Rps6ka1 (ribosomal protein S6 kinase A1) - Rat Genome Database

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Gene: Rps6ka1 (ribosomal protein S6 kinase A1) Rattus norvegicus
Analyze
Symbol: Rps6ka1
Name: ribosomal protein S6 kinase A1
RGD ID: 620675
Description: Predicted to enable DNA-binding transcription factor binding activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; and protein kinase activity. Involved in positive regulation of DNA-templated transcription and protein phosphorylation. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human RPS6KA1 (ribosomal protein S6 kinase A1); PARTICIPATES IN adenosine signaling pathway; fibroblast growth factor signaling pathway; mTOR signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 90 kDa ribosomal protein S6 kinase 1; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; MAPKAPK1A; p90-RSK 1; p90RSK1; p90S6K; pp90RSK1; ribosomal protein S6 kinase alpha-1; ribosomal protein S6 kinase polypeptide 1; ribosomal protein S6 kinase, polypeptide A1; ribosomal S6 kinase 1; RSK-1; S6 protein kinase (Rsk-1); S6K-alpha 1; S6K-alpha-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85151,362,819 - 151,402,064 (-)NCBIGRCr8
mRatBN7.25146,079,018 - 146,118,272 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5146,079,021 - 146,118,272 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5148,781,620 - 148,820,794 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05150,551,233 - 150,590,407 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05150,537,805 - 150,576,980 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05152,078,217 - 152,122,684 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5152,078,220 - 152,122,684 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05155,760,609 - 155,805,563 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45151,274,666 - 151,288,007 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15151,284,704 - 151,298,043 (+)NCBI
Celera5144,500,101 - 144,539,235 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(20R)-protopanaxadiol  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
Ampullosporin  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
avermectin  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzacamene  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fasudil  (ISO)
fenthion  (ISO)
flufenoxuron  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gallic acid  (ISO)
inulin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
letrozole  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
lycopene  (ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
myricetin  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
Nodularin  (EXP)
ochratoxin A  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (EXP,ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
selenium atom  (ISO)
selumetinib  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
SU6656  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
triphenyl phosphate  (ISO)
tungsten  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
cytosol  (IEA,ISO,TAS)
glutamatergic synapse  (IDA,IEP)
nucleoplasm  (IBA,IEA,ISO)
postsynaptic density  (IDA,IEP)
spindle  (ISO)
synapse  (ISO)

References

References - curated
# Reference Title Reference Citation
1. MAPKAP kinases - MKs - two's company, three's a crowd. Gaestel M Nat Rev Mol Cell Biol. 2006 Feb;7(2):120-30.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Regulation of an epitope-tagged recombinant Rsk-1 S6 kinase by phorbol ester and erk/MAP kinase. Grove JR, etal., Biochemistry 1993 Aug 3;32(30):7727-38.
5. 90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling. Hu Y, etal., J Biol Chem. 2004 Jul 9;279(28):29325-35. Epub 2004 Apr 26.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Presence of up-stream and downstream components of a mitogen-activated protein kinase pathway in the PSD of the rat forebrain. Suzuki T, etal., Brain Res. 1999 Sep 4;840(1-2):36-44.
15. Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A. Wu J and Janknecht R, J Biol Chem 2002 Nov 8;277(45):42669-79.
Additional References at PubMed
PMID:8663493   PMID:9915826   PMID:10635333   PMID:10679322   PMID:11684016   PMID:15509711   PMID:15802625   PMID:15893597   PMID:16822942   PMID:16984226   PMID:17805973   PMID:18402937  
PMID:18815614   PMID:20048145   PMID:21148481   PMID:22065586   PMID:22130794   PMID:22205374   PMID:22267842   PMID:22357623   PMID:22797923   PMID:23510923   PMID:24307699   PMID:24330599  
PMID:26022182   PMID:30944250   PMID:31505737   PMID:31582215  


