Hrh4 (histamine receptor H4) - Rat Genome Database

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Gene: Hrh4 (histamine receptor H4) Rattus norvegicus
Analyze
Symbol: Hrh4
Name: histamine receptor H4
RGD ID: 620631
Description: Enables histamine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway; and chemical synaptic transmission. Predicted to be located in membrane. Predicted to be active in dendrite; plasma membrane; and synapse. Orthologous to human HRH4 (histamine receptor H4); INTERACTS WITH 2,4,6-trinitrobenzenesulfonic acid; amitrole; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: H4R; HH4R; histamine H4 receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8184,440,977 - 4,457,132 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl184,440,977 - 4,457,132 (+)EnsemblGRCr8
mRatBN7.2184,166,270 - 4,182,426 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,166,270 - 4,246,345 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx184,389,940 - 4,406,096 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0185,177,508 - 5,193,664 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,436,938 - 4,453,080 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0184,365,429 - 4,382,599 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl184,365,429 - 4,382,599 (+)Ensemblrn6Rnor6.0
Rnor_5.0184,353,104 - 4,368,967 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4184,275,671 - 4,292,259 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera184,215,815 - 4,231,769 (+)NCBICelera
RGSC_v3.1184,275,670 - 4,292,259 (+)NCBI
Cytogenetic Map18p13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
dendrite  (IBA)
membrane  (IEA,ISO)
plasma membrane  (IBA,IEA)
synapse  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation. Liu C, etal., J Pharmacol Exp Ther 2001 Oct;299(1):121-30.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. Thurmond RL, etal., J Pharmacol Exp Ther 2004 Apr;309(1):404-13. Epub 2004 Jan 13.
Additional References at PubMed
PMID:18345490   PMID:19046950   PMID:19053770   PMID:19271139   PMID:19413571   PMID:21055325   PMID:21839070   PMID:22153663   PMID:22569158   PMID:22624822   PMID:23262779   PMID:23413254  
PMID:23488566   PMID:25253872   PMID:25666529   PMID:30528857  


Genomics

Comparative Map Data
Hrh4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8184,440,977 - 4,457,132 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl184,440,977 - 4,457,132 (+)EnsemblGRCr8
mRatBN7.2184,166,270 - 4,182,426 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,166,270 - 4,246,345 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx184,389,940 - 4,406,096 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0185,177,508 - 5,193,664 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,436,938 - 4,453,080 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0184,365,429 - 4,382,599 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl184,365,429 - 4,382,599 (+)Ensemblrn6Rnor6.0
Rnor_5.0184,353,104 - 4,368,967 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4184,275,671 - 4,292,259 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera184,215,815 - 4,231,769 (+)NCBICelera
RGSC_v3.1184,275,670 - 4,292,259 (+)NCBI
Cytogenetic Map18p13NCBI
HRH4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381824,460,637 - 24,479,974 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1824,460,637 - 24,479,961 (+)Ensemblhg38GRCh38
GRCh371822,040,601 - 22,059,938 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361820,294,591 - 20,313,919 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341820,294,590 - 20,313,918NCBI
Celera1818,855,629 - 18,874,954 (+)NCBICelera
Cytogenetic Map18q11.2NCBI
HuRef1818,896,649 - 18,915,969 (+)NCBIHuRef
CHM1_11821,967,599 - 21,986,980 (+)NCBICHM1_1
T2T-CHM13v2.01824,654,947 - 24,674,284 (+)NCBIT2T-CHM13v2.0
Hrh4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391813,140,039 - 13,156,758 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1813,140,047 - 13,155,939 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381813,006,982 - 13,023,701 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1813,006,990 - 13,022,882 (+)Ensemblmm10GRCm38
MGSCv371813,165,499 - 13,181,391 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361813,150,159 - 13,166,051 (+)NCBIMGSCv36mm8
Celera1813,240,031 - 13,255,921 (+)NCBICelera
Cytogenetic Map18A1NCBI
cM Map186.88NCBI
Hrh4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540212,809,146 - 12,824,226 (+)Ensembl
ChiLan1.0NW_00495540212,809,164 - 12,826,952 (+)NCBIChiLan1.0ChiLan1.0
HRH4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21741,891,026 - 41,911,124 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11827,583,621 - 27,600,463 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01817,711,852 - 17,731,500 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11821,332,651 - 21,351,930 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1821,332,651 - 21,351,930 (+)EnsemblpanPan2panpan1.1
HRH4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1763,918,408 - 63,932,258 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl763,918,232 - 63,932,569 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha763,365,578 - 63,381,202 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0763,977,108 - 63,991,060 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl763,976,989 - 63,991,087 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1763,647,725 - 63,661,244 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0763,661,653 - 63,675,492 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0763,966,352 - 63,980,292 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101965352
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494459,983,688 - 59,992,066 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365503,815,372 - 3,831,419 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365503,815,372 - 3,831,481 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HRH4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6109,303,820 - 109,319,479 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16109,302,264 - 109,318,607 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26102,070,555 - 102,076,049 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HRH4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11856,056,522 - 56,095,194 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1856,057,605 - 56,068,482 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605030,801,609 - 30,821,594 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hrh4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247707,792,321 - 7,795,303 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Hrh4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11530,669,527 - 30,684,988 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hrh4
145 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:261
Count of miRNA genes:159
Interacting mature miRNAs:173
Transcripts:ENSRNOT00000022744
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18126032889Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18144930869Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18125022372Rat
1331781Scl28Serum cholesterol level QTL 283.995blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)18125071266Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18115642423Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18381190230809809Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134566578Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18126032889Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134566578Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)18430735449307354Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
7 2 11 22 32 42 17 37 17 6 86 55 2 12 6 24 25

