Lbr (lamin B receptor) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Lbr (lamin B receptor) Rattus norvegicus
Analyze
Symbol: Lbr
Name: lamin B receptor
RGD ID: 620813
Description: Enables nuclear localization sequence binding activity and protein-folding chaperone binding activity. Predicted to be involved in cholesterol biosynthetic process; neutrophil differentiation; and random inactivation of X chromosome. Located in nuclear envelope. Part of nuclear pore. Human ortholog(s) of this gene implicated in Greenberg dysplasia; Pelger-Huet anomaly; and primary biliary cholangitis. Orthologous to human LBR (lamin B receptor); PARTICIPATES IN cholesterol biosynthetic pathway; histone modification pathway; INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; acetamide; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3-beta-hydroxysterol Delta (14)-reductase; C-14 sterol reductase; C14SR; delta(14)-sterol reductase; delta(14)-sterol reductase LBR; delta-14-SR; integral nuclear envelope inner membrane protein; lamin-B receptor; Nbp60; sterol C14-reductase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81396,071,058 - 96,095,709 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1396,071,081 - 96,095,709 (-)EnsemblGRCr8
mRatBN7.21393,539,386 - 93,564,026 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1393,538,920 - 93,564,017 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1396,044,694 - 96,069,333 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01397,444,580 - 97,469,221 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01394,626,760 - 94,651,399 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.013100,431,390 - 100,450,209 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013106,629,770 - 106,648,432 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41397,814,439 - 97,834,860 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1393,078,084 - 93,097,481 (-)NCBICelera
RGSC_v3.11398,003,374 - 98,023,796 (-)NCBI
Cytogenetic Map13q26NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2-bromohexadecanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
doxorubicin  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
glycidol  (EXP)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
imidazopyrazole  (ISO)
indometacin  (ISO)
leflunomide  (ISO)
menadione  (ISO)
methyl methanesulfonate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
obeticholic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
picoxystrobin  (ISO)
piroxicam  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
endoplasmic reticulum  (IEA)
endoplasmic reticulum membrane  (IEA,ISO,ISS)
fibrillar center  (IEA,ISO)
membrane  (IEA,ISO)
nuclear envelope  (IDA,IEA,ISO)
nuclear inner membrane  (IBA,IEA,ISO)
nuclear lamina  (IEA,ISO)
nuclear membrane  (IEA,ISO)
nuclear pore  (IDA)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Lamin B-receptor mutations in Pelger-Huet anomaly. Best S, etal., Br J Haematol. 2003 Nov;123(3):542-4.
2. Mutations causing Greenberg dysplasia but not Pelger anomaly uncouple enzymatic from structural functions of a nuclear membrane protein. Clayton P, etal., Nucleus. 2010 Jul-Aug;1(4):354-66. doi: 10.4161/nucl.1.4.12435. Epub 2010 May 21.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Purification of a 60 kDa nuclear localization signal binding protein in rat liver nuclear envelopes and characterization of its properties. Haino M, etal., J Biochem. 1993 Mar;113(3):308-13.
5. Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes. Herman GE Hum Mol Genet. 2003 Apr 1;12 Spec No 1:R75-88.
6. Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger-Huet anomaly). Hoffmann K, etal., Nat Genet. 2002 Aug;31(4):410-4. Epub 2002 Jul 15.
7. Subcellular distribution and phosphorylation of the nuclear localization signal binding protein, NBP60. Kawahire S, etal., Exp Cell Res. 1996 Feb 1;222(2):385-94.
8. cDNA cloning of nuclear localization signal binding protein NBP60, a rat homologue of lamin B receptor, and identification of binding sites of human lamin B receptor for nuclear localization signals and chromatin. Kawahire S, etal., J Biochem (Tokyo) 1997 May;121(5):881-9.
9. Autoantibodies from patients with primary biliary cirrhosis recognize a region within the nucleoplasmic domain of inner nuclear membrane protein LBR. Lin F, etal., Hepatology. 1996 Jan;23(1):57-61.
10. Tudor: a versatile family of histone methylation 'readers'. Lu R and Wang GG, Trends Biochem Sci. 2013 Nov;38(11):546-55. doi: 10.1016/j.tibs.2013.08.002. Epub 2013 Sep 10.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. Mutations at the mouse ichthyosis locus are within the lamin B receptor gene: a single gene model for human Pelger-Huet anomaly. Shultz LD, etal., Hum Mol Genet. 2003 Jan 1;12(1):61-9.