Genomics

Comparative Map Data
Rps6ka1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85151,362,819 - 151,402,064 (-)NCBIGRCr8
mRatBN7.25146,079,018 - 146,118,272 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5146,079,021 - 146,118,272 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5148,781,620 - 148,820,794 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05150,551,233 - 150,590,407 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05150,537,805 - 150,576,980 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05152,078,217 - 152,122,684 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5152,078,220 - 152,122,684 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05155,760,609 - 155,805,563 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45151,274,666 - 151,288,007 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15151,284,704 - 151,298,043 (+)NCBI
Celera5144,500,101 - 144,539,235 (-)NCBICelera
Cytogenetic Map5q36NCBI
RPS6KA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,529,761 - 26,575,025 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,529,761 - 26,575,030 (+)EnsemblGRCh38hg38GRCh38
GRCh37126,856,252 - 26,901,516 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,728,836 - 26,774,107 (+)NCBINCBI36Build 36hg18NCBI36
Build 34126,540,390 - 26,585,662NCBI
Celera125,253,435 - 25,298,712 (+)NCBICelera
Cytogenetic Map1p36.11NCBI
HuRef125,110,498 - 25,155,787 (+)NCBIHuRef
CHM1_1126,969,231 - 27,014,507 (+)NCBICHM1_1
T2T-CHM13v2.0126,367,713 - 26,412,979 (+)NCBIT2T-CHM13v2.0
Rps6ka1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394133,574,601 - 133,615,466 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4133,574,601 - 133,615,108 (-)EnsemblGRCm39 Ensembl
GRCm384133,847,290 - 133,887,797 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4133,847,290 - 133,887,797 (-)EnsemblGRCm38mm10GRCm38
MGSCv374133,403,205 - 133,443,714 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364133,119,370 - 133,159,860 (-)NCBIMGSCv36mm8
Celera4132,018,889 - 132,060,783 (-)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map466.37NCBI
Rps6ka1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554525,904,762 - 5,939,091 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554525,905,561 - 5,938,096 (+)NCBIChiLan1.0ChiLan1.0
RPS6KA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21200,294,769 - 200,340,289 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11199,395,353 - 199,440,930 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0125,792,428 - 25,837,950 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1126,856,061 - 26,900,532 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl126,856,057 - 26,900,532 (+)Ensemblpanpan1.1panPan2
RPS6KA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,497,128 - 73,533,853 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,497,473 - 73,534,378 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha270,074,045 - 70,110,763 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0274,060,131 - 74,097,008 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl274,060,131 - 74,097,510 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1270,884,942 - 70,921,656 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,890,665 - 71,927,571 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0272,894,123 - 72,930,845 (-)NCBIUU_Cfam_GSD_1.0
Rps6ka1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505845,171,987 - 45,205,720 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647410,996,813 - 11,030,557 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647410,996,867 - 11,030,504 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPS6KA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl683,905,077 - 83,950,963 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1683,905,124 - 83,947,189 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2677,443,084 - 77,480,448 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RPS6KA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120106,180,708 - 106,226,636 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20106,180,418 - 106,226,552 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603310,197,449 - 10,243,985 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rps6ka1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476410,526,948 - 10,569,910 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476410,527,012 - 10,566,625 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rps6ka1
156 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:393
Count of miRNA genes:212
Interacting mature miRNAs:246
Transcripts:ENSRNOT00000068634
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000068634   ⟹   ENSRNOP00000060054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5146,079,021 - 146,103,923 (-)Ensembl
