Tcf21 (transcription factor 21) - Rat Genome Database

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Gene: Tcf21 (transcription factor 21) Rattus norvegicus
Analyze
Symbol: Tcf21
Name: transcription factor 21
RGD ID: 620523
Description: Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and E-box binding activity. Involved in Sertoli cell differentiation; embryonic digestive tract morphogenesis; and gland development. Predicted to be located in nucleoplasm. Predicted to be part of transcription regulator complex. Human ortholog(s) of this gene implicated in coronary artery disease and ventricular septal defect. Orthologous to human TCF21 (transcription factor 21); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 4-tert-Octylphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Capsulin; MGC112908; Msf-1; Pod1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8124,520,499 - 24,523,358 (+)NCBIGRCr8
mRatBN7.2122,701,353 - 22,704,212 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl122,701,353 - 22,704,202 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx122,480,305 - 22,483,164 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0128,480,090 - 28,482,949 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0122,677,349 - 22,680,208 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0123,906,717 - 23,909,576 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl123,906,717 - 23,909,566 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0125,370,183 - 25,373,042 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4123,211,054 - 23,213,913 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1123,214,112 - 23,214,625 (+)NCBI
Celera121,429,543 - 21,432,402 (+)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (EXP)
8-Br-cAMP  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
barium sulfate  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cobalt atom  (ISO)
corticosterone  (EXP)
cytarabine  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
dioxygen  (ISO)
dipentyl phthalate  (EXP)
diquat  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
fenthion  (ISO)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
hydrogen cyanide  (ISO)
kojic acid  (ISO)
L-methionine  (ISO)
Licarin A  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mifepristone  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (EXP)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
potassium cyanide  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. The role of capsulin in the morphogenesis and differentiation of fetal rat gastric mucosa. Andersson M, etal., Int J Dev Biol 2001 Dec;45(8):887-93.
2. MiRNA-Related Polymorphisms in miR-146a and TCF21 Are Associated with Increased Susceptibility to Coronary Artery Disease in an Iranian Population. Bastami M, etal., Genet Test Mol Biomarkers. 2016 May;20(5):241-8. doi: 10.1089/gtmb.2015.0253. Epub 2016 Feb 24.
3. Basic helix-loop-helix transcription factor TCF21 is a downstream target of the male sex determining gene SRY. Bhandari RK, etal., PLoS One. 2011;6(5):e19935. doi: 10.1371/journal.pone.0019935. Epub 2011 May 17.
4. Disrupted gonadogenesis and male-to-female sex reversal in Pod1 knockout mice. Cui S, etal., Development. 2004 Aug;131(16):4095-105.
5. Identification of the rat homologue of the mouse capsulin gene by cDNA representational difference analysis. Familari M and Giraud AS, Gene 1998 Nov 19;222(2):245-8.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Modulation of the expression and transactivation of androgen receptor by the basic helix-loop-helix transcription factor Pod-1 through recruitment of histone deacetylase 1. Hong CY, etal., Mol Endocrinol. 2005 Sep;19(9):2245-57. Epub 2005 May 26.
8. Capsulin: a novel bHLH transcription factor expressed in epicardial progenitors and mesenchyme of visceral organs. Lu J, etal., Mech Dev. 1998 Apr;73(1):23-32.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis. Quaggin SE, etal., Development. 1999 Dec;126(24):5771-83.
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. TCF21 rs12190287 Polymorphisms Are Associated with Ventricular Septal Defects in a Chinese Population. Yang L, etal., Genet Test Mol Biomarkers. 2017 May;21(5):312-315. doi: 10.1089/gtmb.2016.0324. Epub 2017 Mar 27.
15. Association Between TCF21 Gene Polymorphism with the Incidence of Paroxysmal Atrial Fibrillation and the Efficacy of Radiofrequency Ablation for Patients with Paroxysmal Atrial Fibrillation. Zhang X, etal., Int J Gen Med. 2022 May 16;15:4975-4983. doi: 10.2147/IJGM.S366956. eCollection 2022.
Additional References at PubMed
PMID:9507058   PMID:9545526   PMID:10944221   PMID:11287187   PMID:12477932   PMID:12493738   PMID:12493912   PMID:12619136   PMID:23034159   PMID:32661376  


