Gene: Kl (Klotho) Rattus norvegicus
Analyze
Symbol:
Kl
Name:
Klotho
Description:
Predicted to have beta-glucosidase activity; fibroblast growth factor binding activity; and fibroblast growth factor receptor binding activity. Involved in several processes, including norepinephrine biosynthetic process; response to angiotensin; and response to vitamin D. Predicted to localize to membrane. Used to study familial hyperlipidemia; hypertension; and kidney failure. Biomarker of chronic kidney disease (multiple); hypertension; retinitis pigmentosa; secondary hyperparathyroidism; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Prinzmetal angina; coronary artery disease; intracranial embolism; and spondylosis. Orthologous to human KL (klotho); PARTICIPATES IN fibroblast growth factor signaling pathway; pentose and glucuronate interconversion pathway; starch and sucrose metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
KL (klotho) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Kl (klotho) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Kl (klotho) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
KL (klotho) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
KL (klotho) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Kl (klotho) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
KL (klotho) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
KL (klotho) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Kl (klotho) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
LCT (lactase) HGNC
OrthoMCL
Homo sapiens (human):
KLB (klotho beta) HGNC
OrthoMCL
Alliance orthologs 3
Homo sapiens (human):
KL (klotho)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Mus musculus (house mouse):
Kl (klotho)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Danio rerio (zebrafish):
kl (klotho)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Drosophila melanogaster (fruit fly):
CG9701
Alliance
DIOPT (Ensembl Compara|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Caenorhabditis elegans (roundworm):
klo-1
Alliance
DIOPT (Ensembl Compara|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Caenorhabditis elegans (roundworm):
klo-2
Alliance
DIOPT (Ensembl Compara|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 12 942,974 - 987,206 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 12 943,006 - 987,551 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 12 929,158 - 972,144 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 12 3,732,712 - 3,772,371 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 12 3,732,711 - 3,772,371 (-) NCBI Celera 12 2,195,730 - 2,234,485 (+) NCBI Celera Cytogenetic Map 12 p12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
hyperphosphatemic familial tumoral calcinosis ISO RGD:732783 8554872 ClinVar Annotator: match by term: Tumoral calcinosis, familial, hyperphosphatemic ClinVar Hyperphosphatemic Familial Tumoral Calcinosis 1 ISO RGD:732783 8554872 ClinVar Annotator: match by term: Hyperphosphatemic familial tumoral calcinosis 1 ClinVar PMID:17710231 more ... Hyperphosphatemic Familial Tumoral Calcinosis 1 ISO RGD:732783 8554872 ClinVar Annotator: match by term: Hyperphosphatemic familial tumoral calcinosis 1 ClinVar Hyperphosphatemic Familial Tumoral Calcinosis 3 ISO RGD:732783 8554872 ClinVar Annotator: match by term: Hyperphosphatemic familial tumoral calcinosis 3 ClinVar PMID:17710231 more ... Hyperphosphatemic Familial Tumoral Calcinosis 3 ISO RGD:732783 8554872 ClinVar Annotator: match by term: Hyperphosphatemic familial tumoral calcinosis 3 ClinVar PMID:28492532 Hyperphosphatemic Familial Tumoral Calcinosis 3 ISO RGD:732783 8554872 ClinVar Annotator: match by term: Hyperphosphatemic familial tumoral calcinosis 3 ClinVar
Imported Annotations - CTD
