Selenbp1 (selenium binding protein 1)

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Gene: Selenbp1 (selenium binding protein 1) Rattus norvegicus

Analyze

Symbol:

Selenbp1

Name:

selenium binding protein 1

RGD ID:

620571

Description:

Predicted to enable methanethiol oxidase activity. Predicted to be involved in protein transport. Predicted to act upstream of or within brown fat cell differentiation. Predicted to be located in fibrillar center. Orthologous to human SELENBP1 (selenium binding protein 1); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

56 kDa selenium-binding protein; methanethiol oxidase; MTO; rSBP; SBP56; Selenbp2; selenium binding protein 2; selenium-binding protein 1; selenium-binding protein 2; SP56

RGD Orthologs

Human

Mouse

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SELENBP1 (selenium binding protein 1)	RGD	RGD
Mus musculus (house mouse):	Selenbp1 (selenium binding protein 1)	RGD	RGD
Alliance orthologs ³
Homo sapiens (human):	SELENBP1 (selenium binding protein 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Selenbp1 (selenium binding protein 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Selenbp2 (selenium binding protein 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	selenbp1 (selenium binding protein 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	R11G10.2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG7966	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	Y37A1B.5	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	selenbp1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

NCBI Annotation Information:

Note: LOC103689947 appears to be a duplicate placement of Selenbp1 on Rnor_6.0 (Annot. Release 105) that is present on Rn_Celera but is absent from the previous reference assembly (Rnor_5.0) and not supported by syntenic regions in mouse and human. It appears that Selenbp1 was annotated on Rn_Celera as LOC103689947. Selenbp1 annotation on Rnor_6.0 is thus supported by annotation on Rn_Celera (as LOC103689947) and additionally, synteny with mouse and human. BLAST analysis of the LOC103689947 underlying component AABR07012460.1 shows 99% identity with a ~60 kb region of NC_005101.4 including where Selenbp1 is annotated. Annotation of Selenbp1 at this location on Rnor_6.0 is supported by annotation of LOC103689947 on Rn_Celera. This apparent duplication could be explained by misassembly of several underlying components on Rnor_6.0. [17 Mar 2015]

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	182,494,004 - 182,504,594 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	182,493,978 - 182,504,594 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	190,158,745 - 190,169,478 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	187,954,452 - 187,965,170 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	182,791,220 - 182,801,953 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	195,416,472 - 195,423,665 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	196,105,569 - 196,113,149 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	2	195,416,469 - 195,423,787 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	215,588,465 - 215,598,473 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	2	214,896,716 - 214,903,904 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	189,840,450 - 189,881,332 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	189,785,972 - 189,796,482 (+)	NCBI
Celera	2	175,037,375 - 175,046,988 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenocarcinoma (ISO)

Chemical and Drug Induced Liver Injury (ISO)

Colorectal Neoplasms (ISO)

Dravet syndrome (ISO)

Extraoral Halitosis due to Methanethiol Oxidase Deficiency (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

glaucoma (ISO)

Halitosis (ISO)

immunodeficiency 42 (ISO)

inherited metabolic disorder (ISO)

Lung Neoplasms (ISO)

MHC class II deficiency (ISO)

Ovarian Neoplasms (ISO)

parathyroid carcinoma (ISO)

psychotic disorder (ISO)

schizophrenia (ISO)

severe congenital neutropenia 3 (ISO)

severe congenital neutropenia 5 (ISO)

Stomach Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-alpha-phellandrene (ISO)

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrotoluene (EXP)

2,4-dinitrotoluene (EXP)

2-amino-2-deoxy-D-glucopyranose (EXP)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

4-hydroxynon-2-enal (ISO)

4-nitrophenol (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucosamine (EXP)

all-trans-retinoic acid (EXP)

alpha-phellandrene (ISO)

alpha-pinene (ISO)

amitrole (EXP)

ammonium chloride (EXP)

amphetamine (EXP)

aniline (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

Benzo[k]fluoranthene (ISO)

beta-D-glucosamine (EXP)

bilirubin IXalpha (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

bleomycin A2 (EXP)

bromobenzene (EXP)

buta-1,3-diene (ISO)

