Erbb4 (erb-b2 receptor tyrosine kinase 4) - Rat Genome Database

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Gene: Erbb4 (erb-b2 receptor tyrosine kinase 4) Rattus norvegicus
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Symbol: Erbb4
Name: erb-b2 receptor tyrosine kinase 4
RGD ID: 620486
Description: Enables neuregulin receptor activity. Involved in several processes, including cellular response to L-glutamate; modulation of chemical synaptic transmission; and nervous system development. Located in several cellular components, including caveola; postsynaptic density; and postsynaptic membrane. Is active in plasma membrane. Used to study visual epilepsy. Biomarker of several diseases, including amblyopia; bipolar disorder; interstitial cystitis; median neuropathy; and radiculopathy. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 19; colorectal cancer; esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human ERBB4 (erb-b2 receptor tyrosine kinase 4); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; calcium/calcium-mediated signaling pathway; endocytosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: c-erbB-4; proto-oncogene-like protein c-ErbB-4; receptor tyrosine kinase; receptor tyrosine-protein kinase erbB-4; v-erb-a erythroblastic leukemia viral oncogene homolog 4; v-erb-b2 avian erythroblastic leukemia viral oncogene 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Erbb4Tn(sb-T2/Bart3)2.208Mcwi  
Genetic Models: F344-Erbb4Tn(sb-T2/Bart3)2.208Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8976,973,386 - 78,045,633 (-)NCBIGRCr8
mRatBN7.2969,523,733 - 70,596,743 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl969,531,481 - 70,596,595 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx978,025,868 - 79,086,390 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0983,154,766 - 84,215,249 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0981,560,145 - 82,620,859 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0975,021,790 - 76,178,936 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl975,021,790 - 75,528,644 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0974,804,287 - 75,310,350 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4966,843,898 - 67,967,970 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1966,990,879 - 68,114,952 (-)NCBI
Celera967,006,553 - 68,064,842 (-)NCBICelera
Cytogenetic Map9q32-q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
amblyopia  (IEP)
amyotrophic lateral sclerosis  (ISO)
amyotrophic lateral sclerosis type 10  (ISO)
amyotrophic lateral sclerosis type 19  (ISO)
atrial fibrillation  (ISO)
bipolar disorder  (IEP)
Breast Neoplasms  (ISO)
cervical cancer  (ISO)
colorectal cancer  (ISO)
congestive heart failure  (IEP)
Diabetic Cardiomyopathies  (IEP)
ductal carcinoma in situ  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
epilepsy  (IEP)
esophagus squamous cell carcinoma  (ISO)
Experimental Mammary Neoplasms  (ISO)
frontotemporal dementia  (ISO)
Gallbladder Neoplasms  (ISO)
genetic disease  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (ISO)
Hyperalgesia  (IEP)
interstitial cystitis  (IEP)
laryngeal squamous cell carcinoma  (ISO)
lung adenocarcinoma  (ISO)
Lymphatic Metastasis  (ISO)
median neuropathy  (IEP)
melanoma  (ISO)
myocardial infarction  (IEP)
NATURAL KILLER CELL ENTEROPATHY  (ISO)
Neointima  (IEP)
Neoplasm Metastasis  (ISO)
Neurodevelopmental Disorders  (ISO)
oral squamous cell carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
peripheral nervous system disease  (ISO)
Phyllodes Tumor  (ISO)
prostate cancer  (ISO)
radiculopathy  (IEP)
renal cell carcinoma  (ISO)
schizophrenia  (IEP,ISO)
Skin Neoplasms  (ISO)
stomach carcinoma  (ISO)
stress-related disorder  (IEP)
Stroke  (IEP)
Subarachnoid Hemorrhage  (ISO)
teratoma  (ISO)
tongue squamous cell carcinoma  (ISO)
transitional cell carcinoma  (ISO)
trichorhinophalangeal syndrome type I  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
visual epilepsy  (IDA,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
1,4-dioxane  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
26-hydroxycholesterol  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (EXP)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
androgen antagonist  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
batimastat  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
clozapine  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclophosphamide  (ISO)
DDE  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
doxorubicin  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (ISO)
etoposide  (ISO)
GW 4064  (ISO)
haloperidol  (EXP)
ibuprofen  (ISO)
irinotecan  (ISO)
ketamine  (ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
malathion  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
miconazole  (EXP,ISO)
mifepristone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenylarsine oxide  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
ponatinib  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
progesterone  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
