Shc1 (SHC adaptor protein 1) - Rat Genome Database

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Gene: Shc1 (SHC adaptor protein 1) Rattus norvegicus
Analyze
Symbol: Shc1
Name: SHC adaptor protein 1
RGD ID: 620446
Description: Enables enzyme binding activity; epidermal growth factor receptor binding activity; and phosphotyrosine residue binding activity. Involved in several processes, including positive regulation of smooth muscle cell proliferation; positive regulation of vasoconstriction; and response to peptide hormone. Located in endosome membrane. Part of Shc-EGFR complex. Used to study glomerulosclerosis. Biomarker of familial hyperlipidemia and hepatocellular carcinoma. Orthologous to human SHC1 (SHC adaptor protein 1); PARTICIPATES IN mitogen activated protein kinase signaling pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; brain-derived neurotrophic factor signaling pathway; INTERACTS WITH (+)-schisandrin B; (R)-noradrenaline; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: P66shc; SH2 domain protein C1; SHC (Src homology 2 domain containing) transforming protein 1; SHC (Src homology 2 domain-containing) transforming protein 1; SHC-transforming protein 1; src homology 2 domain-containing transforming protein C1; src homology 2 domain-containing-transforming protein C1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Shc1em1Mcwi   Shc1em3Mcwi   Shc1em4Mcwi   Shc1em5Mcwi  
Genetic Models: SS-Shc1em1Mcwi SS-Shc1em5Mcwi SS-Shc1em3Mcwi SS-Shc1em4Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22174,837,937 - 174,849,538 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,837,930 - 174,849,536 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,983,489 - 181,995,027 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02180,005,866 - 180,017,410 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02174,606,456 - 174,618,004 (+)NCBIRnor_WKY
Rnor_6.02188,745,503 - 188,757,066 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,745,503 - 188,757,066 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02208,159,786 - 208,171,348 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,616,581 - 181,628,144 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12181,570,194 - 181,572,439 (+)NCBI
Celera2168,778,680 - 168,790,241 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(R)-noradrenaline  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aluminium oxide  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apocynin  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcium dichloride  (ISO)
calyculin a  (EXP)
carbamazepine  (ISO)
carnosic acid  (ISO)
chloropicrin  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
ethanol  (ISO)
fenamidone  (ISO)
flutamide  (EXP)
folic acid  (ISO)
genistein  (ISO)
ginkgolide B  (ISO)
glafenine  (EXP)
glucose  (ISO)
glycidol  (EXP)
Goe 6976  (EXP)
hispidin  (EXP)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP,ISO)
indometacin  (ISO)
inulin  (ISO)
ivermectin  (ISO)
letrozole  (ISO)
magnesium atom  (ISO)
malathion  (ISO)
malonaldehyde  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodimethylamine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nicotinamide  (ISO)
ochratoxin A  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
prazosin  (EXP)
progesterone  (EXP)
prostaglandin F2alpha  (EXP)
reactive oxygen species  (EXP,ISO)
resveratrol  (ISO)
Salvianolic acid A  (ISO)
SB 431542  (ISO)
selenomethionine  (ISO)
sirtinol  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
streptozocin  (ISO)
sulindac  (ISO)
suramin  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
Tiron  (EXP)
trichostatin A  (ISO)
trimethyltin  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
tyrphostin AG 1478  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA,IMP,ISO)
angiogenesis  (IEA,ISO)
animal organ regeneration  (IEP)
B cell receptor signaling pathway  (ISO)
cell-cell adhesion  (IEA,ISO)
cellular response to growth factor stimulus  (IEA,ISO,ISS)
cellular response to insulin stimulus  (IEP)
defense response to bacterium  (IEA,ISO)
epidermal growth factor receptor signaling pathway  (IBA,IEA,ISO)
heart development  (IEA,ISO)
insulin receptor signaling pathway  (IBA,IDA,IMP,ISO)
insulin-like growth factor receptor signaling pathway  (IEA,ISO)
intracellular signal transduction  (IEA)
negative regulation of angiogenesis  (ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of DNA-templated transcription  (IEA,ISO)
neuron differentiation  (IMP)
neuron projection development  (IMP)
positive regulation of cell population proliferation  (IMP)
positive regulation of cell proliferation in bone marrow  (ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of MAPK cascade  (IMP,ISO)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of vasoconstriction  (IMP)
regulation of cell population proliferation  (IEA,ISO)
regulation of smooth muscle contraction  (IMP)
regulation of superoxide metabolic process  (ISO)
response to endothelin  (IMP)
response to glucocorticoid  (IEP)
response to hydrogen peroxide  (IEP)
response to hypoxia  (IEP)
response to insulin  (IEP)
response to nicotine  (IEP)
response to organic cyclic compound  (IEP)
response to toxic substance  (IEP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Compartmentalization of signaling-competent epidermal growth factor receptors in endosomes. Balbis A, etal., Endocrinology. 2007 Jun;148(6):2944-54. Epub 2007 Mar 15.
