Hr (HR, lysine demethylase and nuclear receptor corepressor) - Rat Genome Database

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Gene: Hr (HR, lysine demethylase and nuclear receptor corepressor) Rattus norvegicus
Analyze
Symbol: Hr
Name: HR, lysine demethylase and nuclear receptor corepressor
RGD ID: 620634
Description: Enables histone deacetylase binding activity; nuclear receptor binding activity; and transcription corepressor activity. Involved in negative regulation of DNA-binding transcription factor activity. Part of histone deacetylase complex. Used to study focal segmental glomerulosclerosis and proteinuria. Human ortholog(s) of this gene implicated in alopecia; alopecia universalis; and atrichia with papular lesions. Orthologous to human HR (HR lysine demethylase and nuclear receptor corepressor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: [histone H3]-dimethyl-L-lysine(9) demethylase hairless; hair growth associated; hairless; hairless homolog; hairless homolog (mouse); lysine-specific demethylase hairless
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81552,036,540 - 52,056,019 (+)NCBIGRCr8
mRatBN7.21545,626,835 - 45,646,313 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1545,626,835 - 45,646,313 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1549,744,700 - 49,764,175 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01550,856,205 - 50,875,680 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01547,715,507 - 47,734,986 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01552,241,801 - 52,261,276 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1552,241,801 - 52,261,276 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01555,967,613 - 55,984,797 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41550,957,053 - 50,972,842 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11550,972,821 - 50,988,623 (+)NCBI
Celera1545,305,217 - 45,324,692 (+)NCBICelera
Cytogenetic Map15p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
butanal  (ISO)
Butylparaben  (EXP)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
copper(II) chloride  (ISO)
Cuprizon  (EXP)
DDE  (ISO)
dioxygen  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
enzacamene  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
Mesaconitine  (EXP)
methamphetamine  (EXP)
methimazole  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
niclosamide  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenite  (ISO)
staurosporine  (EXP,ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
thapsigargin  (ISO)
thyroxine  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
trimethyltin  (ISO)
triptonide  (ISO)
tunicamycin  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IBA)
histone deacetylase complex  (IBA,IDA,IEA)
nuclear body  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Cloning, genomic organization, alternative transcripts and mutational analysis of the gene responsible for autosomal recessive universal congenital alopecia. Cichon S, etal., Hum Mol Genet. 1998 Oct;7(11):1671-9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Physical and functional interaction between the vitamin D receptor and hairless corepressor, two proteins required for hair cycling. Hsieh JC, etal., J Biol Chem. 2003 Oct 3;278(40):38665-74. Epub 2003 Jul 7.
5. Kyoto rhino rats derived by ENU mutagenesis undergo congenital hair loss and exhibit focal glomerulosclerosis. Kuramoto T, etal., Exp Anim. 2011;60(1):57-63. doi: 10.1538/expanim.60.57.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. The Charles River "hairless" rat mutation is distinct from the hairless mouse alleles. Panteleyev AA and Christiano AM, Comp Med 2001 Feb;51(1):49-55.
10. The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor. Potter GB, etal., Genes Dev. 2001 Oct 15;15(20):2687-701.
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. The product of a thyroid hormone-responsive gene interacts with thyroid hormone receptors. Thompson CC and Bottcher MC, Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8527-32.
15. Thyroid hormone-responsive genes in developing cerebellum include a novel synaptotagmin and a hairless homolog. Thompson CC J Neurosci 1996 Dec 15;16(24):7832-40.
16. Congenital atrichia in five Arab Palestinian families resulting from a deletion mutation in the human hairless gene. Zlotogorski A, etal., Hum Genet. 1998 Oct;103(4):400-4.