raloxifene  (ISO)
resveratrol  (ISO)
risperidone  (EXP)
sodium arsenite  (ISO)
succimer  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
tyrphostin AG 1478  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cardiac muscle tissue regeneration  (IEA,ISO,ISS)
cell fate commitment  (IEA,ISO)
cell migration  (ISO,ISS)
cell surface receptor protein tyrosine kinase signaling pathway  (ISO,ISS,TAS)
cell surface receptor signaling pathway  (ISO)
cell surface receptor signaling pathway via JAK-STAT  (IEA,ISO)
cellular response to acetylcholine  (IEP)
cellular response to epidermal growth factor stimulus  (IEA,ISO)
cellular response to L-glutamate  (IEP)
cellular response to mechanical stimulus  (IEP)
central nervous system morphogenesis  (IEA,ISO,ISS)
embryonic pattern specification  (IEA,ISO,ISS)
epidermal growth factor receptor signaling pathway  (IEA)
ERBB signaling pathway  (IEA)
ERBB2-ERBB4 signaling pathway  (IEA,ISO)
ERBB4 signaling pathway  (IDA,ISO)
ERBB4-ERBB4 signaling pathway  (IEA,ISO)
establishment of planar polarity involved in nephron morphogenesis  (IEA,ISO)
female pregnancy  (IEP)
heart development  (IEA,ISO,ISS)
lactation  (IEA,ISO,ISS)
mammary gland alveolus development  (IEA,ISO,ISS)
mammary gland development  (IEP)
mammary gland epithelial cell differentiation  (IEA,ISO,ISS)
mitochondrial fragmentation involved in apoptotic process  (IEA,ISO,ISS)
modulation of excitatory postsynaptic potential  (IMP)
multicellular organismal response to stress  (IEP)
negative regulation of apoptotic process  (IBA,ISO,ISS)
negative regulation of cell population proliferation  (IEA,ISO,ISS)
negative regulation of muscle cell apoptotic process  (IMP)
negative regulation of neuron migration  (IEA)
nervous system development  (IEA,ISO,ISS)
neural crest cell migration  (IEA,ISO,ISS)
neurogenesis  (IBA)
neurotransmitter receptor localization to postsynaptic specialization membrane  (IEA,ISO)
olfactory bulb interneuron differentiation  (IEA,ISO,ISS)
peptidyl-tyrosine phosphorylation  (IEA,ISO,ISS)
positive regulation of cardiac muscle cell proliferation  (IEA,ISO,ISS)
positive regulation of cell migration  (IMP)
positive regulation of cell population proliferation  (IBA,ISO,ISS)
positive regulation of D-glucose import  (IMP)
positive regulation of dendritic spine maintenance  (IMP)
positive regulation of DNA-templated transcription  (IEA,ISO,ISS)
positive regulation of epithelial cell proliferation  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO,ISS)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of phospholipid biosynthetic process  (IMP)
positive regulation of protein localization to cell surface  (IEA,ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (IEA,ISO,ISS)
positive regulation of synaptic transmission, GABAergic  (IMP)
positive regulation of tyrosine phosphorylation of STAT protein  (IEA,ISO,ISS)
protein autophosphorylation  (IEA,ISO,ISS)
protein phosphorylation  (IEA)
regulation of cell communication  (IEA)
regulation of cell migration  (ISO,ISS)
regulation of cell population proliferation  (IEA)
regulation of signaling  (IEA)
response to dexamethasone  (IEP)
response to hydrogen peroxide  (IEP)
response to muscle activity  (IEP)
response to nutrient levels  (IEP)
response to progesterone  (IEP)
response to stress  (IEP)
response to vitamin D  (IEP)
response to xenobiotic stimulus  (IEP)
signal transduction  (ISO)
surfactant homeostasis  (IMP)
synapse assembly  (IEA,ISO)
synapse maturation  (IMP)
telencephalon development  (IEP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Gene expression profiling of ERBB receptors and ligands in human transitional cell carcinoma of the bladder. Amsellem-Ouazana D, etal., J Urol. 2006 Mar;175(3 Pt 1):1127-32.
2. ErbB receptors modulation in different types of peripheral nerve regeneration. Audisio C, etal., Neuroreport. 2008 Oct 29;19(16):1605-9. doi: 10.1097/WNR.0b013e32831313ef.
3. Absence of HER4 expression predicts recurrence of ductal carcinoma in situ of the breast. Barnes NL, etal., Clin Cancer Res. 2005 Mar 15;11(6):2163-8.
4. Prognostic implications of altered human epidermal growth factor receptors (HERs) in gastric carcinomas: HER2 and HER3 are predictors of poor outcome. Begnami MD, etal., J Clin Oncol. 2011 Aug 1;29(22):3030-6. doi: 10.1200/JCO.2010.33.6313. Epub 2011 Jun 27.
5. Nuclear and cytoplasmic expression of ErbB-4 in prostate cancer. Ben-Yosef R, etal., Int J Biol Markers. 2007 Jul-Sep;22(3):181-5.
6. Immunohistochemical expression patterns of the HER4 receptors in normal mucosa and in laryngeal squamous cell carcinomas: antioncogenic significance of the HER4 protein in laryngeal squamous cell carcinoma. Bussu F, etal., Laryngoscope. 2012 Aug;122(8):1724-33. doi: 10.1002/lary.23311. Epub 2012 May 1.
7. Exercise training activates neuregulin 1/ErbB signaling and promotes cardiac repair in a rat myocardial infarction model. Cai MX, etal., Life Sci. 2016 Mar 15;149:1-9. doi: 10.1016/j.lfs.2016.02.055. Epub 2016 Feb 15.
8. Neuregulins mediate calcium-induced glucose transport during muscle contraction. Canto C, etal., J Biol Chem. 2006 Aug 4;281(31):21690-7. Epub 2006 Jun 1.
