Birc2 (baculoviral IAP repeat-containing 2) - Rat Genome Database

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Gene: Birc2 (baculoviral IAP repeat-containing 2) Rattus norvegicus
Analyze
Symbol: Birc2
Name: baculoviral IAP repeat-containing 2
RGD ID: 620690
Description: Predicted to enable several functions, including FBXO family protein binding activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; and zinc ion binding activity. Involved in response to cAMP; response to ethanol; and response to hypoxia. Located in XY body. Part of protein-containing complex. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human BIRC2 (baculoviral IAP repeat containing 2); PARTICIPATES IN FasL mediated signaling pathway; nuclear factor kappa B signaling pathway; tumor necrosis factor mediated signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Api2; apoptosis inhibitor 2; baculoviral IAP repeat-containing protein 2; inhibitor of apoptosis protein; rIAP1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8813,253,697 - 13,273,672 (-)NCBIGRCr8
mRatBN7.284,968,856 - 4,989,325 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl84,968,842 - 4,988,732 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,928,655 - 8,946,533 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.087,226,434 - 7,244,312 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.085,228,536 - 5,246,376 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.086,014,014 - 6,036,668 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl86,013,207 - 6,034,142 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.086,015,753 - 6,035,532 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,649,559 - 4,667,733 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,649,558 - 4,668,104 (-)NCBI
Celera86,528,673 - 6,546,071 (-)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(aminomethyl)phosphonic acid  (ISO)
(S)-nicotine  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-monopalmitoylglycerol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester  (ISO)
2-methylcholine  (ISO)
2-phenylethynesulfonamide  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-aminopyridine  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acrolein  (ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
aprepitant  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP,ISO)
bortezomib  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carboplatin  (ISO)
CGP 52608  (ISO)
chalcones  (ISO)
chlorambucil  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
chrysazin  (ISO)
Cinobufagin  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crizotinib  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
diosgenin  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
elemental selenium  (EXP)
ethanol  (ISO)
etodolac  (ISO)
etoposide  (ISO)
Evodiamine  (ISO)
flavonoids  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fucoidan  (ISO)
furosemide  (EXP)
gallic acid  (ISO)
gastrin-17  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glutathione  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (EXP)
guggulsterone  (ISO)
hemin  (ISO)
homocysteine  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
isoliquiritigenin  (ISO)
isoprenaline  (EXP)
kojic acid  (ISO)
LCL161  (ISO)
lead(0)  (ISO)
leptomycin B  (ISO)
levofloxacin  (ISO)
linalool  (ISO)
lobaplatin  (ISO)
lonafarnib  (ISO)
luteolin  (ISO)
LY294002  (ISO)
methoxyacetic acid  (ISO)
methylseleninic acid  (ISO)
metiram  (ISO)
mitomycin C  (ISO)
mitoxantrone  (ISO)
morin  (ISO)
Myrtucommulone A  (ISO)
N,N'-(hexane-1,6-diyl)bis(1-\{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl\}-L-prolyl-beta-phenyl-L-phenylalaninamide)  (ISO)
N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methylformamide  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nitric oxide  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
Pentoxifylline  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
potassium atom  (ISO)
progesterone  (EXP)
rac-1-monopalmitoylglycerol  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
romidepsin  (ISO)
sanguinarine  (ISO)
selenium atom  (EXP)
semustine  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
SM-164  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tephrosin  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thifluzamide  (ISO)
thiophenes  (ISO)
thiram  (ISO)
tioguanine  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
tributylstannane  (ISO)
trovafloxacin  (ISO)
venom  (ISO)
vincaleukoblastine  (ISO)
vincristine  (ISO)
vitamin E  (EXP,ISO)
vorinostat  (ISO)
wortmannin  (ISO)
zerumbone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts. An MJ, etal., Cancer Lett. 2009 Jun 28;279(1):93-100. doi: 10.1016/j.canlet.2009.01.026. Epub 2009 Feb 18.
2. Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ. Arnt CR, etal., J Biol Chem. 2002 Nov 15;277(46):44236-43. Epub 2002 Sep 5.
3. Additive effects of C(2)-ceramide on paclitaxel-induced premature senescence of human lung cancer cells. Chen JY, etal., Life Sci. 2010 Sep 11;87(11-12):350-7. doi: 10.1016/j.lfs.2010.06.017. Epub 2010 Jul 17.
4. Expression of inhibitor of apoptosis family proteins in human oral squamous cell carcinogenesis. Chen YK, etal., Head Neck. 2011 Jul;33(7):985-98. doi: 10.1002/hed.21582. Epub 2010 Oct 21.
5. Lobaplatin induces pyroptosis through regulating cIAP1/2, Ripoptosome and ROS in nasopharyngeal carcinoma. Chen Z, etal., Biochem Pharmacol. 2020 Jul;177:114023. doi: 10.1016/j.bcp.2020.114023. Epub 2020 May 13.
6. Tumor necrosis factor. Chu WM, Cancer Lett. 2013 Jan 28;328(2):222-5. doi: 10.1016/j.canlet.2012.10.014. Epub 2012 Oct 22.
7. Death receptor 5 (DR5) and a 5-gene apoptotic biomarker panel with significant differential diagnostic potential in colorectal cancer. Devetzi M, etal., Sci Rep. 2016 Nov 9;6:36532. doi: 10.1038/srep36532.
8. Gene promoter of apoptosis inhibitory protein IAP2: identification of enhancer elements and activation by severe hypoxia. Dong Z, etal., Biochem J 2002 Jun 1;364(Pt 2):413-21.
9. The effects of ethanol and the serotonin(1A) agonist ipsapirone on the expression of the serotonin(1A) receptor and several antiapoptotic proteins in fetal rhombencephalic neurons. Druse MJ, etal., Brain Res. 2006 May 30;1092(1):79-86. Epub 2006 May 9.
10. Inhibitors of apoptosis proteins in human cervical cancer. Espinosa M, etal., BMC Cancer. 2006 Feb 27;6:45.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy. Imoto I, etal., Cancer Res. 2002 Sep 1;62(17):4860-6.
14. 2-phenylethynesulfonamide inhibits growth of oral squamous cell carcinoma cells by blocking the function of heat shock protein 70. Jiang L and Xiao J, Biosci Rep. 2020 Mar 27;40(3). pii: 222262. doi: 10.1042/BSR20200079.
15. Expression parameters of the inhibitors of apoptosis cIAP1 and cIAP2 in renal cell carcinomas and their prognostic relevance. Kempkensteffen C, etal., Int J Cancer. 2007 Mar 1;120(5):1081-6.
16. Tumor necrosis factor receptor 1 and its signaling intermediates are recruited to lipid rafts in the traumatized brain. Lotocki G, etal., J Neurosci. 2004 Dec 8;24(49):11010-6.
17. Cyclic AMP increases rat inhibitor of apoptosis protein (RIAP1) mRNA in renal mesangial cells. Manderscheid M, etal., Kidney Int. 2002 Mar;61(3):797-803.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Combined analysis of cell growth and apoptosis-regulating proteins in HPVs associated anogenital tumors. Mitsuishi T, etal., BMC Cancer. 2010 Mar 27;10:118. doi: 10.1186/1471-2407-10-118.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
23. Expression of cIAP-1 correlates with nodal metastasis in squamous cell carcinoma of the tongue. Qi S, etal., Int J Oral Maxillofac Surg. 2008 Nov;37(11):1047-53. doi: 10.1016/j.ijom.2008.06.004. Epub 2008 Jul 14.
