Bcl2l2 (Bcl2-like 2) - Rat Genome Database

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Gene: Bcl2l2 (Bcl2-like 2) Rattus norvegicus
Analyze
Symbol: Bcl2l2
Name: Bcl2-like 2
RGD ID: 620717
Description: Enables BH domain binding activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to estradiol stimulus; and cellular response to glycine. Located in cytosol and mitochondrial membrane. Biomarker of Alzheimer's disease; epilepsy; pterygium; status epilepticus; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to human BCL2L2 (BCL2 like 2); PARTICIPATES IN intrinsic apoptotic pathway; INTERACTS WITH (-)-bornyl-caffeate; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: bcl-2-like protein 2; BCL-W; BCL-WEL; BCL-WS; Bclw; MGC91704
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,326,686 - 32,337,834 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1532,326,020 - 32,335,379 (+)EnsemblGRCr8
mRatBN7.21528,346,449 - 28,361,627 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,356,807 - 28,361,624 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1530,202,463 - 30,207,316 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01531,349,665 - 31,354,518 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,592,361 - 29,597,214 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,543,774 - 33,549,165 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,544,312 - 33,549,164 (+)Ensemblrn6Rnor6.0
Rnor_5.01537,430,718 - 37,436,392 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41532,983,165 - 32,988,018 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1527,934,581 - 27,939,434 (+)NCBICelera
RGSC_v3.11532,998,864 - 33,003,717 (+)NCBI
Cytogenetic Map15p13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-bornyl-caffeate  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
acrylamide  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
DDE  (EXP)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
erlotinib hydrochloride  (ISO)
etoposide  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furosemide  (EXP)
Fusarenone X  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
indometacin  (ISO)
isoflurane  (EXP)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lidocaine  (EXP)
methamphetamine  (ISO)
methapyrilene  (EXP)
methoxyacetic acid  (EXP)
methylparaben  (ISO)
Mitotane  (EXP)
monocrotophos  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (EXP)
niclosamide  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
PF-3758309  (ISO)
picoxystrobin  (ISO)
pinostrobin  (ISO)
propylparaben  (ISO)
pyrazinecarboxamide  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simazine  (ISO)
sodium arsenite  (ISO)
sodium chromate  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrathiomolybdate(2-)  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. BCL-W has a fundamental role in B cell survival and lymphomagenesis. Adams CM, etal., J Clin Invest. 2017 Feb 1;127(2):635-650. doi: 10.1172/JCI89486. Epub 2017 Jan 17.
2. The Bcl-2 apoptotic switch in cancer development and therapy. Adams JM and Cory S, Oncogene. 2007 Feb 26;26(9):1324-37.
3. Regulation of Apoptosis by miR-122 in Pterygium via Targeting Bcl-w. Cui YH, etal., Invest Ophthalmol Vis Sci. 2016 Jul 1;57(8):3723-30. doi: 10.1167/iovs.16-19402.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Beta-asarone improves cognitive function by suppressing neuronal apoptosis in the beta-amyloid hippocampus injection rats. Geng Y, etal., Biol Pharm Bull. 2010;33(5):836-43.
6. RNA expression bcl-w, a new related protein Bcl-2 family, and caspase-3 in isolated sertoli cells from pre-pubertal rat testes. Giannattasio A, etal., J Endocrinol Invest 2002 Jul-Aug;25(7):RC23-5.
7. Differential expression of bcl-w and bcl-x messenger RNA in the developing and adult rat nervous system. Hamner S, etal., Neuroscience 1999;91(2):673-84.
8. Increased Bcl-w expression following focally evoked limbic seizures in the rat. Henshall DC, etal., Neurosci Lett. 2001 Jun 15;305(3):153-6.
9. Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Hsu SY, etal., Proc Natl Acad Sci U S A 1997 Nov 11;94(23):12401-6.
