Inhba (inhibin subunit beta A) - Rat Genome Database

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Gene: Inhba (inhibin subunit beta A) Rattus norvegicus
Analyze
Symbol: Inhba
Name: inhibin subunit beta A
RGD ID: 62074
Description: Predicted to enable identical protein binding activity; peptide hormone binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to decreased oxygen levels; cellular response to hormone stimulus; and positive regulation of DNA-templated transcription. Located in extracellular space. Part of inhibin A complex. Biomarker of congestive heart failure; myocardial infarction; retinal degeneration; and rheumatic heart disease. Orthologous to human INHBA (inhibin subunit beta A); PARTICIPATES IN transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: activin A; activin beta-A chain; inhibin beta A chain; inhibin beta A subunit; inhibin beta-A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21749,091,635 - 49,111,573 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1749,095,920 - 49,108,982 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1752,294,696 - 52,307,755 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01756,297,581 - 56,310,640 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01750,395,401 - 50,408,458 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01751,894,869 - 51,919,998 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1751,898,217 - 51,912,496 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01749,961,222 - 49,985,653 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41757,244,466 - 57,257,531 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11757,247,306 - 57,260,372 (-)NCBI
Celera1745,163,387 - 45,176,397 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-amphetamine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-nitrotoluene  (ISO)
25-hydroxycholesterol  (EXP)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-methylcatechol  (EXP)
4-nitrotoluene  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
allethrin  (EXP)
alpha-pinene  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
aristolochic acid A  (EXP,ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
belinostat  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
busulfan  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
calcitriol  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chlordecone  (ISO)
cholesterol  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
cobalt atom  (ISO)
colforsin daropate hydrochloride  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
diethylstilbestrol  (EXP,ISO)
diisononyl phthalate  (EXP)
dimethylselenide  (ISO)
dioxygen  (EXP,ISO)
dizocilpine maleate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
eugenol  (ISO)
fenthion  (ISO)
fenvalerate  (EXP)
formaldehyde  (ISO)
furan  (EXP)
geldanamycin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
graphite  (EXP)
hydroquinone  (ISO)
Ibotenic acid  (EXP)
indometacin  (ISO)
isoflavones  (ISO)
ketamine  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (ISO)
linuron  (EXP)
lipopolysaccharide  (EXP,ISO)
malathion  (ISO)
maneb  (ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
N-nitrosodiethylamine  (EXP)
naproxen  (EXP)
nefazodone  (EXP)
neomycin  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
oxazepam  (ISO)
ozone  (EXP,ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PCB138  (EXP)
PD 0325901  (ISO)
pentane-2,3-dione  (EXP)
pepstatin A  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenformin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
pyrethrins  (EXP)
pyridaben  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
sumatriptan  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (ISO)
torcetrapib  (ISO)
tremolite asbestos  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vincaleukoblastine  (ISO)
XAV939  (ISO)
xylitol  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activin receptor signaling pathway  (ISO,ISS)
autophagy  (IDA)
cardiac fibroblast cell development  (IDA)
cellular response to angiotensin  (IEP)
cellular response to cholesterol  (IDA)
cellular response to follicle-stimulating hormone stimulus  (IDA)
cellular response to hypoxia  (IEP)
cellular response to oxygen-glucose deprivation  (IEP)
cytokine-mediated signaling pathway  (IEP)
endodermal cell differentiation  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
eyelid development in camera-type eye  (ISO,ISS)
GABAergic neuron differentiation  (ISO)
hair follicle development  (ISO,ISS)
hematopoietic progenitor cell differentiation  (ISO,ISS)
hemoglobin biosynthetic process  (ISO,ISS)
male gonad development  (ISO,ISS)
mesoderm formation  (ISO)
mesodermal cell differentiation  (ISO)
negative regulation of cell growth  (ISO,ISS)
negative regulation of cell population proliferation  (ISO,ISS)
negative regulation of G1/S transition of mitotic cell cycle  (ISO,ISS)
negative regulation of hair follicle development  (ISO)
odontogenesis  (ISO,ISS)
ovarian follicle development  (ISO,ISS)
positive regulation of collagen biosynthetic process  (IDA)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of ERK1 and ERK2 cascade  (IDA)
positive regulation of erythrocyte differentiation  (ISO,ISS)
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO,ISS)
positive regulation of gene expression  (ISO)
positive regulation of ovulation  (ISO,ISS)
positive regulation of protein metabolic process  (ISO)
positive regulation of protein phosphorylation  (IDA)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,ISO,ISS)
positive regulation of transcription by RNA polymerase III  (IEP)
progesterone secretion  (ISO,ISS)
regulation of follicle-stimulating hormone secretion  (ISO,ISS)
regulation of transcription by RNA polymerase II  (ISO,ISS)
response to aldosterone  (IEP)
roof of mouth development  (ISO,ISS)
SMAD protein signal transduction  (IDA)
striatal medium spiny neuron differentiation  (ISO)
transcription by RNA polymerase II  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Regulation of inhibin/activin expression in rat early antral follicles. Andreone L, etal., Mol Cell Endocrinol. 2009 Oct 15;309(1-2):48-54. doi: 10.1016/j.mce.2009.05.003. Epub 2009 May 21.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Activin A stimulates the proliferation and differentiation of cardiac fibroblasts via the ERK1/2 and p38-MAPK pathways. Hu J, etal., Eur J Pharmacol. 2016 Oct 15;789:319-327. doi: 10.1016/j.ejphar.2016.07.053. Epub 2016 Jul 29.
