Acsm3 (acyl-CoA synthetase medium-chain family member 3)

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Gene: Acsm3 (acyl-CoA synthetase medium-chain family member 3) Rattus norvegicus

Analyze

Symbol:

Acsm3

Name:

acyl-CoA synthetase medium-chain family member 3

RGD ID:

62086

Description:

Predicted to enable butyrate-CoA ligase activity; fatty acid ligase activity; and propionate CoA-transferase activity. Predicted to act upstream of or within fatty acid biosynthetic process. Predicted to be located in mitochondrial matrix. Used to study hypertension. Biomarker of ocular hypertension. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human ACSM3 (acyl-CoA synthetase medium chain family member 3); PARTICIPATES IN fatty acid beta degradation pathway; butanoate metabolic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

acyl-coenzyme A synthetase ACSM3, mitochondrial; butyrate--CoA ligase 3; butyryl coenzyme A synthetase 3; butyryl-coenzyme A synthetase 3; middle-chain acyl-CoA synthetase 3; propionate--CoA ligase; Sa; SA hypertension-associated homolog; SA rat hypertension-associated gene; SA rat hypertension-associated homolog; SA rat hypertension-associated protein; Sah; ssubA

RGD Orthologs

Alliance Genes

More Info

more info ...

Is Marker For:

Strains: BB.SHR-(Acsm3-Igf2)/K SHR.WKY-(D1Wox34-Sah)/Njs
QTLs: Bp28 Bp30 Bp44 Bw20 Iddm10

Candidate Gene For:

Bp30 Bp77 Bp78

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	174,133,260 - 174,159,966 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	174,133,288 - 174,160,184 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	182,448,828 - 182,475,531 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	189,634,871 - 189,661,572 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	182,371,819 - 182,397,104 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	189,514,504 - 189,541,233 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	189,514,553 - 189,541,224 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	196,449,042 - 196,475,596 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	178,054,386 - 178,081,751 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	178,212,017 - 178,214,310 (+)	NCBI
Celera	1	171,883,756 - 171,910,443 (+)	NCBI		Celera
Cytogenetic Map	1	q35	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

essential hypertension (ISO)

genetic disease (ISO)

hypertension (IAGP)

IgA glomerulonephritis (ISO)

NEURODEVELOPMENTAL DISORDER WITH SPEECH DELAY AND VARIABLE OCULAR ANOMALIES (ISO)

Neurodevelopmental Disorders (ISO)

ocular hypertension (IEP)

Overweight (ISO)

Prostatic Neoplasms (ISO)

ulcerative colitis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

3,3',4,4'-tetrachlorobiphenyl (ISO)

3-chloropropane-1,2-diol (EXP,ISO)

4-hydroxyphenyl retinamide (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

ammonium chloride (EXP)

belinostat (ISO)

benzo[a]pyrene (ISO)

bexarotene (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorohydrocarbon (EXP)

chromium(6+) (ISO)

ciglitazone (ISO)

cisplatin (EXP,ISO)

clofibric acid (EXP)

cobalt dichloride (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

D-glucose (ISO)

dextran sulfate (ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

dieldrin (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

entinostat (ISO)

epoxiconazole (ISO)

folic acid (ISO)

fructose (ISO)

furan (EXP)

genistein (EXP)

gentamycin (EXP)

glucose (ISO)

glycidol (ISO)

Heliotrine (EXP,ISO)

hydrogen peroxide (ISO)

Indeno[1,2,3-cd]pyrene (ISO)

indole-3-methanol (EXP)

indometacin (EXP)

iron dichloride (ISO)

isotretinoin (ISO)

lead diacetate (EXP)

lipopolysaccharide (ISO)

melatonin (ISO)

metformin (EXP)

methimazole (EXP)

methylmercury chloride (EXP,ISO)

Muraglitazar (EXP)

N-nitrosodiethylamine (EXP)

N-nitrosomorpholine (EXP)

nickel atom (ISO)

nitrofen (EXP)

O-methyleugenol (ISO)

orphenadrine (EXP)

panobinostat (ISO)

paracetamol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

progesterone (ISO)

quercetin (ISO)

resveratrol (ISO)

rotenone (EXP)

SB 431542 (ISO)

senecionine (ISO)

Senkirkine (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sotorasib (ISO)

sulfadimethoxine (EXP)

sulforaphane (ISO)

tamoxifen (EXP)

tetrachloromethane (ISO)

tetracycline (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trametinib (ISO)

trichostatin A (ISO)

triphenyl phosphate (EXP)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

vorinostat (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acyl-CoA metabolic process (IBA)

biological_process (ND)

fatty acid biosynthetic process (IBA,IEA,ISO)

Cellular Component

mitochondrial matrix (IBA,IEA,ISO)

mitochondrion (ISO,ISS)