Sequence


Ensembl Acc Id: ENSRNOT00000022744   ⟹   ENSRNOP00000022744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl184,440,977 - 4,457,132 (+)Ensembl
mRatBN7.2 Ensembl184,166,270 - 4,246,345 (+)Ensembl
Rnor_6.0 Ensembl184,365,429 - 4,382,599 (+)Ensembl
RefSeq Acc Id: NM_131909   ⟹   NP_571984
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8184,440,977 - 4,457,132 (+)NCBI
mRatBN7.2184,166,270 - 4,182,426 (+)NCBI
Rnor_6.0184,365,429 - 4,382,599 (+)NCBI
Rnor_5.0184,353,104 - 4,368,967 (+)NCBI
RGSC_v3.4184,275,671 - 4,292,259 (+)RGD
Celera184,215,815 - 4,231,769 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_571984 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK97381 (Get FASTA)   NCBI Sequence Viewer  
  EDL75027 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022744
GenBank Protein Q91ZY1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_571984   ⟸   NM_131909
- UniProtKB: Q91ZY1 (UniProtKB/Swiss-Prot),   G3V868 (UniProtKB/TrEMBL),   A6KLT2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022744   ⟸   ENSRNOT00000022744
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91ZY1-F1-model_v2 AlphaFold Q91ZY1 1-391 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620631 AgrOrtholog
BioCyc Gene G2FUF-8338 BioCyc
Ensembl Genes ENSRNOG00000016887 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000022744 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Histamine_H4_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:170704 UniProtKB/Swiss-Prot
NCBI Gene 170704 ENTREZGENE
PANTHER 5-HYDROXYTRYPTAMINE RECEPTOR UniProtKB/Swiss-Prot
  HISTAMINE H4 RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Hrh4 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  HISTAMINEH4R UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016887 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A6KLT2 ENTREZGENE, UniProtKB/TrEMBL
  G3V868 ENTREZGENE, UniProtKB/TrEMBL
  HRH4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-19 Hrh4  histamine receptor H4  Hrh4  histamine H4 receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Hrh4  histamine H4 receptor      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Hrh4  histamine H4 receptor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in bone marrow and spleen 708595