Doc2a (double C2 domain alpha) - Rat Genome Database

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Gene: Doc2a (double C2 domain alpha) Rattus norvegicus
Analyze
Symbol: Doc2a
Name: double C2 domain alpha
RGD ID: 620518
Description: Predicted to enable calcium-dependent phospholipid binding activity and metal ion binding activity. Involved in calcium-dependent activation of synaptic vesicle fusion. Located in lysosome. Is active in glutamatergic synapse. Is extrinsic component of synaptic vesicle membrane. Orthologous to human DOC2A (double C2 domain alpha); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: doc2-alpha; double C2, alpha; double C2-like domain-containing protein alpha; double C2-like domains, alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,887,306 - 190,893,057 (+)NCBIGRCr8
mRatBN7.21181,457,415 - 181,462,528 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,458,390 - 181,462,030 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,809,758 - 189,813,398 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01196,995,831 - 196,999,471 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,663,042 - 189,666,682 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01198,282,828 - 198,288,611 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,284,473 - 198,288,113 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,263,516 - 205,268,791 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,027,821 - 186,031,461 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,177,701 - 186,181,341 (+)NCBI
Celera1179,113,629 - 179,117,269 (+)NCBICelera
Cytogenetic Map1q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Doc2 alpha and Munc13-4 regulate Ca(2+) -dependent secretory lysosome exocytosis in mast cells. Higashio H, etal., J Immunol. 2008 Apr 1;180(7):4774-84.
4. Different spatiotemporal expression of DOC2 genes in the developing rat brain argues for an additional, nonsynaptic role of DOC2B in early development. Korteweg N, etal., Eur J Neurosci 2000 Jan;12(1):165-71.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Molecular cloning of mouse Doc2alpha and distribution of its mRNA in adult mouse brain. Naito A, etal., Brain Res Mol Brain Res 1997 Mar;44(2):198-204.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion. Verhage M, etal., Neuron 1997 Mar;18(3):453-61.
12. Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release. Yao J, etal., Cell. 2011 Oct 28;147(3):666-77. doi: 10.1016/j.cell.2011.09.046.
Additional References at PubMed
PMID:9804756   PMID:21521611  


Genomics

Comparative Map Data
Doc2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,887,306 - 190,893,057 (+)NCBIGRCr8
mRatBN7.21181,457,415 - 181,462,528 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,458,390 - 181,462,030 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,809,758 - 189,813,398 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01196,995,831 - 196,999,471 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,663,042 - 189,666,682 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01198,282,828 - 198,288,611 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,284,473 - 198,288,113 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,263,516 - 205,268,791 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,027,821 - 186,031,461 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,177,701 - 186,181,341 (+)NCBI
Celera1179,113,629 - 179,117,269 (+)NCBICelera
Cytogenetic Map1q36NCBI
DOC2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381630,005,514 - 30,023,228 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1630,005,514 - 30,023,270 (-)EnsemblGRCh38hg38GRCh38
GRCh371630,016,835 - 30,024,917 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361629,924,336 - 29,929,902 (-)NCBINCBI36Build 36hg18NCBI36
Build 341629,924,335 - 29,929,902NCBI
Celera1672,773,320 - 72,778,886 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1627,677,850 - 27,683,416 (-)NCBIHuRef
CHM1_11631,232,624 - 31,238,190 (-)NCBICHM1_1
T2T-CHM13v2.01630,288,154 - 30,305,880 (-)NCBIT2T-CHM13v2.0
Doc2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,446,525 - 126,451,877 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,446,588 - 126,451,877 (+)EnsemblGRCm39 Ensembl
GRCm387126,846,983 - 126,852,705 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7126,847,416 - 126,852,705 (+)EnsemblGRCm38mm10GRCm38
MGSCv377133,991,067 - 133,996,219 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367126,638,701 - 126,643,853 (+)NCBIMGSCv36mm8
Celera7126,695,691 - 126,700,843 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.25NCBI
Doc2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554936,947,512 - 6,953,835 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554936,948,089 - 6,953,835 (+)NCBIChiLan1.0ChiLan1.0
DOC2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21830,755,311 - 30,762,196 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11635,463,559 - 35,470,605 (+)NCBINHGRI_mPanPan1
PanPan1.11630,378,922 - 30,385,982 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1630,378,922 - 30,384,142 (-)Ensemblpanpan1.1panPan2
DOC2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1618,041,551 - 18,046,779 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl618,041,296 - 18,046,265 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,618,518 - 19,623,772 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0618,175,690 - 18,180,937 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl618,175,456 - 18,181,065 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1617,974,905 - 17,980,142 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0617,890,274 - 17,895,521 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0618,205,875 - 18,211,122 (-)NCBIUU_Cfam_GSD_1.0
Doc2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344124,359,243 - 124,365,997 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650112,458,482 - 12,463,199 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650112,458,537 - 12,463,857 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DOC2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl318,210,965 - 18,216,102 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1318,211,264 - 18,216,096 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DOC2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1526,649,818 - 26,656,755 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl526,651,949 - 26,656,075 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660682,876,676 - 2,883,649 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Doc2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478213,217,736 - 13,221,457 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478213,217,553 - 13,221,763 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Doc2a
15 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:47
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000027022
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1172949660181830018Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1178810256188377506Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383668Rat

