Nucb2 (nucleobindin 2) - Rat Genome Database

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Gene: Nucb2 (nucleobindin 2) Rattus norvegicus
Symbol: Nucb2
Name: nucleobindin 2
RGD ID: 620888
Description: Enables G-protein alpha-subunit binding activity; guanyl-nucleotide exchange factor activity; and tumor necrosis factor receptor binding activity. Involved in several processes, including negative regulation of cell communication; positive regulation of testosterone secretion; and response to melanocyte-stimulating hormone. Located in Golgi medial cisterna and extracellular space. Biomarker of alcohol dependence; obesity; and type 2 diabetes mellitus. Orthologous to human NUCB2 (nucleobindin 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
Previously known as: DNA-binding protein NEFA; Nefa; NEFA precursor; nesfatin-1; nucleobindin-2; p54; prepronefastin; prepronesfatin
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81180,185,121 - 180,221,644 (+)NCBIGRCr8
mRatBN7.21170,750,830 - 170,787,356 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1170,750,877 - 170,787,353 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1179,067,066 - 179,103,567 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01186,253,570 - 186,290,073 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01178,968,763 - 179,005,140 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01185,106,773 - 185,143,278 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1185,104,656 - 185,143,272 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01192,078,545 - 192,115,045 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41174,605,677 - 174,642,111 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11174,744,922 - 174,781,355 (+)NCBI
Celera1168,570,763 - 168,607,089 (+)NCBICelera
Cytogenetic Map1q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3-chloropropane-1,2-diol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-D-glucosamine  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
captan  (ISO)
chlordecone  (ISO)
choline  (ISO)
chromium atom  (ISO)
ciguatoxin CTX1B  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dioxygen  (EXP)
diquat  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
glafenine  (EXP)
glucose  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
KT 5720  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nefazodone  (EXP)
nickel dichloride  (EXP,ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
quercetin  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)


References - curated
# Reference Title Reference Citation
1. Nucleobindin-2/nesfatin in the endocrine pancreas: distribution and relationship to glycaemic state. Foo KS, etal., J Endocrinol. 2010 Mar;204(3):255-63. doi: 10.1677/JOE-09-0254. Epub 2009 Dec 23.
2. Cellular distribution, regulated expression, and functional role of the anorexigenic peptide, NUCB2/nesfatin-1, in the testis. Garcia-Galiano D, etal., Endocrinology. 2012 Apr;153(4):1959-71. doi: 10.1210/en.2011-2032. Epub 2012 Feb 14.
3. G Protein binding sites on Calnuc (nucleobindin 1) and NUCB2 (nucleobindin 2) define a new class of G(alpha)i-regulatory motifs. Garcia-Marcos M, etal., J Biol Chem. 2011 Aug 12;286(32):28138-49. doi: 10.1074/jbc.M110.204099. Epub 2011 Jun 8.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Nutrient responsive nesfatin-1 regulates energy balance and induces glucose-stimulated insulin secretion in rats. Gonzalez R, etal., Endocrinology. 2011 Oct;152(10):3628-37. doi: 10.1210/en.2010-1471. Epub 2011 Aug 9.
7. A research on the expression of Nucb2/ cAMP / PKA in the hippocampus of alcohol-dependent rats. Li Q, etal., Biochem Biophys Res Commun. 2023 May 28;658:148-152. doi: 10.1016/j.bbrc.2023.02.084. Epub 2023 Mar 9.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. The calcium-binding protein p54/NEFA is a novel luminal resident of medial Golgi cisternae that traffics independently of mannosidase II. Morel-Huaux VM, etal., Eur J Cell Biol 2002 Feb;81(2):87-100.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Oh-I S, etal., Nature. 2006 Oct 12;443(7112):709-12. Epub 2006 Oct 1.
12. Enhanced expression of nesfatin/nucleobindin-2 in white adipose tissue of ventromedial hypothalamus-lesioned rats. Osaki A, etal., Neurosci Lett. 2012 Jul 11;521(1):46-51. doi: 10.1016/j.neulet.2012.05.056. Epub 2012 May 26.
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Nesfatin-1 stimulates glucagon and insulin secretion and beta cell NUCB2 is reduced in human type 2 diabetic subjects. Riva M, etal., Cell Tissue Res. 2011 Dec;346(3):393-405. doi: 10.1007/s00441-011-1268-5. Epub 2011 Nov 23.
16. 14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway. Roy DN, etal., Br J Pharmacol. 2010 Aug;160(7):1823-43.
17. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18. Secreted nucleobindin-2 inhibits 3T3-L1 adipocyte differentiation. Tagaya Y, etal., Protein Pept Lett. 2012 Sep;19(9):997-1004.