Molecular Function

ATP binding (IEA)

butyrate-CoA ligase activity (IEA,ISO,ISS)

fatty acid ligase activity (IBA,IEA,ISO)

fatty-acyl-CoA synthase activity (IBA)

metal ion binding (IEA)

methylbutanoate-CoA ligase activity (IEA)

propionate CoA-transferase activity (IEA,ISO)

propionate-CoA ligase activity (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

butanoate metabolic pathway (IEA)

fatty acid beta degradation pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Overweight, but not hypertension, is associated with SAH polymorphisms in Caucasians with essential hypertension.	Benjafield AV, etal., Hypertens Res. 2003 Aug;26(8):591-5.
2.	Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics	Chen Y, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2001 Oct;18(5):366-70.
3.	Impaired butyrate oxidation in ulcerative colitis is due to decreased butyrate uptake and a defect in the oxidation pathway.	De Preter V, etal., Inflamm Bowel Dis. 2012 Jun;18(6):1127-36. doi: 10.1002/ibd.21894. Epub 2011 Oct 10.
4.	Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats.	Garrett MR, etal., Genome Res 1998 Jul;8(7):711-23
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1.	Gu L, etal., J Clin Invest 1996 Feb 1;97(3):777-88
7.	Three microsatellites defining four alleles for the rat SA gene.	Gu L, etal., Mamm Genome 1994 Dec;5(12):833.
8.	Possible alternative splicing of the rat SA gene.	Gu L, etal., Mamm Genome 1995 Sep;6(9):683-4.
9.	SA gene and blood pressure cosegregation using Dahl salt-sensitive rats.	Harris EL, etal., Am J Hypertens 1993 Apr;6(4):330-4.
10.	Novel quantitative trait loci for blood pressure and related traits on rat chromosomes 1, 10, and 18.	Kovacs P, etal., Biochem Biophys Res Commun 1997 Jun 18;235(2):343-8
11.	Molecular genetics of the SA-gene: cosegregation with hypertension and mapping to rat chromosome 1.	Lindpaintner K, etal., J Hypertens 1993 Jan;11(1):19-23
12.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
13.	Role of genetic polymorphism in the SA gene on the blood pressure and prognosis of renal function in patients with immunoglobulin A nephropathy.	Narita I, etal., Hypertens Res. 2002 Nov;25(6):831-6.
14.	Retinal gene profiling in a hereditary rodent model of elevated intraocular pressure.	Naskar R and Thanos S, Mol Vis. 2006 Oct 18;12:1199-210.
15.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
16.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
17.	GOA pipeline	RGD automated data pipeline
18.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
20.	Comprehensive gene review and curation	RGD comprehensive gene curation
21.	Localization of a blood pressure QTL on rat chromosome 1 using dahl rat congenic strains	Saad Y, etal., Physiol Genomics 1999 Nov 11;1(3):119-25.
22.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
23.	Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome.	Watkins PA, etal., J Lipid Res. 2007 Dec;48(12):2736-50. Epub 2007 Aug 30.

Additional References at PubMed

PMID:11470804	PMID:12477932	PMID:14651853	PMID:18614015	PMID:33923085

Genomics

Comparative Map Data

Acsm3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	174,133,260 - 174,159,966 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	174,133,288 - 174,160,184 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	182,448,828 - 182,475,531 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	189,634,871 - 189,661,572 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	182,371,819 - 182,397,104 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	189,514,504 - 189,541,233 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	189,514,553 - 189,541,224 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	196,449,042 - 196,475,596 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	178,054,386 - 178,081,751 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	178,212,017 - 178,214,310 (+)	NCBI
Celera	1	171,883,756 - 171,910,443 (+)	NCBI		Celera
Cytogenetic Map	1	q35	NCBI

ACSM3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	20,674,405 - 20,797,581 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	20,610,243 - 20,797,581 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	20,775,336 - 20,808,903 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	20,682,813 - 20,715,980 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	20,682,812 - 20,715,979	NCBI
Celera	16	20,085,531 - 20,118,378 (+)	NCBI		Celera
Cytogenetic Map	16	p12.3	NCBI
HuRef	16	19,310,909 - 19,343,750 (+)	NCBI		HuRef
CHM1_1	16	20,862,551 - 20,895,398 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	20,605,311 - 20,728,512 (+)	NCBI		T2T-CHM13v2.0

Acsm3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	119,360,106 - 119,384,119 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	119,360,146 - 119,386,736 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	119,760,883 - 119,784,896 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	119,760,923 - 119,787,513 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	126,904,437 - 126,928,410 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	119,552,072 - 119,576,045 (+)	NCBI		MGSCv36	mm8
Celera	7	119,680,775 - 119,704,303 (+)	NCBI		Celera
Cytogenetic Map	7	F2	NCBI
cM Map	7	64.17	NCBI

Acsm3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955493	72,633 - 96,348 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955493	73,306 - 95,521 (+)	NCBI	ChiLan1.0	ChiLan1.0

ACSM3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	16	26,438,183 - 26,485,179 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	17,611,715 - 17,644,587 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	20,796,425 - 20,829,734 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	20,796,425 - 20,829,315 (+)	Ensembl	panpan1.1		panPan2

ACSM3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	24,558,010 - 24,594,326 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	24,558,142 - 24,582,728 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	22,794,570 - 22,815,828 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	24,713,351 - 24,738,717 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	24,713,760 - 24,738,638 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	24,514,283 - 24,539,642 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	24,409,510 - 24,434,851 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	24,793,586 - 24,812,573 (-)	NCBI		UU_Cfam_GSD_1.0