2. p53 and p66 proteins compete for hypoxia-inducible factor 1 alpha stabilization in young and old rat hearts exposed to intermittent hypoxia. Bianchi G, etal., Gerontology. 2006;52(1):17-23.
3. Met, metastasis, motility and more. Birchmeier C, etal., Nat Rev Mol Cell Biol. 2003 Dec;4(12):915-25.
4. A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors. Blaikie P, etal., J Biol Chem 1994 Dec 23;269(51):32031-4.
5. A systems biology approach to the pathogenesis of obesity-related nonalcoholic fatty liver disease using reverse phase protein microarrays for multiplexed cell signaling analysis. Calvert VS, etal., Hepatology. 2007 Jul;46(1):166-72.
6. Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress. Camici GG, etal., Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5217-22. Epub 2007 Mar 14.
7. EGF-ERBB signalling: towards the systems level. Citri A and Yarden Y, Nat Rev Mol Cell Biol. 2006 Jul;7(7):505-16.
8. Distinct tyrosine autophosphorylation sites negatively and positively modulate neu-mediated transformation. Dankort DL, etal., Mol Cell Biol. 1997 Sep;17(9):5410-25.
9. ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation. Degoutin J, etal., FEBS Lett. 2007 Feb 20;581(4):727-34. Epub 2007 Jan 25.
10. Effects of age on elements of insulin-signaling pathway in central nervous system of rats. Fernandes ML, etal., Endocrine. 2001 Dec;16(3):227-34.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. The Met tyrosine kinase receptor in development and cancer. Gentile A, etal., Cancer Metastasis Rev. 2008 Mar;27(1):85-94.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Genetic deletion of the p66Shc adaptor protein protects from angiotensin II-induced myocardial damage. Graiani G, etal., Hypertension. 2005 Aug;46(2):433-40. Epub 2005 Jul 5.
15. TrkB receptor signalling: implications in neurodegenerative, psychiatric and proliferative disorders. Gupta VK, etal., Int J Mol Sci. 2013 May 13;14(5):10122-42. doi: 10.3390/ijms140510122.
16. ShcA regulates neurite outgrowth stimulated by neural cell adhesion molecule but not by fibroblast growth factor 2: evidence for a distinct fibroblast growth factor receptor response to neural cell adhesion molecule activation. Hinsby AM, etal., J Neurochem. 2004 Nov;91(3):694-703.
17. Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses. Jensen M, etal., J Biol Chem. 2007 Nov 30;282(48):35179-86. Epub 2007 Oct 9.
18. Effect of long-term exercise on gene expression of insulin signaling pathway intermediates in skeletal muscle. Kim YB, etal., Biochem Biophys Res Commun 1999 Jan 27;254(3):720-7.
19. Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor. Kimura T, etal., J Biol Chem. 1996 Nov 1;271(44):27962-8.
20. Influence of obesity and insulin sensitivity on insulin signalling genes in human omental and subcutaneous adipose tissue. Maclaren R, etal., J Lipid Res. 2007 Nov 6;.
21. Activation loop tyrosines contribute varying roles to TrkB autophosphorylation and signal transduction. McCarty JH and Feinstein SC, Oncogene. 1998 Apr 2;16(13):1691-700.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. p66Shc regulates renal vascular tone in hypertension-induced nephropathy. Miller B, etal., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6.
