Myl1_v2 (myosin, light chain 1, variant 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Myl1_v2 (myosin, light chain 1, variant 2) Rattus norvegicus
Analyze
Symbol: Myl1_v2
Name: myosin, light chain 1, variant 2
RGD ID: 620885
Description: variant of the myosin light chain 1 gene; use of alternative promoters provides differential regulation
ENCODES an splice that exhibits structural constituent of muscle (ortholog)
Type: splice  of Myl1  
Previously known as: fast myosin alkali light chain; Mcl3; Mlc3
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
RGSC_v3.1965,864,924 - 65,873,855 (-)NCBI
Cytogenetic Map9q31NCBI


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Cloning and characterization of cDNA sequences corresponding to myosin light chains 1, 2, and 3, troponin-C, troponin-T, alpha-tropomyosin, and alpha-actin. Garfinkel LI, etal., J Biol Chem 1982 Sep 25;257(18):11078-86.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Fast skeletal muscle myosin light chains 1 and 3 are produced from a single gene by a combined process of differential RNA transcription and splicing. Periasamy M, etal., J Biol Chem 1984 Nov 10;259(21):13595-604.
Additional References at PubMed
PMID:Myl1_v2  


Genomics


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_020104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide L00088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Protein Sequences
Protein RefSeqs NP_064489 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA98533 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017838.3
  ENSRNOP00055014115
  ENSRNOP00060026714
  ENSRNOP00065036973
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P02600-F1-model_v2 AlphaFold P02600 1-189 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSRNOG00000013262 UniProtKB/Swiss-Prot
  ENSRNOG00055010340 UniProtKB/Swiss-Prot
  ENSRNOG00060018855 UniProtKB/Swiss-Prot
  ENSRNOG00065026114 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017838.7 UniProtKB/Swiss-Prot
  ENSRNOT00055017516 UniProtKB/Swiss-Prot
  ENSRNOT00060032712 UniProtKB/Swiss-Prot
  ENSRNOT00065045090 UniProtKB/Swiss-Prot
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ca-Reg_Muscle_Contr_Cell_Proc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:56781 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene Myl1_v2
OMIM 160780
PANTHER MYOSIN LIGHT CHAIN 1, 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MYOSIN LIGHT CHAIN 1/3, SKELETAL MUSCLE ISOFORM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EF-hand UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6KFD8_RAT UniProtKB/TrEMBL
  A6KFD9_RAT UniProtKB/TrEMBL
  A6KFE0_RAT UniProtKB/TrEMBL
  MYL1_RAT UniProtKB/Swiss-Prot
UniProt Secondary P02601 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-09-11 Myl1_v2  myosin, light polypeptide 1, variant 2  Mlc3    Data merged from RGD:1553900 737654 APPROVED
2005-10-07 Mlc3        Symbol and Name status set to provisional 70820 PROVISIONAL
2005-10-07 Myl1_v2  myosin, light polypeptide 1, variant 2  Mlc3  fast myosin alkali light chain  Symbol and Name updated 1299863 APPROVED
2002-08-07 Mlc3  fast myosin alkali light chain      Symbol and Name status set to provisional 70820 PROVISIONAL