5. Cytokine modulation of inhibin secretion in cultured rat granulosa cells. Imai M, etal., J Endocrinol. 1996 Dec;151(3):449-57.
6. Downstream mRNA Target Analysis in Neonatal Hypoxic-Ischaemic Encephalopathy Identifies Novel Marker of Severe Injury: a Proof of Concept Paper. Looney AM, etal., Mol Neurobiol. 2017 Dec;54(10):8420-8428. doi: 10.1007/s12035-016-0330-4. Epub 2016 Dec 12.
7. Involvement of Pax-2 in the action of activin A on tubular cell regeneration. Maeshima A, etal., J Am Soc Nephrol 2002 Dec;13(12):2850-9.
8. Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury. Magga J, etal., Mol Ther. 2019 Mar 6;27(3):600-610. doi: 10.1016/j.ymthe.2019.01.013. Epub 2019 Jan 24.
9. Granulosa cell tumor mutant FOXL2C134W suppresses GDF-9 and activin A-induced follistatin transcription in primary granulosa cells. McTavish KJ, etal., Mol Cell Endocrinol. 2013 Jun 15;372(1-2):57-64. doi: 10.1016/j.mce.2013.03.021. Epub 2013 Apr 6.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Inhibin/activin subunits beta-A (-betaA) and beta-B (-betaB) are differentially localised in normal, hyperplastic and malignant human endometrial tissue. Mylonas I, etal., Acta Histochem. 2006;108(1):1-11. Epub 2006 Jan 19.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Gene expression changes in the retina after systemic administration of aldosterone. Ono A, etal., Jpn J Ophthalmol. 2018 Jul;62(4):499-507. doi: 10.1007/s10384-018-0595-4. Epub 2018 Apr 30.
14. Abnormal concentration of maternal serum activin-A in gestational diseases. Petraglia F, etal., J Clin Endocrinol Metab. 1995 Feb;80(2):558-61.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Systemic blockade of ACVR2B ligands attenuates muscle wasting in ischemic heart failure without compromising cardiac function. Szabó Z, etal., FASEB J. 2020 Aug;34(8):9911-9924. doi: 10.1096/fj.201903074RR. Epub 2020 May 19.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Predicting complications of pregnancy with first-trimester maternal serum free-betahCG, PAPP-A and inhibin-A. Tul N, etal., Prenat Diagn. 2003 Dec 15;23(12):990-6.
21. Rat inhibin: molecular cloning of alpha- and beta-subunit complementary deoxyribonucleic acids and expression in the ovary. Woodruff TK, etal., Mol Endocrinol 1987 Aug;1(8):561-8.
22. Expression of the activin axis and neuronal rescue effects of recombinant activin A following hypoxic-ischemic brain injury in the infant rat. Wu DD, etal., Brain Res. 1999 Jul 24;835(2):369-78. doi: 10.1016/s0006-8993(99)01638-8.
23. Activation of activin/Smad2 and 3 signaling pathway and the potential involvement of endothelial‑mesenchymal transition in the valvular damage due to rheumatic heart disease. Xian S, etal., Mol Med Rep. 2021 Jan;23(1):10. doi: 10.3892/mmr.2020.11648. Epub 2020 Nov 12.
24. Activin A/Smads signaling pathway negatively regulates Oxygen Glucose Deprivation-induced autophagy via suppression of JNK and p38 MAPK pathways in neuronal PC12 cells. Xue LX, etal., Biochem Biophys Res Commun. 2016 Nov 18;480(3):355-361. doi: 10.1016/j.bbrc.2016.10.050. Epub 2016 Oct 18.
25. Increasing blunting of inhibin responses to dynamic ovarian challenge is associated with reproductive aging in the rat. Yeh J and Kim B, Reprod Sci. 2007 Jan;14(1):10-9.
26. Elevated levels of activin A in heart failure: potential role in myocardial remodeling. Yndestad A, etal., Circulation. 2004 Mar 23;109(11):1379-85. Epub 2004 Mar 1.
27. Lipopolysaccharide induced activin A-follistatin imbalance affects cardiac fibrosis. Zhang WQ, etal., Chin Med J (Engl). 2012 Jun;125(12):2205-12.