Additional References at PubMed
PMID:8889548   PMID:12403844   PMID:12873232   PMID:19122663   PMID:20512927  


Genomics

Comparative Map Data
Hr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81552,036,540 - 52,056,019 (+)NCBIGRCr8
mRatBN7.21545,626,835 - 45,646,313 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1545,626,835 - 45,646,313 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1549,744,700 - 49,764,175 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01550,856,205 - 50,875,680 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01547,715,507 - 47,734,986 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01552,241,801 - 52,261,276 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1552,241,801 - 52,261,276 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01555,967,613 - 55,984,797 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41550,957,053 - 50,972,842 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11550,972,821 - 50,988,623 (+)NCBI
Celera1545,305,217 - 45,324,692 (+)NCBICelera
Cytogenetic Map15p11NCBI
HR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38822,114,419 - 22,131,052 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl822,114,419 - 22,133,384 (-)EnsemblGRCh38hg38GRCh38
GRCh37821,971,932 - 21,988,565 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36822,027,877 - 22,043,975 (-)NCBINCBI36Build 36hg18NCBI36
Build 34822,028,526 - 22,045,326NCBI
Celera820,934,236 - 20,950,880 (-)NCBICelera
Cytogenetic Map8p21.3NCBI
HuRef820,514,477 - 20,541,503 (-)NCBIHuRef
CHM1_1822,173,616 - 22,190,245 (-)NCBICHM1_1
T2T-CHM13v2.0822,388,371 - 22,405,000 (-)NCBIT2T-CHM13v2.0
Hr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,789,644 - 70,810,988 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1470,789,652 - 70,810,988 (+)EnsemblGRCm39 Ensembl
GRCm381470,554,056 - 70,573,548 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1470,552,212 - 70,573,548 (+)EnsemblGRCm38mm10GRCm38
MGSCv371470,953,863 - 70,973,350 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361469,289,136 - 69,308,623 (+)NCBIMGSCv36mm8
Celera1468,095,776 - 68,115,052 (+)NCBICelera
Cytogenetic Map14D2NCBI
cM Map1436.32NCBI
Hr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540345,605,510 - 45,624,402 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540345,605,870 - 45,624,386 (-)NCBIChiLan1.0ChiLan1.0
HR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2740,616,243 - 40,630,986 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1816,341,438 - 16,357,572 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0821,359,348 - 21,378,315 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1818,298,709 - 18,316,151 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl818,298,709 - 18,316,151 (-)Ensemblpanpan1.1panPan2
HR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12535,120,566 - 35,136,560 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2535,119,784 - 35,135,545 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2535,710,085 - 35,727,556 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02535,332,063 - 35,349,535 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2535,333,417 - 35,347,559 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12535,277,299 - 35,294,762 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02535,131,873 - 35,149,314 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02535,287,349 - 35,304,802 (+)NCBIUU_Cfam_GSD_1.0
Hr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494312,612,526 - 12,634,082 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365555,936,220 - 5,954,974 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365555,936,431 - 5,954,852 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl146,386,903 - 6,407,031 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1146,386,900 - 6,404,968 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2146,822,598 - 6,840,654 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1820,183,797 - 20,207,510 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl820,183,677 - 20,198,700 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605222,028,581 - 22,052,527 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475817,699,400 - 17,715,482 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475817,699,357 - 17,719,188 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hr
43 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:182
