Adam15 (ADAM metallopeptidase domain 15) - Rat Genome Database

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Gene: Adam15 (ADAM metallopeptidase domain 15) Rattus norvegicus
Analyze
Symbol: Adam15
Name: ADAM metallopeptidase domain 15
RGD ID: 620402
Description: Predicted to enable SH3 domain binding activity; metalloendopeptidase activity; and signaling receptor binding activity. Involved in male gonad development; response to hypobaric hypoxia; and tissue regeneration. Predicted to be located in cell surface and extracellular exosome. Predicted to be active in extracellular space. Orthologous to human ADAM15 (ADAM metallopeptidase domain 15); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-amino-2-deoxy-D-glucopyranose; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: a disintegrin and metallopeptidase domain 15 (metargidin); a disintegrin and metalloproteinase domain (ADAM) 15 (metargidin); a disintegrin and metalloproteinase domain 15; a disintegrin and metalloproteinase domain 15 (metargidin); ADAM 15; CRII-7; disintegrin and metalloproteinase domain-containing protein 15; MDC-15; MDC15; metalloprotease RGD disintegrin protein; metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15; metargidin; tMDC VI; tMDCVI
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82177,052,363 - 177,062,879 (-)NCBIGRCr8
mRatBN7.22174,754,629 - 174,765,136 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,754,633 - 174,765,113 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,899,637 - 181,910,172 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,922,013 - 179,932,548 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02174,522,552 - 174,533,074 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,661,831 - 188,672,337 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,661,699 - 188,672,247 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02208,071,874 - 208,082,531 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,527,175 - 181,537,640 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12181,477,282 - 181,487,746 (-)NCBI
Celera2168,696,199 - 168,706,661 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells. Bax DV, etal., J Biol Chem. 2004 May 21;279(21):22377-86. Epub 2004 Feb 16.
2. Homeostatic effects of the metalloproteinase disintegrin ADAM15 in degenerative cartilage remodeling. Bohm BB, etal., Arthritis Rheum. 2005 Apr;52(4):1100-9.
3. Cellular localization of the disintegrin CRII-7/rMDC15 mRNA in rat PNS and CNS and regulated expression in postnatal development and after nerve injury. Bosse F, etal., Glia 2000 Dec;32(3):313-27.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1. Howard L, etal., J Biol Chem. 1999 Oct 29;274(44):31693-9.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Chronological gene expression of ADAMs during testicular development: prespermatogonia (gonocytes) express fertilin beta (ADAM2). Rosselot C, etal., Dev Dyn. 2003 Jul;227(3):458-67.
12. Differential expression of ADAM15 and ADAM17 metalloproteases in the rat brain after severe hypobaric hypoxia and hypoxic preconditioning. Rybnikova E, etal., Neurosci Res. 2012 Apr;72(4):364-73. doi: 10.1016/j.neures.2011.12.010. Epub 2012 Jan 2.
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14. Increased expression of ADAM 9 and ADAM 15 mRNA in pancreatic cancer. Yamada D, etal., Anticancer Res. 2007 Mar-Apr;27(2):793-9.
Additional References at PubMed
PMID:9291465   PMID:12777399   PMID:19156209   PMID:22167186   PMID:22505472   PMID:24006456  


