Cd14 (CD14 molecule) - Rat Genome Database

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Gene: Cd14 (CD14 molecule) Rattus norvegicus
Symbol: Cd14
Name: CD14 molecule
RGD ID: 620588
Description: Predicted to enable lipopolysaccharide binding activity; lipopolysaccharide immune receptor activity; and lipoteichoic acid binding activity. Involved in several processes, including cellular response to lipopolysaccharide; response to magnesium ion; and response to tumor necrosis factor. Located in cell surface and extracellular space. Used to study perinatal necrotizing enterocolitis. Biomarker of Hirschsprung's disease; cholestasis; obstructive jaundice; and periodontitis. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); celiac disease; cystic fibrosis; and pulmonary tuberculosis. Orthologous to human CD14 (CD14 molecule); PARTICIPATES IN cardiovascular system disease pathway; innate immune response pathway; Toll-like receptor signaling pathway; INTERACTS WITH (S)-colchicine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
Previously known as: CD14 antigen; monocyte differentiation antigen CD14; myeloid cell-specific leucine-rich glycoprotein
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Cd14em1Mcwi   Cd14em2Mcwi  
Genetic Models: SS-Cd14em2Mcwi SS-Cd14em1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81828,609,558 - 28,611,409 (-)NCBIGRCr8
mRatBN7.21828,335,522 - 28,337,383 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1828,335,340 - 28,337,261 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1828,462,692 - 28,464,289 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01829,224,772 - 29,226,369 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01828,559,995 - 28,561,592 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01829,560,341 - 29,562,290 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1829,560,365 - 29,562,153 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01829,265,328 - 29,267,236 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41829,374,593 - 29,376,190 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11829,401,242 - 29,402,836 (-)NCBI
Celera1828,056,118 - 28,057,715 (-)NCBICelera
Cytogenetic Map18p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (IEP)
allergic disease  (ISO)
asthma  (ISO)
autosomal dominant intellectual developmental disorder 31  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
bacterial pneumonia  (ISO)
biliary atresia  (ISO)
Brain Injuries  (ISO)
Bronchial Hyperreactivity  (ISO)
Burns  (IEP)
carotid artery disease  (ISO)
celiac disease  (ISO)
Cerebral Hemorrhage  (IEP)
cholestasis  (IEP)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
cystic fibrosis  (ISO)
diarrhea  (ISO)
Eczema  (ISO)
Endotoxemia  (IEP)
Experimental Autoimmune Neuritis  (IEP)
familial adenomatous polyposis 1  (ISO)
genetic disease  (ISO)
gout  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Hirschsprung's disease  (IEP)
Human Influenza  (ISO)
hypertension  (ISO)
IgA glomerulonephritis  (ISO)
Intestinal Reperfusion Injury  (IEP)
juvenile rheumatoid arthritis  (ISO)
Kidney Reperfusion Injury  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (IDA)
lung disease  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Middle East respiratory syndrome  (ISO)
myocardial infarction  (ISO)
Neurodevelopmental Disorders  (ISO)
obstructive jaundice  (IEP)
pancreatitis  (ISO)
perinatal necrotizing enterocolitis  (IDA,ISO)
periodontitis  (IEP)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
pulmonary tuberculosis  (ISO)
rhinitis  (ISO)
sarcoidosis  (ISO)
severe acute respiratory syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
Viral Bronchiolitis  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methylhistamine  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (ISO)
acrolein  (ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
alfacalcidol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
aluminium hydroxide  (ISO)
aluminium oxide  (ISO)
amlexanox  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphotericin B  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (ISO)
Botulinum toxin type A  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cimetidine  (ISO)
ciprofibrate  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclizine  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
D-penicillamine  (EXP)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
Dimaprit  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
doxorubicin  (EXP)
elemental selenium  (ISO)
ellagic acid  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
fenofibrate  (ISO)
ferric oxide  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
ganglioside GM1  (EXP)
gefitinib  (ISO)
Genipin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glutathione  (EXP)
glyphosate  (ISO)
graphene oxide  (ISO)
griseofulvin  (ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (ISO)
histamine  (ISO)
hydrogen cyanide  (ISO)
hydroxychloroquine  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
isoprenaline  (EXP,ISO)
kaempferol  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
Licochalcone B  (ISO)
lipophosphoglycan  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
malathion  (ISO)
melatonin  (EXP)
metacetamol  (ISO)
metformin  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl beta-cyclodextrin  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP)
methylseleninic acid  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
nitric oxide  (EXP)
obeticholic acid  (ISO)
oligomycin A  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
parthenolide  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl caffeate  (EXP,ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pinostrobin  (ISO)
pipoxolan  (ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (EXP)
poly(propylene imine) macromolecule  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
pyrithione  (ISO)
pyrrolidine dithiocarbamate  (ISO)
razoxane  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
selenium atom  (ISO)
sertraline  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
streptozocin  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
triprolidine  (ISO)
troglitazone  (ISO)
undecane  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (EXP)
vancomycin  (ISO)
vincaleukoblastine  (EXP)
vincristine  (EXP)
vitamin D  (ISO)
xestospongin C  (ISO)
Y-27632  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. CD14 and toll-like receptor 4: a link between infection and acute coronary events? Arroyo-Espliguero R, etal., Heart. 2004 Sep;90(9):983-8.