C60 fullerene (EXP)

cadmium atom (EXP,ISO)

cadmium dichloride (ISO)

cadmium sulfate (ISO)

carbon nanotube (ISO)

chlordecone (ISO)

chlorohydrocarbon (EXP)

chloroprene (ISO)

ciguatoxin CTX1B (ISO)

clobetasol (ISO)

clofibrate (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

coumestrol (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

D-penicillamine (EXP)

dexamethasone (ISO)

dibenzofurans (ISO)

dibutyl phthalate (EXP,ISO)

diethylstilbestrol (ISO)

dimethyl sulfoxide (ISO)

dioxygen (ISO)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

endosulfan (ISO)

entinostat (ISO)

enzyme inhibitor (ISO)

epoxiconazole (ISO)

erlotinib hydrochloride (ISO)

estriol (ISO)

estrone (ISO)

flutamide (EXP)

folic acid (ISO)

genistein (ISO)

gentamycin (EXP)

glafenine (EXP)

glyphosate (ISO)

indometacin (ISO)

inulin (ISO)

isoflavones (ISO)

ivermectin (ISO)

leflunomide (EXP)

lipopolysaccharide (ISO)

manganese(II) chloride (EXP)

methanethiol (ISO)

methapyrilene (EXP)

methimazole (EXP)

methoxychlor (ISO)

methylmercury chloride (EXP,ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

N-Nitrosopyrrolidine (ISO)

naphthalene (ISO)

nefazodone (EXP)

nickel atom (ISO)

nitrofen (EXP)

Nonylphenol (ISO)

O-methyleugenol (ISO)

oxaliplatin (EXP)

ozone (ISO)

p-toluidine (EXP)

paracetamol (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenethyl isothiocyanate (EXP)

phenylephrine (EXP)

phenylmercury acetate (ISO)

potassium chromate (ISO)

potassium dichromate (ISO)

progesterone (ISO)

propiconazole (ISO)

quercetin (EXP,ISO)

resveratrol (ISO)

SB 431542 (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

sodium arsenite (EXP,ISO)

Soman (EXP)

succimer (ISO)

sulfadimethoxine (EXP)

sulforaphane (ISO)

sunitinib (ISO)

tamoxifen (ISO)

tanespimycin (ISO)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

topotecan (EXP)

trichloroethene (EXP)

trimellitic anhydride (ISO)

troglitazone (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

zinc atom (EXP)

zinc(0) (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

brown fat cell differentiation (ISO)

protein transport (IEA)

Cellular Component

cytosol (IEA)

fibrillar center (IEA,ISO)

membrane (IEA)

nucleolus (ISO)

nucleus (IEA)

Molecular Function

methanethiol oxidase activity (IEA,ISO)

protein binding (ISO)

selenium binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
2.	Different patterns of regulation of the genes encoding the closely related 56 kDa selenium- and acetaminophen-binding proteins in normal tissues and during carcinogenesis.	Lanfear J, etal., Carcinogenesis 1993 Mar;14(3):335-40.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
8.	Integrated microarray analysis provided novel insights to the pathogenesis of glaucoma.	Wang J, etal., Mol Med Rep. 2017 Dec;16(6):8735-8746. doi: 10.3892/mmr.2017.7711. Epub 2017 Oct 4.

Additional References at PubMed

PMID:15632090	PMID:16502470	PMID:18492766	PMID:19056867	PMID:23376485	PMID:23533145	PMID:25931508	PMID:27578022

Genomics

Comparative Map Data

Selenbp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	182,494,004 - 182,504,594 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	182,493,978 - 182,504,594 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	190,158,745 - 190,169,478 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	187,954,452 - 187,965,170 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	182,791,220 - 182,801,953 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	195,416,472 - 195,423,665 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	196,105,569 - 196,113,149 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	2	195,416,469 - 195,423,787 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	215,588,465 - 215,598,473 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	2	214,896,716 - 214,903,904 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	189,840,450 - 189,881,332 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	189,785,972 - 189,796,482 (+)	NCBI
Celera	2	175,037,375 - 175,046,988 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

SELENBP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	151,364,304 - 151,372,705 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	151,364,304 - 151,372,707 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	151,336,780 - 151,345,181 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	149,603,404 - 149,611,788 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	148,149,853 - 148,158,237	NCBI
Celera	1	124,452,070 - 124,460,453 (-)	NCBI		Celera
Cytogenetic Map	1	q21.3	NCBI
HuRef	1	122,714,749 - 122,723,196 (-)	NCBI		HuRef
CHM1_1	1	152,732,433 - 152,740,866 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	150,487,989 - 150,496,432 (-)	NCBI		T2T-CHM13v2.0