Additional References at PubMed
PMID:10915798   PMID:15308636   PMID:15489334   PMID:16502470   PMID:17627999   PMID:18048495   PMID:19199708   PMID:19248766   PMID:19348732   PMID:19426783   PMID:19461159   PMID:19474390  
PMID:19497050   PMID:19540880   PMID:19733157   PMID:19778412   PMID:19797401   PMID:19883614   PMID:19944727   PMID:19961888   PMID:20380005   PMID:20435076   PMID:20534827   PMID:20966530  
PMID:21418984   PMID:21451359   PMID:21782869   PMID:22293188   PMID:22375892   PMID:22514047   PMID:22688332   PMID:22955491   PMID:22958274   PMID:23300698   PMID:23560056   PMID:23801843  
PMID:24048879   PMID:24120633   PMID:24304576   PMID:24598461   PMID:24829503   PMID:24905431   PMID:24944480   PMID:25089000   PMID:25344190   PMID:25665476   PMID:25916958   PMID:25997563  
PMID:26144374   PMID:26297350   PMID:26522144   PMID:26639940   PMID:26778702   PMID:26801557   PMID:27203571   PMID:27590244   PMID:27599613   PMID:27982684   PMID:28211103   PMID:28277136  
PMID:28838338   PMID:28851749   PMID:28951234   PMID:29604590   PMID:30111257   PMID:31085594   PMID:31141415   PMID:31260713   PMID:31637758   PMID:32200401   PMID:32762481   PMID:33059202  
PMID:33301513   PMID:33928538   PMID:34134629   PMID:35292759   PMID:35787996   PMID:36195118   PMID:36327662   PMID:36424912   PMID:37105355   PMID:38339201   PMID:38511245  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81180,185,121 - 180,221,644 (+)NCBIGRCr8
mRatBN7.21170,750,830 - 170,787,356 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1170,750,877 - 170,787,353 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1179,067,066 - 179,103,567 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01186,253,570 - 186,290,073 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01178,968,763 - 179,005,140 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01185,106,773 - 185,143,278 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1185,104,656 - 185,143,272 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01192,078,545 - 192,115,045 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41174,605,677 - 174,642,111 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11174,744,922 - 174,781,355 (+)NCBI
Celera1168,570,763 - 168,607,089 (+)NCBICelera
Cytogenetic Map1q35NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381117,276,739 - 17,349,980 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1117,208,153 - 17,349,980 (+)EnsemblGRCh38hg38GRCh38
GRCh371117,298,286 - 17,353,758 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361117,254,862 - 17,309,646 (+)NCBINCBI36Build 36hg18NCBI36
Build 341117,254,887 - 17,309,646NCBI
Celera1117,428,095 - 17,482,908 (+)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1116,982,188 - 17,036,934 (+)NCBIHuRef
CHM1_11117,297,833 - 17,352,630 (+)NCBICHM1_1
T2T-CHM13v2.01117,374,367 - 17,447,613 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm397116,103,579 - 116,139,823 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7116,103,604 - 116,139,819 (+)EnsemblGRCm39 Ensembl
GRCm387116,504,352 - 116,540,588 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7116,504,369 - 116,540,584 (+)EnsemblGRCm38mm10GRCm38
MGSCv377123,647,888 - 123,684,102 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367116,295,518 - 116,331,703 (+)NCBIMGSCv36mm8
Celera7116,437,745 - 116,475,120 (+)NCBICelera
Cytogenetic Map7F1NCBI
cM Map761.79NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541432,062,835 - 32,105,975 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541432,062,870 - 32,104,117 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2919,594,993 - 19,665,472 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11119,555,745 - 19,625,901 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01117,331,742 - 17,404,682 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11117,002,296 - 17,072,447 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,036,038 - 17,072,447 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12139,868,756 - 39,918,724 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2139,874,781 - 39,918,689 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2139,368,984 - 39,424,531 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02140,974,304 - 41,029,984 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2140,998,084 - 41,033,034 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12139,987,014 - 40,041,813 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02140,193,641 - 40,249,282 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02140,532,928 - 40,588,133 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494745,684,001 - 45,729,516 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365281,717,049 - 1,763,536 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365281,726,879 - 1,763,483 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1241,782,594 - 41,829,829 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2244,840,114 - 44,888,611 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1147,634,425 - 47,690,723 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl147,634,531 - 47,689,011 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038145,065,338 - 145,121,572 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247668,924,953 - 8,943,838 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247668,907,475 - 8,943,838 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Nucb2
