Lpar1 (lysophosphatidic acid receptor 1) - Rat Genome Database

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Gene: Lpar1 (lysophosphatidic acid receptor 1) Rattus norvegicus
Analyze
Symbol: Lpar1
Name: lysophosphatidic acid receptor 1
RGD ID: 620563
Description: Enables G-protein alpha-subunit binding activity and phospholipid binding activity. Involved in several processes, including cellular response to 1-oleoyl-sn-glycerol 3-phosphate; nervous system development; and regulation of vesicle-mediated transport. Located in dendritic shaft; dendritic spine; and neuronal cell body. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Used to study hepatocellular carcinoma and transient cerebral ischemia. Orthologous to human LPAR1 (lysophosphatidic acid receptor 1); PARTICIPATES IN G protein mediated signaling pathway via Galphai family; G protein mediated signaling pathway via Galphaq family; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Edg2; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2; LPA receptor 1; LPA-1; lysophosphatidic acid receptor Edg-2; MGC105279
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Lpar1m1Hubr  
Genetic Models: WI- Lpar1m1Hubr
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2573,229,047 - 73,347,874 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl573,229,625 - 73,369,895 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx575,113,517 - 75,231,865 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0576,935,105 - 77,053,463 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0576,907,241 - 77,025,601 (-)NCBIRnor_WKY
Rnor_6.0575,557,038 - 75,678,067 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl575,557,042 - 75,676,584 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0579,707,131 - 79,825,313 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4576,449,470 - 76,571,458 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1576,454,582 - 76,576,571 (-)NCBI
Celera572,053,065 - 72,170,436 (-)NCBICelera
Cytogenetic Map5q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-naphthyl isothiocyanate  (EXP)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
calcitriol  (ISO)
chloroprene  (EXP,ISO)
chlorpyrifos  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clothianidin  (ISO)
cocaine  (ISO)
corticosterone  (EXP)
Cuprizon  (EXP)
curcumin  (ISO)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fonofos  (ISO)
furan  (EXP)
genistein  (EXP)
hydrazine  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl beta-cyclodextrin  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
oxaliplatin  (EXP)
paracetamol  (EXP)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenylmercury acetate  (ISO)
progesterone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
terbufos  (ISO)
tetrachloromethane  (ISO)
tipifarnib  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
undecane  (EXP)
valproic acid  (EXP,ISO)
vincaleukoblastine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. A rat G protein-coupled receptor selectively expressed in myelin-forming cells. Allard J, etal., Eur J Neurosci. 1998 Mar;10(3):1045-53.
2. Edg-2 in myelin-forming cells: isoforms, genomic mapping, and exclusion in Charcot-Marie-Tooth disease. Allard J, etal., Glia. 1999 Apr;26(2):176-85.
3. Immunohistological localization of the myelinating cell-specific receptor LP(A1). Cervera P, etal., Glia. 2002 Apr 15;38(2):126-36.
