Elovl6 (ELOVL fatty acid elongase 6) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Elovl6 (ELOVL fatty acid elongase 6) Rattus norvegicus
Analyze
Symbol: Elovl6
Name: ELOVL fatty acid elongase 6
RGD ID: 620585
Description: Enables fatty acid elongase activity. Involved in fatty acid elongation, monounsaturated fatty acid and fatty acid elongation, saturated fatty acid. Predicted to be located in endoplasmic reticulum. Predicted to be part of fatty acid elongase complex. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human ELOVL6 (ELOVL fatty acid elongase 6); PARTICIPATES IN unsaturated fatty acid biosynthetic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3-keto acyl-CoA synthase Elovl6; elongation of very long chain fatty acids protein 6; elongation of very long chain fatty acids protein 6-like; ELOVL FA elongase 6; ELOVL family member 6, elongation of long chain fatty acids; ELOVL family member 6, elongation of long chain fatty acids (yeast); fatty acid elongase 2; fatty acyl-CoA elongase; Lce2; LOC102549542; long-chain fatty-acyl elongase; rELO2; very long chain 3-ketoacyl-CoA synthase 6; very long chain 3-oxoacyl-CoA synthase 6; very long chain fatty acid elongase 6; very-long-chain 3-oxoacyl-CoA synthase 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82220,738,095 - 220,845,528 (+)NCBIGRCr8
mRatBN7.22218,063,682 - 218,174,767 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2218,063,804 - 218,171,186 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2225,752,305 - 225,859,685 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02223,651,982 - 223,759,367 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02218,509,650 - 218,617,033 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02234,187,490 - 234,296,124 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2234,189,105 - 234,296,145 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl2234,375,315 - 234,483,149 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02253,509,516 - 253,616,747 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42226,946,573 - 227,054,321 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12226,933,252 - 227,041,003 (+)NCBI
Celera2210,356,634 - 210,462,671 (+)NCBICelera
Cytogenetic Map2q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-dichloroaniline  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
Azaspiracid  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
diuron  (EXP)
Enterolactone  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (ISO)
farnesol  (ISO)
fenofibrate  (EXP,ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
fluoranthene  (ISO)
fluoxetine  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
furan  (EXP)
gemfibrozil  (EXP)
glafenine  (EXP)
glucose  (EXP,ISO)
GW 4064  (ISO)
Heptachlor epoxide  (ISO)
hexadecanoic acid  (ISO)
hydralazine  (ISO)
imidacloprid  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
inulin  (ISO)
isobutanol  (ISO)
ketoconazole  (EXP)
L-methionine  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
mercury dichloride  (ISO)
metformin  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (EXP)
nickel dichloride  (EXP)
nimesulide  (EXP)
o-xylene  (ISO)
obeticholic acid  (ISO)
oleic acid  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
ritodrine  (ISO)
rotenone  (EXP)
saroglitazar  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Sodium oleate  (ISO)
Soman  (EXP)
succimer  (ISO)
sulforaphane  (EXP,ISO)
tamoxifen  (EXP,ISO)
Tesaglitazar  (EXP,ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Identification and expression of a rat fatty acid elongase involved in the biosynthesis of C18 fatty acids. Inagaki K, etal., Biosci Biotechnol Biochem. 2002 Mar;66(3):613-21.
3. Dysregulation of microRNA-125a contributes to obesity-associated insulin resistance and dysregulates lipid metabolism in mice. Liu R, etal., Biochim Biophys Acta Mol Cell Biol Lipids. 2020 May;1865(5):158640. doi: 10.1016/j.bbalip.2020.158640. Epub 2020 Jan 25.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins. Moon YA, etal., J Biol Chem 2001 Nov 30;276(48):45358-66. Epub 2001 Sep 20.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6. Tan CY, etal., Cell Rep. 2015 Dec 15;13(10):2039-47. doi: 10.1016/j.celrep.2015.11.004. Epub 2015 Nov 25.
Additional References at PubMed
PMID:19429849   PMID:20228221   PMID:20721682   PMID:20937905   PMID:21172452   PMID:21266672   PMID:26214738   PMID:27881420  


