Gfra3 (GDNF family receptor alpha 3)

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Gene: Gfra3 (GDNF family receptor alpha 3) Rattus norvegicus

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Symbol:

Gfra3

Name:

GDNF family receptor alpha 3

RGD ID:

620502

Description:

Predicted to enable axon guidance receptor activity and glial cell-derived neurotrophic factor receptor activity. Predicted to be involved in glial cell-derived neurotrophic factor receptor signaling pathway and nervous system development. Predicted to act upstream of or within axon guidance; neuron migration; and sympathetic nervous system development. Predicted to be located in cytosol and plasma membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Biomarker of sciatic neuropathy. Orthologous to human GFRA3 (GDNF family receptor alpha 3); INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

GDNF family receptor alpha-3; GDNF-family receptor alpha 3; glial cell line derived neurotrophic factor family receptor alpha 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	26,571,952 - 26,600,225 (-)	NCBI		GRCr8
mRatBN7.2	18	26,297,828 - 26,326,105 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	26,297,829 - 26,326,105 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	26,425,209 - 26,453,481 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	27,189,072 - 27,217,348 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	26,523,972 - 26,552,248 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	27,491,860 - 27,520,133 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	27,491,845 - 27,520,295 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	27,205,217 - 27,233,490 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	27,167,576 - 27,195,848 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	27,195,323 - 27,208,736 (-)	NCBI
Celera	18	26,035,434 - 26,063,700 (-)	NCBI		Celera
Cytogenetic Map	18	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant intellectual developmental disorder 31 (ISO)

familial adenomatous polyposis 1 (ISO)

Hereditary Neoplastic Syndromes (ISO)

Neurodevelopmental Disorders (ISO)

prostate cancer (ISO)

sciatic neuropathy (IEP)

STING-associated vasculopathy with onset in infancy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (EXP,ISO)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4-dinitrotoluene (EXP)

2-methylcholine (ISO)

6-propyl-2-thiouracil (EXP)

acetylsalicylic acid (ISO)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

ammonium chloride (EXP)

amphetamine (EXP)

amphotericin B (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

bromuconazole (EXP)

Butylbenzyl phthalate (EXP)

carbamazepine (ISO)

chlorpyrifos (ISO)

cisplatin (EXP)

cyproconazole (ISO)

dibutyl phthalate (EXP)

diethyl phthalate (EXP)

diisobutyl phthalate (EXP)

diisononyl phthalate (EXP)

dorsomorphin (ISO)

endosulfan (EXP)

entinostat (ISO)

flusilazole (ISO)

furan (EXP)

gentamycin (EXP)

hydralazine (ISO)

indole-3-methanol (EXP)

Licochalcone B (ISO)

methimazole (EXP)

N-methyl-4-phenylpyridinium (EXP)

naphthalene (EXP)

nickel atom (ISO)

nitrofen (EXP)

paracetamol (ISO)

paraquat (EXP)

perfluorohexanesulfonic acid (ISO)

rotenone (EXP)

SB 431542 (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

tetrachloromethane (EXP)

thioacetamide (EXP)

Tributyltin oxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triptonide (ISO)

valproic acid (ISO)

XL147 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

axon guidance (ISO)

glial cell-derived neurotrophic factor receptor signaling pathway (ISO)

nervous system development (IBA)

neuron development (ISO)

neuron migration (ISO)

sympathetic nervous system development (ISO)

Cellular Component

cytosol (IEA,ISO)

external side of plasma membrane (IBA,ISO)

plasma membrane (ISO)

receptor complex (IBA)

Molecular Function

axon guidance receptor activity (ISO)

glial cell-derived neurotrophic factor receptor activity (ISO)

protein binding (ISO)

signaling receptor activity (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Expression of glial cell line-derived neurotrophic factor family of growth factors in peripheral nerve injury in rats.	Hoke A, etal., Neuroreport. 2000 Jun 5;11(8):1651-4.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	Online Mendelian Inheritance in Man, OMIM (TM).	Online Mendelian Inheritance in Man, OMIM (TM).
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Expression of the GDNF family members and their receptors in the mature rat cochlea.	Stover T, etal., Brain Res Mol Brain Res 2000 Mar 10;76(1):25-35.

