Slc12a5 (solute carrier family 12 member 5) - Rat Genome Database

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Gene: Slc12a5 (solute carrier family 12 member 5) Rattus norvegicus
Analyze
Symbol: Slc12a5
Name: solute carrier family 12 member 5
RGD ID: 620811
Description: Enables ammonium channel activity and potassium:chloride symporter activity. Involved in several processes, including inorganic cation transmembrane transport; postsynaptic neurotransmitter receptor diffusion trapping; and regulation of postsynapse assembly. Located in dendrite membrane and perikaryon. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 34. Orthologous to human SLC12A5 (solute carrier family 12 member 5); INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: electroneutral potassium-chloride cotransporter 2; furosemide-sensitive K-Cl cotransporter; K-Cl cotransporter 2; Kcc2; neuronal K-Cl cotransporter; neuronal-specific K-Cl cotransporter; rKCC2; solute carrier family 12 (potassium-chloride transporter), member 5; solute carrier family 12, (potassium-chloride transporter) member 5; solute carrier family 12, member 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau4
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83174,115,833 - 174,155,112 (+)NCBIGRCr8
mRatBN7.23153,696,517 - 153,735,801 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3153,696,517 - 153,735,765 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3157,505,210 - 157,544,609 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03166,004,181 - 166,043,578 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03163,747,957 - 163,787,354 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03161,433,303 - 161,465,078 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3161,425,988 - 161,462,879 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03167,617,776 - 167,649,551 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43156,006,017 - 156,037,915 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13155,912,052 - 155,943,951 (+)NCBI
Celera3152,309,197 - 152,341,061 (+)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
all-trans-retinoic acid  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsanilic acid  (EXP)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
butanal  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cobalt dichloride  (ISO)
dexamethasone  (EXP)
diazepam  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fipronil  (EXP)
folic acid  (ISO)
furosemide  (EXP,ISO)
genistein  (ISO)
isoflurane  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
methimazole  (EXP)
mifepristone  (EXP)
N-ethylmaleimide  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP)
PCB138  (EXP)
potassium chloride  (EXP)
potassium dichromate  (ISO)
propiconazole  (EXP)
resveratrol  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
staurosporine  (ISO)
tetrachloroethene  (ISO)
thallium atom  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triadimefon  (EXP)
trichloroethene  (EXP)
trichostatin A  (EXP)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (EXP)
WIN 55212-2  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity. Casula S, etal., J Biol Chem. 2001 Nov 9;276(45):41870-8. doi: 10.1074/jbc.M107155200. Epub 2001 Sep 10.
2. Expression of K+-Cl- cotransporters in the alpha-cells of rat endocrine pancreas. Davies SL, etal., Biochim Biophys Acta 2004 Nov 17;1667(1):7-14.
3. An ion transport-independent role for the cation-chloride cotransporter KCC2 in dendritic spinogenesis in vivo. Fiumelli H, etal., Cereb Cortex. 2013 Feb;23(2):378-88. doi: 10.1093/cercor/bhs027. Epub 2012 Feb 17.
4. The RCC1 domain of protein associated with Myc (PAM) interacts with and regulates KCC2. Garbarini N and Delpire E, Cell Physiol Biochem. 2008;22(1-4):31-44. doi: 10.1159/000149781. Epub 2008 Jul 25.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. The neuronal K-Cl cotransporter KCC2 influences postsynaptic AMPA receptor content and lateral diffusion in dendritic spines. Gauvain G, etal., Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15474-9. doi: 10.1073/pnas.1107893108. Epub 2011 Aug 30.
7. Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family. Gillen CM, etal., J Biol Chem 1996 Jul 5;271(27):16237-44.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Cell type-specific differences in chloride-regulatory mechanisms and GABA(A) receptor-mediated inhibition in rat substantia nigra. Gulacsi A, etal., J Neurosci. 2003 Sep 10;23(23):8237-46.
10. Interaction of neuron-specific K+-Cl- cotransporter, KCC2, with brain-type creatine kinase. Inoue K, etal., FEBS Lett. 2004 Apr 23;564(1-2):131-5.
11. Taurine inhibits K+-Cl- cotransporter KCC2 to regulate embryonic Cl- homeostasis via with-no-lysine (WNK) protein kinase signaling pathway. Inoue K, etal., J Biol Chem. 2012 Jun 15;287(25):20839-50. doi: 10.1074/jbc.M111.319418. Epub 2012 Apr 27.
12. KCC2 interacts with the dendritic cytoskeleton to promote spine development. Li H, etal., Neuron. 2007 Dec 20;56(6):1019-33. doi: 10.1016/j.neuron.2007.10.039.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Reduction of KCC2 expression and GABAA receptor-mediated excitation after in vivo axonal injury. Nabekura J, etal., J Neurosci 2002 Jun 1;22(11):4412-7.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Functional characterization of the neuronal-specific K-Cl cotransporter: implications for [K+]o regulation. Payne JA Am J Physiol. 1997 Nov;273(5 Pt 1):C1516-25.