10. Dynamic changes of the anti- and pro-apoptotic proteins Bcl-w, Bcl-2, and Bax with Smac/Diablo mitochondrial release after photothrombotic ring stroke in rats. Hu XL, etal., Eur J Neurosci. 2004 Sep;20(5):1177-88.
11. Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains. Huynh JL, etal., Nat Neurosci. 2014 Jan;17(1):121-30. doi: 10.1038/nn.3588. Epub 2013 Nov 24.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells. Ortiz DF, etal., J Biol Chem 2004 Jul 30;279(31):32761-70. Epub 2004 May 24.
15. Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant. Print CG, etal., Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12424-31.
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Testicular degeneration in Bclw-deficient mice. Ross AJ, etal., Nat Genet 1998 Mar;18(3):251-6.
19. Subcellular distribution of Bcl-2 family proteins and 14-3-3 within the hippocampus during seizure-induced neuronal death in the rat. Schindler CK, etal., Neurosci Lett. 2004 Feb 19;356(3):163-6.
20. p,p'-DDE induces mitochondria-mediated apoptosis of cultured rat Sertoli cells. Song Y, etal., Toxicology. 2008 Nov 20;253(1-3):53-61. Epub 2008 Sep 4.
21. Adeno-associated virus-mediated delivery of BCL-w gene improves outcome after transient focal cerebral ischemia. Sun Y, etal., Gene Ther. 2003 Jan;10(2):115-22. doi: 10.1038/sj.gt.3301868.
22. Bcl-w expression in colorectal adenocarcinoma. Wilson JW, etal., Br J Cancer. 2000 Jan;82(1):178-85. doi: 10.1054/bjoc.1999.0897.
23. Overexpression of the cell death suppressor Bcl-w in ischemic brain: implications for a neuroprotective role via the mitochondrial pathway. Yan C, etal., J Cereb Blood Flow Metab. 2000 Mar;20(3):620-30. doi: 10.1097/00004647-200003000-00020.
24. Improvement of the viability of cultured rat neurons by the non-essential amino acids L-serine and glycine that upregulates expression of the anti-apoptotic gene product Bcl-w. Yang L, etal., Neurosci Lett. 2000 Dec 8;295(3):97-100.
25. Estrogen regulates Bcl-w and Bim expression: role in protection against beta-amyloid peptide-induced neuronal death. Yao M, etal., J Neurosci. 2007 Feb 7;27(6):1422-33. doi: 10.1523/JNEUROSCI.2382-06.2007.
26. Neuroprotective properties of Bcl-w in Alzheimer disease. Zhu X, etal., J Neurochem. 2004 Jun;89(5):1233-40. doi: 10.1111/j.1471-4159.2004.02416.x.
Additional References at PubMed
PMID:9731710   PMID:10579309   PMID:11161472   PMID:11784036   PMID:11980919   PMID:12115603   PMID:12477932   PMID:12787069   PMID:15689551   PMID:16645638   PMID:17289999   PMID:19766102  
PMID:22000515   PMID:22094713   PMID:23376485   PMID:23516285   PMID:33128129   PMID:34800366   PMID:35894779  


Genomics

Comparative Map Data
Bcl2l2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,326,686 - 32,337,834 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1532,326,020 - 32,335,379 (+)EnsemblGRCr8
mRatBN7.21528,346,449 - 28,361,627 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,356,807 - 28,361,624 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1530,202,463 - 30,207,316 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01531,349,665 - 31,354,518 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,592,361 - 29,597,214 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,543,774 - 33,549,165 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,544,312 - 33,549,164 (+)Ensemblrn6Rnor6.0
Rnor_5.01537,430,718 - 37,436,392 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41532,983,165 - 32,988,018 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1527,934,581 - 27,939,434 (+)NCBICelera
RGSC_v3.11532,998,864 - 33,003,717 (+)NCBI
Cytogenetic Map15p13NCBI