2. Association between inflammatory gene polymorphisms and coronary artery disease in an Indian population. Banerjee I, etal., J Thromb Thrombolysis. 2009 Jan;27(1):88-94. Epub 2007 Dec 23.
3. Gene expression changes in the hypothalamus provide evidence for regionally-selective changes in IL-1 and microglial markers after acute stress. Blandino P Jr, etal., Brain Behav Immun. 2009 May 21.
4. Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. Bresson D, etal., J Clin Invest. 2006 May;116(5):1371-81. Epub 2006 Apr 20.
5. Role of LPS/CD14/TLR4-mediated inflammation in necrotizing enterocolitis: pathogenesis and therapeutic implications. Chan KL, etal., World J Gastroenterol. 2009 Oct 14;15(38):4745-52.
6. Intestinal and cardiac inflammatory response shows enhanced endotoxin receptor (CD14) expression in magnesium deficiency. Chmielinska JJ, etal., Mol Cell Biochem. 2005 Oct;278(1-2):53-7.
7. Endotoxin and CD14 in the progression of biliary atresia. Chou MH, etal., J Transl Med. 2010 Dec 21;8:138. doi: 10.1186/1479-5876-8-138.
8. Effects of hepatocyte CD14 upregulation during cholestasis on endotoxin sensitivity. Chou MH, etal., PLoS One. 2012;7(4):e34903. doi: 10.1371/journal.pone.0034903. Epub 2012 Apr 12.
9. Expression and release of CD14 in astrocytic brain tumors. Deininger MH, etal., Acta Neuropathol. 2003 Sep;106(3):271-7. Epub 2003 Jun 27.
10. CD14 facilitates invasive respiratory tract infection by Streptococcus pneumoniae. Dessing MC, etal., Am J Respir Crit Care Med. 2007 Mar 15;175(6):604-11. Epub 2006 Dec 21.
11. CD14 plays a limited role during influenza A virus infection in vivo. Dessing MC, etal., Immunol Lett. 2007 Oct 31;113(1):47-51. Epub 2007 Aug 22.
12. Frequencies of genetic polymorphisms of TLR4 and CD14 and of HLA-DQ genotypes in children with celiac disease, type 1 diabetes mellitus, or both. Dezsofi A, etal., J Pediatr Gastroenterol Nutr. 2008 Sep;47(3):283-7.
13. Toll-like receptor-4 message is up-regulated in lipopolysaccharide-exposed rat lung pericytes. Edelman DA, etal., J Surg Res. 2006 Jul;134(1):22-7. Epub 2006 Apr 21.
14. Lipopolysaccharide-binding protein and lipopolysaccharide receptor CD14 gene expression after thermal injury and its potential mechanism(s). Fang CW, etal., J Trauma. 2002 Nov;53(5):957-67.
15. Serum LBP levels reflect the impaired synthetic capacity of the remnant liver after partial hepatectomy in rats. Fang H, etal., J Immunol Methods. 2012 Aug 31;382(1-2):68-75. doi: 10.1016/j.jim.2012.05.006. Epub 2012 May 8.
16. [Gene expression of lipopolysaccharide receptor CD14 and tumor necrosis factor-alpha in rats after thermal injury]. Fang W, etal., Zhonghua Wai Ke Za Zhi. 1999 May;37(5):271-3.
17. Association of MBL2, TGF-beta1 and CD14 gene polymorphisms with lung disease severity in cystic fibrosis. Faria EJ, etal., J Bras Pneumol. 2009 Apr;35(4):334-42.