24. Role of the p66Shc isoform in insulin-like growth factor I receptor signaling through MEK/Erk and regulation of actin cytoskeleton in rat myoblasts. Natalicchio A, etal., J Biol Chem. 2004 Oct 15;279(42):43900-9. Epub 2004 Jul 19.
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. Distinct signaling functions for Shc isoforms in the heart. Obreztchikova M, etal., J Biol Chem. 2006 Jul 21;281(29):20197-204. Epub 2006 May 12.
27. Insulin-induced tyrosine phosphorylation of Shc in liver, muscle and adipose tissue of insulin resistant rats. Paez-Espinosa EV, etal., Mol Cell Endocrinol. 1999 Oct 25;156(1-2):121-9.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
30. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
31. Shc and CEACAM1 interact to regulate the mitogenic action of insulin. Poy MN, etal., J Biol Chem. 2002 Jan 11;277(2):1076-84. Epub 2001 Nov 1.
32. Cholesterol diet-induced hyperlipidemia influences gene expression pattern of rat hearts: a DNA microarray study. Puskas LG, etal., FEBS Lett. 2004 Mar 26;562(1-3):99-104.
33. GOA pipeline RGD automated data pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Dual role of SRC homology domain 2-containing inositol phosphatase 2 in the regulation of platelet-derived growth factor and insulin-like growth factor I signaling in rat vascular smooth muscle cells. Sasaoka T, etal., Endocrinology. 2003 Sep;144(9):4204-14.
37. Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor. Sasaoka T, etal., J Biol Chem. 1994 May 6;269(18):13689-94.
38. The critical role of c-Src and the Shc/Grb2/ERK2 signaling pathway in angiotensin II-dependent VSMC proliferation. Sayeski PP and Ali MS, Exp Cell Res 2003 Jul 15;287(2):339-49.
39. Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity. Smith WW, etal., J Cell Biol. 2005 Apr 25;169(2):331-9. Epub 2005 Apr 18.
40. Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling. Ugi S, etal., Mol Cell Biol 2002 Apr;22(7):2375-87.
41. Chronic nicotine exposure enhances insulin-induced mitogenic signaling via up-regulation of alpha7 nicotinic receptors in isolated rat aortic smooth muscle cells. Wada T, etal., Endocrinology. 2007 Feb;148(2):790-9. Epub 2006 Oct 26.
42. P66shc regulates endothelial NO production and endothelium-dependent vasorelaxation: implications for age-associated vascular dysfunction. Yamamori T, etal., J Mol Cell Cardiol. 2005 Dec;39(6):992-5. Epub 2005 Oct 19.
43. Enhanced expression of adaptor molecule p46 Shc in nuclei of hepatocellular carcinoma cells: study of LEC rats. Yoshida S, etal., Int J Oncol. 2004 Oct;25(4):1089-96.
44. Regulation of insulin receptor function. Youngren JF Cell Mol Life Sci. 2007 Apr;64(7-8):873-91.
45. Identification of p46 Shc expressed in the nuclei of hepatocytes with high proliferating activity: Study of regenerating rat liver. Yuji J, etal., Int J Mol Med. 2004 May;13(5):721-8.