19. Reduced lymphocyte longevity and homeostatic proliferation in lamin B receptor-deficient mice results in profound and progressive lymphopenia. Verhagen AM, etal., J Immunol. 2012 Jan 1;188(1):122-34. doi: 10.4049/jimmunol.1100942. Epub 2011 Nov 21.
20. Defects of cholesterol biosynthesis. Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
21. Mapping sites of O-GlcNAc modification using affinity tags for serine and threonine post-translational modifications. Wells L, etal., Mol Cell Proteomics. 2002 Oct;1(10):791-804.
Additional References at PubMed
PMID:9630650   PMID:12618959   PMID:15698635   PMID:15882967   PMID:16784888   PMID:18785926   PMID:19946888   PMID:20457914   PMID:22140257   PMID:22681889   PMID:27336722  


Genomics

Comparative Map Data
Lbr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81396,071,058 - 96,095,709 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1396,071,081 - 96,095,709 (-)EnsemblGRCr8
mRatBN7.21393,539,386 - 93,564,026 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1393,538,920 - 93,564,017 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1396,044,694 - 96,069,333 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01397,444,580 - 97,469,221 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01394,626,760 - 94,651,399 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.013100,431,390 - 100,450,209 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013106,629,770 - 106,648,432 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41397,814,439 - 97,834,860 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1393,078,084 - 93,097,481 (-)NCBICelera
RGSC_v3.11398,003,374 - 98,023,796 (-)NCBI
Cytogenetic Map13q26NCBI
LBR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381225,401,502 - 225,428,821 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1225,401,502 - 225,428,925 (-)Ensemblhg38GRCh38
GRCh371225,589,204 - 225,616,523 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361223,655,827 - 223,683,142 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341221,895,939 - 221,923,254NCBI
Celera1198,779,808 - 198,807,126 (-)NCBICelera
Cytogenetic Map1q42.12NCBI
HuRef1196,108,169 - 196,135,525 (-)NCBIHuRef
CHM1_11226,861,554 - 226,888,910 (-)NCBICHM1_1
T2T-CHM13v2.01224,589,793 - 224,617,112 (-)NCBIT2T-CHM13v2.0
Lbr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391181,642,880 - 181,669,933 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1181,642,900 - 181,670,611 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381181,815,315 - 181,842,401 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1181,815,335 - 181,843,046 (-)Ensemblmm10GRCm38
MGSCv371183,745,446 - 183,772,532 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361183,652,010 - 183,679,007 (-)NCBIMGSCv36mm8
Celera1188,866,925 - 188,894,187 (-)NCBICelera
Cytogenetic Map1H5NCBI
cM Map184.89NCBI
Lbr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955520401,730 - 418,279 (+)Ensembl
ChiLan1.0NW_004955520401,733 - 418,279 (+)NCBIChiLan1.0ChiLan1.0
LBR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2124,104,037 - 24,130,654 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1124,055,083 - 24,081,696 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01200,865,602 - 200,892,199 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11205,870,394 - 205,893,032 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1205,870,394 - 205,893,032 (-)EnsemblpanPan2panpan1.1
LBR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1739,289,517 - 39,309,026 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl739,288,147 - 39,307,606 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha738,769,888 - 38,791,201 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0739,121,962 - 39,143,215 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl739,121,975 - 39,143,213 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1738,961,088 - 38,982,371 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0738,969,806 - 38,991,108 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0739,239,492 - 39,260,863 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lbr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934452,464,512 - 52,492,830 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365262,254,449 - 2,282,785 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365262,254,463 - 2,282,785 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LBR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1013,386,946 - 13,416,759 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11013,389,896 - 13,416,831 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LBR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1254,326,872 - 4,353,208 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl254,330,849 - 4,351,401 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660554,348,972 - 4,376,098 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lbr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248356,469,677 - 6,489,790 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Lbr