Genomics

Comparative Map Data
Tcf21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8124,520,499 - 24,523,358 (+)NCBIGRCr8
mRatBN7.2122,701,353 - 22,704,212 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl122,701,353 - 22,704,202 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx122,480,305 - 22,483,164 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0128,480,090 - 28,482,949 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0122,677,349 - 22,680,208 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0123,906,717 - 23,909,576 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl123,906,717 - 23,909,566 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0125,370,183 - 25,373,042 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4123,211,054 - 23,213,913 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1123,214,112 - 23,214,625 (+)NCBI
Celera121,429,543 - 21,432,402 (+)NCBICelera
Cytogenetic Map1p12NCBI
TCF21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386133,889,113 - 133,895,537 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6133,889,113 - 133,895,553 (+)EnsemblGRCh38hg38GRCh38
GRCh376134,210,251 - 134,216,675 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366134,251,970 - 134,258,368 (+)NCBINCBI36Build 36hg18NCBI36
Build 346134,251,969 - 134,258,368NCBI
Celera6134,951,327 - 134,957,746 (+)NCBICelera
Cytogenetic Map6q23.2NCBI
HuRef6131,779,608 - 131,786,028 (+)NCBIHuRef
CHM1_16134,473,121 - 134,479,537 (+)NCBICHM1_1
T2T-CHM13v2.06135,077,847 - 135,084,271 (+)NCBIT2T-CHM13v2.0
Tcf21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391022,693,162 - 22,696,042 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1022,693,180 - 22,696,073 (-)EnsemblGRCm39 Ensembl
GRCm381022,817,263 - 22,820,143 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1022,817,281 - 22,820,174 (-)EnsemblGRCm38mm10GRCm38
MGSCv371022,537,069 - 22,539,934 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361022,506,679 - 22,509,544 (-)NCBIMGSCv36mm8
Celera1023,754,029 - 23,756,913 (-)NCBICelera
Cytogenetic Map10A3NCBI
cM Map1010.33NCBI
Tcf21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554392,617,492 - 2,620,644 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554392,617,562 - 2,620,613 (-)NCBIChiLan1.0ChiLan1.0
TCF21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25153,862,783 - 153,865,954 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16151,768,855 - 151,775,684 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06131,656,582 - 131,662,983 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16135,754,896 - 135,761,294 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6135,754,896 - 135,761,294 (+)Ensemblpanpan1.1panPan2
TCF21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1126,856,281 - 26,859,654 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl126,856,587 - 26,859,647 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha127,737,867 - 27,741,067 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0127,014,669 - 27,017,873 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl127,015,081 - 27,017,857 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1126,898,755 - 26,901,959 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0126,778,392 - 26,781,591 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0127,087,943 - 27,091,143 (+)NCBIUU_Cfam_GSD_1.0
Tcf21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946121,954,674 - 121,957,679 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365601,733,903 - 1,736,890 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365601,733,903 - 1,736,895 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TCF21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl129,975,280 - 29,978,255 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1129,975,280 - 29,978,273 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2133,477,834 - 33,478,622 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TCF21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11339,607,179 - 39,610,336 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1339,607,182 - 39,610,388 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604011,792,052 - 11,795,253 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tcf21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624942890,365 - 893,811 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624942890,465 - 893,679 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tcf21
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:75
Count of miRNA genes:56
Interacting mature miRNAs:70
Transcripts:ENSRNOT00000022798
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124744506Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128736750Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1132356093Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1592587724697545Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat

Markers in Region
Tcf21  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2122,701,607 - 22,701,731 (+)MAPPERmRatBN7.2
Rnor_6.0123,906,972 - 23,907,095NCBIRnor6.0
Rnor_5.0125,370,438 - 25,370,561UniSTSRnor5.0
RGSC_v3.4123,211,309 - 23,211,432UniSTSRGSC3.4
Celera121,429,798 - 21,429,921UniSTS
Cytogenetic Map1p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 7 49 89 90 89 59 24 59 2 212 93 73 45 60 30

Sequence


Ensembl Acc Id: ENSRNOT00000022798   ⟹   ENSRNOP00000022798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl122,701,353 - 22,704,202 (+)Ensembl
Rnor_6.0 Ensembl123,906,717 - 23,909,566 (+)Ensembl
RefSeq Acc Id: NM_001032397   ⟹   NP_001027569
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8124,520,499 - 24,523,358 (+)NCBI
mRatBN7.2122,701,353 - 22,704,212 (+)NCBI
Rnor_6.0123,906,717 - 23,909,576 (+)NCBI
Rnor_5.0125,370,183 - 25,373,042 (+)NCBI
RGSC_v3.4123,211,054 - 23,213,913 (+)RGD
Celera121,429,543 - 21,432,402 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001027569 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD03823 (Get FASTA)   NCBI Sequence Viewer  
  AAI00107 (Get FASTA)   NCBI Sequence Viewer  
  EDL87735 (Get FASTA)   NCBI Sequence Viewer  
  EDL87736 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022798.4
RefSeq Acc Id: NP_001027569   ⟸   NM_001032397
- UniProtKB: Q498R2 (UniProtKB/TrEMBL),   F7F049 (UniProtKB/TrEMBL),   A6JUP4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022798   ⟸   ENSRNOT00000022798
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q498R2-F1-model_v2 AlphaFold Q498R2 1-179 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689534
Promoter ID:EPDNEW_R59
Type:single initiation site
Name:Tcf21_1
Description:transcription factor 21
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0123,906,699 - 23,906,759EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620523 AgrOrtholog
BioCyc Gene G2FUF-62047 BioCyc
Ensembl Genes ENSRNOG00000016700 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022798.6 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7379660 IMAGE-MGC_LOAD
InterPro E-box_TF_Regulators UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  HLH_DNA_bd UniProtKB/TrEMBL
KEGG Report rno:252856 UniProtKB/TrEMBL
MGC_CLONE MGC:112908 IMAGE-MGC_LOAD
NCBI Gene 252856 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR 21 UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
PhenoGen Tcf21 PhenoGen
PROSITE HLH UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016700 RatGTEx
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP HLH_basic UniProtKB/TrEMBL
UniProt A6JUP4 ENTREZGENE, UniProtKB/TrEMBL
  F7F049 ENTREZGENE, UniProtKB/TrEMBL
  Q498R2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Tcf21  transcription factor 21      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Tcf21  transcription factor 21      Symbol and Name status set to provisional 70820 PROVISIONAL