Plk2 (polo-like kinase 2) - Rat Genome Database

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Gene: Plk2 (polo-like kinase 2) Rattus norvegicus
Analyze
Symbol: Plk2
Name: polo-like kinase 2
RGD ID: 620760
Description: Enables clathrin heavy chain binding activity; enzyme binding activity; and protein serine/threonine kinase activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of protein localization to cell surface; and small GTPase-mediated signal transduction. Located in dendrite. Is active in postsynapse. Orthologous to human PLK2 (polo like kinase 2); INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: PLK-2; polo-like kinase 1; polo-like kinase 2 (Drosophila); serine/threonine-protein kinase PLK2; serine/threonine-protein kinase SNK; serum-inducible kinase; Snk
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8243,702,536 - 43,708,305 (+)NCBIGRCr8
mRatBN7.2241,969,176 - 41,974,945 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl241,969,176 - 41,974,947 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx249,090,164 - 49,095,930 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0247,148,897 - 47,154,663 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0242,001,899 - 42,007,665 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0241,911,143 - 41,916,901 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl241,911,131 - 41,916,901 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0260,970,300 - 60,976,058 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4241,800,745 - 41,806,503 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1241,721,113 - 41,726,872 (+)NCBI
Celera237,785,007 - 37,790,765 (+)NCBICelera
Cytogenetic Map2q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (EXP)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dichloroaniline  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-O-methylguanine  (ISO)
7,12-dimethyltetraphene  (EXP,IEP,ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
azoxystrobin  (EXP)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumarin  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
dexamethasone  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Echimidine  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
etoposide  (ISO)
ferric oxide  (ISO)
ferroheme b  (ISO)
fluoranthene  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (EXP)
heme b  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP,ISO)
imidacloprid  (EXP)
indometacin  (ISO)
irinotecan  (ISO)
iron(III) nitrilotriacetate  (EXP)
isobutanol  (ISO)
L-ascorbic acid  (EXP)
Lasiocarpine  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metformin  (EXP)
methapyrilene  (EXP)
methotrexate  (EXP)
methoxyacetic acid  (ISO)
methylmercury chloride  (ISO)
monocrotaline  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalenes  (EXP)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nicotine  (ISO)
ochratoxin A  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP,IEP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propan-2-ol  (ISO)
propanal  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
riddelliine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sorafenib  (ISO)
succimer  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thiabendazole  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
centriole  (IBA,IEA,ISO,ISS)
centrosome  (IBA,IEA,ISO,ISS)
chromatin  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
dendrite  (IDA)
kinetochore  (IBA)
nucleus  (IBA)
postsynapse  (IDA,IEP,IMP)
spindle pole  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Regulation of postsynaptic RapGAP SPAR by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neurons. Ang XL, etal., J Biol Chem. 2008 Oct 24;283(43):29424-32. doi: 10.1074/jbc.M802475200. Epub 2008 Aug 22.
2. Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation. Evers DM, etal., Nat Neurosci. 2010 Oct;13(10):1199-207. doi: 10.1038/nn.2624. Epub 2010 Aug 29.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity. Kauselmann G, etal., EMBO J 1999 Oct 15;18(20):5528-39.
6. Requirement for Plk2 in orchestrated ras and rap signaling, homeostatic structural plasticity, and memory. Lee KJ, etal., Neuron. 2011 Mar 10;69(5):957-73. doi: 10.1016/j.neuron.2011.02.004.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Targeted protein degradation and synapse remodeling by an inducible protein kinase. Pak DT and Sheng M, Science 2003 Nov 21;302(5649):1368-73. Epub 2003 Oct 23.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity. Seeburg DP, etal., Neuron. 2008 May 22;58(4):571-83. doi: 10.1016/j.neuron.2008.03.021.
14. cDNA microarray profiling of rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenzanthracene. Shan L, etal., Carcinogenesis. 2002 Oct;23(10):1561-8.
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:12761501   PMID:12897130   PMID:12972611   PMID:15242618   PMID:15489334   PMID:16203730   PMID:18579731   PMID:19001868   PMID:20146300   PMID:20352051   PMID:20531387   PMID:21691298  
PMID:22854038   PMID:22870256   PMID:23466428   PMID:23479645   PMID:23850969   PMID:23983262   PMID:26934179   PMID:27579920   PMID:27908889   PMID:29066438   PMID:31134620   PMID:34047419  
PMID:37654026  


Genomics

Comparative Map Data
Plk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8243,702,536 - 43,708,305 (+)NCBIGRCr8
mRatBN7.2241,969,176 - 41,974,945 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl241,969,176 - 41,974,947 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx249,090,164 - 49,095,930 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0247,148,897 - 47,154,663 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0242,001,899 - 42,007,665 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0241,911,143 - 41,916,901 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl241,911,131 - 41,916,901 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0260,970,300 - 60,976,058 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4241,800,745 - 41,806,503 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1241,721,113 - 41,726,872 (+)NCBI
Celera237,785,007 - 37,790,765 (+)NCBICelera
Cytogenetic Map2q14NCBI
PLK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38558,453,982 - 58,460,086 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl558,453,982 - 58,460,139 (-)EnsemblGRCh38hg38GRCh38
GRCh37557,749,809 - 57,755,913 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36557,785,566 - 57,791,670 (-)NCBINCBI36Build 36hg18NCBI36
Build 34557,785,569 - 57,791,844NCBI
Celera554,688,300 - 54,694,404 (-)NCBICelera
Cytogenetic Map5q11.2NCBI
HuRef554,706,921 - 54,713,078 (-)NCBIHuRef
CHM1_1557,749,420 - 57,755,577 (-)NCBICHM1_1
T2T-CHM13v2.0559,272,431 - 59,278,533 (-)NCBIT2T-CHM13v2.0
Plk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913110,531,578 - 110,537,378 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13110,531,580 - 110,537,378 (+)EnsemblGRCm39 Ensembl
GRCm3813110,395,044 - 110,400,844 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13110,395,046 - 110,400,844 (+)EnsemblGRCm38mm10GRCm38
MGSCv3713111,185,252 - 111,191,052 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613111,515,940 - 111,521,722 (+)NCBIMGSCv36mm8
Celera13114,729,888 - 114,735,651 (+)NCBICelera
Cytogenetic Map13D2.1NCBI
cM Map1361.97NCBI
Plk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554469,671,090 - 9,677,188 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554469,671,090 - 9,676,956 (+)NCBIChiLan1.0ChiLan1.0
PLK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2455,454,341 - 55,461,398 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1553,607,973 - 53,614,939 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0555,543,828 - 55,550,116 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1557,178,503 - 57,184,793 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl557,177,836 - 57,184,793 (+)Ensemblpanpan1.1panPan2
PLK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1245,359,865 - 45,365,496 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl245,360,374 - 45,367,441 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha242,431,127 - 42,436,818 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0245,844,932 - 45,850,642 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl245,844,939 - 45,850,697 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1242,914,745 - 42,920,462 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0243,720,594 - 43,726,300 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0244,541,169 - 44,546,873 (-)NCBIUU_Cfam_GSD_1.0
Plk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213200,743,971 - 200,750,098 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364809,680,449 - 9,686,595 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364809,680,461 - 9,686,593 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1637,299,119 - 37,305,114 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11637,299,116 - 37,305,114 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21640,067,358 - 40,073,357 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1454,629,868 - 54,636,134 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl454,629,194 - 54,636,032 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660493,546,484 - 3,552,760 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624759811,316 - 817,474 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624759811,320 - 817,401 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Plk2
22 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:475
Count of miRNA genes:252
Interacting mature miRNAs:298
Transcripts:ENSRNOT00000016768
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22238462767384627Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22997159351729300Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)238573329122609194Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