Acsm3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	117,980,363 - 117,997,679 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936501	6,078,219 - 6,095,538 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936501	6,077,366 - 6,095,432 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ACSM3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	25,247,725 - 25,283,709 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	25,247,723 - 25,284,063 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	26,031,989 - 26,068,440 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ACSM3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	18,876,390 - 18,929,914 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	18,904,110 - 18,929,729 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	10,973,567 - 11,023,810 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Acsm3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624782	6,930,505 - 6,959,069 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624782	6,930,461 - 6,958,867 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Acsm3
97 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	62
Count of miRNA genes:	48
Interacting mature miRNAs:	61
Transcripts:	ENSRNOT00000020039
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32737458	199368955	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49393289	199050459	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	81591954	219808434	Rat
1358902	Bw47	Body weight QTL 47	1.67		body mass (VT:0001259)	body weight (CMO:0000012)	1	90508614	180359386	Rat
1331751	Bp199	Blood pressure QTL 199	3.60022		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	94494440	181830018	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	94494440	198211706	Rat
70209	Niddm23	Non-insulin dependent diabetes mellitus QTL 23	2.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	94494440	198324465	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94642644	214537671	Rat
8655649	Arrd1	Age-related retinal degeneration QTL 1	4.89		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	100357752	183970443	Rat
1354591	Cm36	Cardiac mass QTL 36	4.1		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	102813953	201278233	Rat
1354615	Cm32	Cardiac mass QTL 32	5.2		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	102813953	201278233	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	102813953	218753816	Rat
1300158	Bp173	Blood pressure QTL 173	3.48		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	1	115540693	185145286	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	115540693	238914717	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118608292	241799120	Rat
631205	Bp196	Blood pressure QTL 196	4	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118944897	199050459	Rat
631544	Bp84	Blood pressure QTL 84	5.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350408	181759564	Rat
1358189	Cstrr1	Cold stress response QTL 1		0.0001	catecholamine amount (VT:0010543)	urine norepinephrine level (CMO:0001629)	1	123350408	182418476	Rat
1641895	Bp298	Blood pressure QTL 298			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	123350408	182418476	Rat
1578770	Stresp23	Stress response QTL 23			kidney sympathetic nerve activity (VT:0004050)	stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)	1	123350408	182418476	Rat
631549	Bp89	Blood pressure QTL 89	5.7		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350581	201284552	Rat
738006	Anxrr14	Anxiety related response QTL 14	4	0.00035	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	130636910	175636910	Rat
738028	Anxrr12	Anxiety related response QTL 12	4.9	0.00001	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	130636910	175636910	Rat
6893347	Bw98	Body weight QTL 98	0.2	0.53	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
6893361	Bw104	Body weight QTL 104	0.59	0.27	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
1558645	Bw55	Body weight QTL 55	3.2	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
71118	Thym1	Thymus enlargement QTL 1	10.17	0.001	thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	136829932	181829932	Rat
724550	Thym3	Thymus enlargement QTL 3	7.82	0.001	thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	136829932	181829932	Rat
631519	Pia11	Pristane induced arthritis QTL 11	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	136830018	181830018	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	143506580	212458660	Rat
61348	Bp30	Blood pressure QTL 30	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	144017057	197814409	Rat
70160	Bw18	Body weight QTL 18	5.7		body mass (VT:0001259)	body weight (CMO:0000012)	1	144267353	196383668	Rat
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	144267353	222987745	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	144267353	251128347	Rat
61379	Bp44	Blood pressure QTL 44	19.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	144267916	174133260	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	149448574	221264292	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	150700142	252085212	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	150700247	252085048	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	150700247	252085048	Rat
1354602	Bw35	Body weight QTL 35	12.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	201278233	Rat
1354620	Kidm19	Kidney mass QTL 19	4		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	201278233	Rat
1354634	Kidm12	Kidney mass QTL 12	3.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	1	151162512	201278233	Rat
1354636	Lmblg1	Limb length QTL 1	6.4		tibia length (VT:0004357)	tibia length (CMO:0000450)	1	151162512	201278233	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	256448636	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	151162766	225824951	Rat
61343	Bp28	Blood pressure QTL 28			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	151646613	196646613	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	153136852	260522016	Rat
2303622	Vencon6	Ventilatory control QTL 6		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	1	154561505	199561505	Rat
4889428	Stresp24	Stress response QTL 24		0.05	heart pumping trait (VT:2000009)	absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)	1	155866514	200866514	Rat
631548	Bp88	Blood pressure QTL 88	5	0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	156677124	176484451	Rat
1354618	Kidm15	Kidney mass QTL 15	5		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	1	156677124	201278233	Rat
2312420	Pur17	Proteinuria QTL 17	7.1	0.0001	urine protein amount (VT:0005160)	urine total protein excretion rate (CMO:0000756)	1	156677124	218753816	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	156677124	256448636	Rat
61347	Bp197	Blood pressure QTL 197	4.2		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	1	158633083	203633083	Rat
2292222	Bp307	Blood pressure QTL 307	3.06	0.0014	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	213533942	Rat
2292220	Bp306	Blood pressure QTL 306	3.47	0.00087	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	243914901	Rat
619613	Bp77	Blood pressure QTL 77		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164747424	209747424	Rat
619613	Bp77	Blood pressure QTL 77		0.01	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	164747424	209747424	Rat
737974	Bp161	Blood pressure QTL 161		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	164747558	181133855	Rat
2312558	Glom17	Glomerulus QTL 17	3.9	0.001	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	166532971	191278129	Rat
1354653	Despr9	Despair related QTL 9		0.00019	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	167909849	212909849	Rat
619614	Bp78	Blood pressure QTL 78		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	169112897	197261052	Rat
619614	Bp78	Blood pressure QTL 78		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	169112897	197261052	Rat
61341	Bp26	Blood pressure QTL 26			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	169537671	214537671	Rat
724562	Rends1	Renal damage susceptibility QTL 1		0.05	kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	1	169537671	214537671	Rat
1358294	Bw37	Body weight QTL 37	5	0.000011	body mass (VT:0001259)	body weight (CMO:0000012)	1	171310381	216310381	Rat
2293689	Bss47	Bone structure and strength QTL 47	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	1	171629477	216629477	Rat
2293693	Bss22	Bone structure and strength QTL 22	33.52	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	1	171629477	216629477	Rat
2300161	Bmd43	Bone mineral density QTL 43	8.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	171629477	216629477	Rat
2300174	Bmd42	Bone mineral density QTL 42	8.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	bone mineral density (CMO:0001226)	1	171629477	216629477	Rat
2300187	Bmd41	Bone mineral density QTL 41	8.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	171629477	216629477	Rat
2293654	Bss30	Bone structure and strength QTL 30	32.65	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	1	171629477	216629477	Rat
2293673	Bss27	Bone structure and strength QTL 27	18.63	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	1	171629477	216629477	Rat
2293677	Bss41	Bone structure and strength QTL 41	9.38	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	1	171629477	216629477	Rat
1549830	Bss1	Bone structure and strength QTL 1	4.8		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	172609619	217609619	Rat
61326	Eae6	Experimental allergic encephalomyelitis QTL 6	5.3		body mass (VT:0001259)	change in body weight (CMO:0002045)	1	172949660	181830018	Rat
631214	Bw61	Body weight QTL61	3.4	0.0001	intramuscular adipose amount (VT:0010044)	intramuscular fat area (CMO:0001162)	1	173108781	218108781	Rat
631670	Iddm10	Insulin dependent diabetes mellitus QTL 10	1.9		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	174133260	196383668	Rat
70163	Bw20	Body weight QTL 20	5.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	174133260	219133260	Rat

