Slc38a5 (solute carrier family 38, member 5) - Rat Genome Database

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Gene: Slc38a5 (solute carrier family 38, member 5) Rattus norvegicus
Analyze
Symbol: Slc38a5
Name: solute carrier family 38, member 5
RGD ID: 620702
Description: Enables L-amino acid transmembrane transporter activity and neutral amino acid, sodium:proton antiporter activity. Involved in L-amino acid transport and amino acid export across plasma membrane. Located in plasma membrane. Orthologous to human SLC38A5 (solute carrier family 38 member 5); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AF276870; amino acid transporter system N2; SN2; sodium-coupled neutral amino acid transporter 5; solute carrier family 38 member 5; system N transporter 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X16,885,701 - 16,894,470 (-)NCBIGRCr8
mRatBN7.2X14,213,727 - 14,222,498 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,213,729 - 14,222,498 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX19,027,241 - 19,036,002 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X21,047,080 - 21,055,839 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X17,312,273 - 17,321,032 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X14,963,919 - 14,972,675 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX14,963,921 - 14,972,675 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X15,748,231 - 15,756,314 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,244,421 - 26,253,596 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X26,297,889 - 26,307,057 (-)NCBI
CeleraX14,299,226 - 14,307,991 (-)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,7-dihydropurine-6-thione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
choline  (ISO)
cisplatin  (ISO)
Cuprizon  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
indometacin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
mercaptopurine  (EXP)
methamphetamine  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
nickel sulfate  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
pioglitazone  (ISO)
purine-6-thiol  (EXP)
pyrethrins  (EXP)
quercetin  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (EXP)
XL147  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IDA)

References

References - curated
# Reference Title Reference Citation
1. Evidence for allosteric regulation of pH-sensitive System A (SNAT2) and System N (SNAT5) amino acid transporter activity involving a conserved histidine residue. Baird FE, etal., Biochem J. 2006 Jul 15;397(2):369-75. doi: 10.1042/BJ20060026.
2. Bidirectional substrate fluxes through the system N (SNAT5) glutamine transporter may determine net glutamine flux in rat liver. Baird FE, etal., J Physiol. 2004 Sep 1;559(Pt 2):367-81. doi: 10.1113/jphysiol.2003.060293. Epub 2004 Jun 24.
3. Amino acid transporter SNAT5 localizes to glial cells in the rat brain. Cubelos B, etal., Glia. 2005 Jan 15;49(2):230-44. doi: 10.1002/glia.20106.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. The system N transporter SN2 doubles as a transmitter precursor furnisher and a potential regulator of NMDA receptors. Hamdani el H, etal., Glia. 2012 Nov;60(11):1671-83. doi: 10.1002/glia.22386. Epub 2012 Jul 20.
6. Cloning and functional characterization of a new subtype of the amino acid transport system N. Nakanishi T, etal., Am J Physiol Cell Physiol 2001 Dec;281(6):C1757-68.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Expression and function of glutamine transporters SN1 (SNAT3) and SN2 (SNAT5) in retinal Müller cells. Umapathy NS, etal., Invest Ophthalmol Vis Sci. 2005 Nov;46(11):3980-7. doi: 10.1167/iovs.05-0488.
11. Changes of plasma glutamine concentration and hepatocyte membrane system N transporters expression in early endotoxemia. Wang W, etal., J Surg Res. 2011 Apr;166(2):290-7. doi: 10.1016/j.jss.2009.08.027. Epub 2009 Sep 23.
Additional References at PubMed
PMID:11243884   PMID:12477932   PMID:24333324  


Genomics

Comparative Map Data
Slc38a5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X16,885,701 - 16,894,470 (-)NCBIGRCr8
mRatBN7.2X14,213,727 - 14,222,498 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,213,729 - 14,222,498 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX19,027,241 - 19,036,002 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X21,047,080 - 21,055,839 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X17,312,273 - 17,321,032 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X14,963,919 - 14,972,675 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX14,963,921 - 14,972,675 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X15,748,231 - 15,756,314 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,244,421 - 26,253,596 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X26,297,889 - 26,307,057 (-)NCBI
CeleraX14,299,226 - 14,307,991 (-)NCBICelera
Cytogenetic MapXq12NCBI
SLC38A5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X48,458,544 - 48,470,260 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX48,458,537 - 48,470,260 (-)EnsemblGRCh38hg38GRCh38
GRCh37X48,316,927 - 48,328,648 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,201,871 - 48,213,509 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X48,073,181 - 48,084,819NCBI
CeleraX53,337,091 - 53,348,808 (+)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX45,981,068 - 45,992,834 (-)NCBIHuRef
CHM1_1X48,348,162 - 48,359,900 (-)NCBICHM1_1
T2T-CHM13v2.0X47,867,546 - 47,879,266 (-)NCBIT2T-CHM13v2.0
Slc38a5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X8,137,620 - 8,146,418 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX8,137,372 - 8,146,418 (+)EnsemblGRCm39 Ensembl
GRCm38X8,271,381 - 8,280,179 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX8,271,133 - 8,280,179 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X7,848,518 - 7,857,305 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X7,428,353 - 7,437,133 (+)NCBIMGSCv36mm8
CeleraX3,190,181 - 3,198,970 (-)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.74NCBI
Slc38a5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495554316,089 - 24,668 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495554315,968 - 24,644 (-)NCBIChiLan1.0ChiLan1.0
SLC38A5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X49,947,016 - 49,958,940 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X49,950,398 - 49,962,310 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X40,756,423 - 40,768,327 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X48,621,018 - 48,632,682 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX48,621,018 - 48,632,682 (-)Ensemblpanpan1.1panPan2
SLC38A5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X41,709,441 - 41,718,702 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX41,709,467 - 41,717,080 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX16,085,681 - 16,094,898 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X41,845,558 - 41,854,816 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX41,845,558 - 41,854,758 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X41,832,556 - 41,841,772 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X41,820,836 - 41,830,050 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X41,914,395 - 41,923,619 (-)NCBIUU_Cfam_GSD_1.0
Slc38a5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X34,178,875 - 34,200,906 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936721419,268 - 441,350 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936721419,286 - 441,224 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC38A5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,590,607 - 42,601,502 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,590,608 - 42,601,537 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,547,735 - 47,558,567 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC38A5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X45,588,992 - 45,598,771 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607611,040,195 - 11,052,121 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc38a5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624893275,820 - 284,696 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624893275,906 - 284,883 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc38a5
19 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:63
Count of miRNA genes:49
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000038068
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 9 49 110 81 83 54 23 54 6 202 91 93 42 60 29

