Itih3 (inter-alpha trypsin inhibitor, heavy chain 3) - Rat Genome Database

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Gene: Itih3 (inter-alpha trypsin inhibitor, heavy chain 3) Rattus norvegicus
Analyze
Symbol: Itih3
Name: inter-alpha trypsin inhibitor, heavy chain 3
RGD ID: 620633
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in hyaluronan metabolic process. Predicted to be located in extracellular region. Orthologous to human ITIH3 (inter-alpha-trypsin inhibitor heavy chain 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: inter-alpha-inhibitor heavy chain 3; inter-alpha-trypsin inhibitor heavy chain H3; ITI heavy chain H3; ITI-HC3; PAIHC3; pre-alpha-inhibitor heavy chain 3; pre-alpha-inhibitor, heavy chain 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8166,108,378 - 6,123,609 (-)NCBIGRCr8
mRatBN7.2166,101,922 - 6,117,154 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl166,101,930 - 6,116,924 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx166,113,241 - 6,128,042 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0167,258,702 - 7,273,506 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0166,120,667 - 6,135,331 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0166,983,779 - 7,007,288 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl166,992,062 - 7,007,287 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0166,910,530 - 6,933,416 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,341,043 - 6,358,767 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1166,341,044 - 6,358,765 (-)NCBI
Celera169,072,721 - 9,087,644 (+)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antimony(0)  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP)
cantharidin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
chromium atom  (ISO)
ciglitazone  (ISO)
clotrimazole  (EXP)
cobalt dichloride  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyproconazole  (ISO)
dextran sulfate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diethyl maleate  (ISO)
diiodine  (ISO)
dimethylarsinic acid  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
GW 4064  (ISO)
inulin  (ISO)
isoprenaline  (ISO)
ketamine  (EXP)
lipopolysaccharide  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methimazole  (EXP)
methylarsonic acid  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nitrofen  (EXP)
ozone  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
senecionine  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP)
triadimefon  (ISO)
trimethylarsine oxide  (EXP)
Triptolide  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Intracellular coupling of the heavy chain of pre-alpha-inhibitor to chondroitin sulfate. Kaczmarczyk A, etal., J Biol Chem 2002 Apr 19;277(16):13578-82. Epub 2002 Feb 4.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1299283   PMID:23533145   PMID:29476059  


Genomics

Comparative Map Data
Itih3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8166,108,378 - 6,123,609 (-)NCBIGRCr8
mRatBN7.2166,101,922 - 6,117,154 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl166,101,930 - 6,116,924 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx166,113,241 - 6,128,042 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0167,258,702 - 7,273,506 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0166,120,667 - 6,135,331 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0166,983,779 - 7,007,288 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl166,992,062 - 7,007,287 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0166,910,530 - 6,933,416 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,341,043 - 6,358,767 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1166,341,044 - 6,358,765 (-)NCBI
Celera169,072,721 - 9,087,644 (+)NCBICelera
Cytogenetic Map16p16NCBI
ITIH3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38352,794,796 - 52,808,797 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl352,794,768 - 52,808,799 (+)EnsemblGRCh38hg38GRCh38
GRCh37352,828,812 - 52,842,813 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,803,824 - 52,818,065 (+)NCBINCBI36Build 36hg18NCBI36
Build 34352,803,853 - 52,817,854NCBI
Celera352,807,505 - 52,821,742 (+)NCBICelera
Cytogenetic Map3p21.1NCBI
HuRef352,890,445 - 52,904,683 (+)NCBIHuRef
CHM1_1352,780,986 - 52,795,224 (+)NCBICHM1_1
T2T-CHM13v2.0352,827,705 - 52,841,707 (+)NCBIT2T-CHM13v2.0
Itih3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391430,630,529 - 30,645,748 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1430,630,529 - 30,645,717 (-)EnsemblGRCm39 Ensembl
GRCm381430,908,572 - 30,923,787 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1430,908,572 - 30,923,760 (-)EnsemblGRCm38mm10GRCm38
MGSCv371431,721,758 - 31,736,773 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361429,737,582 - 29,752,553 (-)NCBIMGSCv36mm8
Celera1427,165,744 - 27,180,756 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.09NCBI
Itih3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554302,753,996 - 2,767,324 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554302,753,974 - 2,767,436 (+)NCBIChiLan1.0ChiLan1.0
ITIH3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2252,786,787 - 52,803,297 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1352,791,574 - 52,807,958 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0352,733,966 - 52,750,198 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1353,961,476 - 53,976,065 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl353,961,451 - 53,976,065 (+)Ensemblpanpan1.1panPan2
ITIH3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12037,032,485 - 37,035,941 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2037,003,374 - 37,017,395 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02037,372,140 - 37,386,102 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2037,372,141 - 37,386,063 (-)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.02037,144,184 - 37,158,164 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02037,421,715 - 37,435,675 (-)NCBIUU_Cfam_GSD_1.0
Itih3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118170,414,614 - 170,430,165 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364733,553,210 - 3,568,636 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364733,553,210 - 3,568,636 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITIH3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1334,906,538 - 34,933,706 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11334,911,104 - 34,924,881 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21338,106,334 - 38,120,182 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITIH3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12214,176,656 - 14,191,256 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2214,177,334 - 14,191,353 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041152,706,611 - 152,721,211 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itih3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248224,416,074 - 4,429,623 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248224,415,962 - 4,429,660 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itih3
113 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:204
Count of miRNA genes:143
Interacting mature miRNAs:157
Transcripts:ENSRNOT00000023984, ENSRNOT00000041216
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat

Markers in Region
RH130520  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2166,101,941 - 6,102,137 (+)MAPPERmRatBN7.2
Rnor_6.0166,992,090 - 6,992,285NCBIRnor6.0
Rnor_5.0166,918,696 - 6,918,891UniSTSRnor5.0
RGSC_v3.4166,341,059 - 6,341,254UniSTSRGSC3.4
Celera169,087,433 - 9,087,628UniSTS
RH 3.4 Map1644.0UniSTS
Cytogenetic Map16p16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 23 23 23
Medium 14 12 12 1 1 40 6 2 1
Low 3 10 20 6 19 6 7 8 14 14 20 7 7
Below cutoff 15 2 12 14 15 2

Sequence


RefSeq Acc Id: ENSRNOT00000023984   ⟹   ENSRNOP00000023984
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl166,101,930 - 6,116,924 (-)Ensembl
Rnor_6.0 Ensembl166,992,171 - 7,007,051 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000041216   ⟹   ENSRNOP00000043221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl166,101,930 - 6,116,917 (-)Ensembl
Rnor_6.0 Ensembl166,992,062 - 7,007,287 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109614   ⟹   ENSRNOP00000094283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl166,101,930 - 6,116,924 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110525   ⟹   ENSRNOP00000094838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl166,101,930 - 6,116,924 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115678   ⟹   ENSRNOP00000080066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl166,101,930 - 6,116,917 (-)Ensembl
RefSeq Acc Id: NM_017351   ⟹   NP_059047
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,108,378 - 6,123,374 (-)NCBI
mRatBN7.2166,101,926 - 6,116,924 (-)NCBI
Rnor_6.0166,992,074 - 7,007,058 (-)NCBI
Rnor_5.0166,910,530 - 6,933,416 (-)NCBI
RGSC_v3.4166,341,043 - 6,358,767 (-)RGD
Celera169,072,721 - 9,087,644 (+)RGD
Sequence:
RefSeq Acc Id: XM_063275656   ⟹   XP_063131726
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,114,783 - 6,123,604 (-)NCBI
RefSeq Acc Id: XM_063275657   ⟹   XP_063131727
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,108,378 - 6,123,609 (-)NCBI
RefSeq Acc Id: NP_059047   ⟸   NM_017351
- Peptide Label: precursor
- UniProtKB: Q63416 (UniProtKB/Swiss-Prot),   A6KG20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000043221   ⟸   ENSRNOT00000041216
RefSeq Acc Id: ENSRNOP00000023984   ⟸   ENSRNOT00000023984
RefSeq Acc Id: ENSRNOP00000080066   ⟸   ENSRNOT00000115678
RefSeq Acc Id: ENSRNOP00000094838   ⟸   ENSRNOT00000110525
RefSeq Acc Id: ENSRNOP00000094283   ⟸   ENSRNOT00000109614
RefSeq Acc Id: XP_063131727   ⟸   XM_063275657
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063131726   ⟸   XM_063275656
- Peptide Label: isoform X1
Protein Domains
VIT   VWFA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63416-F1-model_v2 AlphaFold Q63416 1-887 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699916
Promoter ID:EPDNEW_R10440
Type:multiple initiation site
Name:Itih3_1
Description:inter-alpha trypsin inhibitor, heavy chain 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0167,007,059 - 7,007,119EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620633 AgrOrtholog
BioCyc Gene G2FUF-12175 BioCyc
Ensembl Genes ENSRNOG00000017689 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023984 ENTREZGENE
  ENSRNOT00000023984.7 UniProtKB/Swiss-Prot
  ENSRNOT00000041216.5 UniProtKB/TrEMBL
  ENSRNOT00000109614.1 UniProtKB/TrEMBL
  ENSRNOT00000110525.1 UniProtKB/TrEMBL
  ENSRNOT00000115678.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ITI_HC_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWF_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:50693 UniProtKB/Swiss-Prot
NCBI Gene 50693 ENTREZGENE
PANTHER INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ITI_HC_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Itih3 PhenoGen
PROSITE VIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017689 RatGTEx
SMART VIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZPG2_RAT UniProtKB/TrEMBL
  A0A8I6ALV3_RAT UniProtKB/TrEMBL
  A0A8I6GKX5_RAT UniProtKB/TrEMBL
  A6KG20 ENTREZGENE, UniProtKB/TrEMBL
  D3ZBS2_RAT UniProtKB/TrEMBL
  ITIH3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Itih3  inter-alpha trypsin inhibitor, heavy chain 3  PAIHC3  pre-alpha-inhibitor, heavy chain 3  Symbol and Name updated 1299863 APPROVED
2002-08-07 PAIHC3  pre-alpha-inhibitor, heavy chain 3      Symbol and Name status set to provisional 70820 PROVISIONAL