Count of miRNA genes:99
Interacting mature miRNAs:128
Transcripts:ENSRNOT00000015716
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)152788577486257085Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
2306968Anxrr23Anxiety related response QTL 234.83reflex trait (VT:0001961)amplitude of the acoustic startle response (CMO:0001520)154063126846187442Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154028990149308583Rat

Markers in Region
RH134301  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21545,646,018 - 45,646,208 (+)MAPPERmRatBN7.2
Rnor_6.01552,260,982 - 52,261,171NCBIRnor6.0
Rnor_5.01555,984,499 - 55,984,688UniSTSRnor5.0
RGSC_v3.41550,972,549 - 50,972,738UniSTSRGSC3.4
Celera1545,324,398 - 45,324,587UniSTS
Cytogenetic Map15p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 83 82 51 25 51 6 210 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000015716   ⟹   ENSRNOP00000015716
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1545,630,509 - 45,646,313 (+)Ensembl
Rnor_6.0 Ensembl1552,245,475 - 52,261,276 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082639   ⟹   ENSRNOP00000073482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1545,626,835 - 45,646,313 (+)Ensembl
Rnor_6.0 Ensembl1552,241,801 - 52,261,276 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095269   ⟹   ENSRNOP00000092837
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1545,630,509 - 45,646,313 (+)Ensembl
RefSeq Acc Id: NM_024364   ⟹   NP_077340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81552,036,540 - 52,056,015 (+)NCBI
mRatBN7.21545,626,835 - 45,646,313 (+)NCBI
Rnor_6.01552,241,801 - 52,261,276 (+)NCBI
Rnor_5.01555,967,613 - 55,984,797 (+)NCBI
RGSC_v3.41550,957,053 - 50,972,842 (+)RGD
Celera1545,305,217 - 45,324,692 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063274609   ⟹   XP_063130679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81552,038,638 - 52,056,019 (+)NCBI
RefSeq Acc Id: NP_077340   ⟸   NM_024364
- Sequence:
Ensembl Acc Id: ENSRNOP00000073482   ⟸   ENSRNOT00000082639
Ensembl Acc Id: ENSRNOP00000015716   ⟸   ENSRNOT00000015716
Ensembl Acc Id: ENSRNOP00000092837   ⟸   ENSRNOT00000095269
RefSeq Acc Id: XP_063130679   ⟸   XM_063274609
- Peptide Label: isoform X1
- UniProtKB: P97609 (UniProtKB/Swiss-Prot),   A0A0G2K5M5 (UniProtKB/TrEMBL),   A6HTL6 (UniProtKB/TrEMBL)
Protein Domains
JmjC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97609-F1-model_v2 AlphaFold P97609 1-1181 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699813
Promoter ID:EPDNEW_R10337
Type:multiple initiation site
Name:Hr_1
Description:HR, lysine demethylase and nuclear receptor corepressor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01552,244,121 - 52,244,181EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620634 AgrOrtholog
BioCyc Gene G2FUF-13210 BioCyc
Ensembl Genes ENSRNOG00000011427 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000015716 ENTREZGENE
Gene3D-CATH Cupin UniProtKB/Swiss-Prot
InterPro JHDM2-like UniProtKB/Swiss-Prot
  JmjC_dom UniProtKB/Swiss-Prot
NCBI Gene 60563 ENTREZGENE
PANTHER LYSINE-SPECIFIC DEMETHYLASE HAIRLESS UniProtKB/Swiss-Prot
  PTHR12549 UniProtKB/Swiss-Prot
Pfam JmjC UniProtKB/Swiss-Prot
PhenoGen Hr PhenoGen
PROSITE JMJC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011427 RatGTEx
SMART JmjC UniProtKB/Swiss-Prot
Superfamily-SCOP Clavaminate synthase-like UniProtKB/Swiss-Prot
UniProt A0A0G2K5M5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GJZ4_RAT UniProtKB/TrEMBL
  A6HTL4_RAT UniProtKB/TrEMBL
  A6HTL6 ENTREZGENE, UniProtKB/TrEMBL
  G3V7J4_RAT UniProtKB/TrEMBL
  HAIR_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-11-04 Hr  HR, lysine demethylase and nuclear receptor corepressor  Hr  hair growth associated  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-02-22 Hr  hair growth associated  Hr  hairless  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Hr  hairless  Hr  hairless homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-02-07 Hr    hr  hairless homolog (mouse)  Symbol updated 1299863 APPROVED
2004-09-10 hr  hairless homolog (mouse)    hairless  Name updated 1299863 APPROVED
2002-08-07 hr  hairless      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_other hr is not mutated in the "hairless" Charles River rat, thus the mutation responsible for this phenotype is unlikely to be allelic with hr 1299284
gene_regulation expression is induced by thryoid hormone during brain development 730028