392,722NCBIRnor6.0
Rnor_6.0243,999,303 - 43,999,530NCBIRnor6.0
Rnor_5.0263,045,920 - 63,046,147UniSTSRnor5.0
Rnor_5.0262,438,893 - 62,439,120UniSTSRnor5.0
RGSC_v3.4243,125,231 - 43,125,458UniSTSRGSC3.4
Cytogenetic Map2q14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2
Low 2 41 56 40 19 40 8 8 67 35 36 11 8
Below cutoff 1 2 1 1 1 3 7 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000017968   ⟹   ENSRNOP00000017968
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl243,350,765 - 43,414,463 (-)Ensembl
Rnor_6.0 Ensembl243,329,516 - 43,393,207 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000065473   ⟹   ENSRNOP00000063470
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl243,350,765 - 43,413,000 (-)Ensembl
Rnor_6.0 Ensembl243,938,508 - 43,999,107 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114100   ⟹   ENSRNOP00000088035
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl243,350,098 - 43,414,463 (-)Ensembl
RefSeq Acc Id: NM_053887   ⟹   NP_446339
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2243,348,572 - 43,414,706 (-)NCBI
Rnor_6.0243,329,516 - 43,393,203 (-)NCBI
Rnor_5.0262,373,717 - 62,440,715 (-)NCBI
RGSC_v3.4243,062,252 - 43,126,058 (-)RGD
Celera239,134,930 - 39,199,049 (-)RGD
Sequence:
RefSeq Acc Id: XM_039101582   ⟹   XP_038957510
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2243,348,572 - 43,414,521 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_446339   ⟸   NM_053887
- UniProtKB: F1M778 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000017968   ⟸   ENSRNOT00000017968
RefSeq Acc Id: XP_038957510   ⟸   XM_039101582
- Peptide Label: isoform X1
- UniProtKB: F1M778 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000063470   ⟸   ENSRNOT00000065473
RefSeq Acc Id: ENSRNOP00000088035   ⟸   ENSRNOT00000114100
Protein Domains
Protein kinase   RING-type   SWIM-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZUY5-F1-model_v2 AlphaFold D3ZUY5 1-1302 view protein structure
AF-Q62925-F1-model_v2 AlphaFold Q62925 1-1493 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620966 AgrOrtholog
BioCyc Gene G2FUF-54417 BioCyc
Ensembl Genes ENSRNOG00000013177 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000050275 Ensembl
Ensembl Protein ENSRNOP00000017968 ENTREZGENE
  ENSRNOP00000017968.3 UniProtKB/TrEMBL
  ENSRNOP00000063470.4 UniProtKB/TrEMBL
  ENSRNOP00000088035.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017968 ENTREZGENE
  ENSRNOT00000017968.4 UniProtKB/TrEMBL
  ENSRNOT00000065473.5 UniProtKB/TrEMBL
  ENSRNOT00000114100.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_SWIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116667 UniProtKB/Swiss-Prot
NCBI Gene 116667 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SWIM UniProtKB/TrEMBL
PharmGKB MAP3K1 RGD
PhenoGen Map3k1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_SWIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A5B8_RAT UniProtKB/TrEMBL
  D3ZUY5_RAT UniProtKB/TrEMBL
  F1M778 ENTREZGENE, UniProtKB/TrEMBL
  H9BFG7_RAT UniProtKB/TrEMBL
  M3K1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Map3k1  mitogen-activated protein kinase kinase kinase 1  LOC100912399  mitogen-activated protein kinase kinase kinase 1-like  Data Merged 737654 PROVISIONAL
2016-03-22 Map3k1  mitogen-activated protein kinase kinase kinase 1  Map3k1  mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-02 Map3k1  mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase  Map3k1  mitogen activated protein kinase kinase kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100912399  mitogen-activated protein kinase kinase kinase 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Map3k1  mitogen activated protein kinase kinase kinase 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Map3k1  mitogen activated protein kinase kinase kinase 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a PHD domain that has E3 ubiquitin ligase activity 729224
gene_process an upstream activator of the ERK and JNK through its kinase domain 729224