Additional References at PubMed

PMID:9452475	PMID:10482239	PMID:12160745	PMID:12477932	PMID:16773224	PMID:18085594	PMID:23603259

Genomics

Comparative Map Data

Gfra3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	26,571,952 - 26,600,225 (-)	NCBI		GRCr8
mRatBN7.2	18	26,297,828 - 26,326,105 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	26,297,829 - 26,326,105 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	26,425,209 - 26,453,481 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	27,189,072 - 27,217,348 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	26,523,972 - 26,552,248 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	27,491,860 - 27,520,133 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	27,491,845 - 27,520,295 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	27,205,217 - 27,233,490 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	27,167,576 - 27,195,848 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	27,195,323 - 27,208,736 (-)	NCBI
Celera	18	26,035,434 - 26,063,700 (-)	NCBI		Celera
Cytogenetic Map	18	p12	NCBI

GFRA3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	138,252,380 - 138,274,621 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	138,252,380 - 138,274,621 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	137,588,069 - 137,610,310 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	137,615,968 - 137,638,152 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	137,615,969 - 137,638,152	NCBI
Celera	5	133,709,300 - 133,731,054 (-)	NCBI		Celera
Cytogenetic Map	5	q31.2	NCBI
HuRef	5	132,779,039 - 132,801,225 (-)	NCBI		HuRef
CHM1_1	5	137,020,644 - 137,042,862 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	138,778,613 - 138,800,853 (-)	NCBI		T2T-CHM13v2.0

Gfra3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	34,822,951 - 34,853,440 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	34,822,951 - 34,853,440 (-)	Ensembl		GRCm39 Ensembl
GRCm38	18	34,689,898 - 34,720,387 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	34,689,898 - 34,720,387 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	34,849,557 - 34,880,041 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	34,814,720 - 34,845,131 (-)	NCBI		MGSCv36	mm8
Celera	18	35,142,994 - 35,173,839 (-)	NCBI		Celera
Cytogenetic Map	18	B1	NCBI
cM Map	18	18.69	NCBI

Gfra3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955418	2,143,169 - 2,163,286 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955418	2,152,887 - 2,162,883 (+)	NCBI	ChiLan1.0	ChiLan1.0

GFRA3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	133,524,342 - 133,547,975 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	131,663,952 - 131,687,529 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	133,630,274 - 133,652,525 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	139,762,690 - 139,784,942 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	139,762,690 - 139,784,942 (-)	Ensembl	panpan1.1		panPan2

GFRA3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	25,881,523 - 25,897,863 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	25,882,099 - 25,897,817 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	24,652,055 - 24,667,781 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	26,738,265 - 26,754,257 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	26,690,528 - 26,754,264 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	25,445,543 - 25,461,486 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	25,268,312 - 25,284,034 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	25,932,678 - 25,948,643 (-)	NCBI		UU_Cfam_GSD_1.0