18. Association between CD14 gene polymorphisms and disease phenotype in sarcoidosis. Fridlender ZG, etal., Respir Med. 2010 Sep;104(9):1336-43. Epub 2010 Apr 28.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Expression of CD14 protein and its gene in liver sinusoidal endothelial cells during endotoxemia. Gong JP, etal., World J Gastroenterol 2002 Jun;8(3):551-4.
21. The local and systemic inflammatory transcriptome after acute kidney injury. Grigoryev DN, etal., J Am Soc Nephrol. 2008 Mar;19(3):547-58. Epub 2008 Jan 30.
22. Association of the CD14 gene polymorphism C-159T with allergic rhinitis. Han D, etal., Am J Rhinol Allergy. 2010 Jan-Feb;24(1):e1-3.
23. Association study of CD14 polymorphism with myocardial infarction in a Japanese population. Hohda S, etal., Jpn Heart J. 2003 Sep;44(5):613-22.
24. TNF-alpha (-308 G/A) and CD14 (-159T/C) polymorphisms in the bronchial responsiveness of Korean children with asthma. Hong SJ, etal., J Allergy Clin Immunol. 2007 Feb;119(2):398-404. Epub 2006 Dec 28.
25. CD14 -550 C/T, which is related to the serum level of soluble CD14, is associated with the development of respiratory syncytial virus bronchiolitis in the Japanese population. Inoue Y, etal., J Infect Dis. 2007 Jun 1;195(11):1618-24. Epub 2007 Apr 23.
26. Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury. Jeyaseelan S, etal., Infect Immun. 2005 Mar;73(3):1754-63.
27. The CD14 C-159T polymorphism is not associated with asthma or asthma severity in an Australian adult population. Kedda MA, etal., Thorax. 2005 Mar;60(3):211-4.
28. Middle East Respiratory Syndrome-Coronavirus Infection into Established hDPP4-Transgenic Mice Accelerates Lung Damage Via Activation of the Pro-Inflammatory Response and Pulmonary Fibrosis. Kim J, etal., J Microbiol Biotechnol. 2020 Mar 28;30(3):427-438. doi: 10.4014/jmb.1910.10055.
29. Expression of Toll-like receptor 4 in various organs in rats with D-galactosamine-induced acute hepatic failure. Kitazawa T, etal., J Gastroenterol Hepatol. 2008 Aug;23(8 Pt 2):e494-8. Epub 2007 Dec 7.
30. CD14 triggers autoimmune Type 1 diabetes in the NOD mouse. Kloting N, etal., Diabetologia. 2004 Jan;47(1):151-2. Epub 2003 Nov 12.
31. Differential roles of CD14 and toll-like receptors 4 and 2 in murine Acinetobacter pneumonia. Knapp S, etal., Am J Respir Crit Care Med. 2006 Jan 1;173(1):122-9. Epub 2005 Oct 6.
32. Toll-like receptors and CD14 genes polymorphisms and susceptibility to asthma in Tunisian children. Lachheb J, etal., Tissue Antigens. 2008 May;71(5):417-25. Epub 2008 Feb 28.
33. Association between farm exposure and atopy, according to the CD14 C-159T polymorphism. Leynaert B, etal., J Allergy Clin Immunol. 2006 Sep;118(3):658-65. Epub 2006 Jul 28.
34. Association of the -159C/T polymorphism of the endotoxin receptor (CD14) with carotid artery disease and cardiovascular mortality in dialysis patients. Losito A, etal., Blood Purif. 2005;23(2):128-33. Epub 2005 Jan 6.
35. The role of CD14 and Toll-like receptor 4 of Kupffer cells in hepatic ischemia-reperfusion injury in rats. Luan X, etal., Transplant Proc. 2012 May;44(4):937-41. doi: 10.1016/j.transproceed.2011.11.001.
36. Short-term ethanol exposure increases the expression of Kupffer cell CD14 receptor and lipopolysaccharide binding protein in rat liver. Lukkari TA, etal., Alcohol Alcohol. 1999 May-Jun;34(3):311-9.
37. Expression, regulation and clinical significance of soluble and membrane CD14 receptors in pediatric inflammatory lung diseases. Marcos V, etal., Respir Res. 2010 Mar 19;11:32.