Markers in Region

D1Mco13

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	174,149,124 - 174,149,306 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	189,530,391 - 189,530,572	NCBI	Rnor6.0
Rnor_5.0	1	196,464,943 - 196,465,124	UniSTS	Rnor5.0
RGSC_v3.4	1	178,070,773 - 178,070,955	RGD	RGSC3.4
RGSC_v3.4	1	178,070,774 - 178,070,955	UniSTS	RGSC3.4
RGSC_v3.1	1	178,210,019 - 178,210,201	RGD
Celera	1	171,899,582 - 171,899,763	UniSTS
Cytogenetic Map	1	q35	UniSTS

D1Mco14

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	174,144,236 - 174,144,507 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	189,525,503 - 189,525,773	NCBI	Rnor6.0
Rnor_5.0	1	196,460,055 - 196,460,325	UniSTS	Rnor5.0
RGSC_v3.4	1	178,065,885 - 178,066,157	RGD	RGSC3.4
RGSC_v3.4	1	178,065,886 - 178,066,156	UniSTS	RGSC3.4
RGSC_v3.1	1	178,205,131 - 178,205,403	RGD
Celera	1	171,894,694 - 171,894,964	UniSTS
Cytogenetic Map	1	q35	UniSTS

D1Wox50

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	174,144,297 - 174,144,500 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	189,525,564 - 189,525,766	NCBI	Rnor6.0
Rnor_5.0	1	196,460,116 - 196,460,318	UniSTS	Rnor5.0
RGSC_v3.4	1	178,065,947 - 178,066,149	UniSTS	RGSC3.4
Celera	1	171,894,755 - 171,894,957	UniSTS
Cytogenetic Map	1	q35	UniSTS

D1Wox49

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	174,149,124 - 174,149,303 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	189,530,391 - 189,530,569	NCBI	Rnor6.0
Rnor_5.0	1	196,464,943 - 196,465,121	UniSTS	Rnor5.0
RGSC_v3.4	1	178,070,774 - 178,070,952	UniSTS	RGSC3.4
Celera	1	171,899,582 - 171,899,760	UniSTS
Cytogenetic Map	1	q35	UniSTS

BE108110

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	174,153,189 - 174,153,353 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	189,534,457 - 189,534,620	NCBI	Rnor6.0
Rnor_5.0	1	196,468,820 - 196,468,983	UniSTS	Rnor5.0
RGSC_v3.4	1	178,074,930 - 178,075,093	UniSTS	RGSC3.4
Celera	1	171,903,644 - 171,903,807	UniSTS
RH 3.4 Map	1	1376.4	UniSTS
Cytogenetic Map	1	q35	UniSTS

RH144126

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	174,147,791 - 174,148,287 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	189,529,058 - 189,529,553	NCBI	Rnor6.0
Rnor_5.0	1	196,463,610 - 196,464,105	UniSTS	Rnor5.0
RGSC_v3.4	1	178,069,441 - 178,069,936	UniSTS	RGSC3.4
Celera	1	171,898,249 - 171,898,744	UniSTS
Cytogenetic Map	1	q35	UniSTS

BE098160

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	174,158,902 - 174,159,114 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	189,540,170 - 189,540,381	NCBI	Rnor6.0
Rnor_5.0	1	196,474,533 - 196,474,744	UniSTS	Rnor5.0
RGSC_v3.4	1	178,080,688 - 178,080,899	UniSTS	RGSC3.4
Celera	1	171,909,380 - 171,909,591	UniSTS
Cytogenetic Map	1	q35	UniSTS