Animal Disease Models ISO RGD:732783 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25550330 arteriosclerosis ISO RGD:732783 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9363890 calcinosis ISO RGD:732783 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17710231 coronary artery disease ISO RGD:732783 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12669274 Emphysema ISO RGD:732783 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9363890 hypercalcemia ISO RGD:732783 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17710231 Hypercalcemia, Infantile, 1 ISO RGD:732783 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20394945 Hypercalciuria, Childhood Idiopathic ISO RGD:732783 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20394945 hyperphosphatemia ISO RGD:732783 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17710231 infertility ISO RGD:732783 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9363890 kidney disease ISO RGD:732783 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:23665422 learning disability ISO RGD:732783 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25309793 Memory Disorders ISO RGD:732783 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25309793 , PMID:25550330 osteoporosis ISO RGD:732783 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9363890 Premature Aging ISO RGD:732783 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9363890 , PMID:25550330 skin disease ISO RGD:732783 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:9363890 type 2 diabetes mellitus ISO RGD:732783 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28869590 Imported Annotations - MGI
hyperphosphatemic familial tumoral calcinosis ISS RGD:732784 13592920 OMIM:211900 MouseDO pulmonary emphysema ISS RGD:732784 13592920 OMIM:130700 MouseDO Imported Annotations - OMIM
Hyperphosphatemic Familial Tumoral Calcinosis 3 ISO RGD:732783 7240710 OMIM
(-)-epigallocatechin 3-gallate decreases expression ISO RGD:732783 6480464 epigallocatechin gallate results in decreased expression of KL mRNA CTD PMID:20706672 (Z)-ligustilide increases expression ISO RGD:732784 6480464 ligustilide results in increased expression of KL mRNA, ligustilide results in increased expression of KL protein CTD PMID:23973442 (Z)-ligustilide increases expression ISO RGD:732783 6480464 ligustilide results in increased expression of KL mRNA, ligustilide results in increased expression of KL protein CTD PMID:23973442 1,1-dichloroethene decreases expression ISO RGD:732784 6480464 vinylidene chloride results in decreased expression of KL mRNA CTD PMID:26682919 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of KL mRNA CTD PMID:29097150 17beta-estradiol 3-glucosiduronic acid multiple interactions ISO RGD:732784 6480464 estradiol-3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] CTD PMID:14701853 17beta-estradiol 3-glucosiduronic acid increases hydrolysis ISO RGD:732784 6480464 KL protein results in increased hydrolysis of estradiol-3-glucuronide CTD PMID:14701853 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO RGD:732783 6480464 Dihydrotestosterone results in increased expression of KL mRNA CTD PMID:29581250 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:732784 6480464 KL protein inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of PDLIM2 protein]] more ... CTD PMID:29885354 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of KL mRNA CTD PMID:32109520 2,4,6-trinitrobenzenesulfonic acid multiple interactions ISO RGD:732784 6480464 KL protein inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TRPV5 protein] CTD PMID:23747339 2,4,6-trinitrobenzenesulfonic acid decreases expression ISO RGD:732784 6480464 Trinitrobenzenesulfonic Acid results in decreased expression of KL protein CTD PMID:23747339 3,3',4,4',5-pentachlorobiphenyl multiple interactions ISO RGD:732783 6480464 [3 more ... CTD PMID:31820026 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:732784 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of KL mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of KL protein CTD PMID:31009676 4-hydroperoxycyclophosphamide decreases expression ISO RGD:732784 6480464 perfosfamide results in decreased expression of KL mRNA CTD PMID:19429390 amino acid multiple interactions ISO RGD:732784 6480464 Amino Acids inhibits the reaction [KL gene mutant form results in decreased expression of BCL2 protein] more ... CTD PMID:25309793 