Adra1d (adrenoceptor alpha 1D) - Rat Genome Database

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Gene: Adra1d (adrenoceptor alpha 1D) Rattus norvegicus
Analyze
Symbol: Adra1d
Name: adrenoceptor alpha 1D
RGD ID: 62064
Description: Enables alpha1-adrenergic receptor activity. Involved in positive regulation of vasoconstriction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Biomarker of polycystic ovary syndrome. Orthologous to human ADRA1D (adrenoceptor alpha 1D); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; calcium/calcium-mediated signaling pathway; INTERACTS WITH (R)-noradrenaline; 1-(5-isoquinolinesulfonyl)-2-methylpiperazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Adrd1; adrenergic receptor delta1; adrenergic receptor, alpha 1d; adrenergic receptor, delta1; adrenergic, alpha-1D-, receptor; alpha 1D-adrenoceptor; alpha 1D-adrenoreceptor; alpha-1A adrenergic receptor; alpha-1D adrenergic receptor; alpha-1D adrenoceptor; alpha-1D adrenoreceptor; RA42
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83139,246,333 - 139,262,331 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3139,246,323 - 139,262,331 (-)EnsemblGRCr8
mRatBN7.23118,793,356 - 118,809,354 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3118,793,346 - 118,809,354 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3122,686,724 - 122,702,749 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03131,282,512 - 131,298,645 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03128,942,820 - 128,958,851 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03124,129,558 - 124,145,566 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3124,129,558 - 124,145,566 (-)Ensemblrn6Rnor6.0
Rnor_5.03130,621,199 - 130,637,207 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43119,279,974 - 119,295,985 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3117,597,347 - 117,613,356 (-)NCBICelera
RGSC_v3.13119,185,546 - 119,201,558 (-)NCBI
Cytogenetic Map3q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (ISO)
(R)-noradrenaline  (EXP,ISO)
1,2-dichloroethane  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
1D-myo-inositol 1,4,5-trisphosphate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
28-Homobrassinolide  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
Aflatoxin B2 alpha  (ISO)
alfuzosin  (EXP,ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carvedilol  (ISO)
cefaloridine  (EXP)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
cyclosporin A  (EXP)
dexamethasone  (ISO)
diquat  (ISO)
domperidone  (ISO)
doxazosin  (EXP,ISO)
doxorubicin  (ISO)
flavonoids  (EXP)
fulvestrant  (ISO)
furan  (EXP)
ketanserin  (ISO)
lead diacetate  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
methoxamine  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
Naftopidil  (EXP)
okadaic acid  (ISO)
oxymetazoline  (ISO)
ozone  (ISO)
paraquat  (EXP)
perfluorooctanoic acid  (EXP)
phenethyl caffeate  (EXP)
phentolamine  (ISO)
phenylephrine  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP)
prazosin  (EXP,ISO)
propiconazole  (EXP)
quinidine  (ISO)
reserpine  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarpogrelate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
streptozocin  (EXP)
tacrolimus hydrate  (EXP)
tamsulosin  (EXP)
terazosin  (EXP,ISO)
terbutaline  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
triclosan  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
verapamil  (ISO)
vinclozolin  (EXP)
Xylometazoline  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Vascular alpha1-adrenoceptors in isolated perfused rat kidney: influence of ageing. Awe SO and Adeagbo AS, Auton Autacoid Pharmacol. 2007 Jan;27(1):19-26.
2. Phosphorylation and desensitization of alpha1d-adrenergic receptors. Garcia-Sainz JA, etal., Biochem J 2001 Feb 1;353(Pt 3):603-10.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors. Hague C, etal., J Biol Chem. 2004 Apr 9;279(15):15541-9. Epub 2004 Jan 21.
6. Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5. Lomasney JW, etal., J Biol Chem 1991 Apr 5;266(10):6365-9.
7. Ovarian expression of alpha (1)- and beta (2)-adrenoceptors and p75 neurotrophin receptors in rats with steroid-induced polycystic ovaries. Manni L, etal., Auton Neurosci. 2005 Mar 31;118(1-2):79-87.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Alpha1-adrenergic receptors: new insights and directions. Piascik MT and Perez DM, J Pharmacol Exp Ther. 2001 Aug;298(2):403-10.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Alpha-1-adrenoceptor subtype selective regulation of connexin 43 expression in rat cardiomyocytes. Rojas Gomez DM, etal., Naunyn Schmiedebergs Arch Pharmacol. 2008 Mar;377(1):77-85. Epub 2008 Jan 8.
15. Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. Schwinn DA, etal., J Pharmacol Exp Ther 1995 Jan;272(1):134-42.
16. Alpha1-adrenoceptors in the rat cerebral cortex: new insights into the characterization of alpha1L- and alpha1D-adrenoceptors. Segura V, etal., Eur J Pharmacol. 2010 Sep 1;641(1):41-8. Epub 2010 May 23.
17. Role of supraspinal and spinal alpha1-adrenergic receptor subtypes in micturition reflex in conscious rats. Yoshizumi M, etal., Am J Physiol Renal Physiol. 2010 Oct;299(4):F785-91. Epub 2010 Jul 28.
Additional References at PubMed
PMID:1661838   PMID:10493741   PMID:10570042   PMID:12184796   PMID:12595294   PMID:14645668   PMID:16308429   PMID:16760267   PMID:18204069   PMID:18246093   PMID:18257746   PMID:18581117  
PMID:19302553   PMID:19844130   PMID:20102360   PMID:20110686   PMID:20138850   PMID:21376031   PMID:21685341   PMID:21951585   PMID:23283760   PMID:24772448   PMID:25283507   PMID:25630693  
PMID:26593425   PMID:26617989   PMID:27382054   PMID:27605559   PMID:34062902  


Genomics

Comparative Map Data
Adra1d
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83139,246,333 - 139,262,331 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3139,246,323 - 139,262,331 (-)EnsemblGRCr8
mRatBN7.23118,793,356 - 118,809,354 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3118,793,346 - 118,809,354 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3122,686,724 - 122,702,749 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03131,282,512 - 131,298,645 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03128,942,820 - 128,958,851 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03124,129,558 - 124,145,566 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3124,129,558 - 124,145,566 (-)Ensemblrn6Rnor6.0
Rnor_5.03130,621,199 - 130,637,207 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43119,279,974 - 119,295,985 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3117,597,347 - 117,613,356 (-)NCBICelera
RGSC_v3.13119,185,546 - 119,201,558 (-)NCBI
Cytogenetic Map3q36NCBI
ADRA1D
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38204,220,630 - 4,249,287 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl204,220,630 - 4,249,287 (-)Ensemblhg38GRCh38
GRCh37204,201,277 - 4,229,934 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36204,149,278 - 4,177,659 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34204,149,815 - 4,177,659NCBI
Celera204,266,123 - 4,294,513 (-)NCBICelera
Cytogenetic Map20p13NCBI
HuRef204,150,034 - 4,178,575 (-)NCBIHuRef
CHM1_1204,201,589 - 4,229,908 (-)NCBICHM1_1
T2T-CHM13v2.0204,254,950 - 4,283,627 (-)NCBIT2T-CHM13v2.0
Adra1d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392131,387,277 - 131,404,417 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2131,387,770 - 131,404,203 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382131,545,357 - 131,562,497 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2131,545,850 - 131,562,283 (-)Ensemblmm10GRCm38
MGSCv372131,371,093 - 131,388,021 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362131,237,291 - 131,253,726 (-)NCBIMGSCv36mm8
Celera2132,774,260 - 132,791,226 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.5NCBI
Adra1d
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541515,000,257 - 15,022,712 (-)Ensembl
ChiLan1.0NW_00495541515,000,257 - 15,022,712 (-)NCBIChiLan1.0ChiLan1.0
ADRA1D
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2215,163,221 - 5,199,354 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1205,160,045 - 5,196,178 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0204,242,788 - 4,271,295 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1204,040,044 - 4,069,627 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl204,040,888 - 4,068,018 (-)EnsemblpanPan2panpan1.1
ADRA1D
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12417,231,771 - 17,239,110 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2417,213,643 - 17,214,761 (+)EnsemblcanFam3CanFam3.1
CanFam3.1 Ensembl2417,213,643 - 17,214,761 (+)NCBIcanFam3CanFam3.1
Dog10K_Boxer_Tasha2417,037,075 - 17,059,959 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02417,632,268 - 17,650,297 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2417,631,302 - 17,650,297 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12417,226,509 - 17,249,378 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02417,332,470 - 17,355,345 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02417,665,923 - 17,688,810 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Adra1d