4. Specific receptor subtype mediation of LPA-induced dual effects in cardiac fibroblasts. Chen J, etal., FEBS Lett. 2006 Aug 21;580(19):4737-45. Epub 2006 Jul 31.
5. Membrane-derived phospholipids control synaptic neurotransmission and plasticity. García-Morales V, etal., PLoS Biol. 2015 May 21;13(5):e1002153. doi: 10.1371/journal.pbio.1002153. eCollection 2015 May.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors. Hama K, etal., FEBS Lett 2002 Jul 17;523(1-3):187-92.
9. The temporal profile of genomic responses and protein synthesis in ischemic tolerance of the rat brain induced by repeated hyperbaric oxygen. Hirata T, etal., Brain Res. 2007 Jan 26;1130(1):214-22. Epub 2006 Dec 13.
10. Vascular smooth muscle migration and proliferation in response to lysophosphatidic acid (LPA) is mediated by LPA receptors coupling to Gq. Kim J, etal., Cell Signal. 2006 Oct;18(10):1695-701. Epub 2006 Feb 28.
11. Lysophosphatidic acid stimulates cell proliferation in rat chondrocytes. Kim MK, etal., Biochem Pharmacol. 2005 Dec 5;70(12):1764-71. Epub 2005 Oct 20.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. A functional SNP in EDG2 increases susceptibility to knee osteoarthritis in Japanese. Mototani H, etal., Hum Mol Genet. 2008 Jun 15;17(12):1790-7. doi: 10.1093/hmg/ddn069. Epub 2008 Mar 6.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Frequent mutations of lysophosphatidic acid receptor-1 gene in rat liver tumors. Obo Y, etal., Mutat Res. 2009 Jan 15;660(1-2):47-50. Epub 2008 Oct 21.
16. The role of LPA1 in formation of synapses among cultured hippocampal neurons. Pilpel Y and Segal M, J Neurochem. 2006 Jun;97(5):1379-92. Epub 2006 Apr 21.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Hepatic oval (stem) cell expression of endothelial differentiation gene receptors for lysophosphatidic acid in mouse chronic liver injury. Sautin YY, etal., J Hematother Stem Cell Res. 2002 Aug;11(4):643-9.
21. EDG receptors as a potential therapeutic target in retinal ischemia-reperfusion injury. Savitz SI, etal., Brain Res. 2006 Nov 6;1118(1):168-75. Epub 2006 Oct 5.
22. Oligodendroglial expression of Edg-2 receptor: developmental analysis and pharmacological responses to lysophosphatidic acid. Stankoff B, etal., Mol Cell Neurosci 2002 Jul;20(3):415-28.
23. Systematic generation of in vivo G protein-coupled receptor mutants in the rat. van Boxtel R, etal., Pharmacogenomics J. 2011 Oct;11(5):326-36. doi: 10.1038/tpj.2010.44. Epub 2010 Jun 8.
24. The role of lysophosphatidic acid receptor (LPA1) in the oxygen-induced retinal ganglion cell degeneration. Yang C, etal., Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1290-8. Epub 2008 Oct 31.
25. Receptor-Mediated Vascular Smooth Muscle Migration Induced by LPA Involves p38 Mitogen-Activated Protein Kinase Pathway Activation. Zhou ZB, etal., Int J Mol Sci. 2009 Jul 13;10(7):3194-208.
Additional References at PubMed
PMID:8922387   PMID:9070858   PMID:9600933   PMID:11040035   PMID:12477932   PMID:12761501   PMID:12847111   PMID:15489334   PMID:15755723   PMID:16970915   PMID:17135244   PMID:19026987  
PMID:19306925   PMID:19733258   PMID:19757175   PMID:20553953   PMID:21244430   PMID:22021336   PMID:22197817   PMID:22580000   PMID:23451264   PMID:23711961   PMID:24355769   PMID:25888792  
PMID:26169757   PMID:26473723   PMID:27094551   PMID:28342860   PMID:34920725  


