Ppp2r2a (protein phosphatase 2, regulatory subunit B, alpha) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ppp2r2a (protein phosphatase 2, regulatory subunit B, alpha) Rattus norvegicus
Analyze
Symbol: Ppp2r2a
Name: protein phosphatase 2, regulatory subunit B, alpha
RGD ID: 620919
Description: Enables protein phosphatase 2A binding activity and tau protein binding activity. Predicted to be involved in protein dephosphorylation and regulation of chromosome segregation. Predicted to act upstream of or within response to morphine. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and glutamatergic synapse. Orthologous to human PPP2R2A (protein phosphatase 2 regulatory subunit Balpha); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; Chagas disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: B55; PP2A subunit B isoform alpha; PP2A subunit B isoform B55-alpha; PP2A subunit B isoform BRA; PP2A subunit B isoform PR55-alpha; PP2A subunit B isoform R2-alpha; PP2A, subunit B, B-alpha isoform; PP2A, subunit B, B55-alpha isoform; PP2A, subunit B, BRA isoform; PP2A, subunit B, PR55-alpha isoform; PP2A, subunit B, R2-alpha isoform; protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform; protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81545,380,142 - 45,439,428 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1545,379,683 - 45,439,405 (-)EnsemblGRCr8
mRatBN7.21541,204,659 - 41,263,924 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1541,204,200 - 41,263,924 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1543,070,093 - 43,129,122 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01544,220,305 - 44,279,334 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01542,664,940 - 42,724,199 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01543,673,958 - 43,733,182 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1543,673,960 - 43,733,182 (-)Ensemblrn6Rnor6.0
Rnor_5.01547,862,028 - 47,921,336 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41546,546,447 - 46,605,977 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1540,872,027 - 40,931,318 (-)NCBICelera
RGSC_v3.11546,562,545 - 46,621,738 (-)NCBI
Cytogenetic Map15p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
camptothecin  (ISO)
carbamazepine  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clozapine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
flavonoids  (EXP)
flutamide  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
gentamycin  (EXP)
haloperidol  (EXP)
ivermectin  (ISO)
josamycin  (ISO)
methapyrilene  (EXP)
microcystin-LR  (EXP,ISO)
mitomycin C  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
nocodazole  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
riddelliine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA)
glutamatergic synapse  (IEA,ISO)
protein phosphatase type 2A complex  (IBA,IEA,ISO,ISS)
synapse  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest. Bennin DA, etal., J Biol Chem 2002 Jul 26;277(30):27449-67. Epub 2002 Apr 15.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Reduced binding of protein phosphatase 2A to tau protein with frontotemporal dementia and parkinsonism linked to chromosome 17 mutations. Goedert M, etal., J Neurochem. 2000 Nov;75(5):2155-62.
4. Structure- and modeling-based identification of the adenovirus E4orf4 binding site in the protein phosphatase 2A B55alpha subunit. Horowitz B, etal., J Biol Chem. 2013 May 10;288(19):13718-27. doi: 10.1074/jbc.M112.343756. Epub 2013 Mar 25.
5. Mapping the in vitro interactome of cardiac sodium (Na+ )-calcium (Ca2+ ) exchanger 1 (NCX1). Lubelwana Hafver T, etal., Proteomics. 2017 Sep;17(17-18). doi: 10.1002/pmic.201600417.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. The third subunit of protein phosphatase 2A (PP2A), a 55-kilodalton protein which is apparently substituted for by T antigens in complexes with the 36- and 63-kilodalton PP2A subunits, bears little resemblance to T antigens. Pallas DC, etal., J Virol 1992 Feb;66(2):886-93.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer. Seshacharyulu P, etal., Cancer Lett. 2013 Jul 10;335(1):9-18. doi: 10.1016/j.canlet.2013.02.036. Epub 2013 Feb 20.
14. Influence of hypertonic-hyperoncotic solution and furosemide on canine hydrostatic pulmonary oedema resorption. Wickerts CJ, etal., J Physiol 1992 Dec;458:425-38.
Additional References at PubMed
PMID:1849734   PMID:8389301   PMID:12477932   PMID:16102737   PMID:17245430   PMID:20585893   PMID:23775125   PMID:24413018   PMID:24433183   PMID:28343149   PMID:32357304  


Genomics

Comparative Map Data
Ppp2r2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81545,380,142 - 45,439,428 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1545,379,683 - 45,439,405 (-)EnsemblGRCr8
mRatBN7.21541,204,659 - 41,263,924 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1541,204,200 - 41,263,924 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1543,070,093 - 43,129,122 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01544,220,305 - 44,279,334 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01542,664,940 - 42,724,199 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01543,673,958 - 43,733,182 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1543,673,960 - 43,733,182 (-)Ensemblrn6Rnor6.0
Rnor_5.01547,862,028 - 47,921,336 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41546,546,447 - 46,605,977 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1540,872,027 - 40,931,318 (-)NCBICelera
RGSC_v3.11546,562,545 - 46,621,738 (-)NCBI
Cytogenetic Map15p12NCBI
PPP2R2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38826,291,508 - 26,372,680 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl826,291,508 - 26,372,680 (+)Ensemblhg38GRCh38
GRCh37826,149,024 - 26,230,196 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36826,204,951 - 26,284,563 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34826,204,950 - 26,284,562NCBI
Celera825,111,391 - 25,192,579 (+)NCBICelera
Cytogenetic Map8p21.2NCBI
HuRef824,693,626 - 24,775,115 (+)NCBIHuRef
CHM1_1826,350,602 - 26,431,783 (+)NCBICHM1_1
T2T-CHM13v2.0826,567,415 - 26,649,239 (+)NCBIT2T-CHM13v2.0
Ppp2r2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391467,251,505 - 67,309,920 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1467,251,505 - 67,309,893 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381467,014,056 - 67,072,471 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1467,014,056 - 67,072,444 (-)Ensemblmm10GRCm38
MGSCv371467,634,508 - 67,691,266 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361465,968,164 - 66,026,581 (-)NCBIMGSCv36mm8
Celera1464,770,857 - 64,827,586 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.6NCBI
Ppp2r2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540349,042,185 - 49,113,737 (+)Ensembl
ChiLan1.0NW_00495540349,042,188 - 49,113,743 (+)NCBIChiLan1.0ChiLan1.0
PPP2R2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2744,830,012 - 44,910,191 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1820,544,153 - 20,624,350 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0825,569,563 - 25,650,782 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1822,476,159 - 22,555,921 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl822,476,159 - 22,556,963 (+)EnsemblpanPan2panpan1.1
PPP2R2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12531,196,613 - 31,282,027 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2531,197,319 - 31,281,732 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2531,784,273 - 31,929,614 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02531,396,726 - 31,542,249 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2531,395,135 - 31,482,200 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12531,353,652 - 31,499,263 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02531,201,385 - 31,347,009 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02531,368,861 - 31,514,548 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ppp2r2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049439,291,878 - 9,360,545 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936757544,301 - 613,241 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936757546,130 - 613,226 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP2R2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1410,195,351 - 10,284,707 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11410,195,388 - 10,283,741 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21411,360,498 - 11,448,854 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP2R2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1824,390,751 - 24,485,657 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl824,390,781 - 24,487,195 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605217,672,188 - 17,753,857 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp2r2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475821,191,913 - 21,273,897 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475821,191,979 - 21,275,977 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppp2r2a
118 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:66
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000015318
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)152788577486257085Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
2306968Anxrr23Anxiety related response QTL 234.83reflex trait (VT:0001961)amplitude of the acoustic startle response (CMO:0001520)154063126846187442Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154028990149308583Rat

Markers in Region
WI-18898  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21541,204,787 - 41,204,929 (+)MAPPERmRatBN7.2
Rnor_6.01543,674,087 - 43,674,228NCBIRnor6.0
Rnor_5.01547,921,066 - 47,921,207UniSTSRnor5.0
RGSC_v3.41546,546,576 - 46,546,717UniSTSRGSC3.4
Celera1540,872,156 - 40,872,297UniSTS
Cytogenetic Map15p12UniSTS
RH135440  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21541,251,143 - 41,251,326 (+)MAPPERmRatBN7.2
Rnor_6.01543,720,442 - 43,720,624NCBIRnor6.0
Rnor_5.01547,874,688 - 47,874,870UniSTSRnor5.0
RGSC_v3.41546,592,926 - 46,593,108UniSTSRGSC3.4
Celera1540,918,514 - 40,918,696UniSTS
Cytogenetic Map15p12UniSTS
Ppp2r2a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21541,210,884 - 41,211,037 (+)MAPPERmRatBN7.2
Rnor_6.01543,680,186 - 43,680,338NCBIRnor6.0
Rnor_5.01547,914,956 - 47,915,108UniSTSRnor5.0
RGSC_v3.41546,552,675 - 46,552,827UniSTSRGSC3.4
Celera1540,878,255 - 40,878,407UniSTS