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of KL mRNA CTD PMID:16483693 androsterone 3-glucosiduronic acid multiple interactions ISO RGD:732784 6480464 androsterone glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] CTD PMID:14701853 arsenous acid increases expression ISO RGD:732783 6480464 Arsenic Trioxide results in increased expression of KL mRNA CTD PMID:27829220 benzo[a]pyrene increases expression ISO RGD:732783 6480464 Benzo(a)pyrene results in increased expression of KL mRNA CTD PMID:19152381 benzo[a]pyrene increases expression ISO RGD:732784 6480464 Benzo(a)pyrene results in increased expression of KL mRNA CTD PMID:27195522 benzo[a]pyrene multiple interactions ISO RGD:732783 6480464 chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of KL mRNA] CTD PMID:19152381 bis(2-chloroethyl) sulfide decreases expression ISO RGD:732784 6480464 Mustard Gas results in decreased expression of KL mRNA CTD PMID:15674843 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of KL mRNA CTD PMID:25181051 , PMID:29097150 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of KL mRNA CTD PMID:30816183 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of KL gene CTD PMID:28505145 bleomycin A2 decreases expression ISO RGD:732784 6480464 Bleomycin results in decreased expression of KL mRNA CTD PMID:29408570 cadmium atom affects methylation ISO RGD:732783 6480464 Cadmium affects the methylation of KL gene CTD PMID:23665422 cadmium dichloride increases methylation EXP 6480464 Cadmium Chloride results in increased methylation of KL promoter CTD PMID:22457795 calciol multiple interactions ISO RGD:732783 6480464 [3 more ... CTD PMID:31820026 calcium atom affects abundance ISO RGD:732784 6480464 KL protein affects the abundance of Calcium CTD PMID:11796525 calcium atom multiple interactions ISO RGD:732784 6480464 KL protein inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] inhibits the reaction [TRPV5 protein results in increased uptake of Calcium]] CTD PMID:23747339 calcium(0) affects abundance ISO RGD:732784 6480464 KL protein affects the abundance of Calcium CTD PMID:11796525 calcium(0) multiple interactions ISO RGD:732784 6480464 KL protein inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] inhibits the reaction [TRPV5 protein results in increased uptake of Calcium]] CTD PMID:23747339 cocaine increases expression ISO RGD:732783 6480464 Cocaine results in increased expression of KL mRNA CTD PMID:15009677 cyclosporin A decreases expression ISO RGD:732784 6480464 Cyclosporine results in decreased expression of KL protein CTD PMID:23765110 cyclosporin A decreases expression ISO RGD:732783 6480464 Cyclosporine results in decreased expression of KL mRNA CTD PMID:27989131 cyclosporin A multiple interactions ISO RGD:732784 6480464 Acetylcysteine inhibits the reaction [Cyclosporine results in decreased expression of KL protein] CTD PMID:23765110 dehydroepiandrosterone multiple interactions ISO RGD:732784 6480464 Dehydroepiandrosterone analog inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] CTD PMID:14701853 dexamethasone multiple interactions ISO RGD:732784 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of KL mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of KL protein CTD PMID:31009676 diarsenic trioxide increases expression ISO RGD:732783 6480464 Arsenic Trioxide results in increased expression of KL mRNA CTD PMID:27829220 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of KL mRNA, Doxorubicin results in decreased expression of KL protein CTD PMID:20606417 doxorubicin multiple interactions EXP 6480464 EPO protein inhibits the reaction [Doxorubicin results in decreased expression of KL mRNA], EPO protein inhibits the reaction [Doxorubicin results in decreased expression of KL protein] CTD PMID:20606417 elemental selenium multiple interactions ISO RGD:732783 6480464 [Selenium co-treated with Vitamin E] results in increased expression of KL mRNA CTD PMID:19244175 estriol 3-O-(beta-D-glucuronide) increases hydrolysis ISO RGD:732784 6480464 KL protein results in increased hydrolysis of estriol 3-glucuronide CTD PMID:14701853 estriol 