Rab3b (RAB3B, member RAS oncogene family) - Rat Genome Database

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Pathways
Gene: Rab3b (RAB3B, member RAS oncogene family) Rattus norvegicus
Analyze
Symbol: Rab3b
Name: RAB3B, member RAS oncogene family
RGD ID: 620922
Description: Predicted to enable several functions, including GDP binding activity; GTP-dependent protein binding activity; and myosin V binding activity. Predicted to be involved in several processes, including positive regulation of dopamine uptake involved in synaptic transmission; regulation of synaptic vesicle cycle; and regulation of vesicle size. Predicted to act upstream of or within peptidyl-cysteine methylation and regulation of exocytosis. Is active in synaptic vesicle membrane. Orthologous to human RAB3B (RAB3B, member RAS oncogene family); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 3',5'-cyclic AMP.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ras-related protein Rab-3B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85128,859,034 - 128,926,087 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5128,841,716 - 128,926,086 (+)EnsemblGRCr8
mRatBN7.25123,629,562 - 123,697,410 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5123,644,423 - 123,697,401 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5126,253,240 - 126,320,296 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05127,976,344 - 128,043,394 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05128,027,632 - 128,094,680 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05128,501,789 - 128,568,170 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5128,501,847 - 128,568,188 (+)Ensemblrn6Rnor6.0
Rnor_5.05132,343,152 - 132,408,838 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45130,185,155 - 130,284,038 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5122,364,678 - 122,431,394 (+)NCBICelera
RGSC_v3.15130,229,349 - 130,288,894 (+)NCBI
Cytogenetic Map5q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-bromohexadecanoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
diethyl phthalate  (EXP)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
glucose  (ISO)
GSK-J4  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (EXP,ISO)
lead(0)  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
ozone  (EXP)
paracetamol  (EXP)
paraquat  (EXP)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenylephrine  (EXP)
pirinixic acid  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
sulfadimethoxine  (EXP)
temozolomide  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (EXP)
thimerosal  (ISO)
titanium dioxide  (ISO)
torcetrapib  (ISO)
triadimefon  (ISO)
tributylstannane  (EXP)
trichostatin A  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
dopaminergic synapse  (IEA,ISO)
endosome  (IBA)
Golgi apparatus  (IEA)
membrane  (IEA)
perinuclear region of cytoplasm  (IEA,ISO)
plasma membrane  (IBA,IEA)
secretory granule  (IEA,ISO)
synaptic vesicle  (IBA,IEA,ISO)
synaptic vesicle membrane  (EXP,IDA,IEA,IEP,ISO)
vesicle  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Insulin and okadaic acid induce Rab4 redistribution in adipocytes. Cormont M, etal., J Biol Chem. 1993 Sep 15;268(26):19491-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Differential expression of Rab3 isoforms during differentiation of pancreatic acinar cell line AR42J. Klengel R, etal., Biochem Biophys Res Commun 1997 Jul 30;236(3):719-22.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis. Pavlos NJ, etal., J Neurosci. 2010 Oct 6;30(40):13441-53. doi: 10.1523/JNEUROSCI.0907-10.2010.
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Molecular anatomy of a trafficking organelle. Takamori S, etal., Cell. 2006 Nov 17;127(4):831-46.