Genomics

Comparative Map Data
Adam15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82177,052,363 - 177,062,879 (-)NCBIGRCr8
mRatBN7.22174,754,629 - 174,765,136 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,754,633 - 174,765,113 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,899,637 - 181,910,172 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,922,013 - 179,932,548 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02174,522,552 - 174,533,074 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,661,831 - 188,672,337 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,661,699 - 188,672,247 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02208,071,874 - 208,082,531 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,527,175 - 181,537,640 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12181,477,282 - 181,487,746 (-)NCBI
Celera2168,696,199 - 168,706,661 (-)NCBICelera
Cytogenetic Map2q34NCBI
ADAM15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381155,051,316 - 155,062,775 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1155,050,566 - 155,062,775 (+)EnsemblGRCh38hg38GRCh38
GRCh371155,023,792 - 155,035,251 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361153,290,386 - 153,301,876 (+)NCBINCBI36Build 36hg18NCBI36
Build 341151,836,834 - 151,848,325NCBI
Celera1128,094,785 - 128,106,774 (+)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1126,385,749 - 126,397,256 (+)NCBIHuRef
CHM1_11156,419,572 - 156,431,076 (+)NCBICHM1_1
T2T-CHM13v2.01154,190,701 - 154,202,162 (+)NCBIT2T-CHM13v2.0
Adam15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39389,246,947 - 89,257,589 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl389,245,849 - 89,257,303 (-)EnsemblGRCm39 Ensembl
GRCm38389,339,640 - 89,350,028 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,338,542 - 89,349,996 (-)EnsemblGRCm38mm10GRCm38
MGSCv37389,143,562 - 89,153,932 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36389,424,469 - 89,435,909 (-)NCBIMGSCv36mm8
Celera389,374,683 - 89,385,053 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.07NCBI
Adam15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555451,545,635 - 1,555,614 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555451,545,532 - 1,555,826 (+)NCBIChiLan1.0ChiLan1.0
ADAM15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2194,778,158 - 94,789,698 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,510,197 - 94,521,712 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01130,398,961 - 130,410,860 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11134,008,959 - 134,020,467 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1134,008,959 - 134,020,467 (+)Ensemblpanpan1.1panPan2
ADAM15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1742,432,067 - 42,443,463 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl742,428,113 - 42,443,429 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,923,026 - 41,933,600 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0742,301,837 - 42,312,428 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl742,301,842 - 42,312,494 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1742,081,565 - 42,092,138 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0742,135,440 - 42,145,971 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0742,418,961 - 42,429,316 (-)NCBIUU_Cfam_GSD_1.0
Adam15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505825,557,826 - 25,568,277 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365804,588,039 - 4,599,014 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365804,588,182 - 4,598,659 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAM15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl494,736,646 - 94,748,098 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1494,736,639 - 94,748,093 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24103,518,254 - 103,529,683 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAM15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1208,767,836 - 8,779,399 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl208,768,112 - 8,779,311 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660388,102,189 - 8,113,704 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adam15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248852,441,217 - 2,451,057 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248852,441,298 - 2,451,061 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adam15
42 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:260
Count of miRNA genes:160
Interacting mature miRNAs:170
Transcripts:ENSRNOT00000027970, ENSRNOT00000050868
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
61457Niddm8Non-insulin dependent diabetes mellitus QTL 84.10.01blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)2174543008175950118Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921175950118Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921184114403Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2172982062175950118Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat

Markers in Region
RH135252  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,760,548 - 174,760,742 (+)MAPPERmRatBN7.2
Rnor_6.02188,667,749 - 188,667,942NCBIRnor6.0
Rnor_5.02208,077,790 - 208,077,983UniSTSRnor5.0
RGSC_v3.42181,533,091 - 181,533,284UniSTSRGSC3.4
Celera2168,702,118 - 168,702,311UniSTS
RH 3.4 Map21155.9UniSTS
Cytogenetic Map2q34UniSTS
RH139781  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,754,659 - 174,754,849 (+)MAPPERmRatBN7.2
Rnor_6.02188,661,860 - 188,662,049NCBIRnor6.0
Rnor_5.02208,071,901 - 208,072,090UniSTSRnor5.0
RGSC_v3.42181,527,202 - 181,527,391UniSTSRGSC3.4
Celera2168,696,226 - 168,696,415UniSTS
RH 3.4 Map21156.4UniSTS
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 21 102 39 11 27 11 15 6 135 101 96 57 3
Low 39 188 136 42 136 21 39 115 14 49 21
Below cutoff