Genomics

Comparative Map Data
Lpar1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2573,229,047 - 73,347,874 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl573,229,625 - 73,369,895 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx575,113,517 - 75,231,865 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0576,935,105 - 77,053,463 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0576,907,241 - 77,025,601 (-)NCBIRnor_WKY
Rnor_6.0575,557,038 - 75,678,067 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl575,557,042 - 75,676,584 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0579,707,131 - 79,825,313 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4576,449,470 - 76,571,458 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1576,454,582 - 76,576,571 (-)NCBI
Celera572,053,065 - 72,170,436 (-)NCBICelera
Cytogenetic Map5q24NCBI
LPAR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389110,873,263 - 111,038,998 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9110,873,263 - 111,038,470 (-)EnsemblGRCh38hg38GRCh38
GRCh379113,635,543 - 113,801,278 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369112,675,875 - 112,840,186 (-)NCBINCBI36Build 36hg18NCBI36
Build 349110,715,610 - 110,879,920NCBI
Celera984,135,330 - 84,299,600 (-)NCBICelera
Cytogenetic Map9q31.3NCBI
HuRef983,234,370 - 83,398,725 (-)NCBIHuRef
CHM1_19113,782,492 - 113,946,810 (-)NCBICHM1_1
T2T-CHM13v2.09123,044,905 - 123,210,649 (-)NCBIT2T-CHM13v2.0
Lpar1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39458,435,252 - 58,554,601 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl458,435,255 - 58,553,898 (-)EnsemblGRCm39 Ensembl
GRCm38458,435,252 - 58,554,027 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl458,435,255 - 58,553,898 (-)EnsemblGRCm38mm10GRCm38
MGSCv37458,448,124 - 58,566,363 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36458,529,038 - 58,647,573 (-)NCBIMGSCv36mm8
Celera458,350,845 - 58,469,154 (-)NCBICelera
Cytogenetic Map4B3NCBI
cM Map432.2NCBI
Lpar1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541916,191,244 - 16,325,602 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541916,190,109 - 16,324,702 (+)NCBIChiLan1.0ChiLan1.0
LPAR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1928,384,283 - 28,549,576 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0982,013,960 - 82,179,227 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19110,179,600 - 110,344,103 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9110,179,600 - 110,279,038 (-)Ensemblpanpan1.1panPan2
LPAR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11165,690,806 - 65,822,166 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1165,692,973 - 65,822,312 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1164,093,455 - 64,225,618 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01166,821,266 - 66,953,345 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1166,821,279 - 66,953,395 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11165,340,113 - 65,471,961 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01165,362,357 - 65,494,286 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01166,052,210 - 66,184,225 (-)NCBIUU_Cfam_GSD_1.0
Lpar1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947180,933,634 - 181,079,775 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365592,259,420 - 2,332,806 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365592,187,791 - 2,331,587 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LPAR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1251,811,584 - 251,979,159 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11251,811,583 - 251,979,828 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21282,512,052 - 282,513,164 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21282,656,365 - 282,809,534 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LPAR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11228,502,717 - 28,669,581 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1228,503,354 - 28,669,795 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603514,094,822 - 14,262,752 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lpar1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624758519,249 - 669,471 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624758518,070 - 668,915 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lpar1
589 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:771
Count of miRNA genes:318
Interacting mature miRNAs:411
Transcripts:ENSRNOT00000044348
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)55979352890450144Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat

Markers in Region
UniSTS:143241  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2573,230,908 - 73,231,065 (+)MAPPERmRatBN7.2
Rnor_6.0575,558,903 - 75,559,059NCBIRnor6.0
Rnor_5.0579,708,996 - 79,709,152UniSTSRnor5.0
RGSC_v3.4576,451,331 - 76,451,487UniSTSRGSC3.4
Celera572,054,926 - 72,055,082UniSTS
Cytogenetic Map5q24UniSTS
RH131839  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2573,229,253 - 73,229,433 (+)MAPPERmRatBN7.2
Rnor_6.0575,557,248 - 75,557,427NCBIRnor6.0
Rnor_5.0579,707,341 - 79,707,520UniSTSRnor5.0
RGSC_v3.4576,449,676 - 76,449,855UniSTSRGSC3.4
Celera572,053,271 - 72,053,450UniSTS
RH 3.4 Map5499.0UniSTS
Cytogenetic Map5q24UniSTS


Genetic Models
This gene Lpar1 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 20 13 4 18 4 2 2 66 20 31 11 2
Low 23 33 26 1 26 6 9 8 15 10 6
Below cutoff 11 11 11