Cytogenetic Map15p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC132635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D14419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M83297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M83298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000015318   ⟹   ENSRNOP00000015318
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1545,380,146 - 45,439,405 (-)Ensembl
mRatBN7.2 Ensembl1541,204,663 - 41,263,924 (-)Ensembl
Rnor_6.0 Ensembl1543,673,960 - 43,733,182 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097094   ⟹   ENSRNOP00000090822
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1545,379,683 - 45,439,405 (-)Ensembl
mRatBN7.2 Ensembl1541,204,200 - 41,263,890 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099993   ⟹   ENSRNOP00000096687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1541,204,663 - 41,263,013 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107550   ⟹   ENSRNOP00000085487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1545,380,146 - 45,405,972 (-)Ensembl
mRatBN7.2 Ensembl1541,204,662 - 41,230,923 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116246   ⟹   ENSRNOP00000095560
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1541,204,663 - 41,232,507 (-)Ensembl
RefSeq Acc Id: NM_053999   ⟹   NP_446451
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81545,380,142 - 45,439,405 (-)NCBI
mRatBN7.21541,204,659 - 41,263,924 (-)NCBI
Rnor_6.01543,673,958 - 43,733,182 (-)NCBI
Rnor_5.01547,862,028 - 47,921,336 (+)NCBI
RGSC_v3.41546,546,447 - 46,605,977 (-)RGD
Celera1540,872,027 - 40,931,318 (-)RGD
Sequence:
RefSeq Acc Id: XM_008770732   ⟹   XP_008768954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81545,380,142 - 45,437,318 (-)NCBI
mRatBN7.21541,204,659 - 41,261,839 (-)NCBI
Rnor_6.01543,673,958 - 43,698,710 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039092957   ⟹   XP_038948885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81545,380,142 - 45,437,377 (-)NCBI
mRatBN7.21541,204,659 - 41,261,896 (-)NCBI
RefSeq Acc Id: XM_063273915   ⟹   XP_063129985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81545,380,142 - 45,438,520 (-)NCBI
RefSeq Acc Id: XM_063273916   ⟹   XP_063129986
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81545,380,142 - 45,438,520 (-)NCBI
RefSeq Acc Id: XM_063273917   ⟹   XP_063129987
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81545,380,142 - 45,439,428 (-)NCBI
RefSeq Acc Id: XM_063273918   ⟹   XP_063129988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81545,380,142 - 45,437,377 (-)NCBI
RefSeq Acc Id: NP_446451   ⟸   NM_053999
- UniProtKB: O35512 (UniProtKB/Swiss-Prot),   A1A5M9 (UniProtKB/Swiss-Prot),   P36878 (UniProtKB/Swiss-Prot),   P36876 (UniProtKB/Swiss-Prot),   A6K6P0 (UniProtKB/TrEMBL),   A0A8I6AVF8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768954   ⟸   XM_008770732
- Peptide Label: isoform X4
- UniProtKB: A6K6P2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015318   ⟸   ENSRNOT00000015318
RefSeq Acc Id: XP_038948885   ⟸   XM_039092957
- Peptide Label: isoform X4
- UniProtKB: A6K6P2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095560   ⟸   ENSRNOT00000116246
Ensembl Acc Id: ENSRNOP00000096687   ⟸   ENSRNOT00000099993
Ensembl Acc Id: ENSRNOP00000090822   ⟸   ENSRNOT00000097094
Ensembl Acc Id: ENSRNOP00000085487   ⟸   ENSRNOT00000107550
RefSeq Acc Id: XP_063129987   ⟸   XM_063273917
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AVF8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129986   ⟸   XM_063273916
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AVF8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129985   ⟸   XM_063273915
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AVF8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129988   ⟸   XM_063273918
- Peptide Label: isoform X4
- UniProtKB: A6K6P2 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P36876-F1-model_v2 AlphaFold P36876 1-447 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699762
Promoter ID:EPDNEW_R10285
Type:initiation region
Name:Ppp2r2a_1
Description:protein phosphatase 2, regulatory subunit B, alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01543,733,191 - 43,733,251EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620919 AgrOrtholog
BioCyc Gene G2FUF-13316 BioCyc
Ensembl Genes ENSRNOG00000011158 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015318 ENTREZGENE
  ENSRNOT00000015318.7 UniProtKB/Swiss-Prot
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7370343 IMAGE-MGC_LOAD
InterPro PP2A_PR55 UniProtKB/Swiss-Prot
  PP2A_PR55_CS UniProtKB/Swiss-Prot
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot
  WD40_repeat UniProtKB/Swiss-Prot
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:117104 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156605 IMAGE-MGC_LOAD
NCBI Gene 117104 ENTREZGENE
PANTHER PTHR11871 UniProtKB/Swiss-Prot
PhenoGen Ppp2r2a PhenoGen
PIRSF PP2A_PR55 UniProtKB/Swiss-Prot
PRINTS PP2APR55 UniProtKB/Swiss-Prot
PROSITE PR55_1 UniProtKB/Swiss-Prot
  PR55_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011158 RatGTEx
SMART WD40 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot
UniProt 2ABA_RAT UniProtKB/Swiss-Prot
  A0A8I6A457_RAT UniProtKB/TrEMBL
  A0A8I6AAF9_RAT UniProtKB/TrEMBL
  A0A8I6ANX1_RAT UniProtKB/TrEMBL
  A0A8I6AVF8 ENTREZGENE, UniProtKB/TrEMBL
  A1A5M9 ENTREZGENE
  A6K6N9_RAT UniProtKB/TrEMBL
  A6K6P0 ENTREZGENE, UniProtKB/TrEMBL
  A6K6P1_RAT UniProtKB/TrEMBL
  A6K6P2 ENTREZGENE, UniProtKB/TrEMBL
  O35512 ENTREZGENE
  P36876 ENTREZGENE
  P36878 ENTREZGENE
UniProt Secondary A1A5M9 UniProtKB/Swiss-Prot
  O35512 UniProtKB/Swiss-Prot
  P36878 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Ppp2r2a  protein phosphatase 2, regulatory subunit B, alpha  Ppp2r2a  protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-12-15 Ppp2r2a  protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform  Ppp2r2a  protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ppp2r2a  protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Ppp2r2a  protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform      Symbol and Name status set to provisional 70820 PROVISIONAL