9. Expression of neuregulins and their putative receptors, ErbB2 and ErbB3, is induced during Wallerian degeneration. Carroll SL, etal., J Neurosci 1997 Mar 1;17(5):1642-59.
10. EGFR-activating mutations, DNA copy number abundance of ErbB family, and prognosis in lung adenocarcinoma. Chen HY, etal., Oncotarget. 2016 Feb 23;7(8):9017-25. doi: 10.18632/oncotarget.7029.
11. Neuregulin-1-ErbB signaling promotes microglia activation contributing to mechanical allodynia of cyclophosphamide-induced cystitis. Chen JL, etal., Neurourol Urodyn. 2019 Jun;38(5):1250-1260. doi: 10.1002/nau.24005. Epub 2019 Apr 15.
12. Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss. Chen S, etal., Nat Neurosci 2003 Nov;6(11):1186-93. Epub 2003 Oct 12.
13. Cervical small cell neuroendocrine tumor mutation profiles via whole exome sequencing. Cho SY, etal., Oncotarget. 2017 Jan 31;8(5):8095-8104. doi: 10.18632/oncotarget.14098.
14. Neuregulin-1 attenuates neointimal formation following vascular injury and inhibits the proliferation of vascular smooth muscle cells. Clement CM, etal., J Vasc Res. 2007;44(4):303-12. Epub 2007 Apr 16.
15. Protein levels and gene expressions of the epidermal growth factor receptors, HER1, HER2, HER3 and HER4 in benign and malignant ovarian tumors. Dahl Steffensen K, etal., Int J Oncol. 2008 Jul;33(1):195-204.
16. Chronic administration of calcitriol enhanced neuregulin-1/ErbB signaling in rat myocardium. Dang R, etal., Pharmazie. 2016 Apr;71(4):192-5.
17. Chronic stress and excessive glucocorticoid exposure both lead to altered Neuregulin-1/ErbB signaling in rat myocardium. Dang R, etal., Steroids. 2016 Aug;112:47-53. doi: 10.1016/j.steroids.2016.04.011. Epub 2016 Apr 29.
18. Changes in ErbB2 (her-2/neu), ErbB3, and ErbB4 during growth, differentiation, and apoptosis of normal rat mammary epithelial cells. Darcy KM, etal., J Histochem Cytochem. 2000 Jan;48(1):63-80.
19. Expression of ErbB-3 and ErbB-4 protooncogene proteins in oral squamous cell carcinoma: a pilot study. de Vicente JC, etal., Med Oral. 2003 Nov-Dec;8(5):374-81.
20. HER family receptors expression in squamous cell carcinoma of the tongue: study of the possible prognostic and biological significance. Del Sordo R, etal., J Oral Pathol Med. 2010 Jan;39(1):79-86. doi: 10.1111/j.1600-0714.2009.00815.x. Epub 2009 Aug 18.
21. [A study on the expression of erbB4/HER4 in non-small cell lung cancer]. Deng Z, etal., Zhongguo Fei Ai Za Zhi. 2002 Jun 20;5(3):177-9. doi: 10.3779/j.issn.1009-3419.2002.03.06.
22. Identification of nucleolin as new ErbB receptors- interacting protein. Di Segni A, etal., PLoS One. 2008 Jun 4;3(6):e2310. doi: 10.1371/journal.pone.0002310.
23. Neuron-to-glia signaling mediated by excitatory amino acid receptors regulates ErbB receptor function in astroglial cells of the neuroendocrine brain. Dziedzic B, etal., J Neurosci 2003 Feb 1;23(3):915-26.
24. Neuregulin 1 growth factors regulate proliferation but not apoptosis of a CNS neuronal progenitor cell line. Edwards JM and Bottenstein JE, Brain Res. 2006 Sep 7;1108(1):63-75. doi: 10.1016/j.brainres.2006.06.025. Epub 2006 Jul 21.
25. Expression of the epidermal growth factor system in endometrioid endometrial cancer. Ejskjaer K, etal., Gynecol Oncol. 2007 Jan;104(1):158-67. Epub 2006 Sep 7.
26. Exercise training and return to a well-balanced diet activate the neuregulin 1/ErbB pathway in skeletal muscle of obese rats. Ennequin G, etal., J Physiol. 2015 Jun 15;593(12):2665-77. doi: 10.1113/JP270026. Epub 2015 May 14.
27. Expressions of neuregulin 1beta and ErbB4 in prefrontal cortex and hippocampus of a rat schizophrenia model induced by chronic MK-801 administration. Feng Y, etal., J Biomed Biotechnol. 2010;2010:859516. doi: 10.1155/2010/859516. Epub 2010 May 4.
28. Regulation of ErbB4 phosphorylation and cleavage by a novel histidine acid phosphatase. Fleisig H, etal., Neuroscience. 2004;127(1):91-100. doi: 10.1016/j.neuroscience.2004.04.060.
29. Expression of ErbB3, ErbB4, and neuregulin-1 mRNA during tooth development. Fried K, etal., Dev Dyn 2002 Jul;224(3):356-60.
30. The prognostic significance of human epidermal growth factor receptor correlations in squamous cell cervical carcinoma. Fuchs I, etal., Anticancer Res. 2007 Mar-Apr;27(2):959-63.
31. Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt. Fukazawa R, etal., J Mol Cell Cardiol. 2003 Dec;35(12):1473-9.
32. ErbB4 expression in neural progenitor cells (ST14A) is necessary to mediate neuregulin-1beta1-induced migration. Gambarotta G, etal., J Biol Chem. 2004 Nov 19;279(47):48808-16. Epub 2004 Sep 8.
33. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
34. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
35. Neuregulin-1/ErbB signaling is impaired in the rat model of diabetic cardiomyopathy. Gui C, etal., Cardiovasc Pathol. 2012 Sep-Oct;21(5):414-20. doi: 10.1016/j.carpath.2011.12.006. Epub 2012 Jan 28.
36. A novel brain-derived member of the epidermal growth factor family that interacts with ErbB3 and ErbB4. Higashiyama S, etal., J Biochem (Tokyo) 1997 Sep;122(3):675-80.
37. Glutamate-dependent ectodomain shedding of neuregulin-1 type II precursors in rat forebrain neurons. Iwakura Y, etal., PLoS One. 2017 Mar 28;12(3):e0174780. doi: 10.1371/journal.pone.0174780. eCollection 2017.
38. Identification of patients with transitional cell carcinoma of the bladder overexpressing ErbB2, ErbB3, or specific ErbB4 isoforms: real-time reverse transcription-PCR analysis in estimation of ErbB receptor status from cancer patients. Junttila TT, etal., Clin Cancer Res. 2003 Nov 1;9(14):5346-57.
39. Expression of the HER family mRNA in breast cancer tissue and association with cell cycle inhibitors p21(waf1) and p27(kip1). Kalemi TG, etal., Anticancer Res. 2007 Mar-Apr;27(2):913-20.
40. Distinctive expression pattern of ErbB family receptors signifies an aggressive variant of bladder cancer. Kassouf W, etal., J Urol. 2008 Jan;179(1):353-8. Epub 2007 Nov 19.
41. Prognostic significance of HER3 and HER4 protein expression in colorectal adenocarcinomas. Kountourakis P, etal., BMC Cancer. 2006 Feb 28;6:46. doi: 10.1186/1471-2407-6-46.
42. ErbB4-neuregulin signaling modulates synapse development and dendritic arborization through distinct mechanisms. Krivosheya D, etal., J Biol Chem. 2008 Nov 21;283(47):32944-56. doi: 10.1074/jbc.M800073200. Epub 2008 Sep 26.
43. Cardiac endothelial cells regulate reactive oxygen species-induced cardiomyocyte apoptosis through neuregulin-1beta/erbB4 signaling. Kuramochi Y, etal., J Biol Chem. 2004 Dec 3;279(49):51141-7. Epub 2004 Sep 21.
44. Neuregulin 1 is a pronociceptive cytokine that is regulated by progesterone in the spinal cord: implications for sex specific pain modulation. Lacroix-Fralish ML, etal., Eur J Pain. 2008 Jan;12(1):94-103. Epub 2007 Apr 24.
45. Sex differences in lumbar spinal cord gene expression following experimental lumbar radiculopathy. LaCroix-Fralish ML, etal., J Mol Neurosci. 2006;30(3):283-95.
46. Regulation of neuregulin/ErbB signaling by contractile activity in skeletal muscle. Lebrasseur NK, etal., Am J Physiol Cell Physiol. 2003 May;284(5):C1149-55. Epub 2003 Jan 2.
47. Activation of the neuregulin/ErbB system during physiological ventricular remodeling in pregnancy. Lemmens K, etal., Am J Physiol Heart Circ Physiol. 2011 Mar;300(3):H931-42. doi: 10.1152/ajpheart.00385.2010. Epub 2010 Dec 24.
48. The neuregulin-1 receptor erbB4 controls glutamatergic synapse maturation and plasticity. Li B, etal., Neuron. 2007 May 24;54(4):583-97.
49. Neuregulin 1 Attenuates Neuronal Apoptosis Induced by Deep Hypothermic Circulatory Arrest Through ErbB4 Signaling in Rats. Li P, etal., J Cardiovasc Pharmacol. 2015 Dec;66(6):551-7. doi: 10.1097/FJC.0000000000000303.
50. The ErbB4 receptor in fetal rat lung fibroblasts and epithelial type II cells. Liu W, etal., Biochim Biophys Acta. 2007 Jul;1772(7):737-47. Epub 2007 May 5.
51. ErbB4 regulates surfactant synthesis and proliferation in adult rat pulmonary epithelial cells. Liu W, etal., Exp Lung Res. 2009 Feb;35(1):29-47. doi: 10.1080/01902140802395757.
52. Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts. Ma L, etal., J Neurosci. 2003 Apr 15;23(8):3164-75.
53. Prognostic significance of serum ERBB3 and ERBB4 mRNA in lung adenocarcinoma patients. Masroor M, etal., Tumour Biol. 2016 Jan;37(1):857-63. doi: 10.1007/s13277-015-3859-3. Epub 2015 Aug 9.
54. Gene-specific inhibition of breast carcinoma in BALB-neuT mice by active immunization with rat Neu or human ErbB receptors. Masuelli L, etal., Int J Oncol. 2007 Feb;30(2):381-92.