Genomics

Comparative Map Data
Elovl6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82220,738,095 - 220,845,528 (+)NCBIGRCr8
mRatBN7.22218,063,682 - 218,174,767 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2218,063,804 - 218,171,186 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2225,752,305 - 225,859,685 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02223,651,982 - 223,759,367 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02218,509,650 - 218,617,033 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02234,187,490 - 234,296,124 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2234,189,105 - 234,296,145 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl2234,375,315 - 234,483,149 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02253,509,516 - 253,616,747 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42226,946,573 - 227,054,321 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12226,933,252 - 227,041,003 (+)NCBI
Celera2210,356,634 - 210,462,671 (+)NCBICelera
Cytogenetic Map2q43NCBI
ELOVL6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384110,045,846 - 110,199,202 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4110,045,846 - 110,199,199 (-)EnsemblGRCh38hg38GRCh38
GRCh374110,967,002 - 111,119,771 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364111,189,992 - 111,339,220 (-)NCBINCBI36Build 36hg18NCBI36
Build 344111,328,146 - 111,477,375NCBI
Celera4108,263,951 - 108,413,724 (-)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4106,702,334 - 106,852,302 (-)NCBIHuRef
CHM1_14110,946,738 - 111,096,521 (-)NCBICHM1_1
T2T-CHM13v2.04113,347,937 - 113,501,499 (-)NCBIT2T-CHM13v2.0
Elovl6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393129,326,035 - 129,432,144 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3129,326,004 - 129,432,144 (+)EnsemblGRCm39 Ensembl
GRCm383129,532,386 - 129,638,495 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3129,532,355 - 129,638,495 (+)EnsemblGRCm38mm10GRCm38
MGSCv373129,235,304 - 129,341,413 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363129,524,461 - 129,630,513 (+)NCBIMGSCv36mm8
Celera3136,042,332 - 136,148,508 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map358.05NCBI
Elovl6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955496179,977 - 301,918 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955496179,634 - 301,908 (+)NCBIChiLan1.0ChiLan1.0
ELOVL6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23108,141,343 - 108,290,699 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14108,434,611 - 108,583,959 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04102,545,815 - 102,695,536 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14113,112,941 - 113,260,883 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4113,110,466 - 113,260,444 (-)Ensemblpanpan1.1panPan2
ELOVL6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13230,221,858 - 30,360,761 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3230,224,252 - 30,360,138 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3211,669,501 - 11,810,012 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03230,443,342 - 30,581,564 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3230,394,846 - 30,581,340 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13230,436,830 - 30,574,542 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03230,180,868 - 30,318,794 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0329,529,507 - 9,670,539 (+)NCBIUU_Cfam_GSD_1.0
Elovl6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530110,606,241 - 10,727,558 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365631,221,233 - 1,344,810 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365631,224,392 - 1,344,707 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ELOVL6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8112,027,054 - 112,191,274 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18112,038,670 - 112,190,079 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28120,119,621 - 120,219,554 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ELOVL6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1757,949,910 - 58,095,637 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603736,623,125 - 36,769,288 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Elovl6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248384,468,192 - 4,593,556 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248384,469,321 - 4,593,919 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Elovl6
645 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:496
Count of miRNA genes:234
Interacting mature miRNAs:299
Transcripts:ENSRNOT00000071270
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
8693697Alc36Alcohol consumption QTL 3620.592drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2217139753236660713Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631203Gluco14Glucose level QTL 140.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)2206665645219003804Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
2299161Iddm33Insulin dependent diabetes mellitus QTL 332.98blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2206312063220876787Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat

Markers in Region
RH141110  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22218,101,990 - 218,102,173 (-)MAPPERmRatBN7.2
mRatBN7.22218,101,990 - 218,102,173 (+)MAPPERmRatBN7.2
Rnor_6.02234,413,465 - 234,413,647NCBIRnor6.0
Rnor_6.02234,257,796 - 234,257,978NCBIRnor6.0
Rnor_5.02253,578,419 - 253,578,601UniSTSRnor5.0
Rnor_5.02253,733,916 - 253,734,098UniSTSRnor5.0
RGSC_v3.42226,984,724 - 226,984,906UniSTSRGSC3.4
Celera2210,394,926 - 210,395,108UniSTS
RH 3.4 Map4734.31UniSTS
Cytogenetic Map2q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
12 12 62 67 59 35 12 35 12 115 48 38 20 37 24