Gfra3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	154,146,854 - 154,167,704 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936531	7,444,147 - 7,464,523 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936531	7,443,842 - 7,457,518 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GFRA3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	140,263,301 - 140,283,040 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	140,263,297 - 140,283,227 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	145,962,140 - 145,982,527 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GFRA3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	40,927,283 - 40,948,591 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	40,927,289 - 40,946,023 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	36,940,183 - 36,964,179 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gfra3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624743	31,074,302 - 31,096,301 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624743	31,079,591 - 31,095,595 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Gfra3
98 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	88
Count of miRNA genes:	79
Interacting mature miRNAs:	82
Transcripts:	ENSRNOT00000027544
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2301410	Bp317	Blood pressure QTL 317		0.004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	11944273	26548295	Rat
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	24796977	79788953	Rat
1358358	Sradr6	Stress Responsive Adrenal Weight QTL 6	2.49		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	18	11944299	59330563	Rat
1331735	Rf44	Renal function QTL 44	2.981		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	18	18234564	31359530	Rat
61382	Bp46	Blood pressure QTL 46	18.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11941791	31393320	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	21372893	83213037	Rat
61388	Bp2	Blood pressure QTL 2	3.23		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	1	35374722	Rat
6903359	Bp355	Blood pressure QTL 355	3.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944544	59796478	Rat
2313082	Bss85	Bone structure and strength QTL 85	0.8	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	18	14951337	59951337	Rat
1641923	Colcr8	Colorectal carcinoma resistance QTL 8	3.1	0.0014	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	22066242	52293055	Rat
2312568	Glom21	Glomerulus QTL 21	2	0.005	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	5185858	40503530	Rat
1331766	Bp236	Blood pressure QTL 236	3.022		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	11944299	31359530	Rat
1358193	Emca2	Estrogen-induced mammary cancer QTL 2	1.6		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	18	18007599	63571040	Rat
631264	Scl22	Serum cholesterol level QTL 22	6.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	18	11941791	31393320	Rat
1331775	Bp235	Blood pressure QTL 235	3.201		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	18234564	31359530	Rat
12904680	Bw189	Body weight QTL 189		0.019	body mass (VT:0001259)	body weight (CMO:0000012)	18	11944273	26548295	Rat
2325839	Bp348	Blood pressure QTL 348		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	25570985	70570985	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19278901	83218561	Rat
2293708	Bss46	Bone structure and strength QTL 46	8.8	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	18	11791518	63636873	Rat
12904693	Am20	Aortic mass QTL 20		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	11944273	26548295	Rat
9589153	Insul31	Insulin level QTL 31	7.15	0.05	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	18	1	42547119	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	11791518	83218561	Rat
12904695	Kidm73	Kidney mass QTL 73		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	11944273	26548295	Rat
2312598	Bp340	Blood pressure QTL 340		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	1	30558703	Rat
12904689	Cm128	Cardiac mass QTL 128		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	11944273	26548295	Rat
12904690	Cm129	Cardiac mass QTL 129		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	11944273	26548295	Rat
2300180	Bmd67	Bone mineral density QTL 67	4.8	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	18	1	34291613	Rat
12904691	Cm130	Cardiac mass QTL 130		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	11944273	26548295	Rat
2299160	Iddm35	Insulin dependent diabetes mellitus QTL 35	2.79		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	18	4207941	60377792	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	11791518	83218561	Rat
1331753	Bp231	Blood pressure QTL 231	3.643		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944299	52293055	Rat
2293661	Bss50	Bone structure and strength QTL 50	4.64	0.0003	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	18	1	34291613	Rat
61375	Bp41	Blood pressure QTL 41	2.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	18	11944299	41122201	Rat

Markers in Region

D18Got34

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	26,321,009 - 26,321,184 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	27,515,040 - 27,515,214	NCBI	Rnor6.0
Rnor_5.0	18	27,228,397 - 27,228,571	UniSTS	Rnor5.0
RGSC_v3.4	18	27,190,755 - 27,190,929	RGD	RGSC3.4
RGSC_v3.4	18	27,190,755 - 27,190,929	UniSTS	RGSC3.4
RGSC_v3.1	18	27,217,401 - 27,217,575	RGD
Celera	18	26,058,613 - 26,058,785	UniSTS
RH 3.4 Map	18	368.1	RGD
RH 3.4 Map	18	368.1	UniSTS
RH 2.0 Map	18	544.5	RGD
Cytogenetic Map	18	p12	UniSTS

RH128908

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	26,298,050 - 26,298,244 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	27,492,083 - 27,492,276	NCBI	Rnor6.0
Rnor_5.0	18	27,205,440 - 27,205,633	UniSTS	Rnor5.0
RGSC_v3.4	18	27,167,799 - 27,167,992	UniSTS	RGSC3.4
Celera	18	26,035,657 - 26,035,850	UniSTS
Cytogenetic Map	18	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	107	91	90	59	25	59	6	217	96	87	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053398	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF184920	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC079378	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000027544 ⟹ ENSRNOP00000027544

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	26,297,829 - 26,319,289 (-)	Ensembl
Rnor_6.0 Ensembl	18	27,491,845 - 27,520,295 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000114917 ⟹ ENSRNOP00000087494

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	26,297,829 - 26,326,105 (-)	Ensembl

RefSeq Acc Id:

NM_053398 ⟹ NP_445850

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	26,571,952 - 26,600,225 (-)	NCBI
mRatBN7.2	18	26,297,828 - 26,326,105 (-)	NCBI
Rnor_6.0	18	27,491,860 - 27,520,133 (-)	NCBI
Rnor_5.0	18	27,205,217 - 27,233,490 (-)	NCBI
RGSC_v3.4	18	27,167,576 - 27,195,848 (-)	RGD
Celera	18	26,035,434 - 26,063,700 (-)	RGD