55. The relation between survival and expression of HER1 and HER2 depends on the expression of HER3 and HER4: a study in bladder cancer patients. Memon AA, etal., Br J Cancer. 2006 Jun 5;94(11):1703-9.
56. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
57. Neuregulins and cancer. Montero JC, etal., Clin Cancer Res. 2008 Jun 1;14(11):3237-41. doi: 10.1158/1078-0432.CCR-07-5133.
58. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
59. Denervation and reinnervation of adult skeletal muscle modulate mRNA expression of neuregulin-1 and ErbB receptors. Nicolino S, etal., Microsurgery. 2009;29(6):464-72. doi: 10.1002/micr.20636.
60. Overexpression of ErbB4 is an independent marker for lymph node metastasis in Japanese patients with oral squamous cell carcinoma. Ohashi Y, etal., Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Sep;122(3):313-21. doi: 10.1016/j.oooo.2016.04.017. Epub 2016 May 11.
61. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
62. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
63. MicroRNAs related polymorphisms and genetic susceptibility to esophageal squamous cell carcinoma. Qu Y, etal., Mol Genet Genomics. 2014 Dec;289(6):1123-30. doi: 10.1007/s00438-014-0873-x. Epub 2014 Jun 12.
64. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
65. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
66. Neuregulin in cardiac hypertrophy in rats with aortic stenosis. Differential expression of erbB2 and erbB4 receptors. Rohrbach S, etal., Circulation. 1999 Jul 27;100(4):407-12.
67. A novel polymorphism in the promoter region of ERBB4 is associated with breast and colorectal cancer risk. Rokavec M, etal., Clin Cancer Res. 2007 Dec 15;13(24):7506-14.
68. Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. Sardi SP, etal., Cell. 2006 Oct 6;127(1):185-97.
69. Cytogenetic analysis of HER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients. Sassen A, etal., Breast Cancer Res. 2008 Jan 8;10(1):R2.
70. ErbB receptors and fatty acid synthase expression in aggressive head and neck squamous cell carcinomas. Silva SD, etal., Oral Dis. 2010 Nov;16(8):774-80. doi: 10.1111/j.1601-0825.2010.01687.x.
71. Expression of the c-erbB-3/HER-3 and c-erbB-4/HER-4 growth factor receptors and their ligands, neuregulin-1 alpha, neuregulin-1 beta, and betacellulin, in normal endometrium and endometrial cancer. Srinivasan R, etal., Clin Cancer Res. 1999 Oct;5(10):2877-83.
72. Phyllodes tumor of the breast: EGFR family expression and relation to clinicopathological features. Suo Z and Nesland JM, Ultrastruct Pathol. 2000 Nov-Dec;24(6):371-81.
73. Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons. Tan GH, etal., Nat Neurosci. 2011 Dec 11;15(2):258-66. doi: 10.1038/nn.3005.
74. ErbB4 is downregulated in renal cell carcinoma--a quantitative RT-PCR and immunohistochemical analysis of the epidermal growth factor receptor family. Thomasson M, etal., Acta Oncol. 2004;43(5):453-9.
75. Selective expression of ErbB4 in interneurons, but not pyramidal cells, of the rodent hippocampus. Vullhorst D, etal., J Neurosci. 2009 Sep 30;29(39):12255-64. doi: 10.1523/JNEUROSCI.2454-09.2009.
76. A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling. Vullhorst D, etal., Nat Commun. 2015 Jun 1;6:7222. doi: 10.1038/ncomms8222.
77. Chronic antipsychotic drug administration alters the expression of neuregulin 1beta, ErbB2, ErbB3, and ErbB4 in the rat prefrontal cortex and hippocampus. Wang XD, etal., Int J Neuropsychopharmacol. 2008 Jan 10;:1-9.
78. Neuregulin-1 enhances depolarization-induced GABA release. Woo RS, etal., Neuron. 2007 May 24;54(4):599-610.
79. Effect of regulation of the NRG1/ErbB4 signaling pathway on the visual cortex synaptic plasticity of amblyopic adult rats. Xu L, etal., J Biochem Mol Toxicol. 2021 Sep;35(9):e22841. doi: 10.1002/jbt.22841. Epub 2021 Jul 17.
80. Nuclear translocation of HER-4/c-erbB-4 is significantly correlated with prognosis of esophageal squamous cell carcinoma. Xu S, etal., J Surg Oncol. 2008 Jan 1;97(1):44-50. doi: 10.1002/jso.20892.
81. Upregulation of erbB receptors in rat brain after middle cerebral arterial occlusion. Xu Z and Ford BD, Neurosci Lett. 2005 Mar 3;375(3):181-6. Epub 2004 Dec 16.
82. ErbB4 protects against neuronal apoptosis via activation of YAP/PIK3CB signaling pathway in a rat model of subarachnoid hemorrhage. Yan F, etal., Exp Neurol. 2017 Nov;297:92-100. doi: 10.1016/j.expneurol.2017.07.014. Epub 2017 Jul 27.