18. Molecular characterization of a putative K-Cl cotransporter in rat brain. A neuronal-specific isoform. Payne JA, etal., J Biol Chem 1996 Jul 5;271(27):16245-52.
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Dependence of KCC2 K-Cl cotransporter activity on a conserved carboxy terminus tyrosine residue. Strange K, etal., Am J Physiol Cell Physiol. 2000 Sep;279(3):C860-7.
23. Intracellular acidification in neurons induced by ammonium depends on KCC2 function. Titz S, etal., Eur J Neurosci. 2006 Jan;23(2):454-64.
24. Developmental changes in KCC1, KCC2, and NKCC1 mRNA expressions in the rat brain. Wang C, etal., Brain Res Dev Brain Res 2002 Nov 15;139(1):59-66.
25. Cation transport by the neuronal K(+)-Cl(-) cotransporter KCC2: thermodynamics and kinetics of alternate transport modes. Williams JR and Payne JA, Am J Physiol Cell Physiol. 2004 Oct;287(4):C919-31. Epub 2004 Jun 2.
Additional References at PubMed
PMID:9930699   PMID:11395011   PMID:12106695   PMID:12612004   PMID:12657561   PMID:12931188   PMID:14552904   PMID:15305865   PMID:15350966   PMID:15661361   PMID:15813942   PMID:15961425  
PMID:16203042   PMID:16227993   PMID:16336223   PMID:16337915   PMID:17355320   PMID:17715129   PMID:17904674   PMID:18063479   PMID:18457921   PMID:18472345   PMID:18577424   PMID:18799000  
PMID:18845615   PMID:19232517   PMID:19307176   PMID:19430470   PMID:19679663   PMID:19686239   PMID:20044519   PMID:20153734   PMID:20190766   PMID:20536931   PMID:20880357   PMID:21486764  
PMID:21532577   PMID:21700703   PMID:21924329   PMID:22414695   PMID:22441038   PMID:22441041   PMID:22854961   PMID:22871113   PMID:23248270   PMID:23420348   PMID:23440186   PMID:23847084  
PMID:23932891   PMID:24393035   PMID:24668262   PMID:24990918   PMID:25619659   PMID:25716834   PMID:25792562   PMID:25843644   PMID:25926348   PMID:26043076   PMID:26126716   PMID:26333769  
PMID:26464063   PMID:26631461   PMID:26875662   PMID:26924708   PMID:27159133   PMID:27345384   PMID:27688312   PMID:27778437   PMID:28450542   PMID:29476059   PMID:30169756   PMID:30590202  
PMID:30699338   PMID:31269453   PMID:31315039   PMID:31578924   PMID:31672664   PMID:32357304   PMID:32892950   PMID:33183317   PMID:34695562   PMID:34810232   PMID:35504433   PMID:35883093  
PMID:36344870   PMID:36375307   PMID:36567653   PMID:37005931   PMID:37830575   PMID:38191090   PMID:38892438  


Genomics

Comparative Map Data
Slc12a5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83174,115,833 - 174,155,112 (+)NCBIGRCr8
mRatBN7.23153,696,517 - 153,735,801 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3153,696,517 - 153,735,765 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3157,505,210 - 157,544,609 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03166,004,181 - 166,043,578 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03163,747,957 - 163,787,354 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03161,433,303 - 161,465,078 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3161,425,988 - 161,462,879 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03167,617,776 - 167,649,551 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43156,006,017 - 156,037,915 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13155,912,052 - 155,943,951 (+)NCBI
Celera3152,309,197 - 152,341,061 (+)NCBICelera
Cytogenetic Map3q42NCBI
SLC12A5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382046,021,686 - 46,060,150 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2046,021,690 - 46,060,150 (+)EnsemblGRCh38hg38GRCh38
GRCh372044,650,325 - 44,688,789 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362044,091,245 - 44,122,196 (+)NCBINCBI36Build 36hg18NCBI36
Build 342044,091,244 - 44,122,196NCBI
Celera2041,361,790 - 41,400,248 (+)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2041,391,623 - 41,430,078 (+)NCBIHuRef
CHM1_12044,552,972 - 44,591,426 (+)NCBICHM1_1
T2T-CHM13v2.02047,757,715 - 47,796,165 (+)NCBIT2T-CHM13v2.0
Slc12a5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392164,802,766 - 164,841,651 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2164,802,722 - 164,841,651 (+)EnsemblGRCm39 Ensembl
GRCm382164,960,846 - 164,999,731 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2164,960,802 - 164,999,731 (+)EnsemblGRCm38mm10GRCm38
MGSCv372164,793,488 - 164,825,231 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362164,659,524 - 164,690,936 (+)NCBIMGSCv36mm8
Celera2170,905,292 - 170,937,000 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map285.28NCBI
Slc12a5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544511,252,732 - 11,291,501 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544511,252,732 - 11,290,890 (-)NCBIChiLan1.0ChiLan1.0
