Yme1l1 (YME1-like 1 ATPase) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Yme1l1 (YME1-like 1 ATPase) Rattus norvegicus
Analyze
Symbol: Yme1l1
Name: YME1-like 1 ATPase
RGD ID: 620764
Description: Predicted to enable ATP-dependent peptidase activity. Predicted to be involved in several processes, including neuronal stem cell population maintenance; positive regulation of mitochondrial fusion; and protein catabolic process. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in optic atrophy 11. Orthologous to human YME1L1 (YME1 like 1 ATPase); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATP-dependent metalloprotease FtsH1; ATP-dependent metalloprotease FtsH1 homolog; ATP-dependent metalloprotease YME1L1; ATP-dependent zinc metalloprotease YME1L1; FtsH1; LOC108348078; meg-4; MGC93290; YME1 (S.cerevisiae)-like 1; YME1-like 1 (S. cerevisiae); YME1-like protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81790,195,485 - 90,235,675 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1790,195,584 - 90,356,331 (+)EnsemblGRCr8
mRatBN7.21785,287,607 - 85,326,068 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1785,287,554 - 85,326,335 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1788,772,231 - 88,810,234 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01792,607,609 - 92,645,612 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01786,624,386 - 86,662,389 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01789,701,899 - 89,741,919 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1789,704,102 - 89,741,321 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1789,800,934 - 89,838,986 (-)Ensemblrn6Rnor6.0
Rnor_5.01791,464,149 - 91,504,157 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41796,758,634 - 96,796,686 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1783,570,083 - 83,608,132 (-)NCBICelera
RGSC_v3.11796,769,466 - 96,807,518 (+)NCBI
Cytogenetic Map17q12.3NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
mitochondrial inner membrane  (IBA,IEA,ISO,ISS)
mitochondrion  (IEA,ISO)
nuclear body  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification and characterization of YME1L1, a novel paraplegin-related gene. Coppola M, etal., Genomics 2000 May 15;66(1):48-54.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:19946888   PMID:22262461   PMID:27495975   PMID:27786171  


Genomics

Comparative Map Data
Yme1l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81790,195,485 - 90,235,675 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1790,195,584 - 90,356,331 (+)EnsemblGRCr8
mRatBN7.21785,287,607 - 85,326,068 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1785,287,554 - 85,326,335 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1788,772,231 - 88,810,234 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01792,607,609 - 92,645,612 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01786,624,386 - 86,662,389 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01789,701,899 - 89,741,919 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1789,704,102 - 89,741,321 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1789,800,934 - 89,838,986 (-)Ensemblrn6Rnor6.0
Rnor_5.01791,464,149 - 91,504,157 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41796,758,634 - 96,796,686 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1783,570,083 - 83,608,132 (-)NCBICelera
RGSC_v3.11796,769,466 - 96,807,518 (+)NCBI
Cytogenetic Map17q12.3NCBI
YME1L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381027,110,111 - 27,154,384 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1027,110,088 - 27,155,266 (-)Ensemblhg38GRCh38
GRCh371027,399,040 - 27,443,313 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361027,439,389 - 27,483,327 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341027,440,668 - 27,483,327NCBI
Celera1027,115,834 - 27,159,778 (-)NCBICelera
Cytogenetic Map10p12.1NCBI
HuRef1027,067,668 - 27,112,050 (-)NCBIHuRef
CHM1_11027,398,978 - 27,443,293 (-)NCBICHM1_1
T2T-CHM13v2.01027,140,165 - 27,184,407 (-)NCBIT2T-CHM13v2.0
Yme1l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39223,046,517 - 23,089,272 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl223,046,381 - 23,089,272 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38223,155,442 - 23,199,260 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl223,156,369 - 23,199,260 (+)Ensemblmm10GRCm38