83. Neural development of the neuregulin receptor ErbB4 in the cerebral cortex and the hippocampus: preferential expression by interneurons tangentially migrating from the ganglionic eminences. Yau HJ, etal., Cereb Cortex. 2003 Mar;13(3):252-64.
84. A polymorphism within ErbB4 is associated with risk for hepatocellular carcinoma in Chinese population. Yu Q, etal., World J Gastroenterol. 2012 Jan 28;18(4):383-7. doi: 10.3748/wjg.v18.i4.383.
85. Neuregulin-1β Plays a Neuroprotective Role by Inhibiting the Cdk5 Signaling Pathway after Cerebral Ischemia-Reperfusion Injury in Rats. Zhang R, etal., J Mol Neurosci. 2018 Oct;66(2):261-272. doi: 10.1007/s12031-018-1166-3. Epub 2018 Sep 11.
86. Prenatal dexamethasone exposure induces anxiety- and depressive-like behavior of male offspring rats through intrauterine programming of the activation of NRG1-ErbB4 signaling in hippocampal PV interneurons. Zhang S, etal., Cell Biol Toxicol. 2023 Jun;39(3):657-678. doi: 10.1007/s10565-021-09621-0. Epub 2021 Jun 29.
87. Neuregulin signaling in the heart. Dynamic targeting of erbB4 to caveolar microdomains in cardiac myocytes. Zhao YY, etal., Circ Res. 1999 Jun 25;84(12):1380-7.
88. ErbB4 regulates fetal surfactant phospholipid synthesis in primary fetal rat type II cells. Zscheppang K, etal., Am J Physiol Lung Cell Mol Physiol. 2007 Aug;293(2):L429-35. Epub 2007 Jun 1.
Additional References at PubMed
PMID:2025425   PMID:7477376   PMID:8617750   PMID:8702723   PMID:9135143   PMID:9553078   PMID:10348342   PMID:10353604   PMID:10508857   PMID:10572067   PMID:10655590   PMID:10722704  
PMID:12399441   PMID:12646923   PMID:14733940   PMID:15534001   PMID:15543145   PMID:15934939   PMID:15968086   PMID:16778220   PMID:16837552   PMID:17085783   PMID:17120616   PMID:17250808  
PMID:17562386   PMID:17630218   PMID:17646177   PMID:17761534   PMID:18334220   PMID:18458158   PMID:18705011   PMID:19010331   PMID:19505538   PMID:19632177   PMID:20393464   PMID:20495188  
PMID:20943952   PMID:21352860   PMID:21802010   PMID:21962913   PMID:21991932   PMID:22076439   PMID:22244893   PMID:22376909   PMID:23097328   PMID:23382219   PMID:24218551   PMID:24303948  
PMID:24518229   PMID:25177687   PMID:25978692   PMID:26021843   PMID:29674181   PMID:30083275   PMID:35370955   PMID:36584915  


Genomics

Comparative Map Data
Erbb4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8976,973,386 - 78,045,633 (-)NCBIGRCr8
mRatBN7.2969,523,733 - 70,596,743 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl969,531,481 - 70,596,595 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx978,025,868 - 79,086,390 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0983,154,766 - 84,215,249 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0981,560,145 - 82,620,859 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0975,021,790 - 76,178,936 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl975,021,790 - 75,528,644 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0974,804,287 - 75,310,350 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4966,843,898 - 67,967,970 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1966,990,879 - 68,114,952 (-)NCBI
Celera967,006,553 - 68,064,842 (-)NCBICelera
Cytogenetic Map9q32-q33NCBI
ERBB4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382211,375,717 - 212,538,802 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2211,375,717 - 212,538,841 (-)EnsemblGRCh38hg38GRCh38
GRCh372212,240,442 - 213,403,526 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362211,948,687 - 213,111,597 (-)NCBINCBI36Build 36hg18NCBI36
Build 342212,072,320 - 213,228,793NCBI
Celera2206,008,419 - 207,168,130 (-)NCBICelera
Cytogenetic Map2q34NCBI
HuRef2204,087,816 - 205,252,852 (-)NCBIHuRef
CHM1_12212,246,189 - 213,409,602 (-)NCBICHM1_1
T2T-CHM13v2.02211,856,201 - 213,019,445 (-)NCBIT2T-CHM13v2.0
Erbb4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39168,071,063 - 69,147,756 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl168,071,345 - 69,147,218 (-)EnsemblGRCm39 Ensembl
GRCm38168,031,884 - 69,108,576 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl168,032,186 - 69,108,059 (-)EnsemblGRCm38mm10GRCm38
MGSCv37168,086,540 - 69,154,633 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36167,973,174 - 69,041,267 (-)NCBIMGSCv36mm8
Celera168,604,658 - 69,678,621 (-)NCBICelera
Cytogenetic Map1C3NCBI
cM Map133.8NCBI
Erbb4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554573,177,991 - 4,228,558 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554573,177,905 - 4,236,152 (+)NCBIChiLan1.0ChiLan1.0
ERBB4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213113,991,295 - 115,165,716 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B114,006,258 - 115,180,343 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B98,625,630 - 99,795,371 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B217,107,266 - 218,272,621 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B217,069,644 - 218,272,006 (-)Ensemblpanpan1.1panPan2
