Zp2 (zona pellucida glycoprotein 2) - Rat Genome Database

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Gene: Zp2 (zona pellucida glycoprotein 2) Rattus norvegicus
Analyze
Symbol: Zp2
Name: zona pellucida glycoprotein 2
RGD ID: 620605
Description: Predicted to enable acrosin binding activity and identical protein binding activity. Predicted to be a structural constituent of egg coat. Predicted to be involved in binding activity of sperm to zona pellucida; humoral immune response mediated by circulating immunoglobulin; and prevention of polyspermy. Predicted to be located in several cellular components, including endoplasmic reticulum; inclusion body; and multivesicular body. Predicted to be active in collagen-containing extracellular matrix and egg coat. Orthologous to human ZP2 (zona pellucida glycoprotein 2); INTERACTS WITH 1,2-dimethylhydrazine; bis(2-ethylhexyl) phthalate; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: zona pellucida 2 glycoprotein; zona pellucida glycoprotein 2 (sperm receptor); zona pellucida glycoprotein ZP2; zona pellucida protein A; zona pellucida sperm-binding protein 2; Zp-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   WAG.OXYS-(D1Rat219-D1Rat81)/Nov  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81183,944,840 - 183,956,619 (-)NCBIGRCr8
mRatBN7.21174,513,507 - 174,525,288 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1174,513,511 - 174,525,288 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1182,831,061 - 182,842,857 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01190,017,103 - 190,028,901 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01182,751,032 - 182,762,847 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01189,899,906 - 189,911,650 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1189,899,892 - 189,911,650 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01196,829,189 - 196,840,820 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1172,263,179 - 172,274,910 (-)NCBICelera
Cytogenetic Map1q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
collagen-containing extracellular matrix  (IBA,IEA,ISO,ISS)
egg coat  (IBA,IEA,ISO,ISS)
endoplasmic reticulum  (IEA,ISO,ISS)
extracellular region  (IEA)
inclusion body  (ISO)
multivesicular body  (IEA,ISO,ISS)
plasma membrane  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat zona pellucida glycoproteins: molecular cloning and characterization of the three major components. Akatsuka K, etal., Mol Reprod Dev 1998 Dec;51(4):454-67.
2. Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy. Burkart AD, etal., J Cell Biol. 2012 Apr 2;197(1):37-44. doi: 10.1083/jcb.201112094.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10793136   PMID:11739644   PMID:11751269   PMID:11906903   PMID:12052239   PMID:15950651   PMID:16342937   PMID:17047254   PMID:20394732   PMID:26879157   PMID:29895852  


Genomics

Comparative Map Data
Zp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81183,944,840 - 183,956,619 (-)NCBIGRCr8
mRatBN7.21174,513,507 - 174,525,288 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1174,513,511 - 174,525,288 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1182,831,061 - 182,842,857 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01190,017,103 - 190,028,901 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01182,751,032 - 182,762,847 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01189,899,906 - 189,911,650 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1189,899,892 - 189,911,650 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01196,829,189 - 196,840,820 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1172,263,179 - 172,274,910 (-)NCBICelera
Cytogenetic Map1q36NCBI
ZP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381621,197,450 - 21,214,510 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1621,197,450 - 21,214,510 (-)EnsemblGRCh38hg38GRCh38
GRCh371621,208,771 - 21,225,831 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361621,116,274 - 21,130,369 (-)NCBINCBI36Build 36hg18NCBI36
Build 341621,116,273 - 21,130,369NCBI
Celera1620,518,619 - 20,532,706 (-)NCBICelera
Cytogenetic Map16p12.3-p12.2NCBI
HuRef1619,743,981 - 19,758,073 (-)NCBIHuRef
CHM1_11621,296,024 - 21,310,120 (-)NCBICHM1_1
T2T-CHM13v2.01621,128,399 - 21,145,450 (-)NCBIT2T-CHM13v2.0
Zp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397119,725,985 - 119,744,514 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7119,725,995 - 119,744,514 (-)EnsemblGRCm39 Ensembl
GRCm387120,126,762 - 120,145,291 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7120,126,772 - 120,145,291 (-)EnsemblGRCm38mm10GRCm38
MGSCv377127,275,875 - 127,288,804 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367119,923,510 - 119,936,439 (-)NCBIMGSCv36mm8
Celera7120,041,987 - 120,054,607 (-)NCBICelera
Cytogenetic Map7F2NCBI
cM Map764.38NCBI
Zp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955493400,868 - 412,596 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955493400,868 - 412,660 (-)NCBIChiLan1.0ChiLan1.0
ZP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21822,365,697 - 22,380,566 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11626,886,199 - 26,901,082 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01617,193,632 - 17,210,667 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11621,227,285 - 21,244,316 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1621,227,285 - 21,244,316 (-)Ensemblpanpan1.1panPan2
ZP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1624,230,202 - 24,242,441 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl624,230,201 - 24,242,451 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha625,667,939 - 25,680,181 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0624,381,539 - 24,393,787 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl624,381,539 - 24,393,797 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1624,184,937 - 24,197,176 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0624,078,588 - 24,090,826 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0624,463,951 - 24,476,253 (+)NCBIUU_Cfam_GSD_1.0
Zp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344118,296,926 - 118,311,637 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365016,394,838 - 6,407,442 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365016,394,838 - 6,407,512 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl324,863,730 - 24,877,522 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1324,863,730 - 24,877,522 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2325,665,412 - 25,679,349 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1519,318,026 - 19,338,966 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl519,319,034 - 19,338,495 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606810,543,555 - 10,560,816 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247827,275,207 - 7,287,114 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247827,275,156 - 7,287,480 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zp2
62 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:18
Count of miRNA genes:18
Interacting mature miRNAs:18
Transcripts:ENSRNOT00000071108
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1156677124176484451Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1164747558181133855Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169112897197261052Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1172949660181830018Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383668Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat

Markers in Region
BE114043  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21174,524,648 - 174,524,823 (+)MAPPERmRatBN7.2
Rnor_6.01189,911,011 - 189,911,185NCBIRnor6.0
Rnor_5.01196,840,181 - 196,840,355UniSTSRnor5.0
Celera1172,274,271 - 172,274,445UniSTS
RH 3.4 Map11375.9UniSTS
Cytogenetic Map1q34UniSTS


Related Rat Strains
The following Strains have been annotated to Zp2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 16
Low 1 28 18 2 11 2 1 1 8 7 4 10 1
Below cutoff 2 3 11 11 8 11 7 7 33 17 12 1 7

Sequence


RefSeq Acc Id: ENSRNOT00000080996   ⟹   ENSRNOP00000068928
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1189,899,892 - 189,911,571 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000088536   ⟹   ENSRNOP00000072132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1174,513,511 - 174,525,288 (-)Ensembl
Rnor_6.0 Ensembl1189,899,898 - 189,911,650 (-)Ensembl
RefSeq Acc Id: NM_031150   ⟹   NP_112412
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81183,944,844 - 183,956,619 (-)NCBI
mRatBN7.21174,513,511 - 174,525,288 (-)NCBI
Rnor_6.01189,899,906 - 189,911,650 (-)NCBI
Rnor_5.01196,829,189 - 196,840,820 (-)NCBI
Celera1172,263,179 - 172,274,910 (-)RGD
Sequence:
RefSeq Acc Id: XM_039092370   ⟹   XP_038948298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81183,944,840 - 183,949,795 (-)NCBI
mRatBN7.21174,513,507 - 174,518,850 (-)NCBI
Protein Sequences
Protein RefSeqs NP_112412 (Get FASTA)   NCBI Sequence Viewer  
  XP_038948298 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA24487 (Get FASTA)   NCBI Sequence Viewer  
  EDM17629 (Get FASTA)   NCBI Sequence Viewer  
  EDM17630 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072132
  ENSRNOP00000072132.1
  ENSRNOP00055009310
  ENSRNOP00060029596
GenBank Protein O54767 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112412   ⟸   NM_031150
- Peptide Label: precursor
- UniProtKB: O54767 (UniProtKB/Swiss-Prot),   A6I8Q0 (UniProtKB/TrEMBL),   M0R4S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068928   ⟸   ENSRNOT00000080996
RefSeq Acc Id: ENSRNOP00000072132   ⟸   ENSRNOT00000088536
RefSeq Acc Id: XP_038948298   ⟸   XM_039092370
- Peptide Label: isoform X1
Protein Domains
ZP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54767-F1-model_v2 AlphaFold O54767 1-695 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620605 AgrOrtholog
BioCyc Gene G2FUF-57628 BioCyc
Ensembl Genes ENSRNOG00000057989 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055007103 UniProtKB/Swiss-Prot
  ENSRNOG00060020678 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000088536 ENTREZGENE
  ENSRNOT00000088536.2 UniProtKB/TrEMBL
  ENSRNOT00055011781 UniProtKB/Swiss-Prot
  ENSRNOT00060035968 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.4100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zona pellucida, ZP-N domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ZP-C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZP_chr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZP_dom_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81828 UniProtKB/Swiss-Prot
NCBI Gene 81828 ENTREZGENE
PANTHER ZONA PELLUCIDA SPERM-BINDING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZONA PELLUCIDA SPERM-BINDING PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Zona_pellucida UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Zp2 PhenoGen
PRINTS ZPELLUCIDA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ZP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000057989 RatGTEx
  ENSRNOG00055007103 RatGTEx
  ENSRNOG00060020678 RatGTEx
SMART SM00241 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6I8Q0 ENTREZGENE, UniProtKB/TrEMBL
  A6I8Q1_RAT UniProtKB/TrEMBL
  M0R4S4 ENTREZGENE, UniProtKB/TrEMBL
  O54767 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Zp2  zona pellucida glycoprotein 2  Zp2  zona pellucida glycoprotein 2 (sperm receptor)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Zp2  zona pellucida glycoprotein 2 (sperm receptor)  Zp2  zona pellucida glycoprotein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Zp2  zona pellucida glycoprotein 2    zona pellucida 2 glycoprotein  Name updated 1299863 APPROVED
2002-08-07 Zp2  zona pellucida 2 glycoprotein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product may be a member of the ZPA family 634535