Related Rat Strains

The following Strains have been annotated to Acsm3

BB.SHR-(Acsm3-Igf2)/K SHR.WKY-(D1Wox34-Sah)/Njs WKY.SHRSP-Sah/Jr

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			21	21		21				27	12
Low	3	5	28	12	19	12	3	3	40	8	21	11	3
Below cutoff		6	8	8		8	5	7	24		6		5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_033231	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006230105	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006230106	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039100816	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039100820	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY455861	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY456695	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC090325	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ209573	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HC890693	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HC895225	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000044	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S62516	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S62903	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U04637	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U04638	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U19832	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000020039 ⟹ ENSRNOP00000020039

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	174,133,288 - 174,159,957 (+)	Ensembl
Rnor_6.0 Ensembl	1	189,514,553 - 189,541,224 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000100187 ⟹ ENSRNOP00000081130

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	174,133,288 - 174,160,184 (+)	Ensembl

RefSeq Acc Id:

NM_033231 ⟹ NP_150234

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	174,133,288 - 174,159,966 (+)	NCBI
Rnor_6.0	1	189,514,553 - 189,541,233 (+)	NCBI
Rnor_5.0	1	196,449,042 - 196,475,596 (+)	NCBI
RGSC_v3.4	1	178,054,386 - 178,081,751 (+)	RGD
Celera	1	171,883,756 - 171,910,443 (+)	RGD

Sequence:

show sequence

GAGAAATTGGCTTTCTCTCCCATTAAGCAGGTCTACTATCATTCCAGCTGTGGGAAGCAGTATC
TTTAGTGAAAAACAAGGAGGCTCAAGTGGAAAATCTAGAAGAGCTCAAGATCACTGACTTGTGA
GCTTCTCACACAAGGAGGTGGACACCAGGAGCGCCTGGGTTTCAAATGCATCCAGTTCATCAAC
ACGATGCCTAACCACCAAATCCATCTGGAGTAGTCTGCATGGAAATCTCACATTCCAAAACAAT
TAATAATATTGATACTAGCTATCTCTTGTCACCATGGCAATGTTACTTCGTGCTAGGTGTTTTC
ACCGCCTAGCAATCCCTGATCCCAGGAGAATCTTGTATAAAGATTACAGAACAGCGATTCCTCA
GAACTTTTCCAACTATGAGTCCATGAAACATGACTTCAAAATAGAGATTCCAGAGTATTTCAAT
TTTGCAAAAGATGTTTTGGACCAATGGACCAATACGGAAAAGACTGGAAAAAGACTTTCCAATC
CAGCCTTCTGGTGGGTAGATGGAAATGGAAAGGAGGTGAGATGGAGTTTTGAAGAACTTGGGTC
TTTATCCAGGAAATTTGCCAACATACTCACAGAAGCCTGTTCCCTGCAAAGAGGAGATAGAGTA
ATGGTGATTCTGCCCAAGATCCCAGAGTGGTGGCTTGCAAATGTAGCCTGTCTGCGAACAGGGA
CAGTTTTAATTCCAGGAACCACTCAGCTGACCCAGAAAGACATCCTCTACAGGCTACAATCTTC
AAAATCAAAGTGCATTATTACTGATGATACTTTGGCCCCAGCAGTAGATATTGTAGCAGCTAAA
TGTGAAAATCTCCACTCCAAATTAATTGTGTCTCAGCACTCCAGAGAAGGCTGGGGGAACCTCA
AGGAGATGATGAAATATGCCAGTGACAGCCACACCTGTGTGGACACAAAACACAATGAGTTGAT
GGCCATCTACTTCACCAGTGGGACGACTGGGCCTCCGAAGATGATTGGACACACCCACAGCAGT
TTTGGTTTAGGACTGTCTGTCAACGGAAGGTTCTGGCTGGATTTGATAGCCTCTGACGTGATGT
GGAATACGTCAGATACAGGCTGGGCAAAGTCTGCATGGAGTAGTGTTTTTTCTCCGTGGACCCA
AGGAGCATGTGTTTTTGCACACTATTTGCCCCGTTTTGATTCAACTTCCATCTTGCAAACCCTC
TCCAAGTTTCCCATCACTGTCTTCTGTTCTGCACCAACTGCCTACCGGATGCTTATACAGAATG
ACATAACCAGCTATAAGTTCAACAGTTTGAAGCACTGTGTGAGTGCCGGGGAACCCATCAACCC
TGAAGTGATGGAACAATGGAAAAAGAAGACAGGACTAGACATCTACGAAGGATATGGACAGACA
GAAACGGTGCTGATCTGTGGAAATTTCAAGGGGATGAAAATTAAGCCTGGCTCAATGGGGAAGC
CCTCTCCTGCTTTTAATGTGGAGATTTTAGATGAAAATGGCACTATTCTTCCTCCTGGACAAGA
AGGGGATATTGCTGTTCAAGTTCTTCCTGATCGACCATTTGGCCTTTTTACTCATTATGTAGAT
AATCCTTCGAAAACAGCTTCAACTCTACGAGGGAATTTCTACATCACTGGGGACAGAGGCTATA
TGGATGAGGATGGCTATTTCTGGTTTGTTGCAAGATCAGACGATGTCATATTATCCTCTGGTTA
CCGAATTGGACCATTTGAGGTAGAGAGTGCTCTCATAGAGCATCCTTCCATTGCAGAGTCAGCT
GTTGTCAGCAGCCCTGACCCCATCAGAGGAGAGGTAGTAAAGGCCTTTATTGTCCTAAATCCTG
ATTACAAACTCCATGATCAAGAACAACTGAAAAAAGAGATTCAGGAGCATGTGAAAAAGACTAC
AGCACCTTACAAATACCCCAGGAAGATAGAATTTATTGAGGAGCTGCCAAAGACTGTCAGTGGG
AAGGTCAAAAGAAATGAACTGAGGAGAAAGGAATGGACAACAACTTAAACTTGGCCCACTAATC
ACCTGCATATCTACAAGTAAACACAGTGTCTCTGAGTCTACAGGAACCACAGATCACGTGGGCA
GACTGCTTTTAAATTGGATTTAAACTATTTTGTAGAATGAAACCATAGGCTGAATTATGAAATC
ATATAATCACTGAATCCTTCTGCCTTCATGTCAATGTTCCTGTAATTTGCAACATAAAATGAAT
GTTATCAGATGCCGTGATGCCTTAAAATTTATTTTAGGAGCTGTTTCTAAACCAAATCTCTGCC
CCATGGGTTTTCAAAACTTAACTGAACAATTCTAATATGCCAATATACAAATCAGAACAAATCT
TCAAGCTTTGAAGGAAACTGTCATAATTCTTAGAATACTTACCTAAAAGTTGAGTAGGAATTTT
ACTAGTCATAATTTTATTCAAGTAATTTAAAAATAGTTTGAAATTTGTTTCAATGTCAAAGTAT
AAGAGACAGCTGTCATATTCTATGGTTAGTTATTAAATTTAACCTAATAAATATGGTTTATAAA
AATAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006230106 ⟹ XP_006230168