Sequence


Ensembl Acc Id: ENSRNOT00000014155   ⟹   ENSRNOP00000014155
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2218,063,804 - 218,171,186 (+)Ensembl
Rnor_6.0 Ensembl2234,189,105 - 234,296,145 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000071270   ⟹   ENSRNOP00000067070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2218,064,040 - 218,171,186 (+)Ensembl
Rnor_6.0 Ensembl2234,375,315 - 234,483,149 (+)Ensembl
RefSeq Acc Id: NM_134383   ⟹   NP_599210
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82220,738,095 - 220,845,528 (+)NCBI
mRatBN7.22218,063,835 - 218,171,273 (+)NCBI
Rnor_6.02234,187,490 - 234,296,124 (-)NCBI
Rnor_5.02253,509,516 - 253,616,747 (-)NCBI
RGSC_v3.42226,946,573 - 227,054,321 (+)RGD
Sequence:
RefSeq Acc Id: NP_599210   ⟸   NM_134383
- UniProtKB: Q920L6 (UniProtKB/Swiss-Prot),   A6HVP0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014155   ⟸   ENSRNOT00000014155
Ensembl Acc Id: ENSRNOP00000067070   ⟸   ENSRNOT00000071270

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q920L6-F1-model_v2 AlphaFold Q920L6 1-267 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691747
Promoter ID:EPDNEW_R2272
Type:multiple initiation site
Name:LOC102549542_1
Description:elongation of very long chain fatty acids protein 6-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02234,296,158 - 234,296,218EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620585 AgrOrtholog
BioCyc Gene G2FUF-51243 BioCyc
Ensembl Genes ENSRNOG00000010468 Ensembl
  ENSRNOG00000048949 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055027369 UniProtKB/Swiss-Prot
  ENSRNOG00060002609 UniProtKB/Swiss-Prot
  ENSRNOG00065014253 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014155.6 UniProtKB/Swiss-Prot
  ENSRNOT00000071270.2 UniProtKB/TrEMBL
  ENSRNOT00055047384 UniProtKB/Swiss-Prot
  ENSRNOT00060004180 UniProtKB/Swiss-Prot
  ENSRNOT00065023521 UniProtKB/Swiss-Prot
InterPro ELO_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ELO_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ELOVL6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171402 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 171402 ENTREZGENE
PANTHER ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 6 UniProtKB/TrEMBL
  PTHR11157 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11157:SF125 UniProtKB/Swiss-Prot
Pfam ELO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Elovl6 PhenoGen
PROSITE ELO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010468 RatGTEx
  ENSRNOG00000048949 RatGTEx
  ENSRNOG00055027369 RatGTEx
  ENSRNOG00060002609 RatGTEx
  ENSRNOG00065014253 RatGTEx
UniProt A0A8L2QXY1_RAT UniProtKB/TrEMBL
  A6HVN8_RAT UniProtKB/TrEMBL
  A6HVP0 ENTREZGENE, UniProtKB/TrEMBL
  ELOV6_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Elovl6  ELOVL fatty acid elongase 6  LOC102549542  elongation of very long chain fatty acids protein 6-like  Data merged from RGD:7527008 737654 PROVISIONAL
2013-12-17 LOC102549542  elongation of very long chain fatty acids protein 6-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-01-25 Elovl6  ELOVL fatty acid elongase 6  Elovl6  ELOVL family member 6, elongation of long chain fatty acids (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Elovl6  ELOVL family member 6, elongation of long chain fatty acids (yeast)  rELO2  fatty acid elongase 2  Symbol and Name updated 1299863 APPROVED
2002-08-07 rELO2  fatty acid elongase 2      Symbol and Name status set to provisional 70820 PROVISIONAL