Sequence


Ensembl Acc Id: ENSRNOT00000038068   ⟹   ENSRNOP00000038781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,213,729 - 14,222,204 (-)Ensembl
Rnor_6.0 EnsemblX14,963,921 - 14,972,389 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079664   ⟹   ENSRNOP00000073818
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,213,729 - 14,222,498 (-)Ensembl
Rnor_6.0 EnsemblX14,963,921 - 14,972,675 (-)Ensembl
RefSeq Acc Id: NM_138854   ⟹   NP_620209
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X16,885,701 - 16,894,470 (-)NCBI
mRatBN7.2X14,213,727 - 14,222,498 (-)NCBI
Rnor_6.0X14,963,919 - 14,972,675 (-)NCBI
Rnor_5.0X15,748,231 - 15,756,314 (-)NCBI
RGSC_v3.4X26,244,421 - 26,253,596 (-)RGD
CeleraX14,299,226 - 14,307,991 (-)RGD
Sequence:
RefSeq Acc Id: XM_008773068   ⟹   XP_008771290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X16,885,701 - 16,894,268 (-)NCBI
mRatBN7.2X14,213,727 - 14,222,291 (-)NCBI
Rnor_6.0X14,963,919 - 14,972,382 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099444   ⟹   XP_038955372
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X16,885,701 - 16,894,231 (-)NCBI
mRatBN7.2X14,213,727 - 14,222,260 (-)NCBI
RefSeq Acc Id: NP_620209   ⟸   NM_138854
- UniProtKB: A6KP35 (UniProtKB/TrEMBL),   A0A0H2UHW1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771290   ⟸   XM_008773068
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000073818   ⟸   ENSRNOT00000079664
Ensembl Acc Id: ENSRNOP00000038781   ⟸   ENSRNOT00000038068
RefSeq Acc Id: XP_038955372   ⟸   XM_039099444
- Peptide Label: isoform X2
- UniProtKB: A0A0H2UHW1 (UniProtKB/TrEMBL)
Protein Domains
Amino acid transporter transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A2VCW5-F1-model_v2 AlphaFold A2VCW5 1-479 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620702 AgrOrtholog
BioCyc Gene G2FUF-2956 BioCyc
Ensembl Genes ENSRNOG00000027767 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055022355 UniProtKB/Swiss-Prot
  ENSRNOG00060022262 UniProtKB/Swiss-Prot
  ENSRNOG00065011778 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000038068 UniProtKB/TrEMBL
  ENSRNOT00000038068.6 UniProtKB/Swiss-Prot
  ENSRNOT00000079664.2 UniProtKB/Swiss-Prot
  ENSRNOT00055038402 UniProtKB/Swiss-Prot
  ENSRNOT00060038574 UniProtKB/Swiss-Prot
  ENSRNOT00065019140 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:8362014 IMAGE-MGC_LOAD
InterPro AA_transpt_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:192208 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156591 IMAGE-MGC_LOAD
NCBI Gene 192208 ENTREZGENE
PANTHER AMINO ACID TRANSPORTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aa_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc38a5 PhenoGen
RatGTEx ENSRNOG00000027767 RatGTEx
  ENSRNOG00055022355 RatGTEx
  ENSRNOG00060022262 RatGTEx
  ENSRNOG00065011778 RatGTEx
UniProt A0A0H2UHW1 ENTREZGENE, UniProtKB/TrEMBL
  A2VCW5 ENTREZGENE
  A6KP34 ENTREZGENE, UniProtKB/TrEMBL
  A6KP35 ENTREZGENE, UniProtKB/TrEMBL
  Q91XR7 ENTREZGENE
  S38A5_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q91XR7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Slc38a5  solute carrier family 38, member 5  AF276870  amino acid transporter system N2  Symbol and Name updated 1299863 APPROVED
2002-08-07 AF276870  amino acid transporter system N2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression abundant in the liver, also expressed in brain, lung, stomach, kidney, testis, and spleen 628449
gene_homology amino acid sequence identity between rat and human is 86% 628449
gene_process mediates H+ movement across the membrane, and Na+-dependent transport of neutral amino into cells, leading to intracellular alkalization 628449
gene_protein contains 471 amino acids 628449
gene_regulation transport mechanism involves the influx of Na+ and amino acids coupled to the efflux of H+ and is electrogenic, Li+ tolerant, and pH sensitive 628449
gene_transcript cDNA is 1,891 bp in length 628449