ERBB4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13719,029,647 - 20,134,576 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3719,037,217 - 20,134,426 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3719,902,993 - 21,014,297 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03718,975,969 - 20,127,356 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3718,980,387 - 20,127,189 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13718,924,908 - 20,033,426 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03718,881,529 - 19,982,057 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03718,890,858 - 19,999,263 (-)NCBIUU_Cfam_GSD_1.0
Erbb4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303167,518,016 - 168,559,414 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365864,066,498 - 5,100,035 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365864,065,767 - 5,100,690 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERBB4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15113,974,437 - 115,096,565 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115113,966,573 - 115,096,984 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215125,910,709 - 126,652,753 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ERBB4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11097,099,090 - 98,281,697 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040101,138,707 - 102,297,290 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Erbb4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247653,613,379 - 4,734,585 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247653,612,781 - 4,742,219 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Erbb4
6591 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:69
Count of miRNA genes:49
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000019283, ENSRNOT00000057877
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)94996854671098346Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat

Markers in Region
D9Rat174  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2969,844,772 - 69,844,966 (+)MAPPERmRatBN7.2
Rnor_6.0975,336,472 - 75,336,665NCBIRnor6.0
Rnor_5.0975,117,642 - 75,117,835UniSTSRnor5.0
RGSC_v3.4967,158,572 - 67,158,766RGDRGSC3.4
RGSC_v3.4967,158,573 - 67,158,766UniSTSRGSC3.4
RGSC_v3.1967,305,554 - 67,305,748RGD
Celera967,318,354 - 67,318,539UniSTS
RH 3.4 Map9628.3RGD
RH 3.4 Map9628.3UniSTS
RH 2.0 Map9657.6RGD
SHRSP x BN Map947.7898RGD
Cytogenetic Map9q32UniSTS
D9Got74  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2970,172,644 - 70,172,807 (+)MAPPERmRatBN7.2
Rnor_6.0975,738,668 - 75,738,830NCBIRnor6.0
Rnor_5.0975,519,466 - 75,519,628UniSTSRnor5.0
RGSC_v3.4967,537,737 - 67,537,900RGDRGSC3.4
RGSC_v3.4967,537,738 - 67,537,900UniSTSRGSC3.4
RGSC_v3.1967,684,720 - 67,684,882RGD
Celera967,643,743 - 67,643,905UniSTS
RH 3.4 Map9626.3UniSTS
RH 3.4 Map9626.3RGD
RH 2.0 Map9655.0RGD
Cytogenetic Map9q32UniSTS
D9Got77  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2970,459,953 - 70,460,096 (+)MAPPERmRatBN7.2
Rnor_6.0976,028,830 - 76,028,972NCBIRnor6.0
Rnor_5.0975,807,607 - 75,807,749UniSTSRnor5.0
RGSC_v3.4967,828,629 - 67,828,772RGDRGSC3.4
RGSC_v3.4967,828,630 - 67,828,772UniSTSRGSC3.4
RGSC_v3.1967,975,612 - 67,975,754RGD
Celera967,930,679 - 67,930,821UniSTS
RH 3.4 Map9631.7UniSTS
RH 3.4 Map9631.7RGD
RH 2.0 Map9681.1RGD
Cytogenetic Map9q32UniSTS
AU049543  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2970,593,746 - 70,593,927 (+)MAPPERmRatBN7.2
Rnor_6.0976,176,708 - 76,176,888NCBIRnor6.0
Rnor_5.0975,956,839 - 75,957,019UniSTSRnor5.0
RGSC_v3.4967,965,742 - 67,965,922UniSTSRGSC3.4
Celera968,062,613 - 68,062,793UniSTS
Cytogenetic Map9q32UniSTS


Genetic Models
This gene Erbb4 is modified in the following models/strains:
F344-Erbb4Tn(sb-T2/Bart3)2.208Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 8 49 113 67 66 36 24 36 6 188 93 93 45 60 30

Sequence


Ensembl Acc Id: ENSRNOT00000019283   ⟹   ENSRNOP00000019283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl969,531,481 - 70,203,829 (-)Ensembl
Rnor_6.0 Ensembl975,021,790 - 75,528,644 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100527   ⟹   ENSRNOP00000097510
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl969,531,481 - 70,596,595 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103925   ⟹   ENSRNOP00000092095
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl969,531,481 - 70,596,595 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118754   ⟹   ENSRNOP00000092891
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl969,531,481 - 70,596,595 (-)Ensembl
RefSeq Acc Id: NM_021687   ⟹   NP_067719
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8976,981,134 - 78,045,606 (-)NCBI
mRatBN7.2969,531,481 - 70,595,975 (-)NCBI
Rnor_6.0975,021,790 - 76,178,936 (-)NCBI
Rnor_5.0974,804,287 - 75,310,350 (-)NCBI