28. Activin A improves the neurological outcome after ischemic stroke in mice by promoting oligodendroglial ACVR1B-mediated white matter remyelination. Zheng J, etal., Exp Neurol. 2021 Mar;337:113574. doi: 10.1016/j.expneurol.2020.113574. Epub 2020 Dec 18.
Additional References at PubMed
PMID:1310063   PMID:1646080   PMID:2575216   PMID:7577669   PMID:7799920   PMID:7890768   PMID:8133077   PMID:8267637   PMID:9032295   PMID:9239411   PMID:9884026   PMID:10391928  
PMID:10932194   PMID:11948405   PMID:12213882   PMID:12681448   PMID:12702211   PMID:12737440   PMID:12761253   PMID:12782410   PMID:14551263   PMID:15031321   PMID:15070852   PMID:15236469  
PMID:15451575   PMID:15673690   PMID:15821113   PMID:16198295   PMID:16601134   PMID:16935389   PMID:17344471   PMID:17609433   PMID:17680997   PMID:18239071   PMID:18597229   PMID:18781389  
PMID:19029909   PMID:19292055   PMID:19298640   PMID:19524137   PMID:19736306   PMID:19782349   PMID:20573232   PMID:21147108   PMID:21256182   PMID:21281489   PMID:21828274   PMID:22106407  
PMID:23812417   PMID:23831638   PMID:24006456   PMID:24141247   PMID:24299059   PMID:24883308   PMID:25804741   PMID:26721511   PMID:27693962   PMID:27769859   PMID:29113826   PMID:29187373  
PMID:32133888  


Genomics

Comparative Map Data
Inhba
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21749,091,635 - 49,111,573 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1749,095,920 - 49,108,982 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1752,294,696 - 52,307,755 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01756,297,581 - 56,310,640 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01750,395,401 - 50,408,458 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01751,894,869 - 51,919,998 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1751,898,217 - 51,912,496 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01749,961,222 - 49,985,653 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41757,244,466 - 57,257,531 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11757,247,306 - 57,260,372 (-)NCBI
Celera1745,163,387 - 45,176,397 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
INHBA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38741,685,114 - 41,705,406 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl741,667,168 - 41,705,834 (-)EnsemblGRCh38hg38GRCh38
GRCh37741,724,712 - 41,742,688 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36741,695,126 - 41,709,231 (-)NCBINCBI36Build 36hg18NCBI36
Build 34741,502,035 - 41,513,299NCBI
Celera741,719,390 - 41,733,490 (-)NCBICelera
Cytogenetic Map7p14.1NCBI
HuRef741,613,504 - 41,627,622 (-)NCBIHuRef
CHM1_1741,731,917 - 41,746,019 (-)NCBICHM1_1
T2T-CHM13v2.0741,843,512 - 41,867,440 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2741,768,467 - 41,782,571 (-)NCBI
Inhba
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391316,178,841 - 16,206,194 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1316,186,436 - 16,206,206 (+)EnsemblGRCm39 Ensembl
GRCm381316,004,256 - 16,031,609 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1316,011,851 - 16,031,621 (+)EnsemblGRCm38mm10GRCm38
MGSCv371316,106,308 - 16,119,044 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361315,805,362 - 15,818,098 (+)NCBIMGSCv36mm8
Celera1316,301,736 - 16,314,777 (+)NCBICelera
Cytogenetic Map13A1NCBI
cM Map135.85NCBI
Inhba
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554602,046,588 - 2,066,609 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554602,054,879 - 2,066,628 (+)NCBIChiLan1.0ChiLan1.0
INHBA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1795,059,503 - 95,080,165 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0742,538,591 - 42,556,578 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1742,580,730 - 42,598,712 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl742,580,730 - 42,595,097 (+)Ensemblpanpan1.1panPan2
INHBA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1188,272,978 - 8,288,432 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl188,272,872 - 8,283,794 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha188,122,697 - 8,138,128 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0188,321,520 - 8,336,958 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl188,318,003 - 8,332,480 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1188,301,757 - 8,317,182 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0188,269,907 - 8,285,348 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0188,385,256 - 8,400,687 (+)NCBIUU_Cfam_GSD_1.0
Inhba
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511897,666,669 - 97,672,334 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493647816,878,725 - 16,884,065 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INHBA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1852,889,684 - 52,900,967 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11253,115,379 - 53,117,128 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11852,889,684 - 52,909,260 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21857,997,858 - 58,017,387 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21255,481,493 - 55,483,255 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap18q24NCBI
INHBA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12116,936,054 - 16,951,430 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2116,936,175 - 16,946,880 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660625,522,195 - 5,540,211 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Inhba