MGSCv37223,012,066 - 23,054,156 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36222,978,555 - 23,020,645 (+)NCBIMGSCv36mm8
Celera222,888,199 - 22,930,440 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map215.24NCBI
Yme1l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554292,549,954 - 2,572,889 (-)Ensembl
ChiLan1.0NW_0049554292,550,611 - 2,572,472 (-)NCBIChiLan1.0ChiLan1.0
YME1L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2839,740,191 - 39,784,086 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11039,742,838 - 39,789,413 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01027,220,951 - 27,263,841 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11027,584,093 - 27,626,901 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1027,584,099 - 27,626,453 (-)EnsemblpanPan2panpan1.1
YME1L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.126,785,472 - 6,829,188 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl26,737,487 - 6,829,089 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha25,538,660 - 5,582,403 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.024,974,867 - 5,018,866 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl24,972,927 - 5,018,825 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.124,351,996 - 4,395,975 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.024,428,272 - 4,472,481 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.024,595,391 - 4,639,187 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Yme1l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934426,141,811 - 26,187,422 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364842,306,760 - 2,353,507 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364842,306,937 - 2,352,671 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
YME1L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11048,807,654 - 48,855,228 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21054,023,860 - 54,063,147 (+)NCBISscrofa10.2Sscrofa10.2susScr3
YME1L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1926,703,747 - 26,752,274 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl926,703,992 - 26,752,340 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605132,716,565 - 32,761,391 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Yme1l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247962,179,170 - 2,215,903 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247962,178,102 - 2,215,837 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Yme1l1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1141,403,011 - 1,438,729 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:368
Count of miRNA genes:189
Interacting mature miRNAs:208
Transcripts:ENSRNOT00000023395, ENSRNOT00000071812
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176855004093515804Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)174605012691050126Rat
61466Niddm12Non-insulin dependent diabetes mellitus QTL 123.20.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)176515487293515804Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175560459793006569Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)175482950393515804Rat

Markers in Region
D17Got106  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21785,316,005 - 85,316,114 (-)MAPPERmRatBN7.2
Rnor_6.01789,810,888 - 89,810,996NCBIRnor6.0
Rnor_6.01789,713,389 - 89,713,497NCBIRnor6.0
Rnor_5.01791,475,640 - 91,475,748UniSTSRnor5.0
Rnor_5.01791,378,141 - 91,378,249UniSTSRnor5.0
RGSC_v3.41796,786,624 - 96,786,732UniSTSRGSC3.4
RGSC_v3.41796,786,623 - 96,786,732RGDRGSC3.4
RGSC_v3.11796,797,456 - 96,797,565RGD
RH 3.4 Map17839.6UniSTS
RH 3.4 Map17839.6RGD
RH 2.0 Map17728.1RGD
Cytogenetic Map17q12.3UniSTS
AF090430  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21785,325,475 - 85,325,575 (-)MAPPERmRatBN7.2
Rnor_6.01789,801,426 - 89,801,525NCBIRnor6.0
Rnor_6.01789,703,928 - 89,704,027NCBIRnor6.0
Rnor_5.01791,368,680 - 91,368,779UniSTSRnor5.0
Rnor_5.01791,466,178 - 91,466,277UniSTSRnor5.0
RGSC_v3.41796,796,094 - 96,796,193UniSTSRGSC3.4
Celera1783,570,576 - 83,570,675UniSTS
Cytogenetic Map17q12.3UniSTS
PMC290270P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21785,322,164 - 85,322,498 (-)MAPPERmRatBN7.2
Rnor_6.01789,804,503 - 89,804,837NCBIRnor6.0
Rnor_6.01789,707,005 - 89,707,338NCBIRnor6.0
Rnor_5.01791,371,757 - 91,372,090UniSTSRnor5.0
Rnor_5.01791,469,255 - 91,469,589UniSTSRnor5.0
RGSC_v3.41796,792,783 - 96,793,116UniSTSRGSC3.4
Celera1783,573,653 - 83,573,986UniSTS