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Comprehensive gene review and curation RGD comprehensive gene curation
28. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
29. Synergistic effects of IAP inhibitor LCL161 and paclitaxel on hepatocellular carcinoma cells. Tian A, etal., Cancer Lett. 2014 Sep 1;351(2):232-41. doi: 10.1016/j.canlet.2014.06.006. Epub 2014 Jun 27.
30. Functional mismatch repair and inactive p53 drive sensitization of colorectal cancer cells to irinotecan via the IAP antagonist BV6. Tomicic MT, etal., Arch Toxicol. 2019 Aug;93(8):2265-2277. doi: 10.1007/s00204-019-02513-7. Epub 2019 Jul 9.
31. The regulated expression of c-IAP1 and c-IAP2 during the rat seminiferous epithelial cycle plays a role in the protection of germ cells from Fas-mediated apoptosis. Wang Y, etal., Mol Cell Endocrinol. 2005 Dec 21;245(1-2):111-20. Epub 2005 Dec 15.
32. Smac mimetics in combination with TRAIL selectively target cancer stem cells in nasopharyngeal carcinoma. Wu MS, etal., Mol Cancer Ther. 2013 Sep;12(9):1728-37. doi: 10.1158/1535-7163.MCT-13-0017. Epub 2013 May 22.
33. The LEF1/CYLD axis and cIAPs regulate RIP1 deubiquitination and trigger apoptosis in selenite-treated colorectal cancer cells. Wu P, etal., Cell Death Dis. 2014 Feb 27;5:e1085. doi: 10.1038/cddis.2014.13.
34. LCL161 increases paclitaxel-induced apoptosis by degrading cIAP1 and cIAP2 in NSCLC. Yang C, etal., J Exp Clin Cancer Res. 2016 Sep 30;35(1):158. doi: 10.1186/s13046-016-0435-7.
35. Time-dependent apoptosis of alveolar macrophages from rats exposed to bleomycin: involvement of tnf receptor 2. Zhao HW, etal., J Toxicol Environ Health A. 2004 Sep 10;67(17):1391-406.
Additional References at PubMed
PMID:10797013   PMID:11860601   PMID:11907583   PMID:12761501   PMID:12875985   PMID:15640352   PMID:15665297   PMID:16510124   PMID:18239673   PMID:18621737   PMID:19008929   PMID:19153467  
PMID:20447407   PMID:20614026   PMID:21052097   PMID:21525013   PMID:21653699   PMID:21737330   PMID:21931591   PMID:22493164   PMID:22815481   PMID:23028454   PMID:25383668   PMID:28849082  
PMID:30561431   PMID:31515488   PMID:35416269  


Genomics

Comparative Map Data
Birc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8813,253,697 - 13,273,672 (-)NCBIGRCr8
mRatBN7.284,968,856 - 4,989,325 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl84,968,842 - 4,988,732 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,928,655 - 8,946,533 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.087,226,434 - 7,244,312 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.085,228,536 - 5,246,376 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.086,014,014 - 6,036,668 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl86,013,207 - 6,034,142 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.086,015,753 - 6,035,532 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,649,559 - 4,667,733 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,649,558 - 4,668,104 (-)NCBI
Celera86,528,673 - 6,546,071 (-)NCBICelera
Cytogenetic Map8q11NCBI
BIRC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,347,214 - 102,378,670 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11102,347,211 - 102,378,670 (+)EnsemblGRCh38hg38GRCh38
GRCh3711102,217,945 - 102,249,401 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611101,723,176 - 101,754,611 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411101,723,175 - 101,754,610NCBI
Celera1199,379,519 - 99,410,957 (+)NCBICelera
Cytogenetic Map11q22.2NCBI
HuRef1198,144,490 - 98,175,923 (+)NCBIHuRef
CHM1_111102,100,910 - 102,132,418 (+)NCBICHM1_1
T2T-CHM13v2.011102,345,302 - 102,380,795 (+)NCBIT2T-CHM13v2.0
Birc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,818,227 - 7,837,123 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,818,228 - 7,837,065 (-)EnsemblGRCm39 Ensembl
