Enables several functions, including insulin receptor binding activity; nuclear estrogen receptor binding activity; and protein C-terminus binding activity. Involved in several processes, including cellular response to hormone stimulus; positive regulation of phosphorylation; and positive regulation of signal transduction. Located in several cellular components, including caveola; dendrite; and postsynaptic density. Is active in glutamatergic synapse and postsynaptic specialization, intracellular component. Used to study Parkinsonism; brain ischemia; hypertension; status epilepticus; and type 2 diabetes mellitus. Biomarker of hepatocellular carcinoma and pancreatic acinar cell adenocarcinoma. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); ductal carcinoma in situ; prostate cancer; thrombocytopenia; and type 2 diabetes mellitus. Orthologous to human SRC (SRC proto-oncogene, non-receptor tyrosine kinase); PARTICIPATES IN dopamine signaling pathway; epidermal growth factor/neuregulin signaling pathway; estrogen signaling pathway; INTERACTS WITH (+)-pilocarpine; (25R)-cholest-5-ene-3beta,26-diol; 1,2,3,4,6,7,8-Heptachlorodibenzodioxin.
Eucalyptol inhibits the reaction [Glucose results in decreased expression of SRC protein], Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of SRC protein]
geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of SRC protein], SRC protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of SRC protein] more ...
[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in decreased phosphorylation of SRC protein, Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in decreased phosphorylation of SRC protein]
SRC inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]], SRC inhibits the reaction [bisphenol A inhibits the reaction [Triiodothyronine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]
[[Clioquinol binds to Copper] which results in increased activity of SRC protein] which results in increased phosphorylation of and results in increased activity of EGFR protein, [Clioquinol binds to Copper] which results in increased phosphorylation of and results in increased activity of SRC protein
[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of SRC mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of SRC mRNA
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to IL1R1 protein] more ...
allyl isothiocyanate inhibits the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA], allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [[SRC protein co-treated with Rifampin] results in increased expression of CYP3A4 mRNA]]
SRC protein affects the reaction [alpha-naphthoflavone results in increased expression of CYP1A1 mRNA], SRC protein affects the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]
[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of SRC mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of SRC mRNA
SRC protein affects the reaction [Ammonia results in increased expression of ATP1A2 mRNA], SRC protein affects the reaction [Ammonia results in increased expression of ATP1A2 protein]
Arsenic results in increased phosphorylation of and results in increased activity of SRC protein, Iron promotes the reaction [Arsenic results in increased phosphorylation of and results in increased activity of SRC protein]
Arsenic results in increased phosphorylation of and results in increased activity of SRC protein, Iron promotes the reaction [Arsenic results in increased phosphorylation of and results in increased activity of SRC protein]
bisphenol A inhibits the reaction [Genistein results in decreased expression of SRC protein], Genistein inhibits the reaction [bisphenol A results in increased expression of SRC protein]
4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of SRC protein] more ...
SRC protein promotes the reaction [[FGF19 protein results in increased phosphorylation of NR1H4 protein] which results in increased export of Cholesterol]
[cobaltous chloride results in increased activity of SRC protein] promotes the reaction [[[HIF1A protein binds to STAT3 protein modified form] which binds to VEGFA promoter] binds to [APEX1 protein binds to CREBBP promoter]] more ...
[[Clioquinol binds to Copper] which results in increased activity of SRC protein] which results in increased phosphorylation of and results in increased activity of EGFR protein more ...
[[Clioquinol binds to Copper] which results in increased activity of SRC protein] which results in increased phosphorylation of and results in increased activity of EGFR protein more ...
corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of SRC protein], corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of SRC protein]
[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of SRC protein]
[cypermethrin results in decreased susceptibility to Dihydrotestosterone] which results in decreased phosphorylation of SRC protein, cypermethrin inhibits the reaction [AR protein binds to SRC protein]
Dihydrotestosterone inhibits the reaction [Dehydroepiandrosterone results in increased phosphorylation of SRC protein], Pertussis Toxin inhibits the reaction [Dehydroepiandrosterone results in increased phosphorylation of SRC protein]
Dizocilpine Maleate promotes the reaction [GRIN1 protein binds to SRC protein], Dizocilpine Maleate results in increased phosphorylation of and results in increased activity of SRC protein
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SRC mRNA
Doxorubicin promotes the reaction [thymoquinone results in decreased phosphorylation of SRC protein], thymoquinone inhibits the reaction [Doxorubicin results in increased phosphorylation of SRC protein]
Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA], Ellagic Acid inhibits the reaction [TNFSF11 protein results in increased expression of SRC protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Endosulfan results in increased expression of and results in increased phosphorylation of SRC protein], Endosulfan results in increased expression of and results in increased phosphorylation of SRC protein
[AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Equol results in increased activity of and results in increased phosphorylation of NOS3 protein] more ...
Fulvestrant inhibits the reaction [butylbenzyl phthalate results in increased phosphorylation of SRC protein], Fulvestrant inhibits the reaction [Dibutyl Phthalate results in increased phosphorylation of SRC protein]
geldanamycin inhibits the reaction [HSP90AA1 protein binds to SRC protein binds to CDC37 protein], geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of SRC protein]
bisphenol A inhibits the reaction [Genistein results in decreased expression of SRC protein], Genistein inhibits the reaction [bisphenol A results in increased expression of SRC protein]
SRC protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of PPARG mRNA]], SRC protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of SCD1 mRNA]]
[AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein] more ...
afimoxifene inhibits the reaction [icariin results in increased phosphorylation of SRC protein], icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of SRC protein]
myricetin inhibits the reaction [Indomethacin results in increased phosphorylation of SRC protein], Quercetin inhibits the reaction [Indomethacin results in increased phosphorylation of SRC protein]
[AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Indican results in increased phosphorylation of SRC protein], [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Indican results in increased phosphorylation of STAT3 protein]
SRC protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of PPARG mRNA]], SRC protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid] results in increased expression of SCD1 mRNA]]
HSPA5 protein affects the reaction [Lead results in increased phosphorylation of SRC protein], Lead results in increased phosphorylation of and results in increased expression of SRC protein
HSPA5 protein affects the reaction [Lead results in increased phosphorylation of SRC protein], Lead results in increased phosphorylation of and results in increased expression of SRC protein
[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of SRC protein] more ...
[AG 1879 results in decreased activity of SRC protein] promotes the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]], [CGP 77675 results in decreased activity of SRC protein] promotes the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]
maslinic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of SRC protein], maslinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of SRC protein]
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[arsenic trioxide co-treated with PD 173074] results in decreased expression of SRC protein], benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [SRC protein binds to NR1I3 protein]
chromium hexavalent ion inhibits the reaction [Nickel results in increased phosphorylation of SRC protein], U 0126 inhibits the reaction [Nickel results in increased phosphorylation of SRC protein]
Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased phosphorylation of SRC protein]
ITGB1 protein inhibits the reaction [ophiopogonin D inhibits the reaction [TGFB1 protein results in increased phosphorylation of SRC protein]], ophiopogonin D inhibits the reaction [TGFB1 protein results in increased phosphorylation of SRC protein]
oridonin analog inhibits the reaction [EGF protein promotes the reaction [SRC protein modified form binds to STAT3 protein]], oridonin analog inhibits the reaction [SRC protein results in increased phosphorylation of STAT3 protein]
pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of SRC protein], pinocembrin promotes the reaction [Dasatinib inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of SRC protein]]
Protein Kinase Inhibitors inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of SRC protein]
[[[[Cadmium Chloride results in increased abundance of Reactive Oxygen Species] which results in increased activity of SRC protein] which results in increased activity of EGFR protein] which results in increased activity of STAT3 protein] promotes the reaction [STAT3 protein binds to STAT3 protein] more ...
[resveratrol affects the phosphorylation of SRC protein] affects the reaction [sodium arsenite results in increased activity of [MAPK1 protein co-treated with MAPK3 protein]] more ...
Resveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of SRC protein], Resveratrol inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased activity of SRC protein]
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SRC mRNA
[Sirolimus results in increased phosphorylation of and results in increased activity of SRC protein] which results in increased phosphorylation of EGFR protein more ...
[[RTKI cpd results in decreased activity of EGFR protein] co-treated with [SU 6656 results in decreased activity of SRC protein]] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein] more ...
[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SRC mRNA, [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SRC mRNA
[[Azoxymethane co-treated with Sulindac] results in increased expression of CSK protein] which results in increased phosphorylation of and results in decreased activity of SRC protein
SRC protein promotes the reaction [Tamoxifen results in increased phosphorylation of and results in increased activity of MAPK1 protein], SRC protein promotes the reaction [Tamoxifen results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Doxorubicin promotes the reaction [thymoquinone results in decreased phosphorylation of SRC protein], thymoquinone inhibits the reaction [Doxorubicin results in increased phosphorylation of SRC protein]
SRC inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR1 protein binds to and results in decreased activity of THRB protein]]], SRC inhibits the reaction [bisphenol A inhibits the reaction [Thyroxine inhibits the reaction [NCOR2 protein binds to and results in decreased activity of THRB protein]]]
[[RTKI cpd results in decreased activity of EGFR protein] co-treated with [SU 6656 results in decreased activity of SRC protein]] inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein]
RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of SRC protein]
RTKI cpd inhibits the reaction [EGF protein results in increased phosphorylation of SRC protein], RTKI cpd inhibits the reaction [Nicotine results in increased phosphorylation of SRC protein]
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SRC mRNA
Zinc promotes the reaction [EGFR protein binds to SRC protein], Zinc results in increased phosphorylation of and results in increased activity of SRC protein
zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein promotes the reaction [SRC protein binds to NCF1 protein]]], zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [TNF protein promotes the reaction [SRC protein binds to TNFRSF1A protein]]]
Zinc promotes the reaction [EGFR protein binds to SRC protein], Zinc results in increased phosphorylation of and results in increased activity of SRC protein
[Proto-oncogene c-src regulates the viability of rat spermatogonial stem cells in vitro through phosphorylated signal transducer and activator of transcription-3].
Tyrosine kinase and tyrosine phosphatase participate in regulation of interactions of NMDA receptor subunit 2A with Src and Fyn mediated by PSD-95 after transient brain ischemia.
The protein encoded by the transforming gene of avian sarcoma virus (pp60src) and a homologous protein in normal cells (pp60proto-src) are associated with the plasma membrane.
Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver.
Lipoteichoic acid induces matrix metalloproteinase-9 expression via transactivation of PDGF receptors and NF-kappaB activation in rat brain astrocytes.
Interaction between chicken protein tyrosine phosphatase 1 (CPTP1)-like rat protein phosphatase 1 (PTP1) and p60(v-src) in v-src-transformed Rat-1 fibroblasts.
c-Src activation promotes nasopharyngeal carcinoma metastasis by inducing the epithelial-mesenchymal transition via PI3K/Akt signaling pathway: a new and promising target for NPC.
NMDA receptor activation results in tyrosine phosphorylation of NMDA receptor subunit 2A(NR2A) and interaction of Pyk2 and Src with NR2A after transient cerebral ischemia and reperfusion.
17beta-estradiol induces the translocation of the estrogen receptors ESR1 and ESR2 to the cell membrane, MAPK3/1 phosphorylation and proliferation of cultured immature rat Sertoli cells.
Store-operated Ca(2+) entry and tyrosine kinase pp60(src) hyperactivity are modulated by hyperglycemia in platelets from patients with non insulin-dependent diabetes mellitus.
Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src.
Transduced PDZ1 domain of PSD-95 decreases Src phosphorylation and increases nNOS (Ser847) phosphorylation contributing to neuroprotection after cerebral ischemia.
Regulation of ectoplasmic specialization dynamics in the seminiferous epithelium by focal adhesion-associated proteins in testosterone-suppressed rat testes.
Nonreceptor tyrosine protein kinase pp60c-src in spatial learning: synapse-specific changes in its gene expression, tyrosine phosphorylation, and protein-protein interactions.