3-O-(beta-D-glucuronide) multiple interactions ISO RGD:732784 6480464 estriol 3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] CTD PMID:14701853 estrone 3-O-(beta-D-glucuronide) increases hydrolysis ISO RGD:732784 6480464 KL protein results in increased hydrolysis of estrone-3-glucuronide CTD PMID:14701853 estrone 3-O-(beta-D-glucuronide) multiple interactions ISO RGD:732784 6480464 estrone-3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] CTD PMID:14701853 ethanol affects expression ISO RGD:732784 6480464 Ethanol affects the expression of KL mRNA CTD PMID:30319688 fosinopril increases expression EXP 6480464 Fosinopril results in increased expression of KL mRNA, Fosinopril results in increased expression of KL protein CTD PMID:21051829 genistein decreases expression ISO RGD:732783 6480464 Genistein results in decreased expression of KL mRNA CTD PMID:20706672 glycidol increases expression EXP 6480464 glycidol results in increased expression of KL mRNA CTD PMID:24395379 indoxyl sulfate decreases expression EXP 6480464 Indican results in decreased expression of KL mRNA CTD PMID:21389697 indoxyl sulfate decreases expression ISO RGD:732783 6480464 Indican results in decreased expression of KL mRNA, Indican results in decreased expression of KL protein CTD PMID:21389697 indoxyl sulfate multiple interactions ISO RGD:732783 6480464 Acetylcysteine inhibits the reaction [Indican results in decreased expression of KL mRNA] more ... CTD PMID:21389697 lead diacetate affects expression EXP 6480464 lead acetate affects the expression of KL mRNA CTD PMID:21864555 lead diacetate decreases expression ISO RGD:732784 6480464 lead acetate results in decreased expression of KL mRNA CTD PMID:22609695 lipopolysaccharide increases expression ISO RGD:732784 6480464 Lipopolysaccharides results in increased expression of KL mRNA CTD PMID:12057914 malonaldehyde multiple interactions ISO RGD:732784 6480464 Amino Acids inhibits the reaction [KL gene mutant form results in increased abundance of Malondialdehyde], H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in increased abundance of Malondialdehyde]] CTD PMID:25309793 malonaldehyde increases abundance ISO RGD:732784 6480464 KL gene mutant form results in increased abundance of Malondialdehyde CTD PMID:25309793 melatonin multiple interactions ISO RGD:732784 6480464 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]] more ... CTD PMID:25550330 mono(2-ethylhexyl) phthalate decreases expression ISO RGD:732784 6480464 mono-(2-ethylhexyl)phthalate results in decreased expression of KL mRNA CTD PMID:22401849 N-acetyl-L-cysteine multiple interactions ISO RGD:732784 6480464 Acetylcysteine inhibits the reaction [Cyclosporine results in decreased expression of KL protein] CTD PMID:23765110 N-acetyl-L-cysteine increases expression ISO RGD:732783 6480464 Acetylcysteine results in increased expression of KL protein CTD PMID:21389697 N-acetyl-L-cysteine multiple interactions ISO RGD:732783 6480464 Acetylcysteine inhibits the reaction [Indican results in decreased expression of KL mRNA], Acetylcysteine inhibits the reaction [Indican results in decreased expression of KL protein] CTD PMID:21389697 N-acetyl-L-cysteine increases expression EXP 6480464 Acetylcysteine results in increased expression of KL protein CTD PMID:23183129 Osajin decreases expression ISO RGD:732783 6480464 osajin results in decreased expression of KL mRNA CTD PMID:20706672 paraquat decreases response to substance ISO RGD:732784 6480464 KL protein results in decreased susceptibility to Paraquat CTD PMID:16186101 phenobarbital decreases expression ISO RGD:732783 6480464 Phenobarbital results in decreased expression of KL mRNA CTD PMID:19084549 phosphorus atom affects abundance ISO RGD:732784 6480464 KL protein affects the abundance of Phosphorus CTD PMID:11796525 phosphorus(.) affects abundance ISO RGD:732784 6480464 KL protein affects the abundance of Phosphorus CTD PMID:11796525 Pomiferin decreases expression ISO RGD:732783 6480464 pomiferin results in decreased expression of KL mRNA CTD PMID:20706672 potassium dichromate increases expression ISO