Cga (glycoprotein hormones, alpha polypeptide) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Cga (glycoprotein hormones, alpha polypeptide) Rattus norvegicus
Analyze
Symbol: Cga
Name: glycoprotein hormones, alpha polypeptide
RGD ID: 620436
Description: Predicted to enable follicle-stimulating hormone activity. Predicted to be involved in G protein-coupled receptor signaling pathway; positive regulation of steroid biosynthetic process; and regulation of signaling receptor activity. Predicted to act upstream of or within several processes, including gonadotropin secretion; thyroid gland development; and thyroid hormone generation. Predicted to be located in extracellular region. Predicted to be part of follicle-stimulating hormone complex. Predicted to be active in extracellular space. Orthologous to human CGA (glycoprotein hormones, alpha polypeptide); PARTICIPATES IN follicle-stimulating hormone signaling pathway; luteinizing hormone signaling pathway; autoimmune thyroiditis pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: anterior pituitary glycoprotein hormones common subunit alpha; follicle-stimulating hormone alpha chain; follitropin alpha chain; FSH-alpha; glycoprotein hormone alpha subunit; glycoprotein hormones alpha chain; glycoprotein hormones, alpha subunit; Gpa1; LSH-alpha; luteinizing hormone alpha chain; lutropin alpha chain; pituitary hormone; pituitary hormone alpha subunit; thyroid-stimulating hormone alpha chain; thyrotropin alpha chain; TSH-alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8554,283,109 - 54,295,464 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl554,235,019 - 54,295,464 (+)EnsemblGRCr8
mRatBN7.2549,486,915 - 49,499,192 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl549,487,068 - 49,499,191 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx551,680,297 - 51,692,413 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0553,280,529 - 53,292,645 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0553,182,409 - 53,194,594 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0550,362,491 - 50,393,368 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl550,381,244 - 50,393,367 (+)Ensemblrn6Rnor6.0
Rnor_5.0554,950,198 - 54,962,319 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4551,538,259 - 51,550,324 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera548,231,474 - 48,243,595 (+)NCBICelera
RGSC_v3.1551,538,437 - 51,550,503 (+)NCBI
RH 3.4 Map5269.7RGD
Cytogenetic Map5q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (EXP,ISO)
acetaldehyde  (ISO)
amiodarone  (EXP)
amphotericin B  (ISO)
anandamide  (ISO)
androst-4-ene-3,17-dione  (EXP)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
bifenthrin  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyanamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP,ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dorsomorphin  (ISO)
equol  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
ethylparaben  (ISO)
flufenamic acid  (EXP)
flutamide  (EXP)
fulvestrant  (ISO)
iodoacetic acid  (ISO)
iron dichloride  (ISO)
ketoconazole  (ISO)
lead diacetate  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monosodium L-glutamate  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
nickel sulfate  (EXP,ISO)
nicotine  (ISO)
nimodipine  (ISO)
Nonylphenol  (EXP)
Octicizer  (ISO)
octreotide  (ISO)
pentanal  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
Phenelzine  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
progesterone  (EXP,ISO)
propanal  (ISO)
prostaglandin E2  (EXP,ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
sodium perchlorate  (EXP)
sophoraflavanone B  (EXP)
T-2 toxin  (ISO)
tamoxifen  (ISO)
taurine  (EXP,ISO)
tebuconazole  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
thapsigargin  (ISO)
theophylline  (ISO)
thimerosal  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Fetal but not adult Leydig cells are susceptible to adenoma formation in response to persistently high hCG level: a study on hCG overexpressing transgenic mice. Ahtiainen P, etal., Oncogene. 2005 Nov 10;24(49):7301-9.
2. Human chorionic gonadotropin and free subunits' serum levels in patients with partial and complete hydatidiform moles. Berkowitz R, etal., Obstet Gynecol. 1989 Aug;74(2):212-6.
3. CGA gene (coding for the alpha subunit of glycoprotein hormones) overexpression in ER alpha-positive prostate tumors. Bieche I, etal., Eur Urol. 2002 Mar;41(3):335-41.
4. The CGA gene as new predictor of the response to endocrine therapy in ER alpha-positive postmenopausal breast cancer patients. Bieche I, etal., Oncogene. 2001 Oct 18;20(47):6955-9.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. alpha Subunit of rat pituitary glycoprotein hormones. Primary structure of the precursor determined from the nucleotide sequence of cloned cDNAs. Godine JE, etal., J Biol Chem 1982 Jul 25;257(14):8368-71.
7. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Distribution and characterization of alpha hCG in the serum and tumor cytosol of patients with breast cancer. Shindelman JE, etal., Int J Cancer. 1980 May 15;25(5):599-604.
Additional References at PubMed
PMID:2467841   PMID:2494176   PMID:11207219   PMID:12114718   PMID:12477932   PMID:20352046   PMID:21187122   PMID:22206666   PMID:23299500   PMID:24692546  


