Src (SRC proto-oncogene, non-receptor tyrosine kinase) - Rat Genome Database

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Gene: Src (SRC proto-oncogene, non-receptor tyrosine kinase) Rattus norvegicus
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Symbol: Src
Name: SRC proto-oncogene, non-receptor tyrosine kinase
RGD ID: 620795
Description: Enables several functions, including insulin receptor binding activity; nuclear estrogen receptor binding activity; and protein kinase C binding activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; cellular response to peptide hormone stimulus; and positive regulation of signal transduction. Located in several cellular components, including caveola; dendrite; and mitochondrion-derived vesicle. Is active in glutamatergic synapse and postsynaptic specialization, intracellular component. Used to study Parkinsonism; brain ischemia; hypertension; status epilepticus; and type 2 diabetes mellitus. Biomarker of hepatocellular carcinoma; lesion of sciatic nerve; and pancreatic acinar cell adenocarcinoma. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); ductal carcinoma in situ; prostate cancer; thrombocytopenia; and type 2 diabetes mellitus. Orthologous to human SRC (SRC proto-oncogene, non-receptor tyrosine kinase); PARTICIPATES IN dopamine signaling pathway; epidermal growth factor/neuregulin signaling pathway; estrogen signaling pathway; INTERACTS WITH (+)-pilocarpine; (25R)-cholest-5-ene-3beta,26-diol; 1,2,3,4,6,7,8-Heptachlorodibenzodioxin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: c-Src; p60-Src; pp60c-src; proto-oncogene c-Src; proto-oncogene tyrosine-protein kinase Src; Rous sarcoma oncogene; tyrosine protein kinase c-src; tyrosine protein kinase pp60-c-src; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83166,511,616 - 166,559,463 (+)NCBIGRCr8
mRatBN7.23146,091,969 - 146,139,492 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3146,091,841 - 146,139,476 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3149,950,044 - 149,963,314 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03158,451,340 - 158,464,620 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03156,193,067 - 156,206,340 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03153,547,807 - 153,595,643 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3153,580,861 - 153,595,642 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03158,123,674 - 158,171,912 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43148,157,256 - 148,170,524 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13148,063,164 - 148,076,433 (+)NCBI
Celera3144,830,256 - 144,843,524 (+)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-matairesinol  (ISO)
(-)-trans-epsilon-viniferin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (EXP)
(S)-nicotine  (ISO)
1,2,3,4,6,7,8-Heptachlorodibenzodioxin  (EXP)
1,4-benzoquinone  (ISO)
1,8-cineole  (ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2-bis(4-chlorophenyl)ethanol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,6-dimethoxyphenol  (ISO)
2-chloroethanol  (ISO)
2-methoxyethanol  (EXP)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
2-tert-butylhydroquinone  (ISO)
26-hydroxycholesterol  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-methylcholanthrene  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
acetamide  (EXP)
acrolein  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
AH23848  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinol  (EXP)
allyl isothiocyanate  (ISO)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
ammonia  (ISO)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
Auriculasin  (ISO)
Azoxymethane  (EXP)
baicalein  (ISO)
beauvericin  (EXP)
benzamide  (ISO)
benzamidine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (EXP)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bosutinib  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (EXP,ISO)
capillarisin  (ISO)
capsaicin  (EXP,ISO)
captan  (ISO)
carbachol  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (ISO)
cholesterol  (ISO)
cholic acid  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (EXP)
Cyclosporin H  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
D-mannitol  (EXP)
decabromodiphenyl ether  (EXP,ISO)
deguelin  (ISO)
dehydroepiandrosterone  (EXP,ISO)
dehydroepiandrosterone sulfate  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (EXP,ISO)
dioscin  (ISO)
dioxygen  (EXP,ISO)
dizocilpine maleate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
epoxiconazole  (ISO)
equol  (ISO)
eriocitrin  (ISO)
erlotinib hydrochloride  (ISO)
estragole  (EXP)
ethanol  (EXP)
everolimus  (ISO)
Evodiamine  (ISO)
filipin III  (ISO)
flavonoids  (EXP)
flavonol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
gallic acid  (ISO)
Garcinol  (ISO)
geldanamycin  (EXP,ISO)
gemcitabine  (ISO)
genistein  (EXP)
Geraniin  (ISO)
glucose  (EXP,ISO)
glycerol 2-phosphate  (ISO)
glycidyl methacrylate  (ISO)
glycogen  (ISO)
Goe 6976  (ISO)
hexachlorobenzene  (EXP,ISO)
Honokiol  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxyflutamide  (EXP)
icariin  (ISO)
indometacin  (EXP)
indoxyl sulfate  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
ivermectin  (ISO)
KN-93  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lapatinib  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
leukotriene D4  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
maslinic acid  (ISO)
mercury dichloride  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (EXP)
methoxychlor  (EXP)
methyl beta-cyclodextrin  (ISO)
methylarsonic acid  (ISO)
MitoTEMPO  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
Morroniside  (EXP,ISO)
myricetin  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (EXP,ISO)
nickel subsulfide  (EXP)
nickel sulfate  (EXP)
niclosamide  (ISO)
nicotine  (ISO)
nitric oxide  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
Ophiopogonin D  (ISO)
oridonin  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-anisidine  (ISO)
paracetamol  (EXP)
PD173074  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phencyclidine  (EXP)
phenobarbital  (EXP)
phenylarsine oxide  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphane  (EXP)
pinocembrin  (ISO)
pinosylvin  (ISO)
PK-11195  (ISO)
platycodin D  (ISO)
poly(ethylene)  (ISO)
ponatinib  (ISO)
potassium chloride  (EXP)
potassium iodide  (ISO)
propofol  (ISO)
protein kinase inhibitor  (EXP)
quercetin  (EXP,ISO)
quercitrin  (ISO)
quinolinic acid  (EXP)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
riddelliine  (EXP)
rifampicin  (ISO)
rimonabant  (ISO)
ritonavir  (ISO)
rucaparib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salvianolic acid A  (ISO)
saracatinib  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sorafenib  (ISO)
SU6656  (ISO)
succimer  (ISO)
sulindac  (EXP,ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
Theaflavin 3,3'-digallate  (EXP)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
thymoquinone  (ISO)