Selenbp1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	94,840,394 - 94,852,069 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	94,840,367 - 94,852,069 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	94,933,083 - 94,944,758 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	94,933,056 - 94,944,758 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	94,737,005 - 94,748,680 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	95,018,487 - 95,030,162 (+)	NCBI		MGSCv36	mm8
Celera	3	96,364,442 - 96,376,009 (+)	NCBI		Celera
Cytogenetic Map	3	F2.1	NCBI
cM Map	3	40.74	NCBI

Variants

Variants in Selenbp1
59 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	174
Count of miRNA genes:	136
Interacting mature miRNAs:	143
Transcripts:	ENSRNOT00000028510
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	43154682	202446871	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	43154682	202446871	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	43171017	184114403	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	46123260	202447032	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	56043031	202447032	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118275	202447032	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	74786664	206665859	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	76539322	202447032	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	78665619	219826953	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	81689826	221035911	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	81754530	222436696	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	112456140	212696837	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	112456140	212696837	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	114837527	185876470	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	114837527	185876470	Rat
1578648	Bss11	Bone structure and strength QTL 11	4.7		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	2	114837527	211674221	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	114837675	212549332	Rat
1300165	Rf9	Renal function QTL 9	3.28		kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	2	133914684	202447032	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	135552573	202446871	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	135552573	202446871	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	135552573	202446871	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	135552573	202446871	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	2	135552573	202446871	Rat
1298076	Bp166	Blood pressure QTL 166		0.0009	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	136445150	202447032	Rat
1581502	Esta3	Estrogen-induced thymic atrophy QTL 3			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	136916935	189599348	Rat
1359022	Ppulsi1	Prepulse inhibition QTL 1	3.63		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	2	136916935	213594495	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	141194931	223265385	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	141194931	223265385	Rat
71113	Cari2	Carrageenan-induced inflammation QTL 2	2.7	0.009	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	2	141596551	202447032	Rat
724568	Uae13	Urinary albumin excretion QTL 13	4.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	2	143157029	210020885	Rat
10043136	Iddm54	Insulin dependent diabetes mellitus QTL 54	3.4	0.0001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	143657411	190602963	Rat
10043136	Iddm54	Insulin dependent diabetes mellitus QTL 54	3.4	0.0001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	143657411	190602963	Rat
6903312	Bw112	Body weight QTL 112	3.2	0.0013	body mass (VT:0001259)	body weight (CMO:0000012)	2	143657569	184114274	Rat
61401	Niddm2	Non-insulin dependent diabetes mellitus QTL 2	4.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	144599348	189599348	Rat
1598833	Bp295	Blood pressure QTL 295	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	147798556	192798556	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	221167075	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	249053267	Rat
1598805	Memor8	Memory QTL 8	3		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	150341585	189039377	Rat
631501	Bp101	Blood pressure QTL 101	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150341684	202446871	Rat
2301966	Bp322	Blood pressure QTL 322	3.58		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150540301	202447032	Rat
1354609	Niddm62	Non-insulin dependent diabetes mellitus QTL 62	4.72	0.000006	insulin secretion trait (VT:0003564)	plasma insulin level (CMO:0000342)	2	150540301	202447032	Rat
12879836	Kidm61	Kidney mass QTL 61		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	152413072	185122374	Rat
12879837	Am2	Aortic mass QTL 2		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	152413072	185122374	Rat
12879838	Cm86	Cardiac mass QTL 86		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	152413072	185122374	Rat
12879839	Cm85	Cardiac mass QTL 85		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	152413072	185122374	Rat
12879840	Bw179	Body weight QTL 179		0.005	body mass (VT:0001259)	body weight (CMO:0000012)	2	152413072	185122374	Rat
1359032	Hrtrt18	Heart rate QTL 18			heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	157142078	192625452	Rat
1358900	Bw48	Body weight QTL 48	4.88		body mass (VT:0001259)	body weight (CMO:0000012)	2	157142078	211086598	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	157142078	226277316	Rat
1302793	Bw16	Body weight QTL 16	5	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	2	157142209	202446871	Rat
7488925	Bp364	Blood pressure QTL 364		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	160564068	205564068	Rat
1358356	Srcrt1	Stress Responsive Cort QTL1	3.66		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	2	161699179	222436696	Rat
7488927	Bp365	Blood pressure QTL 365		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	162765032	207765032	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	164073756	227146641	Rat
1598838	Bp290	Blood pressure QTL 290	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	166539266	211539266	Rat
1549833	Bp257	Blood pressure QTL 257		0.003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	168354880	185122374	Rat
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	168358098	223265385	Rat
2307174	Activ3	Activity QTL 3	4.83	0.000058	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	168594495	213594495	Rat
61469	Bp16	Blood pressure QTL 16	5.64		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	2	169745596	214745596	Rat
70162	Bp63	Blood pressure QTL 63	5.64		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	2	169745596	214745596	Rat
631522	Bp74	Blood pressure QTL 74		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	172710921	184114403	Rat
2293084	Iddm26	Insulin dependent diabetes mellitus QTL 26	2.9		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	174930955	213594495	Rat
2300189	Bmd48	Bone mineral density QTL 48	5.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	179335906	224335906	Rat
61417	Cia10	Collagen induced arthritis QTL 10	3.4		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	2	179946951	224946951	Rat
8694435	Bw166	Body weight QTL 166	14.08	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	2	182171407	227171407	Rat
9589044	Scfw1	Subcutaneous fat weight QTL 1	5.8	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	2	182171407	227171407	Rat
8694383	Bw158	Body weight QTL 158	7.69	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	2	182171407	227171407	Rat
8694194	Abfw1	Abdominal fat weight QTL 1	11.7	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	2	182171407	227171407	Rat