Additional References at PubMed
PMID:1409579   PMID:7537849   PMID:7541045   PMID:8316835   PMID:9722539   PMID:9748281   PMID:9918770   PMID:10196222   PMID:10809671   PMID:11970986   PMID:12008030   PMID:12167719  
PMID:12218049   PMID:12367511   PMID:12477932   PMID:12882334   PMID:12925710   PMID:13679576   PMID:14676841   PMID:15467833   PMID:15488758   PMID:15705774   PMID:16246731   PMID:16481327  
PMID:18413607   PMID:18588882   PMID:18957618   PMID:19060130   PMID:19168439   PMID:20010870   PMID:20392947   PMID:20624904   PMID:22130185   PMID:23215692   PMID:23846654   PMID:24085465  
PMID:24177325   PMID:25667086   PMID:25810038   PMID:26058566   PMID:26203862   PMID:26845416   PMID:27157635   PMID:27770269   PMID:28155123   PMID:29018139   PMID:29486220   PMID:30131395  
PMID:30417389   PMID:31163256   PMID:31202267   PMID:31686782   PMID:32308389   PMID:32633393   PMID:33628383   PMID:34063460   PMID:34087282   PMID:34714691   PMID:35278882  


Genomics

Comparative Map Data
Shc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22174,837,937 - 174,849,538 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,837,930 - 174,849,536 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,983,489 - 181,995,027 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02180,005,866 - 180,017,410 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02174,606,456 - 174,618,004 (+)NCBIRnor_WKY
Rnor_6.02188,745,503 - 188,757,066 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,745,503 - 188,757,066 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02208,159,786 - 208,171,348 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,616,581 - 181,628,144 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12181,570,194 - 181,572,439 (+)NCBI
Celera2168,778,680 - 168,790,241 (+)NCBICelera
Cytogenetic Map2q34NCBI
SHC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381154,962,298 - 154,974,376 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1154,962,298 - 154,974,395 (-)EnsemblGRCh38hg38GRCh38
GRCh371154,934,774 - 154,946,852 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361153,201,398 - 153,213,464 (-)NCBINCBI36Build 36hg18NCBI36
Build 341151,749,351 - 151,756,075NCBI
Celera1128,005,799 - 128,017,984 (-)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1126,296,519 - 126,308,704 (-)NCBIHuRef
CHM1_11156,331,148 - 156,343,332 (-)NCBICHM1_1
T2T-CHM13v2.01154,101,659 - 154,113,737 (-)NCBIT2T-CHM13v2.0
Shc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39389,325,858 - 89,337,336 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl389,325,750 - 89,337,334 (+)EnsemblGRCm39 Ensembl
GRCm38389,418,551 - 89,430,029 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,418,443 - 89,430,027 (+)EnsemblGRCm38mm10GRCm38
MGSCv37389,222,473 - 89,233,951 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36389,504,530 - 89,515,942 (+)NCBIMGSCv36mm8
Celera389,453,612 - 89,465,090 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.11NCBI
Shc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555451,468,391 - 1,476,814 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555451,468,391 - 1,479,209 (-)NCBIChiLan1.0ChiLan1.0
SHC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1194,598,084 - 94,610,336 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01130,310,778 - 130,323,001 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11133,920,532 - 133,932,730 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1133,920,532 - 133,929,008 (-)Ensemblpanpan1.1panPan2
SHC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1742,501,829 - 42,509,613 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl742,500,185 - 42,508,276 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,992,601 - 42,000,693 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0742,371,672 - 42,379,764 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl742,370,281 - 42,379,765 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1742,151,365 - 42,159,456 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0742,204,970 - 42,213,062 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0742,488,555 - 42,496,647 (+)NCBIUU_Cfam_GSD_1.0
Shc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505825,481,178 - 25,491,621 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365804,512,680 - 4,519,715 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365804,511,560 - 4,522,003 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SHC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl494,810,875 - 94,831,765 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1494,818,226 - 94,831,766 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24103,576,217 - 103,588,162 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SHC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1208,854,189 - 8,866,406 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl208,858,458 - 8,866,610 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660388,189,413 - 8,201,613 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Shc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248852,511,240 - 2,521,155 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248852,511,039 - 2,520,883 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Shc1
