Bcl2a1 (BCL2-related protein A1) - Rat Genome Database

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Gene: Bcl2a1 (BCL2-related protein A1) Rattus norvegicus
Analyze
Symbol: Bcl2a1
Name: BCL2-related protein A1
RGD ID: 620621
Description: Enables BH domain binding activity. Involved in cerebral cortex development and response to cisplatin. Predicted to be located in cytoplasm. Predicted to be active in mitochondrial outer membrane. Orthologous to human BCL2A1 (BCL2 related protein A1); PARTICIPATES IN intrinsic apoptotic pathway; INTERACTS WITH (+)-pilocarpine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: B-cell leukemia/lymphoma 2 related protein A1; B-cell leukemia/lymphoma 2 related protein A1d; bcl-2-related protein A1; BCL2-related protein A1d; Bcl2a1d
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8898,596,806 - 98,604,890 (+)NCBIGRCr8
GRCr8 Ensembl898,596,650 - 98,604,890 (+)EnsemblGRCr8 Ensembl
mRatBN7.2889,716,914 - 89,724,998 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl889,716,914 - 89,724,998 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx895,382,133 - 95,390,252 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0893,581,342 - 93,589,461 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0891,445,125 - 91,453,238 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0896,551,424 - 96,559,527 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl896,551,245 - 96,559,483 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0896,059,040 - 96,067,299 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4894,045,109 - 94,053,777 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera889,278,398 - 89,286,468 (+)NCBICelera
RGSC_v3.1894,064,563 - 94,073,232 (+)NCBI
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-demecolcine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
2-naphthylamine  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
6alpha-methylprednisolone  (ISO)
acetamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
azathioprine  (ISO)
bathocuproine disulfonic acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cholesterol  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
Dibutyl phosphate  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
diethyl maleate  (EXP)
diosgenin  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
eriodictyol  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (ISO)
Evodiamine  (ISO)
fenofibrate  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
furan  (EXP)
furosemide  (EXP)
Fusarenone X  (ISO)
gentamycin  (EXP)
glycochenodeoxycholic acid  (EXP)
glyphosate  (ISO)
guggulsterone  (ISO)
imidazopyrazole  (ISO)
indole-3-methanol  (EXP,ISO)
indometacin  (ISO)
ionomycin  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoflurane  (EXP)
kaempferol  (ISO)
kojic acid  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
lonafarnib  (ISO)
LY294002  (ISO)
maneb  (ISO)
melphalan  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylseleninic acid  (ISO)
Mitotane  (EXP)
Muraglitazar  (EXP)
N-(6-acetamidohexyl)acetamide  (ISO)
N-nitrosodimethylamine  (EXP)
naphthalenes  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
o-xylene  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
oxycodone  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentanal  (ISO)
peptidoglycan  (ISO)
PF-3758309  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
poly(I:C)  (EXP)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
protein kinase inhibitor  (ISO)
pyridaben  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
romidepsin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (EXP,ISO)
simazine  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP)
sulforaphane  (ISO)
tamibarotene  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
troglitazone  (EXP)
undecane  (EXP)
usnic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
VX nerve agent  (ISO)
withaferin A  (ISO)
zerumbone  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The Bcl-2 apoptotic switch in cancer development and therapy. Adams JM and Cory S, Oncogene. 2007 Feb 26;26(9):1324-37.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. Hsu SY, etal., Mol Endocrinol 1998 Sep;12(9):1432-40.
5. Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Hsu SY, etal., Proc Natl Acad Sci U S A 1997 Nov 11;94(23):12401-6.
6. Bcl-2-related protein family gene expression during oligodendroglial differentiation. Itoh T, etal., J Neurochem 2003 Jun;85(6):1500-12.
7. Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease. Kitamura Y, etal., Brain Res. 1998 Jan 12;780(2):260-9.
8. Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary. Leo CP, etal., Endocrinology 1999 Dec;140(12):5469-77.
9. Cisplatin inhibits hippocampal cell proliferation and alters the expression of apoptotic genes. Manohar S, etal., Neurotox Res. 2014 May;25(4):369-80. doi: 10.1007/s12640-013-9443-y. Epub 2013 Nov 26.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Differential expression of rat brain bcl-2 family proteins in development and aging. Shimohama S, etal., Biochem Biophys Res Commun. 1998 Nov 9;252(1):92-6.