Additional References at PubMed
PMID:7508866   PMID:7532276   PMID:8889548   PMID:9252191   PMID:10748113   PMID:11121396   PMID:12167638   PMID:12192047   PMID:12477932   PMID:16043482   PMID:16822953   PMID:19056867  
PMID:19717423   PMID:20007772   PMID:20807725   PMID:21262767   PMID:22321395   PMID:23533145   PMID:24006491   PMID:24891604   PMID:28131823   PMID:29476059  


Genomics

Comparative Map Data
Rab3b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85128,859,034 - 128,926,087 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5128,841,716 - 128,926,086 (+)EnsemblGRCr8
mRatBN7.25123,629,562 - 123,697,410 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5123,644,423 - 123,697,401 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5126,253,240 - 126,320,296 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05127,976,344 - 128,043,394 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05128,027,632 - 128,094,680 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05128,501,789 - 128,568,170 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5128,501,847 - 128,568,188 (+)Ensemblrn6Rnor6.0
Rnor_5.05132,343,152 - 132,408,838 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45130,185,155 - 130,284,038 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5122,364,678 - 122,431,394 (+)NCBICelera
RGSC_v3.15130,229,349 - 130,288,894 (+)NCBI
Cytogenetic Map5q34NCBI
RAB3B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38151,907,956 - 51,990,700 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl151,907,956 - 51,990,700 (-)Ensemblhg38GRCh38
GRCh37152,373,628 - 52,456,372 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36152,157,420 - 52,228,936 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34152,096,857 - 52,168,369NCBI
Celera150,660,966 - 50,743,913 (-)NCBICelera
Cytogenetic Map1p32.3NCBI
HuRef150,490,781 - 50,573,849 (-)NCBIHuRef
CHM1_1152,491,166 - 52,573,953 (-)NCBICHM1_1
T2T-CHM13v2.0151,789,104 - 51,872,214 (-)NCBIT2T-CHM13v2.0
Rab3b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394108,736,267 - 108,800,521 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4108,736,260 - 108,800,521 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384108,879,070 - 108,943,324 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4108,879,063 - 108,943,324 (+)Ensemblmm10GRCm38
MGSCv374108,551,675 - 108,615,929 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364108,377,002 - 108,441,256 (+)NCBIMGSCv36mm8
Celera4107,216,795 - 107,279,795 (+)NCBICelera
Cytogenetic Map4C7NCBI
cM Map450.67NCBI
Rab3b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554647,117,883 - 7,177,534 (+)Ensembl
ChiLan1.0NW_0049554647,117,908 - 7,177,138 (+)NCBIChiLan1.0ChiLan1.0
RAB3B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21174,868,518 - 174,951,571 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11174,010,062 - 174,093,098 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0151,170,956 - 51,242,828 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1152,655,120 - 52,737,856 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl152,666,713 - 52,723,975 (-)EnsemblpanPan2panpan1.1
RAB3B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1159,305,495 - 9,378,003 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl159,319,057 - 9,372,518 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha159,452,491 - 9,534,833 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0159,425,030 - 9,507,475 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl159,386,741 - 9,503,119 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1159,235,627 - 9,317,897 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0159,324,977 - 9,407,250 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0159,342,565 - 9,424,929 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rab3b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505866,430,985 - 66,491,578 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365228,924,617 - 8,989,734 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365228,924,724 - 8,985,309 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAB3B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6160,194,555 - 160,255,632 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16160,194,488 - 160,255,635 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26147,898,185 - 147,958,774 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAB3B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12080,963,320 - 81,036,058 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2080,963,398 - 81,035,657 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603336,204,690 - 36,280,528 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rab3b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248591,193,503 - 1,249,972 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248591,184,733 - 1,250,402 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Rab3b
588 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:278
Count of miRNA genes:179
Interacting mature miRNAs:200
Transcripts:ENSRNOT00000010645