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF014418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF090347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000044348   ⟹   ENSRNOP00000043652
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl573,229,625 - 73,369,895 (-)Ensembl
Rnor_6.0 Ensembl575,557,042 - 75,676,584 (-)Ensembl
RefSeq Acc Id: NM_053936   ⟹   NP_446388
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2573,229,048 - 73,347,025 (-)NCBI
Rnor_6.0575,557,042 - 75,676,584 (-)NCBI
Rnor_5.0579,707,131 - 79,825,313 (-)NCBI
RGSC_v3.4576,449,470 - 76,571,458 (-)RGD
Celera572,053,065 - 72,170,436 (-)RGD
Sequence:
RefSeq Acc Id: XM_006238195   ⟹   XP_006238257
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2573,229,047 - 73,347,874 (-)NCBI
Rnor_6.0575,557,038 - 75,678,067 (-)NCBI
Rnor_5.0579,707,131 - 79,825,313 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238197   ⟹   XP_006238259
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2573,229,047 - 73,314,090 (-)NCBI
Rnor_6.0575,557,038 - 75,644,795 (-)NCBI
Rnor_5.0579,707,131 - 79,825,313 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238200   ⟹   XP_006238262
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2573,229,047 - 73,330,265 (-)NCBI
Rnor_6.0575,557,038 - 75,659,706 (-)NCBI
Rnor_5.0579,707,131 - 79,825,313 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238201   ⟹   XP_006238263
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2573,229,047 - 73,347,477 (-)NCBI
Rnor_6.0575,557,038 - 75,677,100 (-)NCBI
Rnor_5.0579,707,131 - 79,825,313 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593125   ⟹   XP_017448614
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2573,229,047 - 73,347,700 (-)NCBI
Rnor_6.0575,557,038 - 75,677,264 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593127   ⟹   XP_017448616
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2573,229,047 - 73,345,503 (-)NCBI
Rnor_6.0575,557,038 - 75,674,158 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593129   ⟹   XP_017448618
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2573,229,047 - 73,289,162 (-)NCBI
Rnor_6.0575,557,038 - 75,617,387 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593130   ⟹   XP_017448619
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2573,229,047 - 73,289,527 (-)NCBI
Rnor_6.0575,557,038 - 75,617,980 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_446388   ⟸   NM_053936
- UniProtKB: P61794 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006238257   ⟸   XM_006238195
- Peptide Label: isoform X1
- UniProtKB: P61794 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006238263   ⟸   XM_006238201
- Peptide Label: isoform X1
- UniProtKB: P61794 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006238262   ⟸   XM_006238200
- Peptide Label: isoform X1
- UniProtKB: P61794 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006238259   ⟸   XM_006238197
- Peptide Label: isoform X1
- UniProtKB: P61794 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017448614   ⟸   XM_017593125
- Peptide Label: isoform X1
- UniProtKB: P61794 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017448616   ⟸   XM_017593127
- Peptide Label: isoform X1
- UniProtKB: P61794 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017448619   ⟸   XM_017593130
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017448618   ⟸   XM_017593129
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000043652   ⟸   ENSRNOT00000044348

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P61794-F1-model_v2 AlphaFold P61794 1-364 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693764
Promoter ID:EPDNEW_R4289
Type:initiation region
Name:Lpar1_1
Description:lysophosphatidic acid receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0575,676,617 - 75,676,677EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620563 AgrOrtholog
BioCyc Gene G2FUF-41180 BioCyc
Ensembl Genes ENSRNOG00000013656 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000043652 ENTREZGENE
  ENSRNOP00000043652.2 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000044348 ENTREZGENE
  ENSRNOT00000044348.3 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7320884 IMAGE-MGC_LOAD
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  LPA_rcpt UniProtKB/Swiss-Prot
  LPA_rcpt_EDG2 UniProtKB/Swiss-Prot
KEGG Report rno:116744 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105279 IMAGE-MGC_LOAD
NCBI Gene 116744 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
  LYSOPHOSPHATIDIC ACID RECEPTOR 1 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Lpar1 PhenoGen
PRINTS EDG2RECEPTOR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
  LPARECEPTOR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt LPAR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O88584 UniProtKB/Swiss-Prot
  P56487 UniProtKB/Swiss-Prot
  P70420 UniProtKB/Swiss-Prot
  Q5FWS2 UniProtKB/Swiss-Prot
  Q61130 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-25 Lpar1  lysophosphatidic acid receptor 1  Edg2  endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Edg2  endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Edg2  endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2      Symbol and Name status set to provisional 70820 PROVISIONAL