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	174,141,068 - 174,159,966 (+)	NCBI
Rnor_6.0	1	189,514,504 - 189,541,233 (+)	NCBI
Rnor_5.0	1	196,449,042 - 196,475,596 (+)	NCBI

Sequence:

show sequence

AGGTCAAATTCTGTCCACTTTGATCTACTGGCAACACTAAAGCAGAGGTGAAAAACAAGGAGGC
TCAAGTGGAAAATCTAGAAGAGCTCAAGATCACTGACTTGTGAGCTTCTCACACAAGGAGGTGG
ACACCAGGAGCGCCTGGGTTTCAAATGCATCCAGTTCATCAACACGATGCCTAACCACCAAATC
CATCTGGAGTAGTCTGCATGGAAATCTCACATTCCAAAACAATTAATAATATTGATACTAGCTA
TCTCTTGTCACCATGGCAATGTTACTTCGTGCTAGGTGTTTTCACCGCCTAGCAATCCCTGATC
CCAGGAGAATCTTGTATAAAGATTACAGAACAGCGATTCCTCAGAACTTTTCCAACTATGAGTC
CATGAAACATGACTTCAAAATAGAGATTCCAGAGTATTTCAATTTTGCAAAAGATGTTTTGGAC
CAATGGACCAATACGGAAAAGACTGGAAAAAGACTTTCCAATCCAGCCTTCTGGTGGGTAGATG
GAAATGGAAAGGAGGTGAGATGGAGTTTTGAAGAACTTGGGTCTTTATCCAGGAAATTTGCCAA
CATACTCACAGAAGCCTGTTCCCTGCAAAGAGGAGATAGAGTAATGGTGATTCTGCCCAAGATC
CCAGAGTGGTGGCTTGCAAATGTAGCCTGTCTGCGAACAGGGACAGTTTTAATTCCAGGAACCA
CTCAGCTGACCCAGAAAGACATCCTCTACAGGCTACAATCTTCAAAATCAAAGTGCATTATTAC
TGATGATACTTTGGCCCCAGCAGTAGATATTGTAGCAGCTAAATGTGAAAATCTCCACTCCAAA
TTAATTGTGTCTCAGCACTCCAGAGAAGGCTGGGGGAACCTCAAGGAGATGATGAAATATGCCA
GTGACAGCCACACCTGTGTGGACACAAAACACAATGAGTTGATGGCCATCTACTTCACCAGTGG
GACGACTGGGCCTCCGAAGATGATTGGACACACCCACAGCAGTTTTGGTTTAGGACTGTCTGTC
AACGGAAGGTTCTGGCTGGATTTGATAGCCTCTGACGTGATGTGGAATACGTCAGATACAGGCT
GGGCAAAGTCTGCATGGAGTAGTGTTTTTTCTCCGTGGACCCAAGGAGCATGTGTTTTTGCACA
CTATTTGCCCCGTTTTGATTCAACTTCCATCTTGCAAACCCTCTCCAAGTTTCCCATCACTGTC
TTCTGTTCTGCACCAACTGCCTACCGGATGCTTATACAGAATGACATAACCAGAAGCTATAAGT
TCAACAGTTTGAAGCACTGTGTGAGTGCCGGGGAACCCATCAACCCTGAAGTGATGGAACAATG
GAAAAAGAAGACAGGACTAGACATCTACGAAGGATATGGACAGACAGAAACGGTGCTGATCTGT
GGAAATTTCAAGGGGATGAAAATTAAGCCTGGCTCAATGGGGAAGCCCTCTCCTGCTTTTAATG
TGGAGATTTTAGATGAAAATGGCACTATTCTTCCTCCTGGACAAGAAGGGGATATTGCTGTTCA
AGTTCTTCCTGATCGACCATTTGGCCTTTTTACTCATTATGTAGATAATCCTTCGAAAACAGCT
TCAACTCTACGAGGGAATTTCTACATCACTGGGGACAGAGGCTATATGGATGAGGATGGCTATT
TCTGGTTTGTTGCAAGATCAGACGATGTCATATTATCCTCTGGTTACCGAATTGGACCATTTGA
GGTAGAGAGTGCTCTCATAGAGCATCCTTCCATTGCAGAGTCAGCTGTTGTCAGCAGCCCTGAC
CCCATCAGAGGAGAGGTAGTAAAGGCCTTTATTGTCCTAAATCCTGATTACAAACTCCATGATC
AAGAACAACTGAAAAAAGAGATTCAGGAGCATGTGAAAAAGACTACAGCACCTTACAAATACCC
CAGGAAGATAGAATTTATTGAGGAGCTGCCAAAGACTGTCAGTGGGAAGGTCAAAAGAAATGAA
CTGAGGAGAAAGGAATGGACAACAACTTAAACTTGGCCCACTAATCACCTGCATATCTACAAGT
AAACACAGTGTCTCTGAGTCTACAGGAACCACAGATCACGTGGGCAGACTGCTTTTAAATTGGA
TTTAAACTATTTTGTAGAATGAAACCATAGGCTGAATTATGAAATCATATAATCACTGAATCCT
TCTGCCTTCATGTCAATGTTCCTGTAATTTGCAACATAAAATGAATGTTATCAGATGCCGTGAT
GCCTTAAAATTTATTTTAGGAGCTGTTTCTAAACCAAATCTCTGCCCCATGGGTTTTCAAAACT
TAACTGAACAATTCTAATATGCCAATATACAAATCAGAACAAATCTTCAAGCTTTGAAGGAAAC
TGTCATAATTCTTAGAATACTTACCTAAAAGTTGAGTAGGAATTTTACTAGTCATAATTTTATT
CAAGTAATTTAAAAATAGTTTGAAATTTGTTTCAATGTCAAAGTATAAGAGACAGCTGTCATAT
TCTATGGTTAGTTATTAAATTTAACCTAATAAATATGGTTTATAAAAATA

hide sequence

RefSeq Acc Id:

XM_039100816 ⟹ XP_038956744

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	174,133,260 - 174,159,966 (+)	NCBI

RefSeq Acc Id:

XM_039100820 ⟹ XP_038956748

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	174,141,068 - 174,153,259 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_150234	(Get FASTA)	NCBI Sequence Viewer
	XP_006230168	(Get FASTA)	NCBI Sequence Viewer
	XP_038956744	(Get FASTA)	NCBI Sequence Viewer
	XP_038956748	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA95995	(Get FASTA)	NCBI Sequence Viewer
	AAB27107	(Get FASTA)	NCBI Sequence Viewer
	AAB27235	(Get FASTA)	NCBI Sequence Viewer
	AAH90325	(Get FASTA)	NCBI Sequence Viewer
	AAR20710	(Get FASTA)	NCBI Sequence Viewer
	AAR21570	(Get FASTA)	NCBI Sequence Viewer
	CBN59834	(Get FASTA)	NCBI Sequence Viewer
	CBN62051	(Get FASTA)	NCBI Sequence Viewer
	EDM17651	(Get FASTA)	NCBI Sequence Viewer
	EDM17652	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000020039
	ENSRNOP00000081130.1
GenBank Protein	Q6SKG1	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_150234 ⟸ NM_033231

- UniProtKB:

Q62742 (UniProtKB/Swiss-Prot), Q6SKG1 (UniProtKB/Swiss-Prot), A6I8M8 (UniProtKB/TrEMBL), A0A8I6G5I9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAMLLRARCFHRLAIPDPRRILYKDYRTAIPQNFSNYESMKHDFKIEIPEYFNFAKDVLDQWTN
TEKTGKRLSNPAFWWVDGNGKEVRWSFEELGSLSRKFANILTEACSLQRGDRVMVILPKIPEWW
LANVACLRTGTVLIPGTTQLTQKDILYRLQSSKSKCIITDDTLAPAVDIVAAKCENLHSKLIVS
QHSREGWGNLKEMMKYASDSHTCVDTKHNELMAIYFTSGTTGPPKMIGHTHSSFGLGLSVNGRF
WLDLIASDVMWNTSDTGWAKSAWSSVFSPWTQGACVFAHYLPRFDSTSILQTLSKFPITVFCSA
PTAYRMLIQNDITSYKFNSLKHCVSAGEPINPEVMEQWKKKTGLDIYEGYGQTETVLICGNFKG
MKIKPGSMGKPSPAFNVEILDENGTILPPGQEGDIAVQVLPDRPFGLFTHYVDNPSKTASTLRG
NFYITGDRGYMDEDGYFWFVARSDDVILSSGYRIGPFEVESALIEHPSIAESAVVSSPDPIRGE
VVKAFIVLNPDYKLHDQEQLKKEIQEHVKKTTAPYKYPRKIEFIEELPKTVSGKVKRNELRRKE
WTTT