Markers in Region
PMC21657P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21181,461,236 - 181,461,603 (+)MAPPERmRatBN7.2
Rnor_6.01198,287,320 - 198,287,686NCBIRnor6.0
Rnor_5.01205,267,500 - 205,267,866UniSTSRnor5.0
RGSC_v3.41186,030,668 - 186,031,034UniSTSRGSC3.4
Celera1179,116,476 - 179,116,842UniSTS
Cytogenetic Map1q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 44
Low 2 2 27 12 17 12 30 34 41 11
Below cutoff 1 29 21 20 2 20 7 9 1 7

Sequence


RefSeq Acc Id: ENSRNOT00000027022   ⟹   ENSRNOP00000027022
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1181,458,390 - 181,462,030 (+)Ensembl
Rnor_6.0 Ensembl1198,284,473 - 198,288,113 (+)Ensembl
RefSeq Acc Id: NM_022937   ⟹   NP_075226
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,888,919 - 190,892,559 (+)NCBI
mRatBN7.21181,458,390 - 181,462,030 (+)NCBI
Rnor_6.01198,284,473 - 198,288,113 (+)NCBI
Rnor_5.01205,263,516 - 205,268,791 (+)NCBI
RGSC_v3.41186,027,821 - 186,031,461 (+)RGD
Celera1179,113,629 - 179,117,269 (+)RGD
Sequence:
RefSeq Acc Id: XM_006230335   ⟹   XP_006230397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,888,042 - 190,893,057 (+)NCBI
mRatBN7.21181,457,416 - 181,462,528 (+)NCBI
Rnor_6.01198,283,489 - 198,288,611 (+)NCBI
Rnor_5.01205,263,516 - 205,268,791 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230336   ⟹   XP_006230398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,888,175 - 190,893,057 (+)NCBI
mRatBN7.21181,457,642 - 181,462,528 (+)NCBI
Rnor_6.01198,283,720 - 198,288,611 (+)NCBI
Rnor_5.01205,263,516 - 205,268,791 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230337   ⟹   XP_006230399
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,888,081 - 190,893,057 (+)NCBI
mRatBN7.21181,457,416 - 181,462,528 (+)NCBI
Rnor_6.01198,283,489 - 198,288,611 (+)NCBI
Rnor_5.01205,263,516 - 205,268,791 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230339   ⟹   XP_006230401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,888,058 - 190,893,057 (+)NCBI
mRatBN7.21181,457,415 - 181,462,528 (+)NCBI
Rnor_6.01198,283,489 - 198,288,611 (+)NCBI
Rnor_5.01205,263,516 - 205,268,791 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230340   ⟹   XP_006230402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,888,174 - 190,893,057 (+)NCBI
mRatBN7.21181,457,642 - 181,462,528 (+)NCBI
Rnor_6.01198,283,720 - 198,288,611 (+)NCBI
Rnor_5.01205,263,516 - 205,268,791 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039089802   ⟹   XP_038945730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,888,175 - 190,893,057 (+)NCBI
mRatBN7.21181,457,642 - 181,462,528 (+)NCBI
RefSeq Acc Id: XM_063272851   ⟹   XP_063128921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,887,306 - 190,893,057 (+)NCBI
RefSeq Acc Id: NP_075226   ⟸   NM_022937
- UniProtKB: P70611 (UniProtKB/Swiss-Prot),   A6I9G0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230397   ⟸   XM_006230335
- Peptide Label: isoform X1
- UniProtKB: P70611 (UniProtKB/Swiss-Prot),   A6I9G0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230399   ⟸   XM_006230337
- Peptide Label: isoform X1