Genomics

Comparative Map Data
Cga
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8554,283,109 - 54,295,464 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl554,235,019 - 54,295,464 (+)EnsemblGRCr8
mRatBN7.2549,486,915 - 49,499,192 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl549,487,068 - 49,499,191 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx551,680,297 - 51,692,413 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0553,280,529 - 53,292,645 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0553,182,409 - 53,194,594 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0550,362,491 - 50,393,368 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl550,381,244 - 50,393,367 (+)Ensemblrn6Rnor6.0
Rnor_5.0554,950,198 - 54,962,319 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4551,538,259 - 51,550,324 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera548,231,474 - 48,243,595 (+)NCBICelera
RGSC_v3.1551,538,437 - 51,550,503 (+)NCBI
RH 3.4 Map5269.7RGD
Cytogenetic Map5q21NCBI
CGA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38687,085,498 - 87,095,106 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl687,085,498 - 87,095,106 (-)Ensemblhg38GRCh38
GRCh37687,795,216 - 87,804,824 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36687,851,941 - 87,861,543 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34687,851,940 - 87,861,543NCBI
Celera688,213,978 - 88,223,577 (-)NCBICelera
Cytogenetic Map6q14.3NCBI
HuRef685,012,102 - 85,021,750 (-)NCBIHuRef
CHM1_1687,892,792 - 87,902,440 (-)NCBICHM1_1
T2T-CHM13v2.0688,294,252 - 88,303,837 (-)NCBIT2T-CHM13v2.0
Cga
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39434,893,779 - 34,907,374 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl434,893,779 - 34,907,370 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38434,893,779 - 34,907,374 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl434,893,779 - 34,907,370 (+)Ensemblmm10GRCm38
MGSCv37434,841,028 - 34,854,623 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36435,082,666 - 35,096,261 (+)NCBIMGSCv36mm8
Celera434,617,733 - 34,630,763 (+)NCBICelera
Cytogenetic Map4A5NCBI
cM Map416.86NCBI
Cga
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541114,092,743 - 14,095,302 (-)Ensembl
ChiLan1.0NW_00495541114,092,743 - 14,168,297 (-)NCBIChiLan1.0ChiLan1.0
CGA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25107,164,947 - 107,177,621 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16105,061,393 - 105,071,234 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0684,962,974 - 84,972,638 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1688,237,550 - 88,247,051 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl688,236,206 - 88,247,300 (-)EnsemblpanPan2panpan1.1
CGA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11246,610,801 - 46,629,322 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1246,610,973 - 46,636,640 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1246,421,893 - 46,423,957 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01247,386,566 - 47,405,165 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1247,386,743 - 47,405,483 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11246,708,843 - 46,710,907 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01246,638,576 - 46,640,642 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01246,827,170 - 46,829,230 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cga
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494681,774,384 - 81,791,558 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365104,679,321 - 4,696,529 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365104,679,349 - 4,696,511 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CGA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl155,551,320 - 55,568,991 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1155,552,675 - 55,569,057 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2162,245,797 - 62,262,149 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1p21NCBI
CGA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11311,560,543 - 11,578,070 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1311,560,222 - 11,578,093 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040187,751,845 - 187,768,611 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cga
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247997,249,586 - 7,265,999 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247997,249,502 - 7,265,662 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Cga
43 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:36
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000012385
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51757663362576633Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1578774Tcas8Tongue tumor susceptibility QTL 83.47tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)51570745160707451Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)51748608062486080Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51460607859606078Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51748608062486080Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2303577Gluco47Glucose level QTL 473blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51652001961520019Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)52367149368671493Rat