15. Essential role of the prosurvival bcl-2 homologue A1 in mast cell survival after allergic activation. Xiang Z, etal., J Exp Med 2001 Dec 3;194(11):1561-69.
Additional References at PubMed
PMID:23828564   PMID:30816537  


Genomics

Comparative Map Data
Bcl2a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8898,596,806 - 98,604,890 (+)NCBIGRCr8
GRCr8 Ensembl898,596,650 - 98,604,890 (+)EnsemblGRCr8 Ensembl
mRatBN7.2889,716,914 - 89,724,998 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl889,716,914 - 89,724,998 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx895,382,133 - 95,390,252 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0893,581,342 - 93,589,461 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0891,445,125 - 91,453,238 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0896,551,424 - 96,559,527 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl896,551,245 - 96,559,483 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0896,059,040 - 96,067,299 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4894,045,109 - 94,053,777 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera889,278,398 - 89,286,468 (+)NCBICelera
RGSC_v3.1894,064,563 - 94,073,232 (+)NCBI
Cytogenetic Map8q31NCBI
BCL2A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381579,960,892 - 79,971,196 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1579,960,892 - 79,971,196 (-)EnsemblGRCh38hg38GRCh38
GRCh371580,253,234 - 80,263,538 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361578,040,290 - 78,050,698 (-)NCBINCBI36Build 36hg18NCBI36
Build 341578,040,289 - 78,050,698NCBI
Celera1557,189,526 - 57,199,937 (-)NCBICelera
Cytogenetic Map15q25.1NCBI
HuRef1557,011,277 - 57,021,688 (-)NCBIHuRef
CHM1_11580,370,121 - 80,380,532 (-)NCBICHM1_1
T2T-CHM13v2.01577,823,803 - 77,834,097 (-)NCBIT2T-CHM13v2.0
Bcl2a1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39989,081,326 - 89,089,891 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl989,081,262 - 89,089,880 (+)EnsemblGRCm39 Ensembl
GRCm38989,199,273 - 89,207,838 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl989,199,209 - 89,207,827 (+)EnsemblGRCm38mm10GRCm38
MGSCv37989,094,111 - 89,102,676 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36988,997,122 - 89,005,719 (+)NCBIMGSCv36mm8
Celera987,568,132 - 87,573,632 (-)NCBICelera
Cytogenetic Map9E3.1NCBI
cM Map947.24NCBI
Bcl2a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955533773,912 - 785,037 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955533773,912 - 785,040 (-)NCBIChiLan1.0ChiLan1.0
BCL2A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21669,210,990 - 69,220,256 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11573,375,852 - 73,385,125 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01558,925,853 - 58,935,122 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11577,884,030 - 77,893,167 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1577,882,940 - 77,893,628 (-)Ensemblpanpan1.1panPan2
BCL2A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1357,451,512 - 57,463,692 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl357,424,555 - 57,463,692 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha360,109,775 - 60,121,887 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0357,884,668 - 57,896,576 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl357,883,834 - 57,896,576 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1357,383,698 - 57,395,826 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0357,590,934 - 57,602,831 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0357,937,969 - 57,949,867 (+)NCBIUU_Cfam_GSD_1.0
Bcl2a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640120,133,708 - 120,163,718 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647137,981,772 - 37,993,116 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647137,981,851 - 37,993,097 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCL2A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl748,887,094 - 48,897,870 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1748,887,227 - 48,897,667 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2754,395,262 - 54,419,816 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BCL2A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1263,451,773 - 3,461,215 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl263,451,873 - 3,461,180 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048138,408,361 - 138,418,275 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bcl2a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624941907,119 - 933,356 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624941907,382 - 932,751 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bcl2a1