Cytogenetic Map17q12.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 52 67 138 95 11 51 36 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000023395   ⟹   ENSRNOP00000023395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1785,287,554 - 85,325,634 (+)Ensembl
Rnor_6.0 Ensembl1789,704,102 - 89,741,321 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081249   ⟹   ENSRNOP00000071378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1785,288,047 - 85,326,335 (+)Ensembl
Rnor_6.0 Ensembl1789,800,934 - 89,838,986 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108331   ⟹   ENSRNOP00000080549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1785,287,979 - 85,325,020 (+)Ensembl
RefSeq Acc Id: NM_053682   ⟹   NP_446134
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81790,196,087 - 90,234,139 (+)NCBI
mRatBN7.21785,288,016 - 85,326,068 (+)NCBI
Rnor_6.01789,703,435 - 89,741,487 (-)NCBI
Rnor_5.01791,464,149 - 91,504,157 (-)NCBI
RGSC_v3.41796,758,634 - 96,796,686 (+)RGD
Celera1783,570,083 - 83,608,132 (-)RGD
Sequence:
RefSeq Acc Id: XM_006254369   ⟹   XP_006254431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81790,195,485 - 90,235,675 (+)NCBI
mRatBN7.21785,287,607 - 85,325,629 (+)NCBI
Rnor_6.01789,701,899 - 89,741,919 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_446134 (Get FASTA)   NCBI Sequence Viewer  
  XP_006254431 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH81751 (Get FASTA)   NCBI Sequence Viewer  
  AAK57557 (Get FASTA)   NCBI Sequence Viewer  
  EDL83929 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000080549
  ENSRNOP00000110660
GenBank Protein Q925S8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446134   ⟸   NM_053682
- UniProtKB: Q925S8 (UniProtKB/Swiss-Prot),   Q66HP7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254431   ⟸   XM_006254369
- Peptide Label: isoform X1
- UniProtKB: Q925S8 (UniProtKB/Swiss-Prot),   G3V886 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023395   ⟸   ENSRNOT00000023395
Ensembl Acc Id: ENSRNOP00000071378   ⟸   ENSRNOT00000081249
Ensembl Acc Id: ENSRNOP00000080549   ⟸   ENSRNOT00000108331
Protein Domains
AAA+ ATPase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q925S8-F1-model_v2 AlphaFold Q925S8 1-715 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620764 AgrOrtholog
BioCyc Gene G2FUF-8477 BioCyc
Ensembl Genes ENSRNOG00000017100 Ensembl
  ENSRNOG00000055012 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000108331 ENTREZGENE
  ENSRNOT00000170016 ENTREZGENE
Gene3D-CATH 1.10.8.60 UniProtKB/Swiss-Prot
  1.20.58.760 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7108995 IMAGE-MGC_LOAD
InterPro AAA+_ATPase UniProtKB/Swiss-Prot
  AAA_lid_3 UniProtKB/Swiss-Prot
  ATPase_AAA_core UniProtKB/Swiss-Prot
  ATPase_AAA_CS UniProtKB/Swiss-Prot
  FtsH UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Peptidase_M41 UniProtKB/Swiss-Prot
  Peptidase_M41-like UniProtKB/Swiss-Prot
MGC_CLONE MGC:93290 IMAGE-MGC_LOAD
NCBI Gene 114217 ENTREZGENE
PANTHER ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1 UniProtKB/Swiss-Prot
  METALLOPROTEASE M41 FTSH UniProtKB/Swiss-Prot
Pfam AAA UniProtKB/Swiss-Prot
  AAA_lid_3 UniProtKB/Swiss-Prot
  Peptidase_M41 UniProtKB/Swiss-Prot
PhenoGen Yme1l1 PhenoGen
PROSITE AAA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017100 RatGTEx
  ENSRNOG00000055012 RatGTEx
SMART AAA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF140990 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
UniProt A0A0G2K0B5_RAT UniProtKB/TrEMBL
  A0A8I5ZQI4_RAT UniProtKB/TrEMBL
  A0ABK0LY48_RAT UniProtKB/TrEMBL
  A6KRZ1_RAT UniProtKB/TrEMBL
  G3V886 ENTREZGENE, UniProtKB/TrEMBL
  Q66HP7 ENTREZGENE, UniProtKB/TrEMBL
  Q925S8 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Yme1l1  YME1-like 1 ATPase  LOC108348078  ATP-dependent zinc metalloprotease YME1L1  Data merged from RGD:11358998 737654 PROVISIONAL
2016-08-02 LOC108348078  ATP-dependent zinc metalloprotease YME1L1      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-07-09 Yme1l1  YME1-like 1 ATPase  Yme1l1  YME1-like 1 (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Yme1l1  YME1-like 1 (S. cerevisiae)    YME1 (S.cerevisiae)-like 1  Name updated 1299863 APPROVED
2002-08-07 Yme1l1  YME1 (S.cerevisiae)-like 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease human homolog has similarity to human paraplegin (SPG7), which is mutated in an autosomal recessive form of hereditary spastic paraplegia 727774