Markers in Region
RH139948  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map5269.7UniSTS
Cytogenetic Map5q13-q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 1 1 60 17 12 4 9 4 2 63 16 54 33 54 8

Sequence


Ensembl Acc Id: ENSRNOT00000012385   ⟹   ENSRNOP00000012385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl554,235,019 - 54,295,464 (+)Ensembl
mRatBN7.2 Ensembl549,487,068 - 49,499,191 (+)Ensembl
Rnor_6.0 Ensembl550,381,244 - 50,393,367 (+)Ensembl
RefSeq Acc Id: NM_053918   ⟹   NP_446370
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8554,283,340 - 54,295,464 (+)NCBI
mRatBN7.2549,487,068 - 49,499,192 (+)NCBI
Rnor_6.0550,381,244 - 50,393,365 (+)NCBI
Rnor_5.0554,950,198 - 54,962,319 (+)NCBI
RGSC_v3.4551,538,259 - 51,550,324 (+)RGD
Celera548,231,474 - 48,243,595 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063287072   ⟹   XP_063143142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8554,283,109 - 54,295,464 (+)NCBI
RefSeq Acc Id: XM_063287073   ⟹   XP_063143143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8554,283,109 - 54,295,464 (+)NCBI
RefSeq Acc Id: NP_446370   ⟸   NM_053918
- Peptide Label: precursor
- UniProtKB: P11962 (UniProtKB/Swiss-Prot),   P70516 (UniProtKB/Swiss-Prot),   A0A0F7RQ24 (UniProtKB/TrEMBL),   Q6P509 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012385   ⟸   ENSRNOT00000012385
RefSeq Acc Id: XP_063143143   ⟸   XM_063287073
- Peptide Label: isoform X1
- UniProtKB: P70516 (UniProtKB/Swiss-Prot),   P11962 (UniProtKB/Swiss-Prot),   A0A0F7RQ24 (UniProtKB/TrEMBL),   Q6P509 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143142   ⟸   XM_063287072
- Peptide Label: isoform X1
- UniProtKB: P70516 (UniProtKB/Swiss-Prot),   P11962 (UniProtKB/Swiss-Prot),   A0A0F7RQ24 (UniProtKB/TrEMBL),   Q6P509 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11962-F1-model_v2 AlphaFold P11962 1-120 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620436 AgrOrtholog
BioCyc Gene G2FUF-41645 BioCyc
Ensembl Genes ENSRNOG00000009269 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012385.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6922315 IMAGE-MGC_LOAD
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot
  Glyco_hormone UniProtKB/Swiss-Prot
KEGG Report rno:116700 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72733 IMAGE-MGC_LOAD
NCBI Gene 116700 ENTREZGENE
PANTHER GLYCOPROTEIN HORMONES ALPHA CHAIN UniProtKB/Swiss-Prot
  PTHR11509 UniProtKB/Swiss-Prot
Pfam Hormone_6 UniProtKB/Swiss-Prot
PhenoGen Cga PhenoGen
PRINTS GLYCOHORMONE UniProtKB/Swiss-Prot
PROSITE GLYCO_HORMONE_ALPHA_1 UniProtKB/Swiss-Prot
  GLYCO_HORMONE_ALPHA_2 UniProtKB/Swiss-Prot
  GLYCO_HORMONE_ALPHA_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009269 RatGTEx
SMART GHA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniProt A0A0F7RQ24 ENTREZGENE, UniProtKB/TrEMBL
  A6IIP0_RAT UniProtKB/TrEMBL
  GLHA_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P70516 ENTREZGENE
  Q6P509 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P70516 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-02-04 Cga  glycoprotein hormones, alpha polypeptide  Cga  glycoprotein hormones, alpha subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Cga  glycoprotein hormones, alpha subunit      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Cga        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein precursor protein consists of a 24 amino acid leader sequence and a 96 amino acid alpha subunit apoprotein 632382