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640166,083,023 - 166,111,898 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648514,515,494 - 14,537,631 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648514,514,395 - 14,538,389 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADRA1D
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1731,517,021 - 31,538,362 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11731,517,021 - 31,537,361 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21735,851,791 - 35,871,365 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADRA1D
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1234,859,651 - 34,888,684 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl234,860,483 - 34,887,779 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660719,432,699 - 9,461,985 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adra1d
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247415,274,187 - 5,296,986 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247415,276,484 - 5,297,594 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Adra1d
85 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:91
Interacting mature miRNAs:103
Transcripts:ENSRNOT00000028877
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)384091273129091273Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3115638168135181505Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
18 13 71 128 43 42 11 59 11 6 308 160 8 106 111 123 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000028877   ⟹   ENSRNOP00000028877
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3139,246,323 - 139,262,331 (-)Ensembl
mRatBN7.2 Ensembl3118,793,346 - 118,809,354 (-)Ensembl
Rnor_6.0 Ensembl3124,129,558 - 124,145,566 (-)Ensembl
RefSeq Acc Id: NM_024483   ⟹   NP_077809
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83139,246,333 - 139,262,331 (-)NCBI
mRatBN7.23118,793,356 - 118,809,354 (-)NCBI
Rnor_6.03124,129,558 - 124,145,566 (-)NCBI
Rnor_5.03130,621,199 - 130,637,207 (-)NCBI
RGSC_v3.43119,279,974 - 119,295,985 (-)RGD
Celera3117,597,347 - 117,613,356 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_077809 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA63477 (Get FASTA)   NCBI Sequence Viewer  
  AAB59704 (Get FASTA)   NCBI Sequence Viewer  
  AAC25396 (Get FASTA)   NCBI Sequence Viewer  
  EDL80245 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028877
GenBank Protein P23944 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_077809   ⟸   NM_024483
- UniProtKB: Q71UM4 (UniProtKB/Swiss-Prot),   P23944 (UniProtKB/Swiss-Prot),   G3V8W0 (UniProtKB/TrEMBL),   A6HQE4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028877   ⟸   ENSRNOT00000028877
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23944-F1-model_v2 AlphaFold P23944 1-561 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62064 AgrOrtholog
BioCyc Gene G2FUF-47800 BioCyc
Ensembl Genes ENSRNOG00000021256 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000028877 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro ADR_fam UniProtKB/Swiss-Prot
  ADRA1D_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:29413 UniProtKB/Swiss-Prot
NCBI Gene 29413 ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
  PTHR24248:SF14 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB ADRA1D RGD
PhenoGen Adra1d PhenoGen
PRINTS ADRENERGICR UniProtKB/Swiss-Prot
  ADRENRGCA1DR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021256 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A6HQE4 ENTREZGENE, UniProtKB/TrEMBL
  ADA1D_RAT UniProtKB/Swiss-Prot
  G3V8W0 ENTREZGENE, UniProtKB/TrEMBL
  P23944 ENTREZGENE
  Q71UM4 ENTREZGENE
UniProt Secondary Q71UM4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-13 Adra1d  adrenoceptor alpha 1D  Adra1d  adrenergic, alpha-1D-, receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Adra1d  adrenergic, alpha-1D-, receptor  Adra1d  adrenergic receptor, alpha 1d  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Adra1d  adrenergic receptor, alpha 1d      Symbol and Name updated 629477 APPROVED
2003-03-06 Adra1d  adrenergic receptor, alpha 1d  Adrd1  adrenergic receptor, delta1  Data merged from RGD:70333 628472 PROVISIONAL
2002-06-10 Adrd1  adrenergic receptor, delta1      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Adra1d  adrenergic receptor, alpha 1d      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process mediates its effect through the influx of extracellular calcium 724707
gene_transcript exists in 3 forms, a1, a2, b1 61534