- UniProtKB: P70611 (UniProtKB/Swiss-Prot),   A6I9G0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230401   ⟸   XM_006230339
- Peptide Label: isoform X1
- UniProtKB: P70611 (UniProtKB/Swiss-Prot),   A6I9G0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230398   ⟸   XM_006230336
- Peptide Label: isoform X1
- UniProtKB: P70611 (UniProtKB/Swiss-Prot),   A6I9G0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230402   ⟸   XM_006230340
- Peptide Label: isoform X1
- UniProtKB: P70611 (UniProtKB/Swiss-Prot),   A6I9G0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027022   ⟸   ENSRNOT00000027022
RefSeq Acc Id: XP_038945730   ⟸   XM_039089802
- Peptide Label: isoform X1
- UniProtKB: P70611 (UniProtKB/Swiss-Prot),   A6I9G0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128921   ⟸   XM_063272851
- Peptide Label: isoform X1
- UniProtKB: P70611 (UniProtKB/Swiss-Prot),   A6I9G0 (UniProtKB/TrEMBL)
Protein Domains
C2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70611-F1-model_v2 AlphaFold P70611 1-403 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620518 AgrOrtholog
BioCyc Gene G2FUF-57412 BioCyc
Ensembl Genes ENSRNOG00000019920 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055027222 UniProtKB/Swiss-Prot
  ENSRNOG00060031815 UniProtKB/Swiss-Prot
  ENSRNOG00065013819 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027022 ENTREZGENE
  ENSRNOT00000027022.5 UniProtKB/Swiss-Prot
  ENSRNOT00055047077 UniProtKB/Swiss-Prot
  ENSRNOT00060055117 UniProtKB/Swiss-Prot
  ENSRNOT00065022733 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Doc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rabphilin/DOC2/Noc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rabphilin_Doc2_C2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Synaptotagmin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:65031 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 65031 ENTREZGENE
PANTHER DOUBLE C2-LIKE DOMAIN-CONTAINING PROTEIN ALPHA UniProtKB/TrEMBL
  PTHR45729 UniProtKB/Swiss-Prot
  PTHR45729:SF1 UniProtKB/Swiss-Prot
  RABPHILIN, ISOFORM A UniProtKB/TrEMBL
Pfam PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Doc2a PhenoGen
PIRSF Doc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS C2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SYNAPTOTAGMN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019920 RatGTEx
  ENSRNOG00055027222 RatGTEx
  ENSRNOG00060031815 RatGTEx
  ENSRNOG00065013819 RatGTEx
SMART SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP C2 domain (Calcium/lipid-binding domain, CaLB) UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6I9G0 ENTREZGENE, UniProtKB/TrEMBL
  DOC2A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-29 Doc2a  double C2 domain alpha  Doc2a  double C2-like domains, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-17 Doc2a  double C2-like domains, alpha  Doc2a  double C2, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Doc2a  double C2, alpha    Doc2A  Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Doc2a  Doc2A      Symbol and Name status set to provisional 70820 PROVISIONAL