38. Genetic and acquired inflammatory conditions are synergistically associated with early carotid atherosclerosis. Markus HS, etal., Stroke. 2006 Sep;37(9):2253-9. Epub 2006 Jul 27.
39. Acute asthma in children: Relationships among CD14 and CC16 genotypes, plasma levels, and severity. Martin AC, etal., Am J Respir Crit Care Med. 2006 Mar 15;173(6):617-22. Epub 2005 Dec 30.
40. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
41. Induction of CD14 in tubular epithelial cells during kidney disease. Morrissey J, etal., J Am Soc Nephrol. 2000 Sep;11(9):1681-90.
42. Endotoxemia prevents the cerebral inflammatory wave induced by intraparenchymal lipopolysaccharide injection: role of glucocorticoids and CD14. Nadeau S and Rivest S, J Immunol 2002 Sep 15;169(6):3370-81.
43. Role of microglial-derived tumor necrosis factor in mediating CD14 transcription and nuclear factor kappa B activity in the brain during endotoxemia. Nadeau S and Rivest S, J Neurosci. 2000 May 1;20(9):3456-68.
44. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
45. Functional toll-like receptor 4 conferring lipopolysaccharide responsiveness is expressed in thyroid cells. Nicola JP, etal., Endocrinology. 2009 Jan;150(1):500-8. Epub 2008 Sep 11.
46. Myeloid differentiation 2 as a therapeutic target of inflammatory disorders. Park SH, etal., Pharmacol Ther. 2012 Mar;133(3):291-8. doi: 10.1016/j.pharmthera.2011.11.001. Epub 2011 Nov 19.
47. Circulating monocytes in patients with diabetes mellitus, arterial disease, and increased CD14 expression. Patino R, etal., Am J Cardiol. 2000 Jun 1;85(11):1288-91.
48. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
49. Increased serum endotoxin and elevated CD14 and IL-1beta expression in a rat model of cerebrogenic multiple organ dysfunction syndrome. Qu C, etal., Med Chem. 2009 Sep;5(5):462-7. Epub 2009 Sep 1.
50. CD14 gene polymorphism 159C/T in a group of patients with coronary artery disease from a population with high morbidity of cardiovascular diseases. Rechcinski T, etal., Kardiol Pol. 2007 Mar;65(3):237-44; discussion 245.
51. GOA pipeline RGD automated data pipeline
52. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
53. CD14 C(-159)T polymorphism is a risk factor for development of pulmonary tuberculosis. Rosas-Taraco AG, etal., J Infect Dis. 2007 Dec 1;196(11):1698-706. Epub 2007 Oct 25.
54. Impact of toll-like receptor 4 on the severity of acute pancreatitis and pancreatitis-associated lung injury in mice. Sharif R, etal., Gut. 2009 Jun;58(6):813-9. Epub 2009 Feb 6.
55. Gene polymorphisms contributing to hypertension in immunoglobulin A nephropathy. Shinzawa M, etal., Clin Exp Nephrol. 2012 Apr;16(2):250-8. doi: 10.1007/s10157-011-0553-7. Epub 2011 Nov 11.
56. CD14 and toll-like receptor gene polymorphisms, country living, and asthma in adults. Smit LA, etal., Am J Respir Crit Care Med. 2009 Mar 1;179(5):363-8. Epub 2008 Dec 18.
57. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
58. Muscularis inflammation and the loss of interstitial cells of Cajal in the endothelin ETB receptor null rat. Suzuki T, etal., Am J Physiol Gastrointest Liver Physiol. 2004 Sep;287(3):G638-46. Epub 2004 Apr 29.
59. The Kinetic Expression of Lipopolysaccharide-Binding Protein and CD14 Gene in Obstructive Jaundice. Tsai CH, etal., J Invest Surg. 2014 Aug 5.
60. A new promoter polymorphism in the gene of lipopolysaccharide receptor CD14 is associated with expired myocardial infarction in patients with low atherosclerotic risk profile. Unkelbach K, etal., Arterioscler Thromb Vasc Biol. 1999 Apr;19(4):932-8.
61. [Role of endotoxin translocation on mesenteric lymph reperfusion aggravating multiple organ injury in SMAO shock rats]. Yang LN, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2012 Jan;28(1):74-8.
62. Association of the CD14 gene -159C polymorphism with progression of IgA nephropathy. Yoon HJ, etal., J Med Genet. 2003 Feb;40(2):104-8.