71 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:747
Count of miRNA genes:258
Interacting mature miRNAs:314
Transcripts:ENSRNOT00000028038, ENSRNOT00000056652
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921175950118Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921184114403Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2172982062175950118Rat
61457Niddm8Non-insulin dependent diabetes mellitus QTL 84.10.01blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)2174543008175950118Rat

Markers in Region
Shc1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,841,506 - 174,842,904 (+)MAPPERmRatBN7.2
Rnor_6.02188,749,037 - 188,750,434NCBIRnor6.0
Rnor_5.02208,163,320 - 208,164,717UniSTSRnor5.0
Celera2168,782,214 - 168,783,611UniSTS
Cytogenetic Map2q34UniSTS


Genetic Models
This gene Shc1 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 38 57 41 19 41 2 5 60 35 34 11 2
Low 5 6 6 14 7 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000028038   ⟹   ENSRNOP00000028038
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,840,825 - 174,849,536 (+)Ensembl
Rnor_6.0 Ensembl2188,748,359 - 188,757,066 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000056652   ⟹   ENSRNOP00000053490
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,837,930 - 174,849,534 (+)Ensembl
Rnor_6.0 Ensembl2188,745,503 - 188,757,066 (+)Ensembl
RefSeq Acc Id: NM_001164060   ⟹   NP_001157532
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22174,840,829 - 174,849,538 (+)NCBI
Rnor_6.02188,748,359 - 188,757,066 (+)NCBI
Rnor_5.02208,159,786 - 208,171,348 (+)NCBI
RGSC_v3.42181,616,581 - 181,628,144 (+)RGD
Celera2168,781,536 - 168,790,241 (+)NCBI
Sequence:
RefSeq Acc Id: NM_053517   ⟹   NP_445969
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22174,837,973 - 174,849,538 (+)NCBI
Rnor_6.02188,745,503 - 188,757,066 (+)NCBI
Rnor_5.02208,159,786 - 208,171,348 (+)NCBI
RGSC_v3.42181,616,581 - 181,628,144 (+)RGD
Celera2168,778,680 - 168,790,241 (+)RGD
Sequence:
RefSeq Acc Id: XM_039103274   ⟹   XP_038959202
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22174,837,937 - 174,849,025 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_445969   ⟸   NM_053517
- Peptide Label: isoform b
- UniProtKB: Q5M824 (UniProtKB/Swiss-Prot),   F1LN14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001157532   ⟸   NM_001164060
- Peptide Label: isoform a
- UniProtKB: G3V8S2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028038   ⟸   ENSRNOT00000028038
RefSeq Acc Id: ENSRNOP00000053490   ⟸   ENSRNOT00000056652
RefSeq Acc Id: XP_038959202   ⟸   XM_039103274
- Peptide Label: isoform X1
Protein Domains
PID   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5M824-F1-model_v2 AlphaFold Q5M824 1-469 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691476
Promoter ID:EPDNEW_R2001
Type:initiation region
Name:Shc1_2
Description:SHC adaptor protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2002  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02188,745,480 - 188,745,540EPDNEW
RGD ID:13691477
Promoter ID:EPDNEW_R2002
Type:initiation region
Name:Shc1_1
Description:SHC adaptor protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2001  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02188,748,345 - 188,748,405EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620446 AgrOrtholog
BioCyc Gene G2FUF-52405 BioCyc
Ensembl Genes ENSRNOG00000020657 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000028038 ENTREZGENE
  ENSRNOP00000028038.4 UniProtKB/TrEMBL
  ENSRNOP00000053490 ENTREZGENE
  ENSRNOP00000053490.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028038 ENTREZGENE
  ENSRNOT00000028038.7 UniProtKB/TrEMBL
  ENSRNOT00000056652 ENTREZGENE
  ENSRNOT00000056652.5 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7323045 IMAGE-MGC_LOAD
InterPro PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PID_Shc-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTB/PI_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHC_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:85385 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:109497 IMAGE-MGC_LOAD
NCBI Gene 85385 ENTREZGENE
PANTHER PTHR10337:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHC TRANSFORMING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Shc1 PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHCPIDOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1LN14 ENTREZGENE, UniProtKB/TrEMBL
  G3V8S2 ENTREZGENE, UniProtKB/TrEMBL
  Q5M824 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-20 Shc1  SHC adaptor protein 1  Shc1  SHC (Src homology 2 domain containing) transforming protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-04 Shc1  SHC (Src homology 2 domain containing) transforming protein 1  Shc1  src homology 2 domain-containing transforming protein C1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Shc1  src homology 2 domain-containing transforming protein C1    SHC (Src homology 2 domain-containing) transforming protein 1  Name updated 1299863 APPROVED
2002-08-07 Shc1  SHC (Src homology 2 domain-containing) transforming protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL