Aifm1 (apoptosis inducing factor, mitochondria associated 1) - Rat Genome Database

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Gene: Aifm1 (apoptosis inducing factor, mitochondria associated 1) Rattus norvegicus
Analyze
Symbol: Aifm1
Name: apoptosis inducing factor, mitochondria associated 1
RGD ID: 620817
Description: Predicted to enable several functions, including FAD binding activity; NAD(P)H oxidase H2O2-forming activity; and poly-ADP-D-ribose binding activity. Involved in several processes, including cellular response to aldosterone; cellular response to estradiol stimulus; and cellular response to nitric oxide. Predicted to be located in cytosol and mitochondrial intermembrane space. Predicted to be active in mitochondrion and nucleus. Biomarker of middle cerebral artery infarction; retinal detachment; retinitis pigmentosa; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked recessive 4; X-linked deafness 5; and combined oxidative phosphorylation deficiency 6. Orthologous to human AIFM1 (apoptosis inducing factor mitochondria associated 1); PARTICIPATES IN ceramide signaling pathway; apoptotic cell death pathway; INTERACTS WITH (+)-schisandrin B; (+)-sesamin; (Z)-3-butylidenephthalide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Aif; apoptosis-inducing factor 1, mitochondrial; apoptosis-inducing factor 1, mitochondrial-like; apoptosis-inducing factor, mitochondrion-associated 1; LOC103694586; Pdcd8; programmed cell death 8; programmed cell death 8 (apoptosis-inducing factor); programmed cell death protein 8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X132,528,107 - 132,567,237 (-)NCBIGRCr8
mRatBN7.2X127,650,223 - 127,689,356 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX127,650,226 - 127,689,256 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX129,775,936 - 129,815,095 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X133,346,767 - 133,385,907 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X130,873,094 - 130,912,254 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X135,304,063 - 135,343,062 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX135,304,066 - 135,343,087 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X135,375,533 - 135,414,532 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X134,868,878 - 134,908,166 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X134,942,310 - 134,981,599 (-)NCBI
CeleraX126,598,666 - 126,637,656 (-)NCBICelera
Cytogenetic MapXq36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
3-hydroxyisobutryl-CoA hydrolase deficiency  (ISO)
Alzheimer's disease  (ISO)
Auditory Neuropathy  (ISO)
autistic disorder  (ISO)
autosomal hemophilia A  (ISO)
autosomal recessive nonsyndromic deafness 9  (ISO)
Brain Hypoxia-Ischemia  (IEP)
Brain Injuries  (IEP)
Charcot-Marie-Tooth disease  (ISO)
Charcot-Marie-Tooth disease type X  (ISO)
Charcot-Marie-Tooth disease X-linked recessive 4  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
combined oxidative phosphorylation deficiency  (ISO)
combined oxidative phosphorylation deficiency 6  (ISO)
Diabetic Cystopathy  (IDA)
dilated cardiomyopathy 1H  (ISO)
Experimental Diabetes Mellitus  (ISO)
factor VIII deficiency  (ISO)
genetic disease  (ISO)
Huntington's disease  (ISO)
hypomyelinating leukodystrophy  (ISO)
intellectual disability  (ISO)
leukodystrophy  (ISO)
metachromatic leukodystrophy  (ISO)
middle cerebral artery infarction  (IEP)
mitochondrial complex I deficiency  (ISS)
Myocardial Reperfusion Injury  (IEP,ISO)
Necrosis  (ISO)
neuropathy  (ISO)
peripheral nervous system disease  (ISO)
prostate cancer  (ISO)
retinal detachment  (IEP,ISO)
retinitis pigmentosa  (IEP)
Sarcopenia  (IEP)
sensorineural hearing loss  (ISO)
Sketetal Dysplasia Coarse Facies Mental Retardation  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
syndromic X-linked intellectual disability Raymond type  (ISO)
transient cerebral ischemia  (IEP,ISO)
type 1 diabetes mellitus  (ISO)
X-linked deafness 5  (ISO)
X-linked Spondyloepimetaphyseal Dysplasia with Hypomyelinating Leukodystrophy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(+)-sesamin  (EXP)
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-gambogic acid  (ISO)
(-)-selegiline  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-ropivacaine  (ISO)
(Z)-3-butylidenephthalide  (EXP,ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one  (ISO)
3',4'-dimethoxyflavone  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (EXP,ISO)
3-methyladenine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
5-Hydroxycapric acid  (EXP,ISO)
6-bromoindirubin-3'-oxime  (ISO)
8-Br-cAMP  (ISO)
9'-cis-neoxanthin  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-neoxanthin  (ISO)
all-trans-retinoic acid  (ISO)
alpha-mangostin  (ISO)
alpha-pinene  (ISO)
alvocidib  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
arsenic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
astaxanthin  (ISO)
atrazine  (ISO)
Auriculasin  (ISO)
azide  (EXP)
baicalein  (ISO)
beauvericin  (ISO)
benzamide  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
Brodifacoum  (EXP)
bromoacetate  (ISO)
buprofezin  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
canertinib  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
casticin  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (EXP,ISO)
chrysazin  (ISO)
ciguatoxin CTX1B  (ISO)
cilostazol  (ISO)
cisplatin  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
coumarin  (ISO)
coumarins  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
diazoxide  (EXP,ISO)
Dibutyl phosphate  (ISO)
dichlorvos  (EXP)
diclofenac  (ISO)
dimethyl sulfoxide  (ISO)
disodium selenite  (ISO)
dizocilpine maleate  (EXP)
doxorubicin  (ISO)
ellagic acid  (ISO)
enniatin  (EXP)
entinostat  (ISO)
erdosteine  (ISO)
ethanol  (ISO)
excitatory amino acid agonist  (EXP)
fenthion  (ISO)
fisetin  (ISO)
flutamide  (ISO)
fomepizole  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glucose  (EXP)
glutathione  (ISO)
glycidol  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (EXP)
homoeriodictyol  (ISO)
hydrogen peroxide  (EXP,ISO)
inulin  (ISO)
iodoacetic acid  (ISO)
isoflurane  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
kainic acid  (ISO)
KN-93  (ISO)
lactacystin  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
lipopolysaccharide  (EXP)
Lupiwighteone  (ISO)
Maduramicin  (EXP)
mangiferin  (EXP)
mechlorethamine  (ISO)
metformin  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP)
minocycline  (EXP,ISO)
MitoTEMPO  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
monocrotophos  (ISO)
monoethyl phthalate  (ISO)
morin  (EXP)
Myrtucommulone A  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodimethylamine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
nelfinavir  (ISO)
nickel dichloride  (EXP)
niclosamide  (ISO)
nitric oxide  (ISO)
nitrofen  (ISO)
nitroprusside  (ISO)
norfloxacin  (ISO)
ochratoxin A  (ISO)
olaparib  (ISO)
ouabain  (ISO)
oxidopamine  (EXP,ISO)
oxybuprocaine  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
Pachymic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perifosine  (ISO)
phenanthridone  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phosphatidylcholine  (ISO)
phytosphingosine  (ISO)
picoxystrobin  (ISO)
pifithrin-alpha hydrobromide  (ISO)
potassium dichromate  (EXP)
Pranoprofen  (ISO)
pyrethrins  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (EXP,ISO)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
rubitecan  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
sappanchalcone  (ISO)
SB 203580  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sorafenib  (ISO)
streptozocin  (EXP,ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
swainsonine  (EXP)
tephrosin  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
ursolic acid  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
wortmannin  (EXP)
Z-Val-Phe-H  (EXP)
zearalenone  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Elevated caspase and AIF gene expression correlate with progression of sarcopenia during aging in male F344BN rats. Baker DJ and Hepple RT, Exp Gerontol. 2006 Nov;41(11):1149-56. Epub 2006 Oct 6.
2. Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis. Braun JS, etal., J Clin Invest. 2002 Jan;109(1):19-27.
3. Translocation of apoptosis-inducing factor in vulnerable neurons after transient cerebral ischemia and in neuronal cultures after oxygen-glucose deprivation. Cao G, etal., J Cereb Blood Flow Metab. 2003 Oct;23(10):1137-50.
4. Left ventricular global transcriptional profiling in human end-stage dilated cardiomyopathy. Colak D, etal., Genomics. 2009 Jul;94(1):20-31. doi: 10.1016/j.ygeno.2009.03.003. Epub 2009 Mar 28.
5. Translocation of apoptosis-inducing factor in cerebellar granule cells exposed to neurotoxic agents inducing oxidative stress. Fonfria E, etal., Eur J Neurosci 2002 Nov;16(10):2013-6.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Relocalization of apoptosis-inducing factor in photoreceptor apoptosis induced by retinal detachment in vivo. Hisatomi T, etal., Am J Pathol. 2001 Apr;158(4):1271-8.
9. Poly(ADP-ribose) polymerase (PARP)-1-independent apoptosis-inducing factor (AIF) release and cell death are induced by eleostearic acid and blocked by alpha-tocopherol and MEK inhibition. Kondo K, etal., J Biol Chem. 2010 Apr 23;285(17):13079-91. doi: 10.1074/jbc.M109.044206. Epub 2010 Feb 22.
10. Evidence of early involvement of apoptosis inducing factor-induced neuronal death in Alzheimer brain. Lee JH, etal., Anat Cell Biol. 2012 Mar;45(1):26-37. doi: 10.5115/acb.2012.45.1.26. Epub 2012 Mar 31.
11. Diabetic cystopathy is associated with PARP/JNK/mitochondrial apoptotic pathway-mediated bladder apoptosis. Li WJ and Oh SJ, Neurourol Urodyn. 2010 Sep;29(7):1332-7. doi: 10.1002/nau.20869.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. Inhibitory peptide of mitochondrial mu-calpain protects against photoreceptor degeneration in rhodopsin transgenic S334ter and P23H rats. Ozaki T, etal., PLoS One. 2013 Aug 9;8(8):e71650. doi: 10.1371/journal.pone.0071650. eCollection 2013.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. Nuclear translocation of apoptosis-inducing factor after focal cerebral ischemia. Plesnila N, etal., J Cereb Blood Flow Metab. 2004 Apr;24(4):458-66.
19. Molecular mechanism of PC12 cell death evoked by sodium nitroprusside, a nitric oxide donor. Pytlowany M, etal., Acta Biochim Pol. 2008;55(2):339-47. Epub 2008 Jun 14.
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Comprehensive gene review and curation RGD comprehensive gene curation
24. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
25. Similar to spironolactone, oxymatrine is protective in aldosterone-induced cardiomyocyte injury via inhibition of calpain and apoptosis-inducing factor signaling. Xiao TT, etal., PLoS One. 2014 Feb 13;9(2):e88856. doi: 10.1371/journal.pone.0088856. eCollection 2014.
26. Cardioprotection by modulation of mitochondrial respiration during ischemia-reperfusion: role of apoptosis-inducing factor. Xu A, etal., Biochem Biophys Res Commun. 2013 Jun 14;435(4):627-33. doi: 10.1016/j.bbrc.2013.05.033. Epub 2013 May 16.
27. Downregulation of Iduna is associated with AIF nuclear translocation in neonatal brain after hypoxia-ischemia. Yang X, etal., Neuroscience. 2017 Mar 27;346:74-80. doi: 10.1016/j.neuroscience.2017.01.010. Epub 2017 Jan 17.
28. The expression of apoptosis inducing factor (AIF) is associated with aging-related cell death in the cortex but not in the hippocampus in the TgCRND8 mouse model of Alzheimer's disease. Yu W, etal., BMC Neurosci. 2014 Jun 10;15:73. doi: 10.1186/1471-2202-15-73.
29. Intranuclear localization of apoptosis-inducing factor (AIF) and large scale DNA fragmentation after traumatic brain injury in rats and in neuronal cultures exposed to peroxynitrite. Zhang X, etal., J Neurochem. 2002 Jul;82(1):181-91.
30. Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens. Zhang Y and Bhavnani BR, BMC Neurosci. 2006 Jun 15;7:49.
31. Bcl-2 transfection via herpes simplex virus blocks apoptosis-inducing factor translocation after focal ischemia in the rat. Zhao H, etal., J Cereb Blood Flow Metab. 2004 Jun;24(6):681-92.
32. Involvement of apoptosis-inducing factor in neuronal death after hypoxia-ischemia in the neonatal rat brain. Zhu C, etal., J Neurochem. 2003 Jul;86(2):306-17.
Additional References at PubMed
PMID:12963035   PMID:14651853   PMID:14707049   PMID:15271982   PMID:15379992   PMID:15489334   PMID:15703386   PMID:15775970   PMID:16077187   PMID:16469926   PMID:17050806   PMID:17094969  
PMID:17292393   PMID:17632284   PMID:18056262   PMID:18508388   PMID:18559257   PMID:18614015   PMID:18782186   PMID:18845835   PMID:19039676   PMID:19061880   PMID:19094082   PMID:19139267  
PMID:19433269   PMID:19633014   PMID:19833151   PMID:19944742   PMID:20111043   PMID:20360685   PMID:20833797   PMID:20850531   PMID:21387140   PMID:21467298   PMID:21502359   PMID:23006905  
PMID:23217327   PMID:24191052   PMID:25283819   PMID:26004228   PMID:26206088   PMID:26316108   PMID:26963167   PMID:27178839   PMID:27377128   PMID:27735993   PMID:28411026   PMID:31654209  
PMID:32319616   PMID:32338336   PMID:33171392   PMID:33527194   PMID:33940381   PMID:38801174  


Genomics

Comparative Map Data
Aifm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X132,528,107 - 132,567,237 (-)NCBIGRCr8
mRatBN7.2X127,650,223 - 127,689,356 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX127,650,226 - 127,689,256 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX129,775,936 - 129,815,095 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X133,346,767 - 133,385,907 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X130,873,094 - 130,912,254 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X135,304,063 - 135,343,062 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX135,304,066 - 135,343,087 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X135,375,533 - 135,414,532 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X134,868,878 - 134,908,166 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X134,942,310 - 134,981,599 (-)NCBI
CeleraX126,598,666 - 126,637,656 (-)NCBICelera
Cytogenetic MapXq36NCBI
AIFM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X130,129,362 - 130,165,841 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX130,124,666 - 130,165,879 (-)EnsemblGRCh38hg38GRCh38
GRCh37X129,263,337 - 129,299,815 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X129,091,018 - 129,127,489 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X128,988,871 - 129,025,343NCBI
CeleraX129,649,901 - 129,686,423 (-)NCBICelera
Cytogenetic MapXq26.1NCBI
HuRefX118,659,694 - 118,695,647 (-)NCBIHuRef
CHM1_1X129,174,949 - 129,211,491 (-)NCBICHM1_1
T2T-CHM13v2.0X128,448,167 - 128,484,647 (-)NCBIT2T-CHM13v2.0
Aifm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X47,563,821 - 47,602,440 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX47,563,821 - 47,602,440 (-)EnsemblGRCm39 Ensembl
GRCm38X48,474,944 - 48,513,563 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX48,474,944 - 48,513,563 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X45,828,121 - 45,866,603 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X44,719,571 - 44,758,053 (-)NCBIMGSCv36mm8
CeleraX35,976,732 - 36,015,059 (-)NCBICelera
Cytogenetic MapXA5NCBI
cM MapX25.68NCBI
Aifm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554734,891,955 - 4,926,428 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554734,891,955 - 4,925,705 (+)NCBIChiLan1.0ChiLan1.0
AIFM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X129,550,035 - 129,586,229 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X129,551,733 - 129,589,827 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X119,256,425 - 119,292,612 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X129,550,287 - 129,586,271 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX129,550,287 - 129,586,271 (-)Ensemblpanpan1.1panPan2
AIFM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X101,275,027 - 101,307,551 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX101,275,017 - 101,307,367 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX87,452,794 - 87,485,312 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X103,131,319 - 103,163,843 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX103,131,319 - 103,163,788 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X100,548,672 - 100,581,159 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X102,394,696 - 102,427,200 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X102,173,062 - 102,205,583 (-)NCBIUU_Cfam_GSD_1.0
Aifm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X99,510,362 - 99,545,953 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364791,441,437 - 1,478,107 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364791,441,508 - 1,477,133 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AIFM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX106,670,520 - 106,708,317 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X106,676,596 - 106,708,290 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X122,445,239 - 122,476,575 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AIFM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X105,383,408 - 105,419,146 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX105,382,693 - 105,419,095 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606542,809,379 - 42,845,438 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aifm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247979,345,726 - 9,384,645 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247979,346,620 - 9,384,531 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aifm1
69 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:127
Count of miRNA genes:98
Interacting mature miRNAs:102
Transcripts:ENSRNOT00000008503
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat

Markers in Region
RH133831  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X127,685,256 - 127,685,467 (+)MAPPERmRatBN7.2
Rnor_6.0X135,339,092 - 135,339,302NCBIRnor6.0
Rnor_5.0X135,410,562 - 135,410,772UniSTSRnor5.0
RGSC_v3.4X134,904,196 - 134,904,406UniSTSRGSC3.4
CeleraX126,633,686 - 126,633,896UniSTS
RH 3.4 MapX920.4UniSTS
Cytogenetic MapXq35UniSTS
AA901280  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X127,650,284 - 127,650,463 (+)MAPPERmRatBN7.2
Rnor_6.0X135,304,125 - 135,304,303NCBIRnor6.0
Rnor_5.0X135,375,595 - 135,375,773UniSTSRnor5.0
RGSC_v3.4X134,868,940 - 134,869,118UniSTSRGSC3.4
CeleraX126,598,728 - 126,598,906UniSTS
RH 3.4 MapX922.2UniSTS
Cytogenetic MapXq35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000008503   ⟹   ENSRNOP00000008503
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX127,650,226 - 127,689,256 (-)Ensembl
Rnor_6.0 EnsemblX135,304,079 - 135,343,087 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084848   ⟹   ENSRNOP00000074241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX127,650,226 - 127,689,246 (-)Ensembl
Rnor_6.0 EnsemblX135,304,066 - 135,342,996 (-)Ensembl
RefSeq Acc Id: NM_031356   ⟹   NP_112646
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X132,528,107 - 132,567,237 (-)NCBI
mRatBN7.2X127,650,223 - 127,689,356 (-)NCBI
Rnor_6.0X135,304,063 - 135,343,062 (-)NCBI
Rnor_5.0X135,375,533 - 135,414,532 (-)NCBI
RGSC_v3.4X134,868,878 - 134,908,166 (-)RGD
CeleraX126,598,666 - 126,637,656 (-)RGD
Sequence:
RefSeq Acc Id: XM_039100097   ⟹   XP_038956025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X132,528,107 - 132,567,231 (-)NCBI
mRatBN7.2X127,650,223 - 127,689,335 (-)NCBI
RefSeq Acc Id: XM_039100098   ⟹   XP_038956026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X132,528,107 - 132,567,179 (-)NCBI
mRatBN7.2X127,650,223 - 127,689,332 (-)NCBI
RefSeq Acc Id: NP_112646   ⟸   NM_031356
- Peptide Label: precursor
- UniProtKB: Q548E3 (UniProtKB/Swiss-Prot),   Q9JM53 (UniProtKB/Swiss-Prot),   A6JMQ6 (UniProtKB/TrEMBL),   Q924M6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008503   ⟸   ENSRNOT00000008503
Ensembl Acc Id: ENSRNOP00000074241   ⟸   ENSRNOT00000084848
RefSeq Acc Id: XP_038956025   ⟸   XM_039100097
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K7K2 (UniProtKB/TrEMBL),   A6JMQ5 (UniProtKB/TrEMBL),   Q924M6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956026   ⟸   XM_039100098
- Peptide Label: isoform X2
- UniProtKB: Q924M6 (UniProtKB/TrEMBL)
Protein Domains
FAD/NAD(P)-binding   Mitochondrial apoptosis-inducing factor C-terminal   Protein MGARP N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JM53-F1-model_v2 AlphaFold Q9JM53 1-612 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13702018
Promoter ID:EPDNEW_R12536
Type:initiation region
Name:Aifm1_1
Description:apoptosis inducing factor, mitochondria associated 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12537  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X135,343,073 - 135,343,133EPDNEW
RGD ID:13702013
Promoter ID:EPDNEW_R12537
Type:single initiation site
Name:Aifm1_2
Description:apoptosis inducing factor, mitochondria associated 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12536  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X135,343,175 - 135,343,235EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620817 AgrOrtholog
BioCyc Gene G2FUF-1130 BioCyc
Ensembl Genes ENSRNOG00000006067 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055015107 UniProtKB/Swiss-Prot
  ENSRNOG00060018802 UniProtKB/Swiss-Prot
  ENSRNOG00065011395 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008503.6 UniProtKB/Swiss-Prot
  ENSRNOT00000084848.2 UniProtKB/TrEMBL
  ENSRNOT00055025853 UniProtKB/Swiss-Prot
  ENSRNOT00060032463 UniProtKB/Swiss-Prot
  ENSRNOT00065018509 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.390.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.50.50.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7105761 IMAGE-MGC_LOAD
InterPro AIF_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-oxidoreductase/Apoptosis UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-binding_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-linked_Rdtase_dimer_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MGARP_N UniProtKB/TrEMBL
KEGG Report rno:83533 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91436 IMAGE-MGC_LOAD
NCBI Gene 83533 ENTREZGENE
PANTHER APOPTOSIS-INDUCING FACTOR 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AIF-MLS UniProtKB/TrEMBL
  AIF_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyr_redox_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aifm1 PhenoGen
PRINTS FADPNR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PNDRDTASEI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006067 RatGTEx
  ENSRNOG00055015107 RatGTEx
  ENSRNOG00060018802 RatGTEx
  ENSRNOG00065011395 RatGTEx
SMART AIF_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51905 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K7K2 ENTREZGENE, UniProtKB/TrEMBL
  A6JMQ5 ENTREZGENE, UniProtKB/TrEMBL
  A6JMQ6 ENTREZGENE, UniProtKB/TrEMBL
  AIFM1_RAT UniProtKB/Swiss-Prot
  Q548E3 ENTREZGENE
  Q924M6 ENTREZGENE, UniProtKB/TrEMBL
  Q9JM53 ENTREZGENE
UniProt Secondary Q548E3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Aifm1  apoptosis inducing factor, mitochondria associated 1  LOC103694586  apoptosis-inducing factor 1, mitochondrial-like  Data merged from RGD:9081310 737654 PROVISIONAL
2015-11-25 Aifm1  apoptosis inducing factor, mitochondria associated 1  Aifm1  apoptosis-inducing factor, mitochondrion-associated 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103694586  apoptosis-inducing factor 1, mitochondrial-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-02-25 Aifm1  apoptosis-inducing factor, mitochondrion-associated 1  Pdcd8  programmed cell death 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Pdcd8  programmed cell death 8    programmed cell death 8 (apoptosis-inducing factor)  Name updated 1299863 APPROVED
2002-08-07 Pdcd8  programmed cell death 8 (apoptosis-inducing factor)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation undergoes translocation from mitochondria to the nucleus in cerebellar granule cells in response to oxidative stress 633556