thyroxine  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trans-pinosylvin  (ISO)
tributylstannane  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
Tubeimoside II  (ISO)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (ISO)
ursolic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
wogonin  (ISO)
wortmannin  (ISO)
xanthohumol  (ISO)
zinc atom  (ISO)
zinc dichloride  (EXP)
zinc protoporphyrin  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adherens junction organization  (IEP)
angiotensin-activated signaling pathway  (ISO)
behavioral response to cocaine  (IEP)
bone resorption  (ISO,ISS)
branching involved in mammary gland duct morphogenesis  (ISO)
canonical glycolysis  (ISO)
cell adhesion  (IBA,IEA)
cell differentiation  (IBA)
cell migration  (ISO)
cell-cell adhesion  (IEP)
cellular response to angiotensin  (IEP)
cellular response to fatty acid  (IEP)
cellular response to fluid shear stress  (ISO)
cellular response to hydrogen peroxide  (IEP,ISO)
cellular response to hypoxia  (IEP)
cellular response to insulin stimulus  (IEP)
cellular response to lipopolysaccharide  (IEP)
cellular response to peptide hormone stimulus  (ISO)
cellular response to platelet-derived growth factor stimulus  (IEP,ISO)
cellular response to progesterone stimulus  (IMP)
cellular response to prolactin  (IEP)
cellular response to reactive oxygen species  (ISO,ISS)
cellular response to transforming growth factor beta stimulus  (ISO)
DNA biosynthetic process  (IMP)
epidermal growth factor receptor signaling pathway  (IBA,IEP)
focal adhesion assembly  (ISO)
forebrain development  (ISO)
immune system process  (IEA)
integrin-mediated signaling pathway  (ISO)
interleukin-6-mediated signaling pathway  (ISO)
intestinal epithelial cell development  (ISO)
intracellular signal transduction  (ISO)
learning or memory  (IEP)
myoblast proliferation  (IEP)
negative regulation of anoikis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IBA,ISO)
negative regulation of focal adhesion assembly  (IMP)
negative regulation of gene expression  (IMP)
negative regulation of hippo signaling  (ISO)
negative regulation of intrinsic apoptotic signaling pathway  (IBA,ISO)
negative regulation of mitochondrial depolarization  (ISO)
negative regulation of neutrophil activation  (ISO)
negative regulation of protein-containing complex assembly  (ISO)
negative regulation of telomere maintenance  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neurotrophin TRK receptor signaling pathway  (IDA)
odontogenesis  (ISO)
oogenesis  (ISO)
osteoclast development  (ISO)
peptidyl-tyrosine autophosphorylation  (IMP)
peptidyl-tyrosine phosphorylation  (ISO)
phosphorylation  (ISO)
platelet-derived growth factor receptor signaling pathway  (IEP)
positive regulation of apoptotic process  (IDA,IMP)
positive regulation of bone resorption  (IMP)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell adhesion  (IDA)
positive regulation of cell migration  (IMP)
positive regulation of cell population proliferation  (IMP)
positive regulation of cell size  (IMP)
positive regulation of cytokine production  (IMP)
positive regulation of dephosphorylation  (ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IMP,ISO)
positive regulation of gene expression  (IMP)
positive regulation of glucose metabolic process  (IMP)
positive regulation of glycolytic process  (ISO)
positive regulation of insulin receptor signaling pathway  (IDA)
positive regulation of intracellular signal transduction  (IMP)
positive regulation of lamellipodium morphogenesis  (ISO)
positive regulation of male germ cell proliferation  (IMP)
positive regulation of MAP kinase activity  (IMP)
positive regulation of neural precursor cell proliferation  (IMP)
positive regulation of Notch signaling pathway  (ISO)
positive regulation of outer hair cell apoptotic process  (ISO)
positive regulation of ovarian follicle development  (IMP)
positive regulation of peptidyl-tyrosine phosphorylation  (IMP,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IMP,ISO)
positive regulation of platelet-derived growth factor receptor-beta signaling pathway  (ISO)
positive regulation of podosome assembly  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of protein processing  (ISO)
positive regulation of protein serine/threonine kinase activity  (ISO)
positive regulation of protein transport  (IMP)
positive regulation of Ras protein signal transduction  (IMP)
positive regulation of small GTPase mediated signal transduction  (ISO)
positive regulation of smooth muscle cell migration  (IMP)
positive regulation of TORC1 signaling  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IMP)
positive regulation of wound healing  (IMP)
primary ovarian follicle growth  (IMP)
progesterone receptor signaling pathway  (IBA,IMP)
protein autophosphorylation  (ISO)
protein destabilization  (ISO)
protein phosphorylation  (ISO)
regulation of caveolin-mediated endocytosis  (ISO)
regulation of cell projection assembly  (ISO)
regulation of cell-cell adhesion  (ISO)
regulation of early endosome to late endosome transport  (ISO)
regulation of epithelial cell migration  (ISO)
regulation of heart rate by cardiac conduction  (ISO)
regulation of intracellular estrogen receptor signaling pathway  (ISO)
regulation of toll-like receptor 3 signaling pathway  (ISO)
response to acidic pH  (IEP)
response to ATP  (IEP)
response to electrical stimulus  (IEP)
response to fatty acid  (IEP)
response to hydrogen peroxide  (IEP)
response to interleukin-1  (ISO)
response to mechanical stimulus  (IEP)
response to mineralocorticoid  (IEP)
response to nutrient levels  (IEP)
response to xenobiotic stimulus  (IEP)
skeletal muscle cell proliferation  (IEP)
spermatogenesis  (IEP)
stress fiber assembly  (ISO)
substrate adhesion-dependent cell spreading  (ISO)
transcytosis  (IDA)
transforming growth factor beta receptor signaling pathway  (ISO)
uterus development  (ISO)
vasodilation  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Cloning of the proto-oncogene c-src from rat testis. Al-Khalili O, etal., DNA Seq 2001 Dec;12(5-6):425-9.
2. Localization of PTP-1B, SHP-2, and Src exclusively in rat brain mitochondria and functional consequences. Arachiche A, etal., J Biol Chem. 2008 Sep 5;283(36):24406-11. doi: 10.1074/jbc.M709217200. Epub 2008 Jun 26.
3. An intracellular multi-effector complex mediates somatostatin receptor 1 activation of phospho-tyrosine phosphatase eta. Arena S, etal., Mol Endocrinol. 2007 Jan;21(1):229-46. Epub 2006 Oct 4.
4. The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer. Baker AM, etal., J Natl Cancer Inst. 2011 Mar 2;103(5):407-24. doi: 10.1093/jnci/djq569. Epub 2011 Jan 31.
5. Prolactin receptor is associated with c-src kinase in rat liver. Berlanga JJ, etal., Mol Endocrinol. 1995 Nov;9(11):1461-7. doi: 10.1210/mend.9.11.8584023.
6. Met, metastasis, motility and more. Birchmeier C, etal., Nat Rev Mol Cell Biol. 2003 Dec;4(12):915-25.
7. Activation of pp60c-src protein kinase activity in human colon carcinoma. Bolen JB, etal., Proc Natl Acad Sci U S A. 1987 Apr;84(8):2251-5. doi: 10.1073/pnas.84.8.2251.