BCL2L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381423,306,833 - 23,311,751 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1423,298,790 - 23,311,751 (+)Ensemblhg38GRCh38
GRCh371423,776,042 - 23,780,960 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,845,852 - 22,850,808 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341422,845,875 - 22,850,798NCBI
Celera143,638,729 - 3,643,685 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef143,892,647 - 3,897,644 (+)NCBIHuRef
CHM1_11423,774,641 - 23,779,638 (+)NCBICHM1_1
T2T-CHM13v2.01417,507,847 - 17,512,765 (+)NCBIT2T-CHM13v2.0
Bcl2l2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,120,900 - 55,125,691 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,120,834 - 55,125,691 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381454,883,366 - 54,890,858 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,892,500 - 54,898,169 (+)Ensemblmm10GRCm38
GRCm38.p6 Ensembl1454,883,377 - 54,888,234 (+)Ensemblmm10GRCm38
MGSCv371455,502,262 - 55,507,071 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361453,837,630 - 53,842,439 (+)NCBIMGSCv36mm8
Celera1452,689,850 - 52,694,635 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1427.98NCBI
BCL2L2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.183,569,335 - 3,573,922 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl83,569,399 - 3,586,070 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha83,517,730 - 3,520,191 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.083,677,216 - 3,679,677 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl83,677,216 - 3,693,900 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.183,368,789 - 3,371,249 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,430,095 - 3,432,556 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.083,692,030 - 3,694,491 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
BCL2L2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,763,078 - 75,769,763 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1775,765,603 - 75,770,743 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,970,146 - 80,975,278 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Bcl2l2
40 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:574
Count of miRNA genes:267
Interacting mature miRNAs:362
Transcripts:ENSRNOT00000020409
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152024860037896129Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)152788577486257085Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat

Markers in Region
Bcl2l2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21528,358,046 - 28,358,825 (+)MAPPERmRatBN7.2
mRatBN7.2X18,645,579 - 18,645,758 (-)MAPPERmRatBN7.2
Rnor_6.05131,563,338 - 131,563,516NCBIRnor6.0
Rnor_6.01533,545,587 - 33,546,365NCBIRnor6.0
Rnor_5.01537,432,533 - 37,433,311UniSTSRnor5.0
Rnor_5.05135,387,340 - 135,387,518UniSTSRnor5.0
RGSC_v3.41532,984,440 - 32,985,218UniSTSRGSC3.4
RGSC_v3.4X38,831,469 - 38,831,647UniSTSRGSC3.4
CeleraX18,918,630 - 18,918,808UniSTS
Celera1527,935,856 - 27,936,634UniSTS
Cytogenetic Map15p13UniSTS
Cytogenetic MapXq14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 91 59 6 355 191 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000020409   ⟹   ENSRNOP00000020409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1532,326,796 - 32,331,613 (+)Ensembl
mRatBN7.2 Ensembl1528,356,807 - 28,361,624 (+)Ensembl
Rnor_6.0 Ensembl1533,544,312 - 33,549,164 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000121884   ⟹   ENSRNOP00000108168
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1532,327,199 - 32,328,893 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000125076   ⟹   ENSRNOP00000100137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1532,326,020 - 32,335,379 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000132509   ⟹   ENSRNOP00000106792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1532,326,511 - 32,333,063 (+)Ensembl