Sequence:

show sequence

GCCGCGACGCCCAGCACAGGCAGAGCGCTGCCGGGTCCGCGGCGTCCAGACCCGCCATGGGGCT
CTCCCGGAGCCCGCGACCGCCGCCGCTAGTGATCCTGCTACTGGTGCTGTCGCTGTGGCTACCC
CTTGGAACAGGAAACTCCCTTCCCACAGAGAACAGGCTTGTGAACAGCTGTACCCAGGCCAGAA
AAAAATGCGAGGCTAATCCCGCTTGCAAGGCTGCCTACCAGCACCTGGACTCCTGCACCCCCAG
TCTCAGCAGTCCACTGCCCTCAGGGGAGTCTGCCACATCTGCAGCGTGCCTTGAAGCAGCACAG
CAACTCAGGAACAGCTCTCTCATAGACTGCAGGTGCCACCGGCGCATGAAGCACCAAGCTACCT
GTCTGGACATTTATTGGACCGTTCACCCTGTCCGAAGCCTTGGTGACTACGAGTTGGACGTCTC
ACCCTATGAAGACACAGTGACCAGCAAACCCTGGAAAATGAATCTCAGCAAGCTGAGCATGCTC
AAACCAGACTCCGACCTCTGCCTCAAATTTGCTATGCTGTGTACTCTTAACGACAAGTGCGACC
GCCTCCGAAAGGCCTACGGGGAGGCGTGCTCAGGGATCCGCTGCCAGCGCCACCTCTGCCTAGC
TCAGCTGCGCTCCTTCTTCGAGAAGGCGGCAGAGTCCCACGCTCAGGGCCTGCTGCTGTGTCCC
TGTGCACCCGAAGATGCGGGCTGTGGGGAGCGCCGGCGCAACACCATCGCCCCCAGTTGCGCCC
TCCCGTCTGTGGCCCCCAACTGCCTAGATCTTCGGAGCTTCTGCCGTGCGGACCCTCTGTGCAG
ATCACGCCTGATGGACTTCCAGACCCACTGCCACCCTATGGACATCCTCGGGACTTGTGCAACT
GAGCAGTCCAGATGTCTGCGGGCATACCTGGGGCTAATTGGGACTGCCATGACCCCAAACTTCA
TCAGCAAGGTCAACACTACTGTTGCCTTAGGCTGTACCTGCCGAGGCAGTGGCAACCTGCAGGA
CGAGTGTGAACAGCTGGAAAAGTCCTTCTCCCAGAACCCCTGCCTCATGGAGGCCATTGCGGCT
AAAATGCGTTTCCACAGACAACTCTTCTCCCAGGACTGGGCGGACTCTACTTTTTCTGTGATGC
AGCAGCAGAACAGCAGCCCTGCTCTGAGGCCCCAGCTCAGGCTACCCGTTCTGTCTTTCTTCAT
CCTTACCTTGATTCTGCTGCAGACCCTCTGGTAACTGGGCTCCCTCAGGGTCCTTTGTCCTCTC
CACCACACCCAGACCGACTTGCAGCCTGTGATGGGAGAGAAAATGCTGGCCTCTGGAAGAAGAT
GCAACCAGGCTCACTGCACATCCTGTCTGCTCCAGATGAGGTCTTGGAAGAAGCGAGGGCTGTG
ACCGTTCAGAATCCTGAGCGGCCAGCTTTCAAACCTCTCCTACTTACTCCTGCTTGGGCTGCTC
CTCCCTAGGACCTTGTACTCCAGTTTGGCTGTATATTGTGGTGGTGATTAGCTTCCCACCTCCA
GCCCTTCTTCCTGTTTCCCAGGACCACCCAGGGCTAATGACTCACTCATTCCTGGTTGCCTTCT
CCAGGAAGGCAGGCTGAGGGTTCTGAGGCAGCTGAGAAAGATGGTCCCTTTGTGAGGAAGGCTG
GTGGTCCAACCCCACGTCCTTCTGAATGGAAGGTGAAGACCTCCTGTCATGTCTGCCAGGCCAT
CCTGAACACTTGGGCAAGAAGAGCTAAAAGCCTTTGAGTCTTGCTTAACTCCTAGCACTGTCTC
CATGTCCCCCAGTCCCTCAGGTCATGATTAAACATTTTGACTTAAGACTTTGGTCTTTACCCAT
TTCCTTAAATGGTAAGTTTTTACAGAAGTAGTGGTATGTTACAGATACAAGGGGACTAACCGGG
TGAGGAAGAGACCCAGTAACCCTACTGCTAAGTGCTGTGTGACTTCAGGCAAATCTCTCGCCTC
TCTTGTCAGAGCTGGAAGAATAGTAAAAATAAAAGATGGTGTTTGTCCCAGTTCTAAGTGAAAA
AAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_445850	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF01242	(Get FASTA)	NCBI Sequence Viewer
	AAH79378	(Get FASTA)	NCBI Sequence Viewer
	EDL76239	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000027544.4
	ENSRNOP00000087494.1