8. pp60c-Src Kinase mediates growth effects of the full-length precursor progastrin1-80 peptide on rat intestinal epithelial cells, in vitro. Brown D, etal., Endocrinology 2003 Jan;144(1):201-11.
9. Synaptic Microtubule-Associated Protein EB3 and SRC Phosphorylation Mediate Structural and Behavioral Adaptations During Withdrawal From Cocaine Self-Administration. Calipari ES, etal., J Neurosci. 2019 Jul 17;39(29):5634-5646. doi: 10.1523/JNEUROSCI.0024-19.2019. Epub 2019 May 15.
10. c-Src-dependent nongenomic signaling responses to aldosterone are increased in vascular myocytes from spontaneously hypertensive rats. Callera GE, etal., Hypertension. 2005 Oct;46(4):1032-8. Epub 2005 Sep 12.
11. Reduced C-terminal Src kinase activity is correlated inversely with pp60(c-src) activity in colorectal carcinoma. Cam WR, etal., Cancer. 2001 Jul 1;92(1):61-70. doi: 10.1002/1097-0142(20010701)92:1<61::aid-cncr1292>3.0.co;2-d.
12. Role of p38 map kinase in glycine-induced hepatocyte resistance to hypoxic injury. Carini R, etal., J Hepatol. 2007 Apr;46(4):692-9. Epub 2006 Nov 27.
13. pp60c-src expression in the developing rat brain. Cartwright CA, etal., Proc Natl Acad Sci U S A. 1988 May;85(10):3348-52. doi: 10.1073/pnas.85.10.3348.
14. Regulation of an ERG K+ current by Src tyrosine kinase. Cayabyab FS and Schlichter LC, J Biol Chem 2002 Apr 19;277(16):13673-81.
15. [Proto-oncogene c-src regulates the viability of rat spermatogonial stem cells in vitro through phosphorylated signal transducer and activator of transcription-3]. Chen JX, etal., Sheng Li Xue Bao. 2008 Jun 25;60(3):391-6.
16. Learning induces neurotrophin signaling at hippocampal synapses. Chen LY, etal., Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):7030-5. Epub 2010 Mar 30.
17. Tyrosine kinase and tyrosine phosphatase participate in regulation of interactions of NMDA receptor subunit 2A with Src and Fyn mediated by PSD-95 after transient brain ischemia. Chen M, etal., Neurosci Lett. 2003 Mar 13;339(1):29-32.
18. Fer kinase/FerT and adherens junction dynamics in the testis: an in vitro and in vivo study. Chen YM, etal., Biol Reprod. 2003 Aug;69(2):656-72. Epub 2003 Apr 16.
19. Activation of Src tyrosine kinase in microglia in the rat hippocampus following transient forebrain ischemia. Choi JS, etal., Neurosci Lett. 2005 May 20-27;380(1-2):1-5. Epub 2005 Jan 26.
20. c-Src couples PI 3 kinase/Akt and MAPK signaling to PDGF-induced DNA synthesis in mesangial cells. Choudhury GG, etal., Cell Signal. 2006 Nov;18(11):1854-64.
21. Proto-oncogene expression in proliferating and differentiating cardiac and skeletal muscle. Claycomb WC and Lanson NA, Biochem J. 1987 Nov 1;247(3):701-6. doi: 10.1042/bj2470701.
22. The protein encoded by the transforming gene of avian sarcoma virus (pp60src) and a homologous protein in normal cells (pp60proto-src) are associated with the plasma membrane. Courtneidge SA, etal., Proc Natl Acad Sci U S A. 1980 Jul;77(7):3783-7.
23. Tumor metastasis but not tumor growth is dependent on Src-mediated vascular permeability. Criscuoli ML, etal., Blood. 2005 Feb 15;105(4):1508-14. Epub 2004 Oct 14.
24. Interaction of protein tyrosine phosphatase (PTP) 1B with its substrates is influenced by two distinct binding domains. Dadke S and Chernoff J, Biochem J. 2002 Jun 1;364(Pt 2):377-83.
25. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Dikic I, etal., Nature. 1996 Oct 10;383(6600):547-50. doi: 10.1038/383547a0.
26. The proto-oncogene c-src is involved in primordial follicle activation through the PI3K, PKC and MAPK signaling pathways. Du XY, etal., Reprod Biol Endocrinol. 2012 Aug 20;10:58. doi: 10.1186/1477-7827-10-58.
27. Evidence for multiple Src binding sites on the alpha1c L-type Ca2+ channel and their roles in activity regulation. Dubuis E, etal., Cardiovasc Res. 2006 Feb 1;69(2):391-401. Epub 2005 Dec 13.
28. Regulation of connexin43 protein complexes by intracellular acidification. Duffy HS, etal., Circ Res. 2004 Feb 6;94(2):215-22. Epub 2003 Dec 29.
29. Role of Nectin-1/c-Src Signaling in the Analgesic Effect of GDNF on a Rat Model of Chronic Constrictive Injury. Gao YY, etal., J Mol Neurosci. 2016 Oct;60(2):258-66. doi: 10.1007/s12031-016-0792-x. Epub 2016 Jul 9.
30. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
31. The Met tyrosine kinase receptor in development and cancer. Gentile A, etal., Cancer Metastasis Rev. 2008 Mar;27(1):85-94.
32. Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2. Gingrich JR, etal., Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6237-42. Epub 2004 Apr 6.
33. Oxidative stress induces tyrosine phosphorylation of PDGF alpha-and beta-receptors and pp60c-src in mesangial cells. González-Rubio M, etal., Kidney Int. 1996 Jul;50(1):164-73. doi: 10.1038/ki.1996.299.
34. Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver. Gupte RS, etal., Free Radic Biol Med. 2009 Feb 20.
35. Lipoteichoic acid induces matrix metalloproteinase-9 expression via transactivation of PDGF receptors and NF-kappaB activation in rat brain astrocytes. Hsieh HL, etal., Neurotox Res. 2010 May;17(4):344-59. Epub 2009 Sep 10.
36. Extra-nuclear activation of progesterone receptor in regulating arterial smooth muscle cell migration. Hsu SP, etal., Atherosclerosis. 2011 Jul;217(1):83-9. doi: 10.1016/j.atherosclerosis.2011.02.051. Epub 2011 Mar 10.
37. Increase in tyrosine phosphorylation of the NMDA receptor following the induction of status epilepticus. Huo JZ, etal., Neurosci Lett. 2006 Jul 3;401(3):266-70. Epub 2006 Apr 4.
38. Functional impact of PTP1B-mediated Src regulation on oxidative phosphorylation in rat brain mitochondria. Hébert Chatelain E, etal., Cell Mol Life Sci. 2011 Aug;68(15):2603-13. doi: 10.1007/s00018-010-0573-6. Epub 2010 Nov 10.