SLC12A5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22151,761,634 - 51,800,013 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12051,754,742 - 51,793,119 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02042,359,005 - 42,397,412 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12043,445,193 - 43,483,132 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2043,445,182 - 43,483,132 (+)Ensemblpanpan1.1panPan2
SLC12A5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12433,285,773 - 33,322,885 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2433,285,852 - 33,321,567 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2432,812,617 - 32,849,088 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02433,996,109 - 34,032,786 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2433,996,183 - 34,031,468 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12433,254,354 - 33,290,810 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02433,369,649 - 33,406,360 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02433,908,853 - 33,945,337 (+)NCBIUU_Cfam_GSD_1.0
Slc12a5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640191,546,150 - 191,573,184 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365146,998,044 - 7,026,767 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365146,999,793 - 7,027,094 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC12A5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1748,192,075 - 48,230,661 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11748,192,072 - 48,230,674 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21753,839,701 - 53,876,239 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC12A5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1217,823,141 - 17,854,996 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl217,825,676 - 17,854,950 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605066,458,116 - 66,497,517 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc12a5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247908,537,185 - 8,576,861 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247908,539,103 - 8,576,877 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir92a1rno-miR-92a-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20050974

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:50
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000024657, ENSRNOT00000065184
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3166376089177728348Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161799493176036425Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat

Markers in Region
RH131897  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23153,702,051 - 153,702,237 (+)MAPPERmRatBN7.2
Rnor_6.03161,431,453 - 161,431,638NCBIRnor6.0
Rnor_5.03167,615,926 - 167,616,111UniSTSRnor5.0
RGSC_v3.43156,004,167 - 156,004,352UniSTSRGSC3.4
Celera3152,307,347 - 152,307,532UniSTS
RH 3.4 Map31429.2UniSTS
Cytogenetic Map3q42UniSTS
RH132314  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23153,712,804 - 153,713,004 (+)MAPPERmRatBN7.2
Rnor_6.03161,442,206 - 161,442,405NCBIRnor6.0
Rnor_5.03167,626,679 - 167,626,878UniSTSRnor5.0
RGSC_v3.43156,014,920 - 156,015,119UniSTSRGSC3.4
Celera3152,318,099 - 152,318,298UniSTS
RH 3.4 Map31424.5UniSTS
Cytogenetic Map3q42UniSTS
BF403106  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23153,735,833 - 153,736,022 (+)MAPPERmRatBN7.2
Rnor_6.03161,465,147 - 161,465,335NCBIRnor6.0
Rnor_5.03167,649,620 - 167,649,808UniSTSRnor5.0
RGSC_v3.43156,037,984 - 156,038,172UniSTSRGSC3.4
Celera3152,341,130 - 152,341,318UniSTS
RH 3.4 Map31424.5UniSTS
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 9 48 113 90 89 58 25 58 6 214 94 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000024657   ⟹   ENSRNOP00000024657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3153,703,902 - 153,735,765 (+)Ensembl
Rnor_6.0 Ensembl3161,433,410 - 161,462,879 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000065184   ⟹   ENSRNOP00000062103
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3153,696,517 - 153,733,664 (+)Ensembl
Rnor_6.0 Ensembl3161,425,988 - 161,462,879 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114972   ⟹   ENSRNOP00000093106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3153,703,902 - 153,735,765 (+)Ensembl
RefSeq Acc Id: NM_001393675   ⟹   NP_001380604
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83174,115,833 - 174,155,112 (+)NCBI
mRatBN7.23153,696,517 - 153,735,801 (+)NCBI
RefSeq Acc Id: NM_134363   ⟹   NP_599190
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83174,123,215 - 174,155,112 (+)NCBI
mRatBN7.23153,703,902 - 153,735,801 (+)NCBI
Rnor_6.03161,433,303 - 161,465,078 (+)NCBI
Rnor_5.03167,617,776 - 167,649,551 (+)NCBI
RGSC_v3.43156,006,017 - 156,037,915 (+)RGD
Celera3152,309,197 - 152,341,061 (+)RGD