GRCm3897,818,226 - 7,837,131 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,818,227 - 7,837,064 (-)EnsemblGRCm38mm10GRCm38
MGSCv3797,818,226 - 7,835,255 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3697,818,748 - 7,835,776 (-)NCBIMGSCv36mm8
Celera95,209,938 - 5,226,969 (-)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
Birc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554125,659,478 - 5,685,114 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554125,658,322 - 5,685,628 (+)NCBIChiLan1.0ChiLan1.0
BIRC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29103,148,062 - 103,177,617 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111104,239,302 - 104,265,992 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01197,298,736 - 97,324,966 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111100,793,036 - 100,818,455 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11100,793,036 - 100,822,421 (+)Ensemblpanpan1.1panPan2
BIRC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1529,294,080 - 29,314,837 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl529,294,692 - 29,312,771 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha529,243,776 - 29,261,396 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0529,346,845 - 29,367,441 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl529,346,852 - 29,367,441 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1529,381,208 - 29,409,025 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0529,261,674 - 29,279,330 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0529,436,391 - 29,454,076 (-)NCBIUU_Cfam_GSD_1.0
Birc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494786,000,642 - 86,020,605 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365515,515,904 - 5,535,864 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100622859
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl933,041,663 - 33,062,854 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1933,041,592 - 33,062,865 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2936,990,660 - 37,010,024 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BIRC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1193,721,449 - 93,746,638 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604332,117,251 - 32,142,556 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Birc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624878476,460 - 514,637 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Birc2
78 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:57
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000014560
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat

Markers in Region
RH134942  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.284,968,886 - 4,969,075 (+)MAPPERmRatBN7.2
Rnor_6.086,014,045 - 6,014,233NCBIRnor6.0
Rnor_5.086,015,784 - 6,015,972UniSTSRnor5.0
RGSC_v3.484,649,590 - 4,649,778UniSTSRGSC3.4
Celera86,528,704 - 6,528,892UniSTS
Cytogenetic Map8q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000014560   ⟹   ENSRNOP00000014560
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl84,968,856 - 4,988,732 (-)Ensembl
Rnor_6.0 Ensembl86,013,207 - 6,034,142 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105823   ⟹   ENSRNOP00000091109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl84,968,842 - 4,988,732 (-)Ensembl
RefSeq Acc Id: NM_021752   ⟹   NP_068520
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8813,253,697 - 13,271,540 (-)NCBI
mRatBN7.284,968,856 - 4,986,682 (-)NCBI
Rnor_6.086,014,014 - 6,034,587 (-)NCBI
Rnor_5.086,015,753 - 6,035,532 (-)NCBI
RGSC_v3.484,649,559 - 4,667,733 (-)RGD
Celera86,528,673 - 6,546,071 (-)RGD
Sequence:
RefSeq Acc Id: XM_006242494   ⟹   XP_006242556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8813,253,697 - 13,273,672 (-)NCBI
mRatBN7.284,968,856 - 4,988,814 (-)NCBI