39. Activating SRC mutation in a subset of advanced human colon cancers. Irby RB, etal., Nat Genet. 1999 Feb;21(2):187-90.
40. Angiotensin II activates pp60c-src in vascular smooth muscle cells. Ishida M, etal., Circ Res. 1995 Dec;77(6):1053-9. doi: 10.1161/01.res.77.6.1053.
41. The regulatory domain of protein kinase C delta positively regulates insulin receptor signaling. Jacob AI, etal., J Mol Endocrinol. 2010 Mar;44(3):155-69. Epub 2009 Dec 1.
42. Interaction between chicken protein tyrosine phosphatase 1 (CPTP1)-like rat protein phosphatase 1 (PTP1) and p60(v-src) in v-src-transformed Rat-1 fibroblasts. Jung EJ and Kim CW, Exp Mol Med. 2002 Dec 31;34(6):476-80.
43. Interactions between Src family protein tyrosine kinases and PSD-95. Kalia LV and Salter MW, Neuropharmacology. 2003 Nov;45(6):720-8.
44. c-Src activation promotes nasopharyngeal carcinoma metastasis by inducing the epithelial-mesenchymal transition via PI3K/Akt signaling pathway: a new and promising target for NPC. Ke L, etal., Oncotarget. 2016 May 10;7(19):28340-55. doi: 10.18632/oncotarget.8634.
45. Protein kinases and adherens junction dynamics in the seminiferous epithelium of the rat testis. Lee NP and Cheng CY, J Cell Physiol. 2005 Feb;202(2):344-60.
46. Differential expression of protooncogenes related to transformation and cancer progression in rat myoblasts. Leibovitch SA, etal., Cancer Res. 1986 Aug;46(8):4097-103.
47. The role of reelin in adult synaptic function and the genetic and epigenetic regulation of the reelin gene. Levenson JM, etal., Biochim Biophys Acta. 2008 Aug;1779(8):422-31. Epub 2008 Jan 12.
48. Dual phosphorylations underlie modulation of unitary KCNQ K(+) channels by Src tyrosine kinase. Li Y, etal., J Biol Chem. 2004 Oct 29;279(44):45399-407. Epub 2004 Aug 10.
49. Neuroprotective profile of novel SRC kinase inhibitors in rodent models of cerebral ischemia. Liang S, etal., J Pharmacol Exp Ther. 2009 Dec;331(3):827-35. Epub 2009 Sep 9.
50. Expression of tetraspan protein CD63 activates protein-tyrosine kinase (PTK) and enhances the PTK-induced inhibition of ROMK channels. Lin D, etal., J Biol Chem. 2008 Mar 21;283(12):7674-81. Epub 2008 Jan 22.
51. [Role of pp60c-src in mitogen-activated protein kinase activation of vascular smooth muscle cells]. Liu D, etal., Sheng Li Xue Bao. 2000 Dec;52(6):483-6.
52. Pattern formation of vascular smooth muscle cells subject to nonuniform fluid shear stress: role of PDGF-beta receptor and Src. Liu SQ, etal., Am J Physiol Heart Circ Physiol. 2003 Sep;285(3):H1081-90. Epub 2003 May 8.
53. A network-based analysis and experimental validation of traditional Chinese medicine Yuanhu Zhitong Formula in treating neuropathic pain. Liu T, etal., J Ethnopharmacol. 2021 Jun 28;274:114037. doi: 10.1016/j.jep.2021.114037. Epub 2021 Mar 19.
54. NMDA receptor activation results in tyrosine phosphorylation of NMDA receptor subunit 2A(NR2A) and interaction of Pyk2 and Src with NR2A after transient cerebral ischemia and reperfusion. Liu Y, etal., Brain Res. 2001 Aug 3;909(1-2):51-8.
55. Suppression of Pyk2 attenuated the increased tyrosine phosphorylation of NMDA receptor subunit 2A after brain ischemia in rat hippocampus. Liu Y, etal., Neurosci Lett. 2005 Apr 29;379(1):55-8. Epub 2005 Jan 12.
56. Interaction of estrogen receptor alpha with protein kinase C alpha and c-Src in osteoblasts during differentiation. Longo M, etal., Bone. 2004 Jan;34(1):100-11.
57. Regulation of coronary arterial BK channels by caveolae-mediated angiotensin II signaling in diabetes mellitus. Lu T, etal., Circ Res. 2010 Apr 2;106(6):1164-73. Epub 2010 Feb 18.
58. 17beta-estradiol induces the translocation of the estrogen receptors ESR1 and ESR2 to the cell membrane, MAPK3/1 phosphorylation and proliferation of cultured immature rat Sertoli cells. Lucas TF, etal., Biol Reprod. 2008 Jan;78(1):101-14. Epub 2007 Oct 10.
59. Expression and signaling of G protein-coupled estrogen receptor 1 (GPER) in rat sertoli cells. Lucas TF, etal., Biol Reprod. 2010 Aug 1;83(2):307-17. Epub 2010 May 5.
60. Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites. Lundby A, etal., Cell. 2019 Oct 3;179(2):543-560.e26. doi: 10.1016/j.cell.2019.09.008.
61. Butyrate reduced lipopolysaccharide-mediated macrophage migration by suppression of Src enhancement and focal adhesion kinase activity. Maa MC, etal., J Nutr Biochem. 2010 Feb 8.
62. Peroxynitrite induces tyrosine residue modifications in synaptophysin C-terminal domain, affecting its interaction with src. Mallozzi C, etal., J Neurochem. 2009 Nov;111(3):859-69. Epub 2009 Sep 8.
63. Donepezil promotes neurogenesis via Src signaling pathway in a rat model of chronic cerebral hypoperfusion. Man J, etal., Brain Res. 2020 Jun 1;1736:146782. doi: 10.1016/j.brainres.2020.146782. Epub 2020 Mar 14.
64. pp60(c-src) modulates microvascular endothelial phenotype and in vitro angiogenesis. Marx M, etal., Exp Mol Pathol. 2001 Jun;70(3):201-13. doi: 10.1006/exmp.2001.2358.
65. pp60c-src activation in lung adenocarcinoma. Masaki T, etal., Eur J Cancer. 2003 Jul;39(10):1447-55. doi: 10.1016/s0959-8049(03)00276-4.
66. pp60c-src activation in hepatocellular carcinoma of humans and LEC rats. Masaki T, etal., Hepatology. 1998 May;27(5):1257-64. doi: 10.1002/hep.510270511.
67. Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin. Melendez J, etal., J Biol Chem. 2004 Dec 17;279(51):53516-23. Epub 2004 Aug 22.
68. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
69. Elevated Src kinase activity attenuates Tamoxifen response in vitro and is associated with poor prognosis clinically. Morgan L, etal., Cancer Biol Ther. 2009 Aug;8(16):1550-8.
70. Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src. Muller MM, etal., J Cell Biol. 2009 Nov 16;187(4):569-81.
71. Involvement of EGF receptor and c-Src in the survival signals induced by TGF-beta1 in hepatocytes. Murillo MM, etal., Oncogene. 2005 Jun 30;24(28):4580-7.
72. L-DOPA treatment of parkinsonian rats changes the expression of Src, Lyn and PKC kinases. Napolitano M, etal., Neurosci Lett. 2006 May 8;398(3):211-4. Epub 2006 Mar 9.
73. Molecular basis for regulation of Src by the docking protein p130Cas. Nasertorabi F, etal., J Mol Recognit. 2006 Jan-Feb;19(1):30-8.
74. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
75. FGF-1-induced reactions for biogenesis of apoE-HDL are mediated by src in rat astrocytes. Nishida T, etal., J Biochem. 2009 Dec;146(6):881-6. Epub 2009 Aug 27.
76. pp60c-src expression in rat spermatogenesis. Nishio H, etal., Biochem Biophys Res Commun. 1995 Jan 17;206(2):502-10. doi: 10.1006/bbrc.1995.1072.
77. Periodic mechanical stress enhances rat chondrocyte area expansion and migration through Src-PLCgamma1-ERK1/2 signaling. Nong L, etal., Eur J Cell Biol. 2010 Sep;89(9):705-11. doi: 10.1016/j.ejcb.2010.04.005. Epub 2010 May 26.
78. PKA phosphorylation of Src mediates Rap1 activation in NGF and cAMP signaling in PC12 cells. Obara Y, etal., J Cell Sci. 2004 Dec 1;117(Pt 25):6085-94. Epub 2004 Nov 16.
79. MEK mediates v-Src-induced disruption of the actin cytoskeleton via inactivation of the Rho-ROCK-LIM kinase pathway. Pawlak G and Helfman DM, J Biol Chem 2002 Jul 26;277(30):26927-33.
80. The rat tyrosine phosphatase eta increases cell adhesion by activating c-Src through dephosphorylation of its inhibitory phosphotyrosine residue. Pera IL, etal., Oncogene. 2005 Apr 28;24(19):3187-95.
81. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
82. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
83. Src-dependent STAT-3-mediated expression of monocyte chemoattractant protein-1 is required for 15(S)-hydroxyeicosatetraenoic acid-induced vascular smooth muscle cell migration. Potula HS, etal., J Biol Chem. 2009 Nov 6;284(45):31142-55. Epub 2009 Sep 7.
84. c-Cbl ubiquitin ligase regulates focal adhesion protein turnover and myofibril degeneration induced by neutrophil protease cathepsin G. Rafiq K, etal., J Biol Chem. 2012 Feb 17;287(8):5327-39. doi: 10.1074/jbc.M111.307009. Epub 2011 Dec 27.
85. GOA pipeline RGD automated data pipeline
86. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
87. Src tyrosine kinase regulates insulin-induced activation of protein kinase C (PKC) delta in skeletal muscle. Rosenzweig T, etal., Cell Signal. 2004 Nov;16(11):1299-308.
88. Store-operated Ca(2+) entry and tyrosine kinase pp60(src) hyperactivity are modulated by hyperglycemia in platelets from patients with non insulin-dependent diabetes mellitus. Saavedra FR, etal., Arch Biochem Biophys. 2004 Dec 15;432(2):261-8.
89. Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src. Saito S, etal., J Biol Chem. 2002 Nov 22;277(47):44695-700. Epub 2002 Sep 10.
90. Characterization and location of Src-dependent tyrosine phosphorylation in rat brain mitochondria. Salvi M, etal., Biochim Biophys Acta 2002 Apr 3;1589(2):181-95.
91. G protein-coupled receptors control vascular smooth muscle cell proliferation via pp60c-src and p21ras. Schieffer B, etal., Am J Physiol. 1997 Jun;272(6 Pt 1):C2019-30. doi: 10.1152/ajpcell.1997.272.6.C2019.
92. Angiotensin II controls p21ras activity via pp60c-src. Schieffer B, etal., J Biol Chem. 1996 Apr 26;271(17):10329-33. doi: 10.1074/jbc.271.17.10329.
93. Involvement of integrins and Src in insulin signaling toward autophagic proteolysis in rat liver. Schliess F, etal., J Biol Chem. 2004 May 14;279(20):21294-301. Epub 2004 Feb 24.
94. Caveolin-1 facilitates mechanosensitive protein kinase B (Akt) signaling in vitro and in vivo. Sedding DG, etal., Circ Res. 2005 Apr 1;96(6):635-42. Epub 2005 Feb 24.
95. Role of Src-induced dynamin-2 phosphorylation in caveolae-mediated endocytosis in endothelial cells. Shajahan AN, etal., J Biol Chem. 2004 May 7;279(19):20392-400. Epub 2004 Mar 8.
96. Localization of pp60c-src in growth cone of PC12 cell. Sobue K and Kanda K, Biochem Biophys Res Commun. 1988 Dec 30;157(3):1383-9. doi: 10.1016/s0006-291x(88)81028-3.
97. Apigetrin inhibits gastric cancer progression through inducing apoptosis and regulating ROS-modulated STAT3/JAK2 pathway. Sun Q, etal., Biochem Biophys Res Commun. 2018 Mar 25;498(1):164-170. doi: 10.1016/j.bbrc.2018.02.009. Epub 2018 Mar 5.
98. Activation of Src kinase in platelet-derived growth factor-B-dependent tubular regeneration after acute ischemic renal injury. Takikita-Suzuki M, etal., Am J Pathol. 2003 Jul;163(1):277-86.
99. Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer. Talamonti MS, etal., J Clin Invest. 1993 Jan;91(1):53-60. doi: 10.1172/JCI116200.
100. ErbB2 promotes Src synthesis and stability: novel mechanisms of Src activation that confer breast cancer metastasis. Tan M, etal., Cancer Res. 2005 Mar 1;65(5):1858-67.
101. SRC family kinase activity is up-regulated in hormone-refractory prostate cancer. Tatarov O, etal., Clin Cancer Res. 2009 May 15;15(10):3540-9. Epub 2009 May 15.
102. Site-specific differences in pp60c-src activity in human colorectal metastases. Termuhlen PM, etal., J Surg Res. 1993 Apr;54(4):293-8. doi: 10.1006/jsre.1993.1046.
103. H-Ras modulates N-methyl-D-aspartate receptor function via inhibition of Src tyrosine kinase activity. Thornton C, etal., J Biol Chem. 2003 Jun 27;278(26):23823-9. Epub 2003 Apr 14.