RGD:732784 6480464 Potassium Dichromate results in increased expression of KL mRNA CTD PMID:23608068 propanal decreases expression ISO RGD:732783 6480464 propionaldehyde results in decreased expression of KL mRNA CTD PMID:26079696 puerarin decreases expression ISO RGD:732783 6480464 puerarin results in decreased expression of KL mRNA CTD PMID:20706672 pyrrolidine dithiocarbamate increases expression ISO RGD:732783 6480464 pyrrolidine dithiocarbamic acid results in increased expression of KL protein CTD PMID:21389697 pyrrolidine dithiocarbamate multiple interactions ISO RGD:732783 6480464 pyrrolidine dithiocarbamic acid inhibits the reaction [Indican results in decreased expression of KL mRNA], pyrrolidine dithiocarbamic acid inhibits the reaction [Indican results in decreased expression of KL protein] CTD PMID:21389697 resveratrol decreases expression ISO RGD:732783 6480464 resveratrol results in decreased expression of KL mRNA CTD PMID:20706672 resveratrol multiple interactions ISO RGD:732783 6480464 ATF3 protein affects the reaction [resveratrol results in increased expression of KL mRNA] CTD PMID:24911970 resveratrol increases expression EXP 6480464 resveratrol results in increased expression of KL mRNA, resveratrol results in increased expression of KL protein CTD PMID:24911970 resveratrol multiple interactions EXP 6480464 ATF3 protein affects the reaction [resveratrol results in increased expression of KL mRNA] more ... CTD PMID:24911970 resveratrol increases expression ISO RGD:732784 6480464 resveratrol results in increased expression of KL mRNA, resveratrol results in increased expression of KL protein CTD PMID:24911970 resveratrol increases expression ISO RGD:732783 6480464 Resveratrol results in increased expression of KL mRNA, Resveratrol results in increased expression of KL protein CTD PMID:24911970 retinyl acetate increases expression ISO RGD:732784 6480464 retinol acetate results in increased expression of KL mRNA CTD PMID:16772331 Rosavin decreases expression ISO RGD:732783 6480464 rosavin results in decreased expression of KL mRNA CTD PMID:20706672 selenium atom multiple interactions ISO RGD:732783 6480464 [Selenium co-treated with Vitamin E] results in increased expression of KL mRNA CTD PMID:19244175 SL-327 multiple interactions ISO RGD:732784 6480464 SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]] more ... CTD PMID:25550330 sodium chlorate decreases expression ISO RGD:732783 6480464 sodium chlorate results in decreased expression of KL protein CTD PMID:27432882 streptozocin decreases expression EXP 6480464 Streptozocin results in decreased expression of KL CTD PMID:24136780 streptozocin multiple interactions EXP 6480464 rosiglitazone inhibits the reaction [Streptozocin results in decreased expression of KL] CTD PMID:24136780 taurocholic acid multiple interactions ISO RGD:732784 6480464 Taurocholic Acid inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] CTD PMID:14701853 testosterone 17-glucosiduronic acid multiple interactions ISO RGD:732784 6480464 testosterone glucuronate inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] CTD PMID:14701853 troglitazone increases expression EXP 6480464 troglitazone results in increased expression of KL mRNA CTD PMID:11768731 valproic acid decreases methylation ISO RGD:732783 6480464 Valproic Acid results in decreased methylation of KL gene CTD PMID:29154799 valsartan increases expression EXP 6480464 Valsartan results in increased expression of KL mRNA, Valsartan results in increased expression of KL protein CTD PMID:21051829 vancomycin increases expression ISO RGD:732784 6480464 Vancomycin results in increased expression of KL mRNA CTD PMID:18930951 vitamin D multiple interactions ISO RGD:732783 6480464 KL protein affects the reaction [FGF23 protein affects the abundance of Vitamin D] CTD PMID:17710231 vitamin E multiple interactions ISO RGD:732783 6480464 [Selenium co-treated with Vitamin E] results in increased expression of KL mRNA CTD PMID:19244175 zinc atom decreases expression ISO RGD:732783 6480464 Zinc deficiency results in decreased expression of KL mRNA CTD PMID:18356318 zinc(0) decreases expression ISO RGD:732783 6480464 Zinc deficiency results in decreased expression of KL mRNA CTD PMID:18356318