RefSeq Acc Id:	NP_445850 ⟸ NM_053398
- Peptide Label:	precursor
- UniProtKB:	Q6AXR3 (UniProtKB/TrEMBL), F7F1M3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGLSRSPRPPPLVILLLVLSLWLPLGTGNSLPTENRLVNSCTQARKKCEANPACKAAYQHLDSC TPSLSSPLPSGESATSAACLEAAQQLRNSSLIDCRCHRRMKHQATCLDIYWTVHPVRSLGDYEL DVSPYEDTVTSKPWKMNLSKLSMLKPDSDLCLKFAMLCTLNDKCDRLRKAYGEACSGIRCQRHL CLAQLRSFFEKAAESHAQGLLLCPCAPEDAGCGERRRNTIAPSCALPSVAPNCLDLRSFCRADP LCRSRLMDFQTHCHPMDILGTCATEQSRCLRAYLGLIGTAMTPNFISKVNTTVALGCTCRGSGN LQDECEQLEKSFSQNPCLMEAIAAKMRFHRQLFSQDWADSTFSVMQQQNSSPALRPQLRLPVLS FFILTLILLQTLW hide sequence

Ensembl Acc Id:

ENSRNOP00000027544 ⟸ ENSRNOT00000027544

Ensembl Acc Id:

ENSRNOP00000087494 ⟸ ENSRNOT00000114917

Protein Domains

GDNF/GAS1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6AXR3-F1-model_v2	AlphaFold	Q6AXR3	1-397	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700699

Promoter ID:

EPDNEW_R11222

Type:

single initiation site

Name:

Gfra3_1

Description:

GDNF family receptor alpha 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	18	27,520,296 - 27,520,356	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620502	AgrOrtholog
BioCyc Gene	G2FUF-7950	BioCyc
Ensembl Genes	ENSRNOG00000020309	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000027544.6	UniProtKB/TrEMBL
	ENSRNOT00000114917.1	UniProtKB/TrEMBL
Gene3D-CATH	GDNF binding domain	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7110848	IMAGE-MGC_LOAD
InterPro	GDNF/GAS1	UniProtKB/TrEMBL
	GDNF_alpha	UniProtKB/TrEMBL
	GDNF_rcpt	UniProtKB/TrEMBL
	GDNF_rcpt_A3	UniProtKB/TrEMBL
KEGG Report	rno:84422	UniProtKB/TrEMBL
MGC_CLONE	MGC:94884	IMAGE-MGC_LOAD
NCBI Gene	84422	ENTREZGENE
PANTHER	GDNF FAMILY RECEPTOR ALPHA-3	UniProtKB/TrEMBL
	PTHR10269	UniProtKB/TrEMBL
Pfam	GDNF	UniProtKB/TrEMBL
PhenoGen	Gfra3	PhenoGen
PRINTS	GDNFRALPHA3	UniProtKB/TrEMBL
	GDNFRECEPTOR	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000020309	RatGTEx
SMART	GDNF	UniProtKB/TrEMBL
Superfamily-SCOP	SSF110035	UniProtKB/TrEMBL
UniProt	A6J2V7_RAT	UniProtKB/TrEMBL
	F7F1M3	ENTREZGENE, UniProtKB/TrEMBL
	Q6AXR3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-10-17	Gfra3	GDNF family receptor alpha 3	Gfra3	glial cell line derived neurotrophic factor family receptor alpha 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Gfra3	glial cell line derived neurotrophic factor family receptor alpha 3		GDNF-family receptor alpha 3	Name updated	1299863	APPROVED
2002-08-07	Gfra3	GDNF-family receptor alpha 3			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in the cochlea and substantia nigra	631959
gene_product	member of the GDNF family which is a subgroup of TGF-beta superfamily of growth factors	631959

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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