63. Evaluation of the CD14/-260 polymorphism and house dust endotoxin exposure in the Barbados Asthma Genetics Study. Zambelli-Weiner A, etal., J Allergy Clin Immunol. 2005 Jun;115(6):1203-9.
64. [Expression of lipopolysaccharide receptors CD14 and TLR4 in a model of rat molar apical periodontitis]. Zhang C and Hou BX, Zhonghua Kou Qiang Yi Xue Za Zhi. 2007 Mar;42(3):148-9.
65. Opposite gene by environment interactions in Karelia for CD14 and CC16 single nucleotide polymorphisms and allergy. Zhang G, etal., Allergy. 2009 Sep;64(9):1333-41. Epub 2009 Feb 14.
66. Intraarticular gene delivery of CTLA4-FasL suppresses experimental arthritis. Zhang W, etal., Int Immunol. 2012 Jun;24(6):379-88. doi: 10.1093/intimm/dxs041. Epub 2012 Feb 21.
67. Toll-like receptor-2, CD14 and heat-shock protein 70 in inflammatory lesions of rat experimental autoimmune neuritis. Zhang ZY, etal., Neuroscience. 2009 Mar 3;159(1):136-42. Epub 2009 Jan 1.
68. Renal CD14 expression correlates with the progression of cystic kidney disease. Zhou J, etal., Kidney Int. 2010 Sep;78(6):550-60. doi: 10.1038/ki.2010.175. Epub 2010 Jun 16.
69. Expression of lipopolysaccharide binding protein and lipopolysaccharide receptor CD14 in experimental alcoholic liver disease Zuo G, etal., Zhonghua Gan Zang Bing Za Zhi 2002 Jun;10(3):207-10.
Additional References at PubMed
PMID:3385210   PMID:8598386   PMID:8612135   PMID:9201265   PMID:9784508   PMID:10854787   PMID:11274165   PMID:12594207   PMID:12632533   PMID:14572767   PMID:14599981   PMID:15039339  
PMID:15153652   PMID:15294986   PMID:15493995   PMID:16502470   PMID:16879219   PMID:16880211   PMID:19034968   PMID:19056867   PMID:19199708   PMID:19299737   PMID:19584052   PMID:20302880  
PMID:20348223   PMID:20586888   PMID:22078883   PMID:23012479   PMID:23376485   PMID:23533145   PMID:23613625   PMID:24380872   PMID:27816522   PMID:33249861   PMID:35070875  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81828,609,558 - 28,611,409 (-)NCBIGRCr8
mRatBN7.21828,335,522 - 28,337,383 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1828,335,340 - 28,337,261 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1828,462,692 - 28,464,289 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01829,224,772 - 29,226,369 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01828,559,995 - 28,561,592 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01829,560,341 - 29,562,290 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1829,560,365 - 29,562,153 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01829,265,328 - 29,267,236 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41829,374,593 - 29,376,190 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11829,401,242 - 29,402,836 (-)NCBI
Celera1828,056,118 - 28,057,715 (-)NCBICelera
Cytogenetic Map18p11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh385140,631,732 - 140,633,701 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5140,631,728 - 140,633,700 (-)EnsemblGRCh38hg38GRCh38
GRCh375140,011,317 - 140,013,286 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365139,991,501 - 139,993,439 (-)NCBINCBI36Build 36hg18NCBI36
Build 345139,991,504 - 139,992,956NCBI
Celera5136,088,058 - 136,090,031 (-)NCBICelera
Cytogenetic Map5q31.3NCBI
HuRef5135,156,588 - 135,158,561 (-)NCBIHuRef
CHM1_15139,444,555 - 139,446,528 (-)NCBICHM1_1
T2T-CHM13v2.05141,157,140 - 141,159,109 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391836,858,117 - 36,859,868 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1836,858,120 - 36,859,851 (-)EnsemblGRCm39 Ensembl
GRCm381836,725,064 - 36,726,815 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1836,725,067 - 36,726,798 (-)EnsemblGRCm38mm10GRCm38
MGSCv371836,884,721 - 36,886,308 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361836,851,041 - 36,852,628 (-)NCBIMGSCv36mm8
Celera1837,177,144 - 37,178,731 (-)NCBICelera
Cytogenetic Map18B2NCBI
cM Map1819.46NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541873,897 - 75,224 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541873,736 - 75,345 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v24135,889,430 - 135,891,081 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15134,028,981 - 134,030,618 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05135,996,265 - 135,997,909 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15142,113,082 - 142,115,023 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5142,113,082 - 142,118,966 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1235,790,505 - 35,792,967 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha232,830,342 - 32,831,881 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0236,246,733 - 36,248,272 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl236,246,328 - 36,248,163 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1233,299,603 - 33,301,142 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0234,167,141 - 34,168,680 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0234,919,848 - 34,921,387 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024407213152,034,627 - 152,037,248 