139 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:63
Interacting mature miRNAs:68
Transcripts:ENSRNOT00000029841
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 52 67 138 95 11 51 36 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000090712   ⟹   ENSRNOP00000069002
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1396,071,081 - 96,095,709 (-)Ensembl
mRatBN7.2 Ensembl1393,539,386 - 93,564,017 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095219   ⟹   ENSRNOP00000090637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1396,071,081 - 96,095,709 (-)Ensembl
mRatBN7.2 Ensembl1393,538,920 - 93,563,988 (-)Ensembl
RefSeq Acc Id: NM_001393665   ⟹   NP_001380594
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,071,070 - 96,095,709 (-)NCBI
mRatBN7.21393,539,386 - 93,564,026 (-)NCBI
RefSeq Acc Id: XM_039091131   ⟹   XP_038947059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,071,058 - 96,095,603 (-)NCBI
mRatBN7.21393,539,393 - 93,563,652 (-)NCBI
RefSeq Acc Id: XM_039091132   ⟹   XP_038947060
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,071,058 - 96,095,603 (-)NCBI
mRatBN7.21393,539,393 - 93,563,648 (-)NCBI
RefSeq Acc Id: XM_039091133   ⟹   XP_038947061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,071,058 - 96,095,535 (-)NCBI
mRatBN7.21393,539,393 - 93,563,785 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001380594 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947059 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947060 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947061 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA20471 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000090637
GenBank Protein O08984 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_038947061   ⟸   XM_039091133
- Peptide Label: isoform X1
- UniProtKB: A6JGK3 (UniProtKB/TrEMBL),   A0A8I6AEP6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038947059   ⟸   XM_039091131
- Peptide Label: isoform X1
- UniProtKB: A6JGK3 (UniProtKB/TrEMBL),   A0A8I6AEP6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038947060   ⟸   XM_039091132
- Peptide Label: isoform X1
- UniProtKB: A6JGK3 (UniProtKB/TrEMBL),   A0A8I6AEP6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000069002   ⟸   ENSRNOT00000090712
Ensembl Acc Id: ENSRNOP00000090637   ⟸   ENSRNOT00000095219
RefSeq Acc Id: NP_001380594   ⟸   NM_001393665
- UniProtKB: A6JGK3 (UniProtKB/TrEMBL),   A0A8I6AEP6 (UniProtKB/TrEMBL)
Protein Domains
Tudor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JU83-F1-model_v2 AlphaFold A0A0G2JU83 1-620 view protein structure
AF-O08984-F1-model_v2 AlphaFold O08984 1-620 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620813 AgrOrtholog
BioCyc Gene G2FUF-17090 BioCyc
Ensembl Genes ENSRNOG00000052574 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000095219 ENTREZGENE
Gene3D-CATH 1.20.120.1630 UniProtKB/Swiss-Prot
  2.30.30.140 UniProtKB/Swiss-Prot
InterPro Ergosterol_biosynth_ERG4_ERG24 UniProtKB/Swiss-Prot
  Lamin-B_rcpt_of_tudor UniProtKB/Swiss-Prot
  Sterol_reductase_CS UniProtKB/Swiss-Prot
  Tudor UniProtKB/Swiss-Prot
NCBI Gene 89789 ENTREZGENE
PANTHER DELTA(14)-STEROL REDUCTASE UniProtKB/Swiss-Prot
  DELTA(14)-STEROL REDUCTASE LBR UniProtKB/Swiss-Prot
Pfam ERG4_ERG24 UniProtKB/Swiss-Prot
  LBR_tudor UniProtKB/Swiss-Prot
PhenoGen Lbr PhenoGen
PROSITE STEROL_REDUCT_1 UniProtKB/Swiss-Prot
  STEROL_REDUCT_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000052574 RatGTEx
SMART TUDOR UniProtKB/Swiss-Prot
Superfamily-SCOP Tudor/PWWP/MBT UniProtKB/Swiss-Prot
UniProt A0A0G2JU83_RAT UniProtKB/TrEMBL
  A0A8I6AEP6 ENTREZGENE, UniProtKB/TrEMBL
  A6JGK3 ENTREZGENE, UniProtKB/TrEMBL
  LBR_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Lbr  lamin B receptor      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Lbr  lamin B receptor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains amino terminal domain has an NLS-binding site 633039
gene_expression present in the nuclear envelope of the liver cells 633039
gene_homology amino acids 79 and 63% identical to human and chicken LBR respectively 633039
gene_protein encodes a protein of 620 amino acids 633039