Sequence:
RefSeq Acc Id: XM_039104204   ⟹   XP_038960132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83174,115,857 - 174,155,112 (+)NCBI
mRatBN7.23153,696,544 - 153,735,801 (+)NCBI
RefSeq Acc Id: XM_039104205   ⟹   XP_038960133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83174,123,682 - 174,155,112 (+)NCBI
mRatBN7.23153,704,360 - 153,735,801 (+)NCBI
RefSeq Acc Id: XM_039104206   ⟹   XP_038960134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83174,123,682 - 174,155,112 (+)NCBI
mRatBN7.23153,704,360 - 153,735,801 (+)NCBI
RefSeq Acc Id: XM_039104208   ⟹   XP_038960136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83174,124,732 - 174,155,112 (+)NCBI
mRatBN7.23153,705,412 - 153,735,801 (+)NCBI
RefSeq Acc Id: XM_039104209   ⟹   XP_038960137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83174,123,474 - 174,155,112 (+)NCBI
mRatBN7.23153,704,163 - 153,735,801 (+)NCBI
RefSeq Acc Id: NP_599190   ⟸   NM_134363
- Peptide Label: isoform 2
- UniProtKB: A6JXD2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000062103   ⟸   ENSRNOT00000065184
Ensembl Acc Id: ENSRNOP00000024657   ⟸   ENSRNOT00000024657
RefSeq Acc Id: XP_038960132   ⟸   XM_039104204
- Peptide Label: isoform X1
- UniProtKB: F1LNP4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960137   ⟸   XM_039104209
- Peptide Label: isoform X5
- UniProtKB: A6JXD2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960134   ⟸   XM_039104206
- Peptide Label: isoform X3
- UniProtKB: A6JXD2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960133   ⟸   XM_039104205
- Peptide Label: isoform X2
- UniProtKB: A6JXD2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960136   ⟸   XM_039104208
- Peptide Label: isoform X4
- UniProtKB: A6JXD2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000093106   ⟸   ENSRNOT00000114972
RefSeq Acc Id: NP_001380604   ⟸   NM_001393675
- Peptide Label: isoform 1
- UniProtKB: Q63633 (UniProtKB/Swiss-Prot),   A7Y821 (UniProtKB/Swiss-Prot),   F1LNP4 (UniProtKB/TrEMBL)
Protein Domains
Amino acid permease/ SLC12A   SLC12A transporter C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63633-F1-model_v2 AlphaFold Q63633 1-1139 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692673
Promoter ID:EPDNEW_R3197
Type:initiation region
Name:Slc12a5_1
Description:solute carrier family 12 member 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03161,433,318 - 161,433,378EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620811 AgrOrtholog
BioCyc Gene G2FUF-46816 BioCyc
Ensembl Genes ENSRNOG00000018111 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024657 ENTREZGENE
  ENSRNOT00000065184.5 UniProtKB/Swiss-Prot
  ENSRNOT00000114972 ENTREZGENE
  ENSRNOT00000114972.1 UniProtKB/Swiss-Prot
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/Swiss-Prot
InterPro AA-permease/SLC12A_dom UniProtKB/Swiss-Prot
  KCL_cotranspt UniProtKB/Swiss-Prot
  SLC12_C UniProtKB/Swiss-Prot
  SLC12A_fam UniProtKB/Swiss-Prot
KEGG Report rno:171373 UniProtKB/Swiss-Prot
NCBI Gene 171373 ENTREZGENE
PANTHER PTHR11827 UniProtKB/Swiss-Prot
  PTHR11827:SF54 UniProtKB/Swiss-Prot
Pfam AA_permease UniProtKB/Swiss-Prot
  SLC12 UniProtKB/Swiss-Prot
PhenoGen Slc12a5 PhenoGen
PRINTS KCLTRNSPORT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018111 RatGTEx
UniProt A6JXD2 ENTREZGENE, UniProtKB/TrEMBL
  A6JXD3_RAT UniProtKB/TrEMBL
  A7Y821 ENTREZGENE
  D3ZGI9_RAT UniProtKB/TrEMBL
  F1LNP4 ENTREZGENE, UniProtKB/TrEMBL
  Q63633 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A7Y821 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc12a5  solute carrier family 12 member 5  Slc12a5  solute carrier family 12 (potassium-chloride transporter), member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-19 Slc12a5  solute carrier family 12 (potassium-chloride transporter), member 5  Slc12a5  solute carrier family 12, member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-25 Slc12a5  solute carrier family 12, member 5  Slc12a5  solute carrier family 12, (potassium-chloride transporter) member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Slc12a5  solute carrier family 12, (potassium-chloride transporter) member 5      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Slc12a5  solute carrier family 12, (potassium-chloride transporter) member 5      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed predominately in the CNS 628350
gene_function transports Cl- out of the cell with K+ 628350
gene_process may mediate maintenance of GABAergic inhibitory synaptic potentials during repetitive stimulation 628350
gene_regulation mRNA in dorsal motor neurons of the vagus (DMV neurons) is greatly reduced after axotomy and expression is also reduced in the hypoglossal and facial nuclei ipsilateral to axotomy 628350