42 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:18
Count of miRNA genes:18
Interacting mature miRNAs:18
Transcripts:ENSRNOT00000039850
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
8693654Alc32Alcohol consumption QTL 3220.755drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)897492344116428905Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 45 113 91 90 59 25 59 6 214 93 11 93 45 60 31 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000039850   ⟹   ENSRNOP00000038537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl898,596,650 - 98,604,890 (+)Ensembl
mRatBN7.2 Ensembl889,716,914 - 89,724,998 (+)Ensembl
Rnor_6.0 Ensembl896,551,245 - 96,559,483 (+)Ensembl
RefSeq Acc Id: NM_133416   ⟹   NP_596907
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8898,596,806 - 98,604,890 (+)NCBI
mRatBN7.2889,716,914 - 89,724,998 (+)NCBI
Rnor_6.0896,551,424 - 96,559,527 (+)NCBI
Rnor_5.0896,059,040 - 96,067,299 (+)NCBI
RGSC_v3.4894,045,109 - 94,053,777 (+)RGD
Celera889,278,398 - 89,286,468 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_596907 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK55419 (Get FASTA)   NCBI Sequence Viewer  
  EDL77577 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000038537
  ENSRNOP00000038537.2
RefSeq Acc Id: NP_596907   ⟸   NM_133416
- UniProtKB: Q925A9 (UniProtKB/TrEMBL),   A6I200 (UniProtKB/TrEMBL),   G3V977 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000038537   ⟸   ENSRNOT00000039850
Protein Domains
Bcl-2 Bcl-2 homology region 1-3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V977-F1-model_v2 AlphaFold G3V977 1-175 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620621 AgrOrtholog
BioCyc Gene G2FUF-29592 BioCyc
Ensembl Genes ENSRNOG00000047606 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039850 ENTREZGENE
  ENSRNOT00000039850.4 UniProtKB/TrEMBL
Gene3D-CATH 1.10.437.10 UniProtKB/TrEMBL
InterPro Apop_reg_Bcl2Rel UniProtKB/TrEMBL
  Bcl-2_BH1-3 UniProtKB/TrEMBL
  Bcl2-like_apoptosis UniProtKB/TrEMBL
  Bcl2_BH1_motif_CS UniProtKB/TrEMBL
  Bcl2_BH2_motif_CS UniProtKB/TrEMBL
  Blc2-like_sf UniProtKB/TrEMBL
  Blc2_fam UniProtKB/TrEMBL
KEGG Report rno:170929 UniProtKB/TrEMBL
NCBI Gene 170929 ENTREZGENE
PANTHER PTHR11256 UniProtKB/TrEMBL
  PTHR11256:SF10 UniProtKB/TrEMBL
Pfam Bcl-2 UniProtKB/TrEMBL
PhenoGen Bcl2a1 PhenoGen
PRINTS BCL2FAMILY UniProtKB/TrEMBL
  BCL2RLATEDA1 UniProtKB/TrEMBL
PROSITE BCL2_FAMILY UniProtKB/TrEMBL
  BH1 UniProtKB/TrEMBL
  BH2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047606 RatGTEx
SMART BCL UniProtKB/TrEMBL
Superfamily-SCOP SSF56854 UniProtKB/TrEMBL
UniProt A6I200 ENTREZGENE, UniProtKB/TrEMBL
  G3V977 ENTREZGENE, UniProtKB/TrEMBL
  Q925A9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-01-30 Bcl2a1d  BCL2-related protein A1D  Bcl2a1  BCL2-related protein A1  Name and Symbol changed 629549 APPROVED
2015-01-30 Bcl2a1  BCL2-related protein A1  Bcl2a1d  BCL2-related protein A1d  Name and Symbol changed 629549 APPROVED
2015-01-30 Bcl2a1d  BCL2-related protein A1d  Bcl2a1d  BCL2-related protein A1D  Name changed 629549 APPROVED
2012-07-13 Bcl2a1  BCL2-related protein A1  Bcl2a1d  BCL2-related protein A1d  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-06 Bcl2a1d  BCL2-related protein A1d  Bcl2a1d  B-cell leukemia/lymphoma 2 related protein A1d  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Bcl2a1d  B-cell leukemia/lymphoma 2 related protein A1d  Bcl2a1  B-cell leukemia/lymphoma 2 related protein A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Bcl2a1  B-cell leukemia/lymphoma 2 related protein A1    BCL2-related protein A1  Name updated 1299863 APPROVED
2002-08-07 Bcl2a1  BCL2-related protein A1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression not express in oligodendroglial lineage cells (OLC) 631874