Rnor_6.0 Ensembl5152,078,987 - 152,122,542 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077248   ⟹   ENSRNOP00000070880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5146,079,021 - 146,118,272 (-)Ensembl
Rnor_6.0 Ensembl5152,078,220 - 152,122,684 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102878   ⟹   ENSRNOP00000096254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5146,079,021 - 146,110,943 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110057   ⟹   ENSRNOP00000076673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5146,079,021 - 146,118,272 (-)Ensembl
RefSeq Acc Id: NM_031107   ⟹   NP_112369
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85151,362,819 - 151,402,064 (-)NCBI
mRatBN7.25146,079,018 - 146,118,272 (-)NCBI
Rnor_6.05152,078,217 - 152,122,684 (-)NCBI
Rnor_5.05155,760,609 - 155,805,563 (-)NCBI
RGSC_v3.45151,274,666 - 151,288,007 (+)RGD
Celera5144,500,101 - 144,539,235 (-)RGD
Sequence:
RefSeq Acc Id: XM_006239083   ⟹   XP_006239145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85151,362,819 - 151,389,485 (-)NCBI
mRatBN7.25146,079,018 - 146,105,695 (-)NCBI
Rnor_6.05152,078,217 - 152,109,074 (-)NCBI
Rnor_5.05155,760,609 - 155,805,563 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006239084   ⟹   XP_006239146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85151,362,819 - 151,391,150 (-)NCBI
mRatBN7.25146,079,018 - 146,107,396 (-)NCBI
Rnor_6.05152,078,217 - 152,110,708 (-)NCBI
Rnor_5.05155,760,609 - 155,805,563 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039110841   ⟹   XP_038966769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85151,362,819 - 151,393,373 (-)NCBI
mRatBN7.25146,079,018 - 146,109,593 (-)NCBI
RefSeq Acc Id: XM_063288477   ⟹   XP_063144547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85151,367,480 - 151,389,494 (-)NCBI
RefSeq Acc Id: NP_112369   ⟸   NM_031107
- UniProtKB: Q63531 (UniProtKB/Swiss-Prot),   A0A0G2JZ20 (UniProtKB/TrEMBL),   A6ISY9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239146   ⟸   XM_006239084
- Peptide Label: isoform X2
- UniProtKB: F1LXV0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239145   ⟸   XM_006239083
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AP54 (UniProtKB/TrEMBL),   F1LXV0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070880   ⟸   ENSRNOT00000077248
Ensembl Acc Id: ENSRNOP00000060054   ⟸   ENSRNOT00000068634
RefSeq Acc Id: XP_038966769   ⟸   XM_039110841
- Peptide Label: isoform X3
- UniProtKB: F1LXV0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000076673   ⟸   ENSRNOT00000110057
Ensembl Acc Id: ENSRNOP00000096254   ⟸   ENSRNOT00000102878
RefSeq Acc Id: XP_063144547   ⟸   XM_063288477
- Peptide Label: isoform X4
Protein Domains
AGC-kinase C-terminal   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63531-F1-model_v2 AlphaFold Q63531 1-735 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694122
Promoter ID:EPDNEW_R4647
Type:initiation region
Name:Rps6ka1_1
Description:ribosomal protein S6 kinase A1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05152,122,700 - 152,122,760EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620675 AgrOrtholog
BioCyc Gene G2FUF-39608 BioCyc
Ensembl Genes ENSRNOG00000042411 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068634.4 UniProtKB/TrEMBL
  ENSRNOT00000077248.2 UniProtKB/TrEMBL
  ENSRNOT00000102878.1 UniProtKB/TrEMBL
  ENSRNOT00000110057.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosomal_S6_kinase_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RSK_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81771 UniProtKB/Swiss-Prot
NCBI Gene 81771 ENTREZGENE
PANTHER RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIBOSOMAL PROTEIN S6 KINASE ALPHA-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rps6ka1 PhenoGen
PIRSF Ribsml_S6_kin_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042411 RatGTEx
SMART S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JZ20 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y5G7_RAT UniProtKB/TrEMBL
  A0A8I6AP54 ENTREZGENE, UniProtKB/TrEMBL
  A6ISY8_RAT UniProtKB/TrEMBL
  A6ISY9 ENTREZGENE, UniProtKB/TrEMBL
  F1LXV0 ENTREZGENE, UniProtKB/TrEMBL
  KS6A1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-16 Rps6ka1  ribosomal protein S6 kinase A1  Rps6ka1  ribosomal protein S6 kinase, polypeptide A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-03-13 Rps6ka1  ribosomal protein S6 kinase, polypeptide A1  Rps6ka1  ribosomal protein S6 kinase polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Rps6ka1  ribosomal protein S6 kinase polypeptide 1    S6 protein kinase (Rsk-1)  Name updated 1299863 APPROVED
2002-08-07 Rps6ka1  S6 protein kinase (Rsk-1)      Symbol and Name status set to provisional 70820 PROVISIONAL