Biological Process acute inflammatory response IDA 633145 RGD aging TAS 633145 RGD aging IEA UniProtKB:Q9UEF7 , ensembl:ENSP000003694421600115 GO_REF:0000107 Ensembl GO_REF:0000107 aging IEA UniProtKB:O35082 , ensembl:ENSMUSP000000778991600115 GO_REF:0000107 Ensembl GO_REF:0000107 aging IEP 10403069 RGD aging ISO RGD:732783 1624291 (PMID:11792841) RGD PMID:11792841 aging ISO RGD:732784 1624291 MGI:MGI:1889570 (MGI:MGI:1099360 , PMID:9363890) RGD MGI:MGI:1099360 , PMID:9363890 calcium ion homeostasis ISO RGD:732784 1624291 MGI:MGI:1316731 (MGI:MGI:5318164 , PMID:22285620) RGD MGI:MGI:5318164 , PMID:22285620 calcium ion homeostasis IEA UniProtKB:O35082 , ensembl:ENSMUSP000000778991600115 GO_REF:0000107 Ensembl GO_REF:0000107 carbohydrate metabolic process IEA InterPro:IPR001360 1600115 GO_REF:0000002 InterPro GO_REF:0000002 energy reserve metabolic process ISO RGD:732784 1624291 MGI:MGI:1889570 (MGI:MGI:1927946 , PMID:11095966) RGD MGI:MGI:1927946 , PMID:11095966 energy reserve metabolic process IEA UniProtKB:O35082 , ensembl:ENSMUSP000000778991600115 GO_REF:0000107 Ensembl GO_REF:0000107 fibroblast growth factor receptor signaling pathway IBA MGI:MGI:1101771 more ... 13792537 PMID:21873635 GO_Central insulin receptor signaling pathway IEA InterPro:IPR028546 1600115 GO_REF:0000002 InterPro GO_REF:0000002 negative regulation of systemic arterial blood pressure IMP 10403068 RGD norepinephrine biosynthetic process IMP 10403068 RGD positive regulation of bone mineralization ISO RGD:732783 1624291 (PMID:12110410) RGD PMID:12110410 positive regulation of bone mineralization IEA UniProtKB:Q9UEF7 , ensembl:ENSP000003694421600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway ISO RGD:732784 1624291 MGI:MGI:1890427 (MGI:MGI:3640642 , PMID:16436388) RGD MGI:MGI:3640642 , PMID:16436388 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway IEA UniProtKB:O35082 , ensembl:ENSMUSP000000778991600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to activity IEP 10401895 RGD response to angiotensin IEP 70544 RGD response to fibroblast growth factor IEP 8554413 RGD response to vitamin D IEP 10403078 RGD Cellular Component apical plasma membrane IEA UniProtKB-SubCell:SL-0015 1600115 GO_REF:0000044 UniProt GO_REF:0000044 endoplasmic reticulum IBA MGI:MGI:2183549 , PANTHER:PTN004151052 13792537 PMID:21873635 GO_Central extracellular space IEA InterPro:IPR028546 1600115 GO_REF:0000002 InterPro GO_REF:0000002 integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000043 UniProt GO_REF:0000043 membrane TAS 633145 RGD Molecular Function beta-glucosidase activity IBA PANTHER:PTN000039458 more ... 13792537 PMID:21873635 GO_Central beta-glucuronidase activity IEA EC:3.2.1.31 1600115 GO_REF:0000003 UniProt GO_REF:0000003 fibroblast growth factor binding ISO RGD:732783 1624291 UniProtKB:O95750 (PMID:18829467) RGD PMID:18829467 fibroblast growth factor binding IBA MGI:MGI:1101771 more ... 13792537 PMID:21873635 GO_Central fibroblast growth factor binding ISO RGD:732784 1624291 UniProtKB:Q9EPC2 (MGI:MGI:3696596 , PMID:17086194) RGD MGI:MGI:3696596 , PMID:17086194 fibroblast growth factor binding IEA UniProtKB:Q9UEF7 , ensembl:ENSP000003694421600115 GO_REF:0000107 Ensembl GO_REF:0000107 fibroblast growth factor binding IEA UniProtKB:O35082 , ensembl:ENSMUSP000000778991600115 GO_REF:0000107 Ensembl GO_REF:0000107 fibroblast growth factor receptor binding IEA UniProtKB:O35082 , ensembl:ENSMUSP000000778991600115 GO_REF:0000107 Ensembl GO_REF:0000107 fibroblast growth factor receptor binding IBA MGI:MGI:1101771 more ... 13792537 PMID:21873635 GO_Central fibroblast growth factor receptor binding ISO RGD:732784 1624291 UniProtKB:P16092 (MGI:MGI:3696596 , PMID:17086194) RGD MGI:MGI:3696596 , PMID:17086194 hydrolase activity, hydrolyzing O-glycosyl compounds IEA InterPro:IPR001360 1600115 GO_REF:0000002 InterPro GO_REF:0000002 protein binding ISO RGD:732784 1624291 MGI:MGI:95524 more ... RGD MGI:MGI:3640642 more ...
Gene-Chemical Interaction Annotations