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474019,464,289 - 19,482,888 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474019,458,835 - 19,482,570 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Inhba
96 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:57
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000019272
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173199078450909196Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174135465160463643Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)174207316069599340Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)174207316069599340Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat

Markers in Region
INHBA-STS  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21749,096,032 - 49,096,354 (+)MAPPERmRatBN7.2
Rnor_6.01751,899,267 - 51,899,588NCBIRnor6.0
Rnor_5.01749,965,620 - 49,965,941UniSTSRnor5.0
RGSC_v3.41757,244,587 - 57,244,908UniSTSRGSC3.4
Celera1745,163,508 - 45,163,829UniSTS
Cytogenetic Map17q12.1UniSTS
UniSTS:143589  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21749,096,024 - 49,096,369 (+)MAPPERmRatBN7.2
Rnor_6.01751,899,259 - 51,899,603NCBIRnor6.0
Rnor_5.01749,965,612 - 49,965,956UniSTSRnor5.0
RGSC_v3.41757,244,579 - 57,244,923UniSTSRGSC3.4
Celera1745,163,500 - 45,163,844UniSTS
Cytogenetic Map17q12.1UniSTS
UniSTS:496691  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21749,095,992 - 49,096,207 (+)MAPPERmRatBN7.2
Rnor_6.01751,899,227 - 51,899,441NCBIRnor6.0
Rnor_5.01749,965,580 - 49,965,794UniSTSRnor5.0
RGSC_v3.41757,244,547 - 57,244,761UniSTSRGSC3.4
Celera1745,163,468 - 45,163,682UniSTS
Cytogenetic Map17q12.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 9 9 9 13
Low 3 43 37 22 15 22 8 9 56 27 25 10 8
Below cutoff 11 10 4 10 2 16 8 3 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000019272   ⟹   ENSRNOP00000019272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1749,095,920 - 49,108,982 (-)Ensembl
Rnor_6.0 Ensembl1751,898,217 - 51,912,496 (-)Ensembl
RefSeq Acc Id: NM_017128   ⟹   NP_058824
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21749,095,912 - 49,108,982 (-)NCBI
Rnor_6.01751,899,146 - 51,912,423 (-)NCBI
Rnor_5.01749,961,222 - 49,985,653 (-)NCBI
RGSC_v3.41757,244,466 - 57,257,531 (-)RGD
Celera1745,163,387 - 45,176,397 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006254001   ⟹   XP_006254063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21749,091,635 - 49,111,573 (-)NCBI
Rnor_6.01751,894,869 - 51,918,092 (-)NCBI
Rnor_5.01749,961,222 - 49,985,653 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771712   ⟹   XP_008769934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21749,091,635 - 49,111,204 (-)NCBI
Rnor_6.01751,894,869 - 51,918,092 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_058824 (Get FASTA)   NCBI Sequence Viewer  
  XP_006254063 (Get FASTA)   NCBI Sequence Viewer  
  XP_008769934 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41436 (Get FASTA)   NCBI Sequence Viewer  
  EDL87403 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019272
GenBank Protein P18331 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_058824   ⟸   NM_017128
- Peptide Label: preproprotein
- UniProtKB: P18331 (UniProtKB/Swiss-Prot),   A6K9B0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254063   ⟸   XM_006254001
- Peptide Label: isoform X1
- UniProtKB: P18331 (UniProtKB/Swiss-Prot),   A6K9B0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769934   ⟸   XM_008771712
- Peptide Label: isoform X1
- UniProtKB: P18331 (UniProtKB/Swiss-Prot),   A6K9B0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019272   ⟸   ENSRNOT00000019272
Protein Domains
TGF-beta family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18331-F1-model_v2 AlphaFold P18331 1-424 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700511
Promoter ID:EPDNEW_R11033
Type:initiation region
Name:Inhba_1
Description:inhibin beta A subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01751,912,433 - 51,912,493EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62074 AgrOrtholog
BioCyc Gene G2FUF-9095 BioCyc
Ensembl Genes ENSRNOG00000014320 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019272 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
  2.60.120.970 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cystine-knot cytokines UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Inhibin_betaA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29200 UniProtKB/Swiss-Prot
NCBI Gene 29200 ENTREZGENE
PANTHER INHIBIN BETA A CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11848 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Inhba PhenoGen
PRINTS INHIBINBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014320 RatGTEx
SMART TGFB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Cystine-knot cytokines UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC221252
UniProt A6K9B0 ENTREZGENE, UniProtKB/TrEMBL
  INHBA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-25 Inhba  inhibin subunit beta A  Inhba  inhibin beta A subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-06-01 Inhba  inhibin beta A subunit  Inhba  inhibin beta-A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Inhba  inhibin beta-A      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction interacts with beta B subunit to produce heterodimer which inhibits secretion of FSH from pituitary gonadotrophs 61638
gene_regulation expression is stimulated by FSH 61638