Stk17b (serine/threonine kinase 17b) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Stk17b (serine/threonine kinase 17b) Rattus norvegicus
Analyze
Symbol: Stk17b
Name: serine/threonine kinase 17b
RGD ID: 620457
Description: Enables ATP binding activity and protein serine/threonine kinase activity. Involved in apoptotic process; intracellular signal transduction; and protein autophosphorylation. Located in actin cytoskeleton and nucleus. Orthologous to human STK17B (serine/threonine kinase 17b); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DAP kinase-related apoptosis-inducing protein kinase 2; death-associated protein kinase-related 2; Drak2; serine/threonine kinase 17b (apoptosis-inducing); serine/threonine-protein kinase 17B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8962,801,912 - 62,832,511 (-)NCBIGRCr8
mRatBN7.2955,307,485 - 55,338,085 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl955,307,668 - 55,338,031 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx963,816,526 - 63,846,044 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0968,932,306 - 68,961,824 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0967,228,148 - 67,257,666 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0960,399,261 - 60,430,081 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl960,399,261 - 60,430,081 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0960,084,854 - 60,115,674 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4952,567,310 - 52,596,817 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1952,568,723 - 52,598,231 (-)NCBI
Celera952,803,380 - 52,832,885 (-)NCBICelera
Cytogenetic Map9q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-ethoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
depsipeptide  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dieldrin  (EXP)
doxorubicin  (ISO)
fenamidone  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (EXP)
gentamycin  (EXP)
iloprost  (ISO)
indometacin  (ISO)
inulin  (ISO)
L-ascorbic acid  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
nickel atom  (ISO)
Nonylphenol  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. The apoptosis-inducing protein kinase DRAK2 is inhibited in a calcium-dependent manner by the calcium-binding protein CHP. Kuwahara H, etal., J Biochem. 2003 Aug;134(2):245-50.
4. A serine/threonine kinase which causes apoptosis-like cell death interacts with a calcineurin B-like protein capable of binding Na(+)/H(+) exchanger. Matsumoto M, etal., J Biochem (Tokyo) 2001 Aug;130(2):217-25.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. CFU-C in Agar. Praloran V and Bartocci A, Methods Mol Biol. 1990;5:323-30. doi: 10.1385/0-89603-150-0:323.
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9786912   PMID:18084041  


Genomics

Comparative Map Data
Stk17b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8962,801,912 - 62,832,511 (-)NCBIGRCr8
mRatBN7.2955,307,485 - 55,338,085 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl955,307,668 - 55,338,031 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx963,816,526 - 63,846,044 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0968,932,306 - 68,961,824 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0967,228,148 - 67,257,666 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0960,399,261 - 60,430,081 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl960,399,261 - 60,430,081 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0960,084,854 - 60,115,674 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4952,567,310 - 52,596,817 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1952,568,723 - 52,598,231 (-)NCBI
Celera952,803,380 - 52,832,885 (-)NCBICelera
Cytogenetic Map9q31NCBI
STK17B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382196,133,583 - 196,176,483 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2196,133,583 - 196,176,503 (-)EnsemblGRCh38hg38GRCh38
GRCh372196,998,307 - 197,036,302 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362196,710,102 - 196,744,520 (-)NCBINCBI36Build 36hg18NCBI36
Build 342196,827,364 - 196,861,781NCBI
Celera2190,754,094 - 190,792,103 (-)NCBICelera
Cytogenetic Map2q32.3NCBI
HuRef2188,851,130 - 188,889,152 (-)NCBIHuRef
CHM1_12197,004,189 - 197,042,201 (-)NCBICHM1_1
T2T-CHM13v2.02196,617,655 - 196,666,801 (-)NCBIT2T-CHM13v2.0
Stk17b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39153,794,671 - 53,824,374 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl153,794,665 - 53,824,383 (-)EnsemblGRCm39 Ensembl
GRCm38153,755,512 - 53,785,237 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl153,755,506 - 53,785,224 (-)EnsemblGRCm38mm10GRCm38
MGSCv37153,812,356 - 53,842,059 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36153,700,057 - 53,729,697 (-)NCBIMGSCv36mm8
Celera154,295,821 - 54,325,524 (-)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.99NCBI
Stk17b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554034,115,766 - 4,145,698 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554034,116,130 - 4,145,698 (+)NCBIChiLan1.0ChiLan1.0
STK17B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21398,760,466 - 98,802,611 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B98,775,320 - 98,817,601 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B83,384,562 - 83,422,642 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B201,285,119 - 201,323,314 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B201,285,119 - 201,323,314 (-)Ensemblpanpan1.1panPan2
STK17B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1375,801,482 - 5,822,724 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl375,801,938 - 5,819,903 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha376,747,886 - 6,776,684 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0375,687,153 - 5,715,988 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl375,689,562 - 5,708,010 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1375,687,773 - 5,716,640 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0375,655,102 - 5,683,802 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0375,676,401 - 5,705,213 (-)NCBIUU_Cfam_GSD_1.0
Stk17b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303153,874,501 - 153,903,983 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365062,934,173 - 2,966,614 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365062,934,130 - 2,963,571 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STK17B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15100,029,994 - 100,066,238 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115100,029,987 - 100,066,297 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215111,026,262 - 111,052,787 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STK17B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11081,674,258 - 81,712,148 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1081,674,199 - 81,712,123 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040117,733,618 - 117,771,145 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stk17b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624854853,005 - 879,316 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624854847,030 - 878,617 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Stk17b
65 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:122
Count of miRNA genes:96
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000016856
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)94996854671098346Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat

Markers in Region
UniSTS:498358  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2955,308,204 - 55,308,349 (+)MAPPERmRatBN7.2
Rnor_6.0960,399,981 - 60,400,125NCBIRnor6.0
Rnor_5.0960,085,574 - 60,085,718UniSTSRnor5.0
RGSC_v3.4952,566,937 - 52,567,081UniSTSRGSC3.4
Celera952,803,007 - 52,803,151UniSTS
Cytogenetic Map9q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000016856   ⟹   ENSRNOP00000016857
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl955,307,668 - 55,338,031 (-)Ensembl
Rnor_6.0 Ensembl960,399,261 - 60,430,081 (-)Ensembl
RefSeq Acc Id: NM_133392   ⟹   NP_596883
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8962,803,005 - 62,832,511 (-)NCBI
mRatBN7.2955,308,578 - 55,338,085 (-)NCBI
Rnor_6.0960,400,354 - 60,430,081 (-)NCBI
Rnor_5.0960,084,854 - 60,115,674 (-)NCBI
RGSC_v3.4952,567,310 - 52,596,817 (-)RGD
Celera952,803,380 - 52,832,885 (-)RGD
Sequence:
RefSeq Acc Id: XM_006244908   ⟹   XP_006244970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8962,801,912 - 62,832,509 (-)NCBI
mRatBN7.2955,307,485 - 55,337,330 (-)NCBI
Rnor_6.0960,399,261 - 60,429,951 (-)NCBI
Rnor_5.0960,084,854 - 60,115,674 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039082990   ⟹   XP_038938918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8962,801,912 - 62,832,492 (-)NCBI
mRatBN7.2955,307,485 - 55,337,404 (-)NCBI
RefSeq Acc Id: XM_039082991   ⟹   XP_038938919
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8962,801,912 - 62,820,955 (-)NCBI
mRatBN7.2955,307,485 - 55,326,526 (-)NCBI
RefSeq Acc Id: NP_596883   ⟸   NM_133392
- UniProtKB: Q91XS8 (UniProtKB/Swiss-Prot),   A6INZ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244970   ⟸   XM_006244908
- Peptide Label: isoform X1
- UniProtKB: Q91XS8 (UniProtKB/Swiss-Prot),   A6INZ2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016857   ⟸   ENSRNOT00000016856
RefSeq Acc Id: XP_038938918   ⟸   XM_039082990
- Peptide Label: isoform X1
- UniProtKB: Q91XS8 (UniProtKB/Swiss-Prot),   A6INZ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938919   ⟸   XM_039082991
- Peptide Label: isoform X2
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91XS8-F1-model_v2 AlphaFold Q91XS8 1-371 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696664
Promoter ID:EPDNEW_R7188
Type:multiple initiation site
Name:Stk17b_1
Description:serine/threonine kinase 17b
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0960,430,065 - 60,430,125EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620457 AgrOrtholog
BioCyc Gene G2FUF-27554 BioCyc
Ensembl Genes ENSRNOG00000012502 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055004754 UniProtKB/Swiss-Prot
  ENSRNOG00060022912 UniProtKB/Swiss-Prot
  ENSRNOG00065003146 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016856.5 UniProtKB/Swiss-Prot
  ENSRNOT00055007559 UniProtKB/Swiss-Prot
  ENSRNOT00060039686 UniProtKB/Swiss-Prot
  ENSRNOT00065004420 UniProtKB/Swiss-Prot
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  ST17B_STKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:170904 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 170904 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE 17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE 17B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Stk17b PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012502 RatGTEx
  ENSRNOG00055004754 RatGTEx
  ENSRNOG00060022912 RatGTEx
  ENSRNOG00065003146 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6INZ2 ENTREZGENE, UniProtKB/TrEMBL
  Q91XS8 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Stk17b  serine/threonine kinase 17b  Stk17b  serine/threonine kinase 17b (apoptosis-inducing)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Stk17b  serine/threonine kinase 17b (apoptosis-inducing)      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Stk17b  serine/threonine kinase 17b (apoptosis-inducing)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the nucleus 634154
gene_physical_interaction bind in vitro with calcineurin homologous protein (CHP) 634154