259 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:74
Interacting mature miRNAs:77
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1164747558181133855Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1155422851172949803Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1156677124176484451Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21170,764,529 - 170,764,749 (-)MAPPERmRatBN7.2
Rnor_6.01185,129,380 - 185,129,597NCBIRnor6.0
Rnor_5.01192,101,152 - 192,101,369UniSTSRnor5.0
RGSC_v3.41174,619,286 - 174,619,504RGDRGSC3.4
RGSC_v3.41174,619,287 - 174,619,504UniSTSRGSC3.4
RGSC_v3.11174,758,476 - 174,758,780RGD
Celera1168,584,373 - 168,584,590UniSTS
SHRSP x BN Map185.7999RGD
SHRSP x BN Map185.7999UniSTS
Cytogenetic Map1q35UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21170,783,246 - 170,783,399 (-)MAPPERmRatBN7.2
Rnor_6.01185,110,730 - 185,110,882NCBIRnor6.0
Rnor_5.01192,082,502 - 192,082,654UniSTSRnor5.0
RGSC_v3.41174,638,002 - 174,638,154UniSTSRGSC3.4
Celera1168,602,977 - 168,603,129UniSTS
RH 3.4 Map11589.31UniSTS
Cytogenetic Map1q35UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01185,109,262 - 185,109,287NCBIRnor6.0
Rnor_5.01192,081,034 - 192,081,059UniSTSRnor5.0
Cytogenetic Map1q35UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 31 43 27 19 27 1 1 71 25 39 11 1
Low 12 14 14 14 7 10 3 10 2 7
Below cutoff


RefSeq Acc Id: ENSRNOT00000027752   ⟹   ENSRNOP00000027753
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1170,750,877 - 170,787,277 (+)Ensembl
Rnor_6.0 Ensembl1185,104,656 - 185,143,272 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107803   ⟹   ENSRNOP00000088880
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1170,769,341 - 170,787,353 (+)Ensembl
RefSeq Acc Id: NM_021663   ⟹   NP_067695
Rat AssemblyChrPosition (strand)Source
GRCr81180,185,210 - 180,221,644 (+)NCBI
mRatBN7.21170,750,920 - 170,787,356 (+)NCBI
Rnor_6.01185,106,773 - 185,143,207 (-)NCBI
Rnor_5.01192,078,545 - 192,115,045 (-)NCBI
RGSC_v3.41174,605,677 - 174,642,111 (+)RGD
Celera1168,570,763 - 168,607,089 (+)RGD
RefSeq Acc Id: XM_006230095   ⟹   XP_006230157
Rat AssemblyChrPosition (strand)Source
GRCr81180,185,121 - 180,221,644 (+)NCBI
mRatBN7.21170,750,830 - 170,787,356 (+)NCBI
Rnor_6.01185,106,773 - 185,143,278 (-)NCBI
Rnor_5.01192,078,545 - 192,115,045 (-)NCBI
RefSeq Acc Id: NP_067695   ⟸   NM_021663
- Peptide Label: precursor
- UniProtKB: Q9JI85 (UniProtKB/Swiss-Prot),   A6I8F1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230157   ⟸   XM_006230095
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GHJ0 (UniProtKB/TrEMBL),   A6I8F0 (UniProtKB/TrEMBL),   A6I8F1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027753   ⟸   ENSRNOT00000027752
RefSeq Acc Id: ENSRNOP00000088880   ⟸   ENSRNOT00000107803
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JI85-F1-model_v2 AlphaFold Q9JI85 1-420 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690334
Promoter ID:EPDNEW_R859
Type:initiation region
Description:nucleobindin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01185,143,194 - 185,143,254EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620888 AgrOrtholog
BioCyc Gene G2FUF-57713 BioCyc
Ensembl Genes ENSRNOG00000020456 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055006787 UniProtKB/Swiss-Prot
  ENSRNOG00060017872 UniProtKB/Swiss-Prot
  ENSRNOG00065029150 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027752.6 UniProtKB/TrEMBL
  ENSRNOT00000107803.1 UniProtKB/TrEMBL
  ENSRNOT00055011151 UniProtKB/Swiss-Prot
  ENSRNOT00060030920 UniProtKB/Swiss-Prot
  ENSRNOT00065050545 UniProtKB/Swiss-Prot
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleobindin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:59295 UniProtKB/Swiss-Prot
PANTHER PTHR19237 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19237:SF22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nucb2 PhenoGen
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020456 RatGTEx
  ENSRNOG00055006787 RatGTEx
  ENSRNOG00060017872 RatGTEx
  ENSRNOG00065029150 RatGTEx
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Nucb2  nucleobindin 2    NEFA precursor  Name updated 1299863 APPROVED
2002-08-07 Nucb2  NEFA precursor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds calcium 633331
gene_protein an extrinsic membrane protein, facing the luminal Golgi compartment 633331