Markers in Region

D2Rat126

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	182,534,917 - 182,535,150 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	196,134,296 - 196,134,528	NCBI	Rnor6.0
Rnor_5.0	2	215,628,982 - 215,629,214	UniSTS	Rnor5.0
RGSC_v3.4	2	189,869,153 - 189,869,386	RGD	RGSC3.4
RGSC_v3.4	2	189,869,154 - 189,869,386	UniSTS	RGSC3.4
RGSC_v3.1	2	189,828,562 - 189,828,794	RGD
Celera	2	175,076,961 - 175,077,193	UniSTS
RH 3.4 Map	2	1212.1	RGD
RH 3.4 Map	2	1212.1	UniSTS
RH 2.0 Map	2	884.4	RGD
SHRSP x BN Map	2	70.0098	RGD
Cytogenetic Map	2	q34	UniSTS

RH144445

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	182,540,402 - 182,540,529 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	196,139,781 - 196,139,907	NCBI	Rnor6.0
Rnor_5.0	2	215,634,467 - 215,634,593	UniSTS	Rnor5.0
RGSC_v3.4	2	189,874,639 - 189,874,765	UniSTS	RGSC3.4
Celera	2	175,082,442 - 175,082,568	UniSTS
RH 3.4 Map	2	1199.1	UniSTS
Cytogenetic Map	2	q34	UniSTS

AI072618

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	182,528,466 - 182,528,601 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	196,127,845 - 196,127,979	NCBI	Rnor6.0
Rnor_5.0	2	215,622,531 - 215,622,665	UniSTS	Rnor5.0
RGSC_v3.4	2	189,862,703 - 189,862,837	UniSTS	RGSC3.4
Celera	2	175,070,511 - 175,070,645	UniSTS
RH 3.4 Map	2	1199.1	UniSTS
Cytogenetic Map	2	q34	UniSTS

BE115799

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	182,537,643 - 182,537,862 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	196,137,022 - 196,137,240	NCBI	Rnor6.0
Rnor_5.0	2	215,631,708 - 215,631,926	UniSTS	Rnor5.0
RGSC_v3.4	2	189,871,880 - 189,872,098	UniSTS	RGSC3.4
Celera	2	175,079,683 - 175,079,901	UniSTS
RH 3.4 Map	2	1197.2	UniSTS
Cytogenetic Map	2	q34	UniSTS

RH135301

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	182,495,388 - 182,495,596 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	196,096,163 - 196,096,370	NCBI	Rnor6.0
Rnor_6.0	2	195,407,048 - 195,407,255	NCBI	Rnor6.0
Rnor_5.0	2	215,589,882 - 215,590,089	UniSTS	Rnor5.0
Rnor_5.0	2	214,887,287 - 214,887,494	UniSTS	Rnor5.0
RGSC_v3.4	2	189,831,021 - 189,831,228	UniSTS	RGSC3.4
Celera	2	175,038,799 - 175,039,006	UniSTS
RH 3.4 Map	2	1200.9	UniSTS
Cytogenetic Map	2	q34	UniSTS