104. Role of c-SRC and ERK in acid-induced activation of NHE3. Tsuganezawa H, etal., Kidney Int 2002 Jul;62(1):41-50.
105. EV71 induces COX-2 expression via c-Src/PDGFR/PI3K/Akt/p42/p44 MPAK/AP-1 and NF-kappaB in rat brain astrocytes. Tung WH, etal., J Cell Physiol. 2010 Mar 23.
106. Increased immunoreactivity and protein tyrosine kinase activity of the protooncogene pp60c-src in preneoplastic lesions in rat pancreas. Visser CJ, etal., Lab Invest. 1996 Jan;74(1):2-11.
107. Rat testicular Src: normal distribution and involvement in ethylene glycol monomethyl ether-induced apoptosis. Wang W, etal., Toxicol Appl Pharmacol. 2000 Mar 1;163(2):125-34. doi: 10.1006/taap.1999.8870.
108. Transduced PDZ1 domain of PSD-95 decreases Src phosphorylation and increases nNOS (Ser847) phosphorylation contributing to neuroprotection after cerebral ischemia. Wang WW, etal., Brain Res. 2010 Apr 30;1328:162-70. Epub 2010 Mar 1.
109. Decay accelerating factor (CD55) protects neuronal cells from chemical hypoxia-induced injury. Wang Y, etal., J Neuroinflammation. 2010 Apr 9;7:24.
110. A decrease in dietary K intake stimulates the generation of superoxide anions in the kidney and inhibits K secretory channels in the CCD. Wang ZJ, etal., Am J Physiol Renal Physiol. 2010 Mar 31.
111. Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses. Wei H, etal., Biochim Biophys Acta. 2015 Oct;1853(10 Pt B):2784-90. doi: 10.1016/j.bbamcr.2015.03.013. Epub 2015 Apr 1.
112. Activated c-SRC in ductal carcinoma in situ correlates with high tumour grade, high proliferation and HER2 positivity. Wilson GR, etal., Br J Cancer. 2006 Nov 20;95(10):1410-4. Epub 2006 Oct 24.
113. Regulation of ectoplasmic specialization dynamics in the seminiferous epithelium by focal adhesion-associated proteins in testosterone-suppressed rat testes. Wong CH, etal., Endocrinology. 2005 Mar;146(3):1192-204. Epub 2004 Dec 9.
114. Herbimycin A, a pp60c-src tyrosine kinase inhibitor, inhibits osteoclastic bone resorption in vitro and hypercalcemia in vivo. Yoneda T, etal., J Clin Invest. 1993 Jun;91(6):2791-5. doi: 10.1172/JCI116521.
115. NMDA channel regulation by channel-associated protein tyrosine kinase Src. Yu XM, etal., Science. 1997 Jan 31;275(5300):674-8.
116. Src-dependent phosphorylation of μ-opioid receptor at Tyr336 modulates opiate withdrawal. Zhang L, etal., EMBO Mol Med. 2017 Nov;9(11):1521-1536. doi: 10.15252/emmm.201607324.
117. Neuroimmune modulation following traumatic stress in rats: evidence for an immunoregulatory cascade mediated by c-Src, miRNA222 and PAK1. Zhao H, etal., J Neuroinflammation. 2011 Nov 14;8:159. doi: 10.1186/1742-2094-8-159.
118. Nonreceptor tyrosine protein kinase pp60c-src in spatial learning: synapse-specific changes in its gene expression, tyrosine phosphorylation, and protein-protein interactions. Zhao W, etal., Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8098-103. doi: 10.1073/pnas.97.14.8098.
119. Active Src expression is induced after rat peripheral nerve injury. Zhao YL, etal., Glia. 2003 Apr 15;42(2):184-93. doi: 10.1002/glia.10223.
Additional References at PubMed
PMID:1381360   PMID:8070403   PMID:8402898   PMID:8438166   PMID:8657134   PMID:8805372   PMID:8910389   PMID:8953041   PMID:9582366   PMID:9799234   PMID:10082587   PMID:10861086  
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PMID:18314882   PMID:18353971   PMID:18498770   PMID:18541665   PMID:18559349   PMID:18599541   PMID:18616564   PMID:18616680   PMID:18667434   PMID:18678878   PMID:18680145   PMID:18682436  
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PMID:28952414   PMID:29462885   PMID:30142894   PMID:34662809   PMID:35043508  


Genomics

Comparative Map Data
Src
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83166,511,616 - 166,559,463 (+)NCBIGRCr8
mRatBN7.23146,091,969 - 146,139,492 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3146,091,841 - 146,139,476 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3149,950,044 - 149,963,314 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03158,451,340 - 158,464,620 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03156,193,067 - 156,206,340 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03153,547,807 - 153,595,643 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3153,580,861 - 153,595,642 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03158,123,674 - 158,171,912 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43148,157,256 - 148,170,524 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13148,063,164 - 148,076,433 (+)NCBI
Celera3144,830,256 - 144,843,524 (+)NCBICelera
Cytogenetic Map3q42NCBI
SRC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382037,344,699 - 37,406,050 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2037,344,685 - 37,406,050 (+)EnsemblGRCh38hg38GRCh38
GRCh372035,973,102 - 36,034,453 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362035,406,502 - 35,467,235 (+)NCBINCBI36Build 36hg18NCBI36
Build 342035,407,970 - 35,467,233NCBI
Celera2032,680,370 - 32,741,098 (+)NCBICelera
Cytogenetic Map20q11.23NCBI
HuRef2032,708,654 - 32,769,187 (+)NCBIHuRef
CHM1_12035,876,016 - 35,936,689 (+)NCBICHM1_1
T2T-CHM13v2.02039,068,774 - 39,130,114 (+)NCBIT2T-CHM13v2.0
Src
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392157,265,828 - 157,313,758 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2157,260,364 - 157,313,782 (+)EnsemblGRCm39 Ensembl
GRCm382157,423,906 - 157,471,838 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2157,418,444 - 157,471,862 (+)EnsemblGRCm38mm10GRCm38
MGSCv372157,250,029 - 157,297,574 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362157,115,734 - 157,163,279 (+)NCBIMGSCv36mm8
Celera2163,383,913 - 163,416,616 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map278.35NCBI
Src
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544519,215,161 - 19,228,695 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544519,213,210 - 19,227,670 (-)NCBIChiLan1.0ChiLan1.0
SRC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22143,073,049 - 43,132,588 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12043,066,176 - 43,127,531 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02033,667,614 - 33,727,126 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12034,822,287 - 34,841,523 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2034,822,271 - 34,839,634 (+)Ensemblpanpan1.1panPan2
SRC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12425,982,499 - 26,019,748 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2425,999,048 - 26,018,077 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2425,618,275 - 25,668,243 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02426,666,859 - 26,717,079 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2426,666,617 - 26,717,074 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12425,944,146 - 25,994,080 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02426,074,538 - 26,099,748 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02426,538,700 - 26,589,113 (+)NCBIUU_Cfam_GSD_1.0
Src