Rnor_6.086,014,014 - 6,036,668 (-)NCBI
Rnor_5.086,015,753 - 6,035,532 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242495   ⟹   XP_006242557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8813,253,697 - 13,273,573 (-)NCBI
mRatBN7.284,968,856 - 4,988,630 (-)NCBI
Rnor_6.086,014,014 - 6,036,548 (-)NCBI
Rnor_5.086,015,753 - 6,035,532 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595882   ⟹   XP_017451371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8813,253,697 - 13,273,672 (-)NCBI
mRatBN7.284,968,856 - 4,989,325 (-)NCBI
Rnor_6.086,014,014 - 6,036,668 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063266063   ⟹   XP_063122133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8813,253,697 - 13,269,906 (-)NCBI
RefSeq Acc Id: NP_068520   ⟸   NM_021752
- UniProtKB: Q6P6S1 (UniProtKB/TrEMBL),   F1M6X6 (UniProtKB/TrEMBL),   A0A9K3Y7W9 (UniProtKB/TrEMBL),   Q9QZC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242556   ⟸   XM_006242494
- Peptide Label: isoform X1
- UniProtKB: Q6P6S1 (UniProtKB/TrEMBL),   F1M6X6 (UniProtKB/TrEMBL),   A0A9K3Y7W9 (UniProtKB/TrEMBL),   Q9QZC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242557   ⟸   XM_006242495
- Peptide Label: isoform X1
- UniProtKB: Q6P6S1 (UniProtKB/TrEMBL),   F1M6X6 (UniProtKB/TrEMBL),   A0A9K3Y7W9 (UniProtKB/TrEMBL),   Q9QZC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451371   ⟸   XM_017595882
- Peptide Label: isoform X2
- UniProtKB: Q9QZC6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014560   ⟸   ENSRNOT00000014560
Ensembl Acc Id: ENSRNOP00000091109   ⟸   ENSRNOT00000105823
RefSeq Acc Id: XP_063122133   ⟸   XM_063266063
- Peptide Label: isoform X3
Protein Domains
CARD   RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P6S1-F1-model_v2 AlphaFold Q6P6S1 1-589 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620690 AgrOrtholog
BioCyc Gene G2FUF-31767 BioCyc
Ensembl Genes ENSRNOG00000010602 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014560.7 UniProtKB/TrEMBL
  ENSRNOT00000105823.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598786 IMAGE-MGC_LOAD
InterPro BIR UniProtKB/TrEMBL
  BIRC2-3-like_UBA UniProtKB/TrEMBL
  BIRC2/BIRC3_UBA UniProtKB/TrEMBL
  CARD UniProtKB/TrEMBL
  DEATH-like UniProtKB/TrEMBL
  IAP UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
KEGG Report rno:60371 UniProtKB/TrEMBL
MGC_CLONE MGC:72464 IMAGE-MGC_LOAD
NCBI Gene 60371 ENTREZGENE
PANTHER BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
  INHIBITOR OF APOPTOSIS UniProtKB/TrEMBL
Pfam BIR UniProtKB/TrEMBL
  BIRC2-3-like_UBA UniProtKB/TrEMBL
  CARD UniProtKB/TrEMBL
  zf-C3HC4_3 UniProtKB/TrEMBL
PhenoGen Birc2 PhenoGen
PROSITE BIR_REPEAT_1 UniProtKB/TrEMBL
  BIR_REPEAT_2 UniProtKB/TrEMBL
  CARD UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010602 RatGTEx
SMART BIR UniProtKB/TrEMBL
  CARD UniProtKB/TrEMBL
  RING UniProtKB/TrEMBL
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
  Inhibitor of apoptosis (IAP) repeat UniProtKB/TrEMBL
UniProt A0A8I6ADV9_RAT UniProtKB/TrEMBL
  A0A9K3Y7W9 ENTREZGENE, UniProtKB/TrEMBL
  F1M6X6 ENTREZGENE
  Q6P6S1 ENTREZGENE, UniProtKB/TrEMBL
  Q9QZC6 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1M6X6 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Birc2  baculoviral IAP repeat-containing 2  Api2  apoptosis inhibitor 2  Symbol and Name updated 1299863 APPROVED
2002-08-07 Api2  apoptosis inhibitor 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology at amino acid level, 81.6 % and 89.3 % identity to human and mouse homologs, respectively 631961
gene_process may play an important antiapoptotic role in spermatogenesis 631961
gene_protein 589 amino acids 631960
gene_protein 66.7 kDa 631961
gene_regulation expression is induced by severe hypoxia and may be independent of hypoxia-inducible factor 631960
gene_transcript 5' region contains an enhancer of approximately 200 bp 631960