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365319,571,796 - 9,575,923 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365319,572,392 - 9,575,771 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl2142,346,360 - 142,349,581 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12142,348,036 - 142,349,686 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22148,291,971 - 148,293,621 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q28NCBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12343,264,917 - 43,266,825 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2343,264,336 - 43,266,993 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603434,617,693 - 34,619,669 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462474333,367,898 - 33,373,922 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474333,372,023 - 33,374,438 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Cd14
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:30
Interacting mature miRNAs:36
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194179131393320Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181194179131393320Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194429931359530Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181823456431359530Rat
1331775Bp235Blood pressure QTL 2353.201arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181823456431359530Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)182206624252293055Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182654808246969551Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182654808246969551Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182654808246969551Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182654808246969551Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182654808246969551Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182654808246969551Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182654808246969551Rat

Genetic Models
This gene Cd14 is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 34 20 18 20 13 11
Low 35 23 21 1 21 8 11 68 35 28 8
Below cutoff 8 6


RefSeq Acc Id: ENSRNOT00000023977   ⟹   ENSRNOP00000023977
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1828,335,340 - 28,337,261 (-)Ensembl
Rnor_6.0 Ensembl1829,560,365 - 29,562,153 (-)Ensembl
RefSeq Acc Id: NM_021744   ⟹   NP_068512
Rat AssemblyChrPosition (strand)Source
GRCr81828,609,561 - 28,611,158 (-)NCBI
mRatBN7.21828,335,538 - 28,337,135 (-)NCBI
Rnor_6.01829,560,362 - 29,561,959 (-)NCBI
Rnor_5.01829,265,328 - 29,267,236 (-)NCBI
RGSC_v3.41829,374,593 - 29,376,190 (-)RGD
Celera1828,056,118 - 28,057,715 (-)RGD
RefSeq Acc Id: XM_006254603   ⟹   XP_006254665
Rat AssemblyChrPosition (strand)Source
GRCr81828,609,558 - 28,611,409 (-)NCBI
mRatBN7.21828,335,522 - 28,337,383 (-)NCBI
Rnor_6.01829,560,341 - 29,562,290 (-)NCBI
Rnor_5.01829,265,328 - 29,267,236 (-)NCBI
RefSeq Acc Id: NP_068512   ⟸   NM_021744
- Peptide Label: precursor
- UniProtKB: Q6GT04 (UniProtKB/Swiss-Prot),   Q63691 (UniProtKB/Swiss-Prot),   A6J327 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254665   ⟸   XM_006254603
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000023977   ⟸   ENSRNOT00000023977

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63691-F1-model_v2 AlphaFold Q63691 1-372 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700725
Promoter ID:EPDNEW_R11249
Type:initiation region
Description:CD14 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_R11250  
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01829,562,003 - 29,562,063EPDNEW
RGD ID:13700726
Promoter ID:EPDNEW_R11250
Type:single initiation site
Description:CD14 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_R11249  
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01829,562,140 - 29,562,200EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620588 AgrOrtholog
BioCyc Gene G2FUF-7864 BioCyc
Ensembl Genes ENSRNOG00000017819 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00065013294 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023977 ENTREZGENE
  ENSRNOT00000023977.7 UniProtKB/Swiss-Prot
  ENSRNOT00065021846 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Monocyte_diff_Ag_CD14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10630 UniProtKB/Swiss-Prot
PhenoGen Cd14 PhenoGen
PIRSF CD14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017819 RatGTEx
  ENSRNOG00065013294 RatGTEx
Superfamily-SCOP RNI-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CD14_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q6GT04 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-06-27 Cd14  Cd14 molecule  Cd14  CD14 antigen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-27 Cd14  CD14 molecule  Cd14  Cd14 molecule  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cd14  CD14 antigen      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Cd14  CD14 antigen      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed by liver sinusoidal endothelial cells (LSECs) during endotoxemia 724637
gene_regulation expression is upregulated by ethanol administration 727639