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640174,890,047 - 174,922,678 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365613,825,787 - 3,844,483 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365613,826,802 - 3,844,406 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1740,471,009 - 40,524,860 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11740,470,970 - 40,524,862 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21745,907,305 - 45,942,026 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1226,344,480 - 26,367,448 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl226,343,450 - 26,367,776 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605075,217,493 - 75,278,886 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Src
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248422,211,020 - 2,230,132 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248422,212,561 - 2,260,514 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Src
227 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:149
Count of miRNA genes:110
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000012739
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145956084157309487Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141339236155617360Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3145956084161299569Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3140069424146976080Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat

Markers in Region
BE110190  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23146,137,743 - 146,137,930 (+)MAPPERmRatBN7.2
Rnor_6.03153,593,895 - 153,594,081NCBIRnor6.0
Rnor_5.03158,125,236 - 158,125,422UniSTSRnor5.0
RGSC_v3.43148,170,282 - 148,170,468UniSTSRGSC3.4
Celera3144,843,282 - 144,843,468UniSTS
Cytogenetic Map3q42UniSTS
WI-14593  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23146,124,907 - 146,126,213 (+)MAPPERmRatBN7.2
Rnor_6.03153,581,062 - 153,582,367NCBIRnor6.0
Rnor_5.03158,136,949 - 158,138,254UniSTSRnor5.0
RGSC_v3.43148,157,449 - 148,158,754UniSTSRGSC3.4
Celera3144,830,449 - 144,831,754UniSTS
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001431489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC095852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF130457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF157016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ120509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ120510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000012739   ⟹   ENSRNOP00000012739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3146,091,841 - 146,137,986 (+)Ensembl
Rnor_6.0 Ensembl3153,580,869 - 153,593,765 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080516   ⟹   ENSRNOP00000071837
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3146,091,841 - 146,139,476 (+)Ensembl
Rnor_6.0 Ensembl3153,580,861 - 153,595,642 (+)Ensembl
RefSeq Acc Id: NM_031977   ⟹   NP_114183
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,544,688 - 166,557,957 (+)NCBI
mRatBN7.23146,124,715 - 146,137,986 (+)NCBI
Rnor_6.03153,580,869 - 153,594,137 (+)NCBI
Rnor_5.03158,123,674 - 158,171,912 (-)NCBI
RGSC_v3.43148,157,256 - 148,170,524 (+)RGD
Celera3144,830,256 - 144,843,524 (+)RGD
Sequence:
RefSeq Acc Id: XM_017592066   ⟹   XP_017447555
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,511,957 - 166,559,463 (+)NCBI
mRatBN7.23146,091,969 - 146,139,492 (+)NCBI
Rnor_6.03153,548,217 - 153,595,643 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592068   ⟹   XP_017447557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,515,778 - 166,559,463 (+)NCBI
mRatBN7.23146,095,810 - 146,139,492 (+)NCBI
Rnor_6.03153,551,574 - 153,595,643 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592071   ⟹   XP_017447560
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,516,067 - 166,559,463 (+)NCBI
mRatBN7.23146,095,810 - 146,139,492 (+)NCBI
Rnor_6.03153,551,574 - 153,595,643 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105957   ⟹   XP_038961885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,511,957 - 166,559,463 (+)NCBI
mRatBN7.23146,091,969 - 146,139,492 (+)NCBI
RefSeq Acc Id: XM_039105958   ⟹   XP_038961886
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,515,778 - 166,559,463 (+)NCBI
mRatBN7.23146,095,810 - 146,139,492 (+)NCBI
RefSeq Acc Id: XM_039105960   ⟹   XP_038961888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,515,778 - 166,559,463 (+)NCBI
mRatBN7.23146,095,810 - 146,139,492 (+)NCBI
RefSeq Acc Id: XM_039105961   ⟹   XP_038961889
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,511,960 - 166,559,463 (+)NCBI
mRatBN7.23146,092,087 - 146,139,492 (+)NCBI
RefSeq Acc Id: XM_039105962   ⟹   XP_038961890
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,511,956 - 166,559,463 (+)NCBI
mRatBN7.23146,091,969 - 146,139,492 (+)NCBI
RefSeq Acc Id: XM_039105963   ⟹   XP_038961891
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,534,406 - 166,559,463 (+)NCBI
mRatBN7.23146,114,301 - 146,139,492 (+)NCBI
RefSeq Acc Id: XM_039105964   ⟹   XP_038961892
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,511,957 - 166,559,463 (+)NCBI
mRatBN7.23146,092,558 - 146,139,492 (+)NCBI
RefSeq Acc Id: XM_039105965   ⟹   XP_038961893
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,511,960 - 166,559,463 (+)NCBI
mRatBN7.23146,092,105 - 146,139,492 (+)NCBI
RefSeq Acc Id: XM_039105966   ⟹   XP_038961894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,511,843 - 166,559,463 (+)NCBI
mRatBN7.23146,091,969 - 146,139,492 (+)NCBI
RefSeq Acc Id: XM_063284664   ⟹   XP_063140734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,511,956 - 166,559,463 (+)NCBI
RefSeq Acc Id: XM_063284665   ⟹   XP_063140735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,511,957 - 166,559,463 (+)NCBI
RefSeq Acc Id: XM_063284666   ⟹   XP_063140736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,511,957 - 166,559,463 (+)NCBI
RefSeq Acc Id: XM_063284667   ⟹   XP_063140737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,511,960 - 166,559,463 (+)NCBI
RefSeq Acc Id: XM_063284668   ⟹   XP_063140738
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,511,959 - 166,559,463 (+)NCBI
RefSeq Acc Id: XM_063284669   ⟹   XP_063140739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,515,784 - 166,559,463 (+)NCBI
RefSeq Acc Id: XM_063284670   ⟹   XP_063140740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,511,943 - 166,559,463 (+)NCBI
RefSeq Acc Id: XM_063284671   ⟹   XP_063140741
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,511,616 - 166,559,463 (+)NCBI
RefSeq Acc Id: XM_063284672   ⟹   XP_063140742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,511,960 - 166,559,463 (+)NCBI
RefSeq Acc Id: XM_063284673   ⟹   XP_063140743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,515,781 - 166,559,463 (+)NCBI
RefSeq Acc Id: XM_063284674   ⟹   XP_063140744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,511,960 - 166,559,463 (+)NCBI
RefSeq Acc Id: XM_063284675   ⟹   XP_063140745
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,515,986 - 166,559,463 (+)NCBI
RefSeq Acc Id: XM_063284676   ⟹   XP_063140746
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,511,960 - 166,559,463 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001418418 (Get FASTA)   NCBI Sequence Viewer  
  NP_001418419 (Get FASTA)   NCBI Sequence Viewer  
  NP_001418420 (Get FASTA)   NCBI Sequence Viewer  
  NP_001418421 (Get FASTA)   NCBI Sequence Viewer  
  NP_001418422 (Get FASTA)   NCBI Sequence Viewer  
  NP_114183 (Get FASTA)   NCBI Sequence Viewer  
  XP_017447555 (Get FASTA)   NCBI Sequence Viewer  
  XP_017447557 (Get FASTA)   NCBI Sequence Viewer  
  XP_017447560 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961885 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961886 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961888 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961889 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961890 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961891 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961892 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961893 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961894 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140734 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140735 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140736 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140737 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140738 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140739 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140740 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140741 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140742 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140743 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140744 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140745 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140746 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD24180 (Get FASTA)   NCBI Sequence Viewer  
  AAF80335 (Get FASTA)   NCBI Sequence Viewer  
  AAZ23848 (Get FASTA)   NCBI Sequence Viewer  
  AAZ23849 (Get FASTA)   NCBI Sequence Viewer  
  EDL96675 (Get FASTA)   NCBI Sequence Viewer  
  EDL96676 (Get FASTA)   NCBI Sequence Viewer  
  EDL96677 (Get FASTA)   NCBI Sequence Viewer  
  EDL96678 (Get FASTA)   NCBI Sequence Viewer  
  EDL96679 (Get FASTA)   NCBI Sequence Viewer  
  EDL96680 (Get FASTA)   NCBI Sequence Viewer  
  EDL96681 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012739
  ENSRNOP00000012739.3
  ENSRNOP00000071837
  ENSRNOP00000071837.2
GenBank Protein Q9WUD9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_114183   ⟸   NM_031977
- UniProtKB: Q9WUD9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017447555   ⟸   XM_017592066
- Peptide Label: isoform X1
- UniProtKB: Q9WUD9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017447557   ⟸   XM_017592068
- Peptide Label: isoform X1
- UniProtKB: Q9WUD9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017447560   ⟸   XM_017592071
- Peptide Label: isoform X1
- UniProtKB: Q9WUD9 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071837   ⟸   ENSRNOT00000080516
Ensembl Acc Id: ENSRNOP00000012739   ⟸   ENSRNOT00000012739
RefSeq Acc Id: XP_038961890   ⟸   XM_039105962
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038961885   ⟸   XM_039105957
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038961894   ⟸   XM_039105966
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038961889   ⟸   XM_039105961
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038961893   ⟸   XM_039105965
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038961892   ⟸   XM_039105964
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038961886   ⟸   XM_039105958
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038961888   ⟸   XM_039105960
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038961891   ⟸   XM_039105963
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063140741   ⟸   XM_063284671
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063140740   ⟸   XM_063284670
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063140734   ⟸   XM_063284664
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063140736   ⟸   XM_063284666
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063140735   ⟸   XM_063284665
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063140738   ⟸   XM_063284668
- Peptide Label: isoform X2
- UniProtKB: Q9WUD9 (UniProtKB/Swiss-Prot),   Q9JJ10 (UniProtKB/Swiss-Prot),   Q45QJ2 (UniProtKB/Swiss-Prot),   G3V776 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063140737   ⟸   XM_063284667
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063140746   ⟸   XM_063284676
- Peptide Label: isoform X2
- UniProtKB: Q9WUD9 (UniProtKB/Swiss-Prot),   Q9JJ10 (UniProtKB/Swiss-Prot),   Q45QJ2 (UniProtKB/Swiss-Prot),   G3V776 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063140742   ⟸   XM_063284672
- Peptide Label: isoform X2
- UniProtKB: Q9WUD9 (UniProtKB/Swiss-Prot),   Q9JJ10 (UniProtKB/Swiss-Prot),   Q45QJ2 (UniProtKB/Swiss-Prot),   G3V776 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063140744   ⟸   XM_063284674
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063140743   ⟸   XM_063284673
- Peptide Label: isoform X2
- UniProtKB: Q9WUD9 (UniProtKB/Swiss-Prot),   Q9JJ10 (UniProtKB/Swiss-Prot),   Q45QJ2 (UniProtKB/Swiss-Prot),   G3V776 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063140739   ⟸   XM_063284669
- Peptide Label: isoform X2
- UniProtKB: Q9WUD9 (UniProtKB/Swiss-Prot),   Q9JJ10 (UniProtKB/Swiss-Prot),   Q45QJ2 (UniProtKB/Swiss-Prot),   G3V776 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063140745   ⟸   XM_063284675
- Peptide Label: isoform X2
- UniProtKB: Q9WUD9 (UniProtKB/Swiss-Prot),   Q9JJ10 (UniProtKB/Swiss-Prot),   Q45QJ2 (UniProtKB/Swiss-Prot),   G3V776 (UniProtKB/Swiss-Prot)
Protein Domains
Protein kinase   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WUD9-F1-model_v2 AlphaFold Q9WUD9 1-536 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620795 AgrOrtholog
BioCyc Gene G2FUF-47052 BioCyc
Ensembl Genes ENSRNOG00000009495 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012739 ENTREZGENE
  ENSRNOT00000012739.5 UniProtKB/Swiss-Prot
  ENSRNOT00000080516 ENTREZGENE
  ENSRNOT00000080516.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Non-receptor_tyrosine_kinases UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
KEGG Report rno:83805 UniProtKB/Swiss-Prot
NCBI Gene 83805 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/Swiss-Prot
Pfam Pkinase_Tyr UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
PhenoGen Src PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot
  SH3DOMAIN UniProtKB/Swiss-Prot
  TYRKINASE UniProtKB/Swiss-Prot
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009495 RatGTEx
SMART SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
  TyrKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A6JWS8_RAT UniProtKB/TrEMBL
  G3V776 ENTREZGENE
  Q45QJ2 ENTREZGENE
  Q9JJ10 ENTREZGENE
  Q9WUD9 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary G3V776 UniProtKB/Swiss-Prot
  Q45QJ2 UniProtKB/Swiss-Prot
  Q9JJ10 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-10 Src  SRC proto-oncogene, non-receptor tyrosine kinase  Src  v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Src  v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog  Src  v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Src  v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)  Src  Rous sarcoma oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Src  Rous sarcoma oncogene    tyrosine protein kinase pp60-c-src  Name updated 1299863 APPROVED
2002-08-07 Src  tyrosine protein kinase pp60-c-src      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation Tyr phosphorylation is increased in response to the fully processed form of gastrin 634205