hide sequence

RefSeq Acc Id:	XP_006230168 ⟸ XM_006230106
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6G5I9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAMLLRARCFHRLAIPDPRRILYKDYRTAIPQNFSNYESMKHDFKIEIPEYFNFAKDVLDQWTN TEKTGKRLSNPAFWWVDGNGKEVRWSFEELGSLSRKFANILTEACSLQRGDRVMVILPKIPEWW LANVACLRTGTVLIPGTTQLTQKDILYRLQSSKSKCIITDDTLAPAVDIVAAKCENLHSKLIVS QHSREGWGNLKEMMKYASDSHTCVDTKHNELMAIYFTSGTTGPPKMIGHTHSSFGLGLSVNGRF WLDLIASDVMWNTSDTGWAKSAWSSVFSPWTQGACVFAHYLPRFDSTSILQTLSKFPITVFCSA PTAYRMLIQNDITRSYKFNSLKHCVSAGEPINPEVMEQWKKKTGLDIYEGYGQTETVLICGNFK GMKIKPGSMGKPSPAFNVEILDENGTILPPGQEGDIAVQVLPDRPFGLFTHYVDNPSKTASTLR GNFYITGDRGYMDEDGYFWFVARSDDVILSSGYRIGPFEVESALIEHPSIAESAVVSSPDPIRG EVVKAFIVLNPDYKLHDQEQLKKEIQEHVKKTTAPYKYPRKIEFIEELPKTVSGKVKRNELRRK EWTTT hide sequence

RefSeq Acc Id:

ENSRNOP00000020039 ⟸ ENSRNOT00000020039

RefSeq Acc Id:	XP_038956744 ⟸ XM_039100816
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6G5I9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038956748 ⟸ XM_039100820
- Peptide Label:	isoform X3

RefSeq Acc Id:

ENSRNOP00000081130 ⟸ ENSRNOT00000100187

Protein Domains

AMP-binding enzyme C-terminal AMP-dependent synthetase/ligase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6SKG1-F1-model_v2	AlphaFold	Q6SKG1	1-580	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690354

Promoter ID:

EPDNEW_R879

Type:

initiation region

Name:

Acsm3_1

Description:

acyl-CoA synthetase medium-chain family member 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	189,514,516 - 189,514,576	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:62086	AgrOrtholog
BioCyc Gene	G2FUF-57640	BioCyc
BioCyc Pathway	FAO-PWY [fatty acid beta-oxidation I (generic)]	BioCyc
	PWY-5143 [long-chain fatty acid activation]	BioCyc
	PWY-5972 [stearate biosynthesis I (animals)]	BioCyc
	PWY-6000 [gamma-linolenate biosynthesis II (animals)]	BioCyc
	PWY-7049 [icosapentaenoate biosynthesis II (6-desaturase, mammals)]	BioCyc
	PWY-8181 [2-methyl-branched fatty acid beta-oxidation]	BioCyc
	PWY3DJ-11470 [sphingosine and sphingosine-1-phosphate metabolism]	BioCyc
	PWY66-387 [3-methyl-branched fatty acid alpha-oxidation]	BioCyc
	PWY66-388 [ceramide degradation by alpha-oxidation]	BioCyc
	PWY66-389 [phytol degradation]	BioCyc
	PWY66-391 [fatty acid beta-oxidation VI (mammalian peroxisome)]	BioCyc
Ensembl Genes	ENSRNOG00000032246	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000020039	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000100187.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.300.30	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.50.12780	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	AMP-bd_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	AMP-bd_C_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	AMP-binding_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	AMP-dep_Synth/Lig	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	AMP-dep_Synthh-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:24763	UniProtKB/Swiss-Prot
NCBI Gene	24763	ENTREZGENE
PANTHER	ACYL-COENZYME A SYNTHETASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ACYL-COENZYME A SYNTHETASE ACSM3, MITOCHONDRIAL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	AMP-binding	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	AMP-binding_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Acsm3	PhenoGen
PROSITE	AMP_BINDING	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000032246	RatGTEx
Superfamily-SCOP	Acetyl-CoA synthetase-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC224408
UniProt	A0A8I6G5I9	ENTREZGENE, UniProtKB/TrEMBL
	A6I8M8	ENTREZGENE, UniProtKB/TrEMBL
	ACSM3_RAT	UniProtKB/Swiss-Prot
	Q62742	ENTREZGENE
	Q6SKG1	ENTREZGENE
UniProt Secondary	Q62742	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2007-09-13	Acsm3	acyl-CoA synthetase medium-chain family member 3	Sah	SA rat hypertension-associated gene	Symbol and Name updated to reflect Human and Mouse nomenclature	1299863	APPROVED
2005-11-17	Sah	SA rat hypertension-associated gene			Name updated	1299863	APPROVED
2003-04-09	Sah	SA rat hypertension-associated homolog			Symbol and Name updated	629477	APPROVED
2003-03-06	Sah	SA rat hypertension-associated homolog	Sa	ssubA gene	Data merged from RGD:3616	628472	PROVISIONAL
2002-06-10	Sa	ssubA gene			Symbol and Name status set to provisional	70585	PROVISIONAL
2002-06-10	Sah	SA rat hypertension-associated homolog			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)