BI282436

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	182,504,372 - 182,504,544 (-)	MAPPER	mRatBN7.2
Rnor_6.0	2	196,105,642 - 196,105,813	NCBI	Rnor6.0
Rnor_6.0	2	195,416,527 - 195,416,698	NCBI	Rnor6.0
Rnor_5.0	2	215,598,247 - 215,598,418	UniSTS	Rnor5.0
Rnor_5.0	2	214,896,766 - 214,896,937	UniSTS	Rnor5.0
RGSC_v3.4	2	189,840,500 - 189,840,671	UniSTS	RGSC3.4
Celera	2	175,046,762 - 175,046,933	UniSTS
RH 3.4 Map	2	1195.1	UniSTS
Cytogenetic Map	2	q34	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	nervous system	renal system	reproductive system	respiratory system
High
Medium
Low	2									2
Below cutoff		4	15	11	9	11	1	12	8	9

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001329893	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761279	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008775217	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB036799	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC130969	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC074008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219337	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000076	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000071603 ⟹ ENSRNOP00000064790

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	182,497,282 - 182,504,594 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000088465 ⟹ ENSRNOP00000071154

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	182,497,535 - 182,504,594 (+)	Ensembl
Rnor_6.0 Ensembl	2	196,105,569 - 196,113,149 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000097461 ⟹ ENSRNOP00000083317

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	182,493,978 - 182,504,594 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000101667 ⟹ ENSRNOP00000094007

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	182,493,978 - 182,504,594 (+)	Ensembl

RefSeq Acc Id:

NM_001329893 ⟹ NP_001316822

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	182,494,004 - 182,504,594 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001316822	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH74008	(Get FASTA)	NCBI Sequence Viewer
	BAB83134	(Get FASTA)	NCBI Sequence Viewer
	EDL85767	(Get FASTA)	NCBI Sequence Viewer
	Q8VIF7	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

ENSRNOP00000071154 ⟸ ENSRNOT00000088465

RefSeq Acc Id:

ENSRNOP00000064790 ⟸ ENSRNOT00000071603

RefSeq Acc Id:

ENSRNOP00000083317 ⟸ ENSRNOT00000097461

RefSeq Acc Id:

ENSRNOP00000094007 ⟸ ENSRNOT00000101667

RefSeq Acc Id:	NP_001316822 ⟸ NM_001329893
- UniProtKB:	Q8VIF7 (UniProtKB/Swiss-Prot), A6K2T3 (UniProtKB/TrEMBL)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8VIF7-F1-model_v2	AlphaFold	Q8VIF7	1-472	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620571	AgrOrtholog
Ensembl Genes	ENSRNOG00000047158	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00000053812	Ensembl
Ensembl Protein	ENSRNOP00000064790.2	UniProtKB/TrEMBL
	ENSRNOP00000071154.2	UniProtKB/TrEMBL
	ENSRNOP00000083317.1	UniProtKB/TrEMBL
	ENSRNOP00000094007	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000071603.3	UniProtKB/TrEMBL
	ENSRNOT00000088465.2	UniProtKB/TrEMBL
	ENSRNOT00000097461.1	UniProtKB/TrEMBL
	ENSRNOT00000101667	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	2.130.10.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7100467	IMAGE-MGC_LOAD
InterPro	Se-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:103689947	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:91524	IMAGE-MGC_LOAD
NCBI Gene	Selenbp1	ENTREZGENE
PANTHER	METHANETHIOL OXIDASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR23300	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	SBP56	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Selenbp1	PhenoGen
Superfamily-SCOP	3-carboxy-cis,cis-mucoante lactonizing enzyme	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2JZR8_RAT	UniProtKB/TrEMBL
	A0A8I5ZWC7_RAT	UniProtKB/TrEMBL
	A6K2T3	ENTREZGENE, UniProtKB/TrEMBL
	F1LRJ9_RAT	UniProtKB/TrEMBL
	Q8VIF7	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-03-01	Selenbp1	selenium binding protein 1	Selenbp2	selenium binding protein 2	Data Merged	737654	PROVISIONAL
2021-12-20	Selenbp2	selenium binding protein 2	LOC103689947	selenium-binding protein 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2014-08-25	LOC103689947	selenium-binding protein 1			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-02-22	Selenbp1	selenium binding protein 1	Selenbp1	selenium binding protein 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Selenbp1	selenium binding protein 2	Selenbp2		Symbol and Name updated	1299863	APPROVED
2002-08-07	Selenbp2	selenium binding protein 2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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