9685065Swd6Spike wave discharge measurement QTL 65.80.01brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge rate (CMO:0001739)23922393748793699Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22699957143154682Rat
731179Mamtr3Mammary tumor resistance QTL 30.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)23237377043665178Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
12879863Bp402Blood pressure QTL 4020.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24112578956532139Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)228484589169504100Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)228484589169504100Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat

Markers in Region
IB1671  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2241,974,662 - 41,974,824 (+)MAPPERmRatBN7.2
Rnor_6.0241,916,622 - 41,916,783NCBIRnor6.0
Rnor_5.0260,975,779 - 60,975,940UniSTSRnor5.0
RGSC_v3.4241,806,224 - 41,806,385UniSTSRGSC3.4
Celera237,790,486 - 37,790,647UniSTS
Cytogenetic Map2q14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000016768   ⟹   ENSRNOP00000016768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl241,969,176 - 41,974,947 (+)Ensembl
Rnor_6.0 Ensembl241,911,131 - 41,916,901 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111192   ⟹   ENSRNOP00000092527
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl241,969,176 - 41,974,947 (+)Ensembl
RefSeq Acc Id: NM_031821   ⟹   NP_114009
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8243,702,536 - 43,708,305 (+)NCBI
mRatBN7.2241,969,176 - 41,974,945 (+)NCBI
Rnor_6.0241,911,143 - 41,916,901 (+)NCBI
Rnor_5.0260,970,300 - 60,976,058 (+)NCBI
RGSC_v3.4241,800,745 - 41,806,503 (+)RGD
Celera237,785,007 - 37,790,765 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_114009 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF08366 (Get FASTA)   NCBI Sequence Viewer  
  AAH70878 (Get FASTA)   NCBI Sequence Viewer  
  EDM10332 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016768.3
  ENSRNOP00000092527.1
  ENSRNOP00055016070
  ENSRNOP00060004930
  ENSRNOP00065026746
GenBank Protein Q9R012 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_114009   ⟸   NM_031821
- UniProtKB: Q9R012 (UniProtKB/Swiss-Prot),   A6I5M4 (UniProtKB/TrEMBL),   A0A8I6ADU0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016768   ⟸   ENSRNOT00000016768
Ensembl Acc Id: ENSRNOP00000092527   ⟸   ENSRNOT00000111192
Protein Domains
POLO box   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R012-F1-model_v2 AlphaFold Q9R012 1-682 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691133
Promoter ID:EPDNEW_R1657
Type:single initiation site
Name:Plk2_1
Description:polo-like kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0241,911,135 - 41,911,195EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620760 AgrOrtholog
BioCyc Gene G2FUF-54435 BioCyc
Ensembl Genes ENSRNOG00000011951 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055011728 UniProtKB/Swiss-Prot
  ENSRNOG00060003936 UniProtKB/Swiss-Prot
  ENSRNOG00065019840 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016768.5 UniProtKB/Swiss-Prot
  ENSRNOT00000111192.1 UniProtKB/TrEMBL
  ENSRNOT00055019942 UniProtKB/Swiss-Prot
  ENSRNOT00060006581 UniProtKB/Swiss-Prot
  ENSRNOT00065033443 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1120.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7096750 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLK2_STKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_box_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_box_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_box_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_box_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83722 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91616 IMAGE-MGC_LOAD
NCBI Gene 83722 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE PLK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE PLK2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLO_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Plk2 PhenoGen
PROSITE POLO_BOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011951 RatGTEx
  ENSRNOG00055011728 RatGTEx
  ENSRNOG00060003936 RatGTEx
  ENSRNOG00065019840 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Polo-box domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ADU0 ENTREZGENE, UniProtKB/TrEMBL
  A6I5M4 ENTREZGENE, UniProtKB/TrEMBL
  PLK2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Plk2  polo-like kinase 2  Plk2  polo-like kinase 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Plk2  polo-like kinase 2 (Drosophila)  Snk  serum-inducible kinase  Symbol and Name updated 1299863 APPROVED
2002-08-07 Snk  serum-inducible kinase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression is induced by neuronal activity 61555
gene_product member of the polo family of cell cycle associated kinases 61555