Sequence


Ensembl Acc Id: ENSRNOT00000027970   ⟹   ENSRNOP00000027970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,754,635 - 174,765,098 (-)Ensembl
Rnor_6.0 Ensembl2188,661,699 - 188,672,226 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000050868   ⟹   ENSRNOP00000039351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,754,665 - 174,765,088 (-)Ensembl
Rnor_6.0 Ensembl2188,661,835 - 188,672,247 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105677   ⟹   ENSRNOP00000091249
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,754,633 - 174,765,113 (-)Ensembl
RefSeq Acc Id: NM_001399128   ⟹   NP_001386057
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,052,363 - 177,062,849 (-)NCBI
mRatBN7.22174,754,629 - 174,765,116 (-)NCBI
RefSeq Acc Id: NM_001399129   ⟹   NP_001386058
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,052,363 - 177,062,849 (-)NCBI
mRatBN7.22174,754,629 - 174,765,116 (-)NCBI
RefSeq Acc Id: NM_020308   ⟹   NP_064704
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,052,363 - 177,062,849 (-)NCBI
mRatBN7.22174,754,629 - 174,765,116 (-)NCBI
Rnor_6.02188,661,833 - 188,672,297 (-)NCBI
Rnor_5.02208,071,874 - 208,082,531 (-)NCBI
RGSC_v3.42181,527,175 - 181,537,640 (-)RGD
Celera2168,696,199 - 168,706,661 (-)RGD
Sequence:
RefSeq Acc Id: XM_006232744   ⟹   XP_006232806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,052,365 - 177,062,865 (-)NCBI
mRatBN7.22174,754,631 - 174,765,136 (-)NCBI
Rnor_6.02188,661,831 - 188,672,337 (-)NCBI
Rnor_5.02208,071,874 - 208,082,531 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761203   ⟹   XP_008759425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,052,365 - 177,062,879 (-)NCBI
mRatBN7.22174,754,631 - 174,765,136 (-)NCBI
Rnor_6.02188,661,831 - 188,672,337 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761204   ⟹   XP_008759426
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,052,365 - 177,062,865 (-)NCBI
mRatBN7.22174,754,631 - 174,765,136 (-)NCBI
Rnor_6.02188,661,831 - 188,672,337 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591056   ⟹   XP_017446545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,053,217 - 177,062,866 (-)NCBI
mRatBN7.22174,755,487 - 174,765,136 (-)NCBI
Rnor_6.02188,662,680 - 188,672,337 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063282423   ⟹   XP_063138493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,053,184 - 177,062,866 (-)NCBI
RefSeq Acc Id: NP_064704   ⟸   NM_020308
- Peptide Label: isoform 3 precursor
- UniProtKB: A6J6F0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232806   ⟸   XM_006232744
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AF83 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759426   ⟸   XM_008761204
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008759425   ⟸   XM_008761203
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017446545   ⟸   XM_017591056
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000027970   ⟸   ENSRNOT00000027970
Ensembl Acc Id: ENSRNOP00000039351   ⟸   ENSRNOT00000050868
Ensembl Acc Id: ENSRNOP00000091249   ⟸   ENSRNOT00000105677
RefSeq Acc Id: NP_001386057   ⟸   NM_001399128
- Peptide Label: isoform 1 precursor
- UniProtKB: Q9QYV0 (UniProtKB/Swiss-Prot),   Q6P779 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001386058   ⟸   NM_001399129
- Peptide Label: isoform 2 precursor
RefSeq Acc Id: XP_063138493   ⟸   XM_063282423
- Peptide Label: isoform X5
Protein Domains
Disintegrin   EGF-like   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QYV0-F1-model_v2 AlphaFold Q9QYV0 1-864 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691486
Promoter ID:EPDNEW_R1996
Type:initiation region
Name:Adam15_1
Description:ADAM metallopeptidase domain 15
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02188,672,315 - 188,672,375EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620402 AgrOrtholog
BioCyc Gene G2FUF-52412 BioCyc
Ensembl Genes ENSRNOG00000020590 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027970.5 UniProtKB/Swiss-Prot
  ENSRNOT00000050868.5 UniProtKB/Swiss-Prot
  ENSRNOT00000105677.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5597908 IMAGE-MGC_LOAD
InterPro ADAM_Cys-rich UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:57025 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72471 IMAGE-MGC_LOAD
NCBI Gene 57025 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11905:SF130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Reprolysin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adam15 PhenoGen
PROSITE ADAM_MEPRO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020590 RatGTEx
SMART ACR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DISIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57552 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AF83 ENTREZGENE, UniProtKB/TrEMBL
  A6J6F0 ENTREZGENE, UniProtKB/TrEMBL
  ADA15_RAT UniProtKB/Swiss-Prot
  Q6P779 ENTREZGENE
  Q9QYV0 ENTREZGENE
UniProt Secondary Q6P779 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-02-21 Adam15  ADAM metallopeptidase domain 15  Adam15  a disintegrin and metallopeptidase domain 15 (metargidin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Adam15  a disintegrin and metallopeptidase domain 15 (metargidin)    a disintegrin and metalloproteinase domain 15 (metargidin)  Name updated 1299863 APPROVED
2004-09-10 Adam15  a disintegrin and metalloproteinase domain 15 (metargidin)    a disintegrin and metalloproteinase domain (ADAM) 15 (metargidin)  Name updated 1299863 APPROVED
2002-08-07 Adam15  a disintegrin and metalloproteinase domain (ADAM) 15 (metargidin)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a disintegrin and a metalloprotease domain 632016
gene_expression expressed in Schwann cells, brain, spinal cord and endothelial cells of peripheral nerve 632016
gene_expression differentially expressed during Wallerian degeneration and nerve regeneration 632016
gene_protein 85 kDa 632016