Nucb2 (nucleobindin 2) - Rat Genome Database

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Gene: Nucb2 (nucleobindin 2) Rattus norvegicus
Analyze
Symbol: Nucb2
Name: nucleobindin 2
RGD ID: 620888
Description: Enables G-protein alpha-subunit binding activity; guanyl-nucleotide exchange factor activity; and tumor necrosis factor receptor binding activity. Involved in several processes, including negative regulation of cell communication; positive regulation of testosterone secretion; and response to melanocyte-stimulating hormone. Located in Golgi medial cisterna and extracellular space. Biomarker of alcohol dependence; obesity; and type 2 diabetes mellitus. Orthologous to human NUCB2 (nucleobindin 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DNA-binding protein NEFA; Nefa; NEFA precursor; nesfatin-1; nucleobindin-2; p54; prepronefastin; prepronesfatin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81180,185,121 - 180,221,644 (+)NCBIGRCr8
GRCr8 Ensembl1180,199,551 - 180,230,116 (+)EnsemblGRCr8 Ensembl
mRatBN7.21170,750,830 - 170,787,356 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1170,750,877 - 170,787,353 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1179,067,066 - 179,103,567 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01186,253,570 - 186,290,073 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01178,968,763 - 179,005,140 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01185,106,773 - 185,143,278 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1185,104,656 - 185,143,272 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01192,078,545 - 192,115,045 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41174,605,677 - 174,642,111 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1168,570,763 - 168,607,089 (+)NCBICelera
RGSC_v3.11174,744,922 - 174,781,355 (+)NCBI
Cytogenetic Map1q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
captan  (ISO)
chlordecone  (ISO)
choline  (ISO)
chromium atom  (ISO)
ciguatoxin CTX1B  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dioxygen  (EXP)
diquat  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
glafenine  (EXP)
glucose  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
KT 5720  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nefazodone  (EXP)
nickel dichloride  (EXP,ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
quercetin  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Nucleobindin-2/nesfatin in the endocrine pancreas: distribution and relationship to glycaemic state. Foo KS, etal., J Endocrinol. 2010 Mar;204(3):255-63. doi: 10.1677/JOE-09-0254. Epub 2009 Dec 23.
2. Cellular distribution, regulated expression, and functional role of the anorexigenic peptide, NUCB2/nesfatin-1, in the testis. Garcia-Galiano D, etal., Endocrinology. 2012 Apr;153(4):1959-71. doi: 10.1210/en.2011-2032. Epub 2012 Feb 14.
3. G Protein binding sites on Calnuc (nucleobindin 1) and NUCB2 (nucleobindin 2) define a new class of G(alpha)i-regulatory motifs. Garcia-Marcos M, etal., J Biol Chem. 2011 Aug 12;286(32):28138-49. doi: 10.1074/jbc.M110.204099. Epub 2011 Jun 8.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Nutrient responsive nesfatin-1 regulates energy balance and induces glucose-stimulated insulin secretion in rats. Gonzalez R, etal., Endocrinology. 2011 Oct;152(10):3628-37. doi: 10.1210/en.2010-1471. Epub 2011 Aug 9.
7. A research on the expression of Nucb2/ cAMP / PKA in the hippocampus of alcohol-dependent rats. Li Q, etal., Biochem Biophys Res Commun. 2023 May 28;658:148-152. doi: 10.1016/j.bbrc.2023.02.084. Epub 2023 Mar 9.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. The calcium-binding protein p54/NEFA is a novel luminal resident of medial Golgi cisternae that traffics independently of mannosidase II. Morel-Huaux VM, etal., Eur J Cell Biol 2002 Feb;81(2):87-100.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Oh-I S, etal., Nature. 2006 Oct 12;443(7112):709-12. Epub 2006 Oct 1.
12. Enhanced expression of nesfatin/nucleobindin-2 in white adipose tissue of ventromedial hypothalamus-lesioned rats. Osaki A, etal., Neurosci Lett. 2012 Jul 11;521(1):46-51. doi: 10.1016/j.neulet.2012.05.056. Epub 2012 May 26.
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Nesfatin-1 stimulates glucagon and insulin secretion and beta cell NUCB2 is reduced in human type 2 diabetic subjects. Riva M, etal., Cell Tissue Res. 2011 Dec;346(3):393-405. doi: 10.1007/s00441-011-1268-5. Epub 2011 Nov 23.
16. 14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway. Roy DN, etal., Br J Pharmacol. 2010 Aug;160(7):1823-43.
17. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18. Secreted nucleobindin-2 inhibits 3T3-L1 adipocyte differentiation. Tagaya Y, etal., Protein Pept Lett. 2012 Sep;19(9):997-1004.
Additional References at PubMed
PMID:10915798   PMID:15308636   PMID:15489334   PMID:16502470   PMID:17627999   PMID:18048495   PMID:19199708   PMID:19248766   PMID:19348732   PMID:19426783   PMID:19461159   PMID:19474390  
PMID:19497050   PMID:19540880   PMID:19733157   PMID:19778412   PMID:19797401   PMID:19883614   PMID:19944727   PMID:19961888   PMID:20380005   PMID:20435076   PMID:20534827   PMID:20966530  
PMID:21418984   PMID:21451359   PMID:21782869   PMID:22293188   PMID:22375892   PMID:22514047   PMID:22688332   PMID:22955491   PMID:22958274   PMID:23300698   PMID:23560056   PMID:23801843  
PMID:24048879   PMID:24120633   PMID:24304576   PMID:24598461   PMID:24829503   PMID:24905431   PMID:24944480   PMID:25089000   PMID:25344190   PMID:25665476   PMID:25916958   PMID:25997563  
PMID:26144374   PMID:26297350   PMID:26522144   PMID:26639940   PMID:26778702   PMID:26801557   PMID:27203571   PMID:27590244   PMID:27599613   PMID:27982684   PMID:28211103   PMID:28277136  
PMID:28838338   PMID:28851749   PMID:28951234   PMID:29604590   PMID:30111257   PMID:31085594   PMID:31141415   PMID:31260713   PMID:31637758   PMID:32200401   PMID:32762481   PMID:33059202  
PMID:33301513   PMID:33928538   PMID:34134629   PMID:35292759   PMID:35787996   PMID:36195118   PMID:36327662   PMID:36424912   PMID:37105355   PMID:38339201   PMID:38511245   PMID:39097921  


Genomics

Comparative Map Data
Nucb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81180,185,121 - 180,221,644 (+)NCBIGRCr8
GRCr8 Ensembl1180,199,551 - 180,230,116 (+)EnsemblGRCr8 Ensembl
mRatBN7.21170,750,830 - 170,787,356 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1170,750,877 - 170,787,353 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1179,067,066 - 179,103,567 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01186,253,570 - 186,290,073 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01178,968,763 - 179,005,140 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01185,106,773 - 185,143,278 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1185,104,656 - 185,143,272 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01192,078,545 - 192,115,045 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41174,605,677 - 174,642,111 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1168,570,763 - 168,607,089 (+)NCBICelera
RGSC_v3.11174,744,922 - 174,781,355 (+)NCBI
Cytogenetic Map1q35NCBI
NUCB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381117,276,739 - 17,349,980 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1117,208,153 - 17,349,980 (+)EnsemblGRCh38hg38GRCh38
GRCh371117,298,286 - 17,353,758 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361117,254,862 - 17,309,646 (+)NCBINCBI36Build 36hg18NCBI36
Build 341117,254,887 - 17,309,646NCBI
Celera1117,428,095 - 17,482,908 (+)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1116,982,188 - 17,036,934 (+)NCBIHuRef
CHM1_11117,297,833 - 17,352,630 (+)NCBICHM1_1
T2T-CHM13v2.01117,374,367 - 17,447,613 (+)NCBIT2T-CHM13v2.0
Nucb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397116,103,579 - 116,139,823 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7116,103,604 - 116,139,819 (+)EnsemblGRCm39 Ensembl
GRCm387116,504,352 - 116,540,588 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7116,504,369 - 116,540,584 (+)EnsemblGRCm38mm10GRCm38
MGSCv377123,647,888 - 123,684,102 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367116,295,518 - 116,331,703 (+)NCBIMGSCv36mm8
Celera7116,437,745 - 116,475,120 (+)NCBICelera
Cytogenetic Map7F1NCBI
cM Map761.79NCBI
Nucb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541432,062,835 - 32,105,975 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541432,062,870 - 32,104,117 (+)NCBIChiLan1.0ChiLan1.0
NUCB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2919,594,993 - 19,665,472 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11119,555,745 - 19,625,901 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01117,331,742 - 17,404,682 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11117,002,296 - 17,072,447 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,036,038 - 17,072,447 (+)Ensemblpanpan1.1panPan2
NUCB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12139,868,756 - 39,918,724 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2139,874,781 - 39,918,689 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2139,368,984 - 39,424,531 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02140,974,304 - 41,029,984 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2140,998,084 - 41,033,034 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12139,987,014 - 40,041,813 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02140,193,641 - 40,249,282 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02140,532,928 - 40,588,133 (+)NCBIUU_Cfam_GSD_1.0
Nucb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494745,684,001 - 45,729,516 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365281,717,049 - 1,763,536 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365281,726,879 - 1,763,483 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUCB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1241,782,594 - 41,829,829 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2244,840,114 - 44,888,611 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NUCB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1147,634,425 - 47,690,723 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl147,634,531 - 47,689,011 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038145,065,338 - 145,121,572 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nucb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247668,924,953 - 8,943,838 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247668,907,475 - 8,943,838 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nucb2
244 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:74
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000027752
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1153680016182383862Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1153680016183564652Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1175967553200707874Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1170078537182384005Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
D1Rat187  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81180,198,819 - 180,199,037 (+)Marker Load Pipeline
mRatBN7.21170,764,529 - 170,764,749 (-)MAPPERmRatBN7.2
Rnor_6.01185,129,380 - 185,129,597NCBIRnor6.0
Rnor_5.01192,101,152 - 192,101,369UniSTSRnor5.0
RGSC_v3.41174,619,287 - 174,619,504UniSTSRGSC3.4
RGSC_v3.41174,619,286 - 174,619,504RGDRGSC3.4
Celera1168,584,373 - 168,584,590UniSTS
RGSC_v3.11174,758,476 - 174,758,780RGD
SHRSP x BN Map185.7999RGD
SHRSP x BN Map185.7999UniSTS
Cytogenetic Map1q35UniSTS
BI275463  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21170,783,246 - 170,783,399 (-)MAPPERmRatBN7.2
Rnor_6.01185,110,730 - 185,110,882NCBIRnor6.0
Rnor_5.01192,082,502 - 192,082,654UniSTSRnor5.0
RGSC_v3.41174,638,002 - 174,638,154UniSTSRGSC3.4
Celera1168,602,977 - 168,603,129UniSTS
RH 3.4 Map11589.31UniSTS
Cytogenetic Map1q35UniSTS
GDB:177399  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01185,109,262 - 185,109,287NCBIRnor6.0
Rnor_5.01192,081,034 - 192,081,059UniSTSRnor5.0
Cytogenetic Map1q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 218 97 11 93 45 60 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027752   ⟹   ENSRNOP00000027753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1180,203,629 - 180,221,565 (+)Ensembl
mRatBN7.2 Ensembl1170,750,877 - 170,787,277 (+)Ensembl
Rnor_6.0 Ensembl1185,104,656 - 185,143,272 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107803   ⟹   ENSRNOP00000088880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1180,203,629 - 180,230,116 (+)Ensembl
mRatBN7.2 Ensembl1170,769,341 - 170,787,353 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000147565   ⟹   ENSRNOP00000104887
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1180,199,551 - 180,224,432 (+)Ensembl
RefSeq Acc Id: NM_021663   ⟹   NP_067695
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81180,185,210 - 180,221,644 (+)NCBI
mRatBN7.21170,750,920 - 170,787,356 (+)NCBI
Rnor_6.01185,106,773 - 185,143,207 (-)NCBI
Rnor_5.01192,078,545 - 192,115,045 (-)NCBI
RGSC_v3.41174,605,677 - 174,642,111 (+)RGD
Celera1168,570,763 - 168,607,089 (+)RGD
Sequence:
RefSeq Acc Id: XM_006230095   ⟹   XP_006230157
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81180,185,121 - 180,221,644 (+)NCBI
mRatBN7.21170,750,830 - 170,787,356 (+)NCBI
Rnor_6.01185,106,773 - 185,143,278 (-)NCBI
Rnor_5.01192,078,545 - 192,115,045 (-)NCBI
Sequence:
RefSeq Acc Id: NP_067695   ⟸   NM_021663
- Peptide Label: precursor
- UniProtKB: Q9JI85 (UniProtKB/Swiss-Prot),   A6I8F1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230157   ⟸   XM_006230095
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GHJ0 (UniProtKB/TrEMBL),   A6I8F0 (UniProtKB/TrEMBL),   A6I8F1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027753   ⟸   ENSRNOT00000027752
Ensembl Acc Id: ENSRNOP00000088880   ⟸   ENSRNOT00000107803
Ensembl Acc Id: ENSRNOP00000104887   ⟸   ENSRNOT00000147565
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JI85-F1-model_v2 AlphaFold Q9JI85 1-420 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690334
Promoter ID:EPDNEW_R859
Type:initiation region
Name:Nucb2_1
Description:nucleobindin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01185,143,194 - 185,143,254EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620888 AgrOrtholog
BioCyc Gene G2FUF-57713 BioCyc
Ensembl Genes ENSRNOG00000020456 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000027752 ENTREZGENE
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5621784 IMAGE-MGC_LOAD
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
  Nucleobindin UniProtKB/Swiss-Prot
KEGG Report rno:59295 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72469 IMAGE-MGC_LOAD
NCBI Gene 59295 ENTREZGENE
PANTHER PTHR19237 UniProtKB/Swiss-Prot
  PTHR19237:SF22 UniProtKB/Swiss-Prot
Pfam EF-hand_7 UniProtKB/Swiss-Prot
PhenoGen Nucb2 PhenoGen
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot
  EF_HAND_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020456 RatGTEx
SMART EFh UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot
UniProt A0A8I6GHJ0 ENTREZGENE, UniProtKB/TrEMBL
  A6I8F0 ENTREZGENE, UniProtKB/TrEMBL
  A6I8F1 ENTREZGENE, UniProtKB/TrEMBL
  A6I8F2_RAT UniProtKB/TrEMBL
  A6I8F3_RAT UniProtKB/TrEMBL
  A6I8F4_RAT UniProtKB/TrEMBL
  G3V8R1_RAT UniProtKB/TrEMBL
  NUCB2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Nucb2  nucleobindin 2    NEFA precursor  Name updated 1299863 APPROVED
2002-08-07 Nucb2  NEFA precursor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds calcium 633331
gene_protein an extrinsic membrane protein, facing the luminal Golgi compartment 633331