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)584630798129630798Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1582230Bw78Body weight QTL 783.20.0016epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)5124314582133270832Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)584630798129630798Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)592583776137583776Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584630798129630798Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)595062526133270832Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)589369373134369373Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)597492524133270832Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)592881678137881678Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)595062526133270832Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
RH128978  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25123,697,183 - 123,697,368 (+)MAPPERmRatBN7.2
Rnor_6.05128,567,944 - 128,568,128NCBIRnor6.0
Rnor_5.05132,408,612 - 132,408,796UniSTSRnor5.0
RGSC_v3.45130,283,815 - 130,283,999UniSTSRGSC3.4
Celera5122,431,171 - 122,431,355UniSTS
RH 3.4 Map5812.5UniSTS
Cytogenetic Map5q35UniSTS
RH136876  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25123,697,117 - 123,697,267 (+)MAPPERmRatBN7.2
Rnor_6.05128,567,878 - 128,568,027NCBIRnor6.0
Rnor_5.05132,408,546 - 132,408,695UniSTSRnor5.0
RGSC_v3.45130,283,749 - 130,283,898UniSTSRGSC3.4
Celera5122,431,105 - 122,431,254UniSTS
RH 3.4 Map5812.7UniSTS
Cytogenetic Map5q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 150 61 60 30 40 30 6 265 139 11 129 72 87 30 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000010645   ⟹   ENSRNOP00000010645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5128,873,109 - 128,926,086 (+)Ensembl
mRatBN7.2 Ensembl5123,644,423 - 123,697,401 (+)Ensembl
Rnor_6.0 Ensembl5128,501,847 - 128,568,188 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098899   ⟹   ENSRNOP00000078014
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5128,841,716 - 128,926,086 (+)Ensembl
mRatBN7.2 Ensembl5123,644,423 - 123,688,140 (+)Ensembl
RefSeq Acc Id: NM_031091   ⟹   NP_112353
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85128,859,091 - 128,926,087 (+)NCBI
mRatBN7.25123,630,402 - 123,697,407 (+)NCBI
Rnor_6.05128,501,833 - 128,568,167 (+)NCBI
Rnor_5.05132,343,152 - 132,408,838 (+)NCBI
RGSC_v3.45130,185,155 - 130,284,038 (+)RGD
Celera5122,364,678 - 122,431,394 (+)RGD
Sequence:
RefSeq Acc Id: XM_006238531   ⟹   XP_006238593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85128,859,034 - 128,926,087 (+)NCBI
mRatBN7.25123,630,351 - 123,697,410 (+)NCBI
Rnor_6.05128,501,789 - 128,568,170 (+)NCBI
Rnor_5.05132,343,152 - 132,408,838 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063288471   ⟹   XP_063144541
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85128,859,078 - 128,926,087 (+)NCBI
RefSeq Acc Id: XM_063288472   ⟹   XP_063144542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85128,859,093 - 128,926,087 (+)NCBI
RefSeq Acc Id: NP_112353   ⟸   NM_031091
- UniProtKB: Q63941 (UniProtKB/Swiss-Prot),   A6JYX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238593   ⟸   XM_006238531
- Peptide Label: isoform X1
- UniProtKB: Q6P9W6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010645   ⟸   ENSRNOT00000010645
Ensembl Acc Id: ENSRNOP00000078014   ⟸   ENSRNOT00000098899
RefSeq Acc Id: XP_063144541   ⟸   XM_063288471
- Peptide Label: isoform X1
- UniProtKB: Q6P9W6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144542   ⟸   XM_063288472
- Peptide Label: isoform X2
- UniProtKB: Q63941 (UniProtKB/Swiss-Prot),   A6JYX0 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63941-F1-model_v2 AlphaFold Q63941 1-219 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693906
Promoter ID:EPDNEW_R4430
Type:initiation region
Name:Rab3b_1
Description:RAB3B, member RAS oncogene family
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05128,501,835 - 128,501,895EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620922 AgrOrtholog
BioCyc Gene G2FUF-40370 BioCyc
Ensembl Genes ENSRNOG00000008001 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000010645 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6918181 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/Swiss-Prot
  Rab3 UniProtKB/Swiss-Prot
  Small_GTP-bd_dom UniProtKB/Swiss-Prot
  Small_GTPase UniProtKB/Swiss-Prot
  Small_GTPase_Rab UniProtKB/Swiss-Prot
KEGG Report rno:81755 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72799 IMAGE-MGC_LOAD
NCBI Gene 81755 ENTREZGENE
PANTHER LD44762P UniProtKB/Swiss-Prot
Pfam Ras UniProtKB/Swiss-Prot
PhenoGen Rab3b PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot
PROSITE RAB UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008001 RatGTEx
SMART RAB UniProtKB/Swiss-Prot
  RAN UniProtKB/Swiss-Prot
  RAS UniProtKB/Swiss-Prot
  RHO UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8I5Y826_RAT UniProtKB/TrEMBL
  A6JYX0 ENTREZGENE, UniProtKB/TrEMBL
  A6JYX1_RAT UniProtKB/TrEMBL
  Q63941 ENTREZGENE
  Q6P9W6 ENTREZGENE, UniProtKB/TrEMBL
  Q9QYT8_RAT UniProtKB/TrEMBL
  RAB3B_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Rab3b  RAB3B, member RAS oncogene family    Rab3B protein  Name updated 1299863 APPROVED
2002-08-07 Rab3b  Rab3B protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation mRNA expression is induced by dexamethasone in pancreatic acinar cells 729749