RGSC_v3.4966,843,898 - 67,967,970 (-)RGD
Celera967,006,553 - 68,064,842 (-)RGD
Sequence:
RefSeq Acc Id: XM_039084149   ⟹   XP_038940077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8976,973,386 - 78,045,633 (-)NCBI
mRatBN7.2969,523,733 - 70,596,743 (-)NCBI
RefSeq Acc Id: XM_039084150   ⟹   XP_038940078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8976,973,386 - 78,045,633 (-)NCBI
mRatBN7.2969,523,733 - 70,596,742 (-)NCBI
RefSeq Acc Id: XM_039084151   ⟹   XP_038940079
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8976,973,386 - 78,045,633 (-)NCBI
mRatBN7.2969,523,733 - 70,596,742 (-)NCBI
RefSeq Acc Id: XM_063267662   ⟹   XP_063123732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8976,973,386 - 78,045,633 (-)NCBI
RefSeq Acc Id: NP_067719   ⟸   NM_021687
- Peptide Label: precursor
- UniProtKB: Q9Z2N7 (UniProtKB/Swiss-Prot),   Q6UA29 (UniProtKB/Swiss-Prot),   Q6UA28 (UniProtKB/Swiss-Prot),   Q62956 (UniProtKB/Swiss-Prot),   A0A8I6AIL0 (UniProtKB/TrEMBL),   A6KFE7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019283   ⟸   ENSRNOT00000019283
RefSeq Acc Id: XP_038940077   ⟸   XM_039084149
- Peptide Label: isoform X1
- UniProtKB: Q9Z2N7 (UniProtKB/Swiss-Prot),   Q6UA29 (UniProtKB/Swiss-Prot),   Q6UA28 (UniProtKB/Swiss-Prot),   Q62956 (UniProtKB/Swiss-Prot),   A0A8I6AGX1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940078   ⟸   XM_039084150
- Peptide Label: isoform X2
- UniProtKB: Q9Z2N7 (UniProtKB/Swiss-Prot),   Q6UA29 (UniProtKB/Swiss-Prot),   Q6UA28 (UniProtKB/Swiss-Prot),   Q62956 (UniProtKB/Swiss-Prot),   A0A8I6GMJ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940079   ⟸   XM_039084151
- Peptide Label: isoform X4
- UniProtKB: Q9Z2N7 (UniProtKB/Swiss-Prot),   Q6UA29 (UniProtKB/Swiss-Prot),   Q6UA28 (UniProtKB/Swiss-Prot),   Q62956 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000092095   ⟸   ENSRNOT00000103925
Ensembl Acc Id: ENSRNOP00000092891   ⟸   ENSRNOT00000118754
Ensembl Acc Id: ENSRNOP00000097510   ⟸   ENSRNOT00000100527
RefSeq Acc Id: XP_063123732   ⟸   XM_063267662
- Peptide Label: isoform X3
- UniProtKB: Q9Z2N7 (UniProtKB/Swiss-Prot),   Q6UA29 (UniProtKB/Swiss-Prot),   Q6UA28 (UniProtKB/Swiss-Prot),   Q62956 (UniProtKB/Swiss-Prot)
Protein Domains
Epidermal growth factor receptor-like transmembrane-   Furin-like cysteine-rich   Growth factor receptor   Protein kinase   Receptor L-domain

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62956-F1-model_v2 AlphaFold Q62956 1-1308 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620486 AgrOrtholog
BioCyc Gene G2FUF-27277 BioCyc
Ensembl Genes ENSRNOG00000014248 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019283.7 UniProtKB/TrEMBL
  ENSRNOT00000100527.1 UniProtKB/TrEMBL
  ENSRNOT00000103925.1 UniProtKB/TrEMBL
  ENSRNOT00000118754.1 UniProtKB/TrEMBL
Gene3D-CATH 3.80.20.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.880 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  membrane-bound form of the juxtamembrane domain of the epidermal growth factor receptor like domain UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Furin-like_Cys-rich_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Furin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GF_recep_IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rcpt_L-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rcpt_L-dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RTK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TM_ErbB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_EGF/ERB/XmrK_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:59323 UniProtKB/Swiss-Prot
NCBI Gene 59323 ENTREZGENE
PANTHER RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Furin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GF_recep_IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Recep_L_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TM_ErbB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ERBB4 RGD
PhenoGen Erbb4 PhenoGen
PIRSF TyrPK_EGF-R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014248 RatGTEx
SMART SM00261 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AGX1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AIL0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GMJ5 ENTREZGENE, UniProtKB/TrEMBL
  A6KFE7 ENTREZGENE, UniProtKB/TrEMBL
  A6KFE8_RAT UniProtKB/TrEMBL
  ERBB4_RAT UniProtKB/Swiss-Prot
  F1M7X4_RAT UniProtKB/TrEMBL
  Q62956 ENTREZGENE
  Q6UA27_RAT UniProtKB/TrEMBL
  Q6UA28 ENTREZGENE
  Q6UA29 ENTREZGENE
  Q9Z2N7 ENTREZGENE
UniProt Secondary Q6UA28 UniProtKB/Swiss-Prot
  Q6UA29 UniProtKB/Swiss-Prot
  Q9Z2N7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-06-27     Erbb4  v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Erbb4  v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)    receptor tyrosine kinase  Name updated 1299863 APPROVED
2002-08-07 Erbb4  receptor tyrosine kinase      Symbol and Name status set to provisional 70820 PROVISIONAL