RefSeq Acc Id: NM_021850   ⟹   NP_068622
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81532,326,761 - 32,331,614 (+)NCBI
mRatBN7.21528,356,772 - 28,361,625 (+)NCBI
Rnor_6.01533,544,312 - 33,549,165 (+)NCBI
Rnor_5.01537,430,718 - 37,436,392 (+)NCBI
RGSC_v3.41532,983,165 - 32,988,018 (+)RGD
Celera1527,934,581 - 27,939,434 (+)RGD
Sequence:
RefSeq Acc Id: XM_017599793   ⟹   XP_017455282
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81532,327,629 - 32,331,611 (+)NCBI
mRatBN7.21528,357,257 - 28,361,622 (+)NCBI
Rnor_6.01533,544,793 - 33,549,165 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063274606   ⟹   XP_063130676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81532,326,686 - 32,337,834 (+)NCBI
RefSeq Acc Id: XM_063274607   ⟹   XP_063130677
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81532,326,686 - 32,337,834 (+)NCBI
RefSeq Acc Id: NP_068622   ⟸   NM_021850
- UniProtKB: O88996 (UniProtKB/TrEMBL),   F7ELB1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455282   ⟸   XM_017599793
- Peptide Label: isoform X1
- UniProtKB: Q7TS60 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020409   ⟸   ENSRNOT00000020409
RefSeq Acc Id: XP_063130676   ⟸   XM_063274606
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063130677   ⟸   XM_063274607
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000100137   ⟸   ENSRNOT00000125076
Ensembl Acc Id: ENSRNOP00000108168   ⟸   ENSRNOT00000121884
Ensembl Acc Id: ENSRNOP00000106792   ⟸   ENSRNOT00000132509
Protein Domains
Apoptosis regulator Bcl-2 family BH4

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88996-F1-model_v2 AlphaFold O88996 1-193 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699661
Promoter ID:EPDNEW_R10184
Type:multiple initiation site
Name:Bcl2l2_1
Description:Bcl2-like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01533,544,343 - 33,544,403EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620717 AgrOrtholog
BIND 133989
  133990
BioCyc Gene G2FUF-13770 BioCyc
Ensembl Genes ENSRNOG00000015732 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020409 ENTREZGENE
  ENSRNOT00000020409.5 UniProtKB/TrEMBL
  ENSRNOT00000121884 ENTREZGENE
  ENSRNOT00000132509 ENTREZGENE
Gene3D-CATH 1.10.437.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7105621 IMAGE-MGC_LOAD
InterPro Apop_reg_BclW UniProtKB/TrEMBL
  Bcl-2_BH1-3 UniProtKB/TrEMBL
  BCL2_apoptsis UniProtKB/TrEMBL
  Bcl2_BH1_motif_CS UniProtKB/TrEMBL
  Bcl2_BH2_motif_CS UniProtKB/TrEMBL
  Bcl2_BH4 UniProtKB/TrEMBL
  Bcl2_BH4_motif_CS UniProtKB/TrEMBL
  Blc2-like_sf UniProtKB/TrEMBL
  Blc2_fam UniProtKB/TrEMBL
KEGG Report rno:60434 UniProtKB/TrEMBL
MGC_CLONE MGC:91704 IMAGE-MGC_LOAD
NCBI Gene 60434 ENTREZGENE
PANTHER BCL-2-LIKE PROTEIN 2 UniProtKB/TrEMBL
  PTHR11256 UniProtKB/TrEMBL
Pfam Bcl-2 UniProtKB/TrEMBL
  BH4 UniProtKB/TrEMBL
PhenoGen Bcl2l2 PhenoGen
PRINTS APOPREGBCLW UniProtKB/TrEMBL
  BCL2FAMILY UniProtKB/TrEMBL
PROSITE BCL2_FAMILY UniProtKB/TrEMBL
  BH1 UniProtKB/TrEMBL
  BH2 UniProtKB/TrEMBL
  BH4_1 UniProtKB/TrEMBL
  BH4_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015732 RatGTEx
SMART BCL UniProtKB/TrEMBL
  BH4 UniProtKB/TrEMBL
Superfamily-SCOP SSF56854 UniProtKB/TrEMBL
UniProt F7ELB1 ENTREZGENE, UniProtKB/TrEMBL
  O88996 ENTREZGENE, UniProtKB/TrEMBL
  Q7TS60 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Bcl2l2  Bcl2-like 2    Bcl-w protein  Name updated 1299863 APPROVED
2002-08-07 Bcl2l2  Bcl-w protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of the Bcl-2 family of anti-apoptotic proteins 632001